Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma.

Abstract:

:There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma samples were obtained from The Cancer Genome Atlas (TCGA) database. The coexpression network of lncRNAs and autophagy-related genes was utilized to select autophagy-related lncRNAs. The lncRNAs were further screened using univariate Cox regression. In addition, Lasso regression and multivariate Cox regression were used to develop an autophagy-related lncRNA signature. A risk score based on the signature was established, and Cox regression was used to test whether it was an independent prognostic factor. The functional enrichment of autophagy-related lncRNAs was visualized using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Ten prognostic autophagy-related lncRNAs (AC027307.2, AC068580.3, AL138756.1, CD27-AS1, EIF3J-DT, LINC01011, LINC01063, LINC02381, AC073896.3, and SNHG16) were identified to be significantly different, which made up an autophagy-related lncRNA signature. The signature divided patients with colon adenocarcinoma into the low-risk group and the high-risk group. A risk score based on the signature was a significantly independent factor for the patients with colon adenocarcinoma (HR = 1.088, 95%CI = 1.057 - 1.120; P < 0.001). Additionally, the ten lncRNAs were significantly enriched in autophagy process, metabolism, and tumor classical pathways. In conclusion, the ten autophagy-related lncRNAs and their signature might be molecular biomarkers and therapeutic targets for the patients with colon adenocarcinoma.

journal_name

Biomed Res Int

authors

Zhou W,Zhang S,Li HB,Cai Z,Tang S,Chen LX,Lang JY,Chen Z,Chen XL

doi

10.1155/2020/9807918

subject

Has Abstract

pub_date

2020-09-02 00:00:00

pages

9807918

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

杂志文章
  • Inhibitory Effect of Lactobacillus plantarum FL75 and Leuconostoc mesenteroides FL14 against Foodborne Pathogens in Artificially Contaminated Fermented Tomato Juices.

    abstract::Tomatoes and tomato based-foods contain beneficial microorganisms and various organic acids that have important nutritional values for human. The objective of this study was to access the physiochemical properties of fermented tomatoes juices and to evaluate the competitiveness of lactic acid bacteria (LAB) against Li...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6937837

    authors: Bah A,Albano H,Barbosa JB,Fhoula I,Gharbi Y,Najjari A,Boudabous A,Teixeira P,Ouzari HI

    更新日期:2019-02-26 00:00:00

  • Aesthetic evaluation of the nasolabial region in children with unilateral cleft lip and palate comparing expert versus nonexperience health professionals.

    abstract::Esthetic evaluation of cleft lip and palate rehabilitation outcomes may assist in the determination of new surgical interventions and aid in reevaluation of treatment protocols. Our objective was to compare esthetics assessments of the nasolabial region in children with a unilateral cleft lip and palate between health...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/460106

    authors: Paiva TS,Andre M,Paiva WS,Mattos BS

    更新日期:2014-01-01 00:00:00

  • Morphophysiological and Comparative Metabolic Profiling of Purslane Genotypes (Portulaca oleracea L.) under Salt Stress.

    abstract::Purslane, a fleshy herbaceous plant, plays a pivotal role in various preventive and therapeutic purposes. To date, no report has documented the consequence of salt stress on metabolite accumulation in purslane. Herein, we proposed an insight into the metabolic and physiological traits of purslane under saline stress e...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4827045

    authors: Zaman S,Bilal M,Du H,Che S

    更新日期:2020-06-17 00:00:00

  • The influence of hypoxia during different pregnancy stages on cardiac collagen accumulation in the adult offspring.

    abstract::We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/419805

    authors: Wang L,Li M,Huang Z,Wang Z

    更新日期:2014-01-01 00:00:00

  • Downregulation of miR-224-5p Promotes Migration and Proliferation in Human Dental Pulp Stem Cells.

    abstract:Introduction:Pulp regeneration, as a treatment for pulp necrosis, has significant advantages over root canal therapy for the preservation of living pulp. To date, research on pulp regeneration has mainly focused on the transplantation of pulp stem cells into the root canal, but there is still a lack of research on the ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4759060

    authors: Ke Z,Qiu Z,Xiao T,Zeng J,Zou L,Lin X,Hu X,Lin S,Lv H

    更新日期:2019-07-18 00:00:00

  • Genome-Wide Identification of Putative MicroRNAs in Cassava (Manihot esculenta Crantz) and Their Functional Landscape in Cellular Regulation.

    abstract::MicroRNAs are small noncoding RNAs, involved in the regulation of many cellular processes in plants. Hundreds of miRNAs have been identified in cassava by various techniques, yet these identifications were constrained by a lack of miRNA templates and the narrow range of conditions in transcriptome study. In this resea...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2019846

    authors: Yawichai A,Kalapanulak S,Thammarongtham C,Saithong T

    更新日期:2019-06-19 00:00:00

  • Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction.

    abstract::Cognitive dysfunction is an important complicated disease in obesity. Exercise ameliorates obesity and the related cognitive dysfunction. However, the underlying mechanism is still unclear. In this study, we investigated whether aerobic interval training (AIT) could attenuate high-fat-diet- (HFD-) associated cognitive...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2708491

    authors: Shi Z,Li C,Yin Y,Yang Z,Xue H,Mu N,Wang Y,Liu M,Ma H

    更新日期:2018-03-22 00:00:00

  • Intratumoral Heterogeneity of MAGE-C1/CT7 and MAGE-C2/CT10 Expression in Mucosal Melanoma.

    abstract::Mucosal melanoma is a rare disease, which differs from its cutaneous counterpart genetically and for its clinical behaviour. Moreover this is a heterogeneous disease based on the tissue of origin. As CT7 and CT10 are highly expressed in cutaneous melanoma and are immunogenic in this disease, we analysed their expressi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/432479

    authors: Curioni-Fontecedro A,Pitocco R,Schoenewolf NL,Holzmann D,Soldini D,Dummer R,Calvieri S,Moch H,Mihic-Probst D,Fitsche A

    更新日期:2015-01-01 00:00:00

  • MicroRNAs: new regulators of Toll-like receptor signalling pathways.

    abstract::Toll-like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are responsible for the innate immune responses via signalling pathways to provide effective host defence against pathogen infections. However, TLR-signalling pathways are also likely to stringently regulate tissue maintenance and h...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/945169

    authors: He X,Jing Z,Cheng G

    更新日期:2014-01-01 00:00:00

  • The Coumarin Derivative 5'-Hydroxy Auraptene Suppresses Osteoclast Differentiation via Inhibiting MAPK and c-Fos/NFATc1 Pathways.

    abstract::The phytochemical substances, coumarin derivatives, have demonstrated antiresorptive bone effects by suppressing osteoclast differentiation in vitro and in vivo. Recently, we have identified 5'-hydroxy auraptene (5'-HA), a coumarin derivative isolated from Lotus lalambensis Schweinf, as a novel stimulator for osteobla...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9395146

    authors: Abdallah BM,Ali EM,Elsawy H,Badr GM,Abdel-Moneim AM,Alzahrani AM

    更新日期:2019-12-28 00:00:00

  • Factor XIII Subunit A in the Skin: Applications in Diagnosis and Treatment.

    abstract::The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controve...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/3571861

    authors: Paragh L,Törőcsik D

    更新日期:2017-01-01 00:00:00

  • Detection of Folliculin Gene Mutations in Two Chinese Families with Birt-Hogg-Dube Syndrome.

    abstract::Birt-Hogg-Dube syndrome (BHD, OMIM#135150) is a rare disease in clinic; it is characterized by skin fibrofolliculomas, pulmonary cysts with an increased risk of recurrent pneumothorax, renal cysts, and renal neoplasms. Previous studies have demonstrated that variants in folliculin (FLCN, NM_144997) are mainly responsi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/8751384

    authors: Liu L,Yang K,Wang X,Shi Z,Yang Y,Yuan Y,Guo T,Xiao X,Luo H

    更新日期:2017-01-01 00:00:00

  • Circular RNA cir-ITCH Is a Potential Therapeutic Target for the Treatment of Castration-Resistant Prostate Cancer.

    abstract::cir-ITCH, a well-known tumor-suppressive circular RNA, plays a critical role in different cancers. However, its expression and functional role in prostate cancer (PCa) are unclear. Herein, we explored the potential mechanism and tumor-inhibiting role of cir-ITCH in PCa. Using reverse transcriptase polymerase chain rea...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7586521

    authors: Li S,Yu C,Zhang Y,Liu J,Jia Y,Sun F,Zhang P,Li J,Guo L,Xiao H,Gao F,Deng X,Cai Z,Cai J

    更新日期:2020-08-20 00:00:00

  • Distinct Epitopes on CD13 Mediate Opposite Consequences for Cell Adhesion.

    abstract::CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metas...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4093435

    authors: Garay-Canales CA,Licona-Limón I,Ortega E

    更新日期:2018-03-29 00:00:00

  • Involved-field radiotherapy versus elective nodal irradiation in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer: a prospective randomized study.

    abstract::This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that higher dose could be de...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2013/371819

    authors: Chen M,Bao Y,Ma HL,Hu X,Wang J,Wang Y,Peng F,Zhou QC,Xie CH

    更新日期:2013-01-01 00:00:00

  • Psoriasis: female skin changes in various hormonal stages throughout life--puberty, pregnancy, and menopause.

    abstract::Psoriasis is one of the most prevalent immune mediated skin diseases worldwide. Despite the large prevalence in both men and women, the pathogenesis of this disease has not yet been fully clarified. Nowadays, it is believed that psoriasis is most likely a T helper Th1/Th17 induced inflammatory disease. Stressful life ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/571912

    authors: Ceovic R,Mance M,Bukvic Mokos Z,Svetec M,Kostovic K,Stulhofer Buzina D

    更新日期:2013-01-01 00:00:00

  • Expression and Functional Characterization of a Novel Antimicrobial Peptide: Human Beta-Defensin 118.

    abstract:Purpose:β-Defensin 118 (DEFB118) is a novel host defense peptide (HDP) identified in humans. To evaluate its potentials for future utilization, the DEFB118 gene was expressed in Escherichia coli (E. coli) and the recombinant protein was fully characterized. Methods:The DEFB118 protein was obtained by heterologous expr...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1395304

    authors: Lin Q,Xie K,Chen D,Yu B,Mao X,Yu J,Luo J,Zheng P,Luo Y,Yan H,He J

    更新日期:2020-11-09 00:00:00

  • Glutamine/glutamate metabolism studied with magnetic resonance spectroscopic imaging for the characterization of adrenal nodules and masses.

    abstract:PURPOSE:To assess glutamine/glutamate (Glx) and lactate (Lac) metabolism using proton magnetic resonance spectroscopic imaging (1H-MRS) in order to differentiate between adrenal gland nodules and masses (adenomas, pheochromocytomas, carcinomas, and metastases). MATERIALS AND METHODS:Institutional review board approval...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/835385

    authors: Goldman SM,Nunes TF,Melo HJ,Dalavia C,Szejnfeld D,Kater C,Andreoni C,Szejnfeld J,Ajzen SA

    更新日期:2013-01-01 00:00:00

  • Malnutrition among 6-59-Month-Old Children at District 2 Hospital, Ho Chi Minh City, Vietnam: Prevalence and Associated Factors.

    abstract:Objectives:Childhood malnutrition is major health concern in many low- and middle-income countries, including Vietnam. It was a major risk factor for child mortality and adult ill-health. Malnutrition could increase the risk of serious infections; conversely current diseases also had a negative impact on the growth of ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6921312

    authors: Huynh G,Huynh QHN,Nguyen NHT,Do QT,Khanh Tran V

    更新日期:2019-02-05 00:00:00

  • Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation.

    abstract:Background:The pathogenesis of abdominal aortic aneurysm (AAA) is characterized by atherosclerosis with chronic inflammation in the aortic wall. Montelukast is a selective cys-LT 1 receptor antagonist that can suppress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activit...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9104680

    authors: Kawai Y,Narita Y,Yamawaki-Ogata A,Usui A,Komori K

    更新日期:2019-05-27 00:00:00

  • Labeling of Chromosomes in Cell Development and the Appearance of Monozygotic Twins.

    abstract::Understanding the mechanism behind the structure of the internal cellular clock can lead to advances in the knowledge of origins of pairs of monozygotic twins and higher order multiples as well as other biological phenomena. To gain insight into this mechanism, we analyze possible cell labeling schemes that model an o...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/628092

    authors: Jim C,Berkovich S

    更新日期:2015-01-01 00:00:00

  • The association between autoantibodies and peripheral neuropathy in lupus nephritis.

    abstract:BACKGROUND AND AIM:The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. METHODS:Dat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/524940

    authors: Su YJ,Huang CR,Chang WN,Tsai NW,Kung CT,Lin WC,Huang CC,Su CM,Cheng BC,Chang YT,Lu CH

    更新日期:2014-01-01 00:00:00

  • Analysis of the Clinicopathological Characteristics and Risk Factors in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease.

    abstract:Objective:To investigate the clinicopathological characteristics and risk factors in patients with lung cancer and COPD. Materials and Methods:We retrospectively reviewed the clinical data of 282 patients with lung cancer, including 174 and 108 patients with and without COPD, respectively. Information on age, sex, smo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8398156

    authors: Miao JL,Cai JJ,Qin XF,Liu RJ

    更新日期:2018-02-14 00:00:00

  • Differences in trunk kinematic between frail and nonfrail elderly persons during turn transition based on a smartphone inertial sensor.

    abstract:OBJECTIVE:Firstly, to, through instrumentation with the iPhone4 smartphone, measure and describe variability of tridimensional acceleration, angular velocity, and displacement of the trunk in the turn transition during the ten-meter Extended Timed-Get-up-and-Go test in two groups of frail and physically active elderly ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/279197

    authors: Galán-Mercant A,Cuesta-Vargas AI

    更新日期:2013-01-01 00:00:00

  • Histochemical Study of the Rat Uterine Glycoconjugate Alteration following Treatment with Exogenous Gonadotropic Hormones during the Implantation Period.

    abstract::One of the female causes of infertility is anovulation which is treatable with gonadotropin hormones. These hormones affect the molecular organization of the uterus such as glycoconjugates that are the first site of contact between the blastocyst and the uterus. The objective of this project was to study the alteratio...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3967427

    authors: Aliabadi E,Makoolati Z,Talaei-Khozani T,Ardekani FM,Aliabadi A

    更新日期:2020-12-04 00:00:00

  • Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma.

    abstract::The objective of this study was the synthesis of folic acid- (FA-) targeted polymeric micelles of Synperonic PE/F 127-cholesteryl hemisuccinate (PF127-Chol) for specific delivery of docetaxel (DTX). Targeted or nontargeted micelles loaded with DTX were prepared via dialysis method. The effects of processing variables ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/746093

    authors: Varshosaz J,Taymouri S,Hassanzadeh F,Javanmard SH,Rostami M

    更新日期:2015-01-01 00:00:00

  • Peripheral leukocyte apoptosis in patients with Parkinsonism: correlation with clinical characteristics and neuroimaging findings.

    abstract::Apoptosis of both brain neurons and peripheral blood leukocyte is believed to be an important biomarker for evaluating the functional status of Parkinson's disease (PD). However, their correlation remains unknown. A better understanding of the pathophysiology of neurodegeneration is essential for the treatment and pre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/635923

    authors: Lin WC,Tsai NW,Huang YC,Cheng KY,Chen HL,Li SH,Kung CT,Su YJ,Lin WM,Chen MH,Chiu TM,Yang IH,Lu CH

    更新日期:2014-01-01 00:00:00

  • Determining the Clinical Value and Critical Pathway of GTPBP4 in Lung Adenocarcinoma Using a Bioinformatics Strategy: A Study Based on Datasets from The Cancer Genome Atlas.

    abstract::Lung cancer is the leading cause of cancer-related death worldwide, and the most common histologic subtype is lung adenocarcinoma (LUAD). Due to the significant mortality and morbidity rates among patients with LUAD, the identification of novel biomarkers to guide diagnosis, prognosis, and therapy is urgent. Guanosine...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5171242

    authors: Zhang Z,Wang J,Mao J,Li F,Chen W,Wang W

    更新日期:2020-10-19 00:00:00

  • Edited Magnetic Resonance Spectroscopy Detects an Age-Related Decline in Nonhuman Primate Brain GABA Levels.

    abstract::Recent research had shown a correlation between aging and decreasing Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. However, how GABA level varies with age in the medial portion of the brain has not yet been studied. The purpose of this study was to investigate the GABA level var...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6523909

    authors: He X,Koo BB,Killiany RJ

    更新日期:2016-01-01 00:00:00

  • Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling.

    abstract::Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions and molecular mechanisms in ovarian cancer remain unclear. In this study, we found that TNKS was aberrantly overexpressed in human ovarian cancer ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2686340

    authors: Yang HY,Shen JX,Wang Y,Liu Y,Shen DY,Quan S

    更新日期:2019-02-20 00:00:00