Abstract:
:A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Baktybayeva L,Yu V,Zazybin A,Zolotareva D,Dauletbakov Adoi
10.1155/2020/7636290subject
Has Abstractpub_date
2020-01-13 00:00:00pages
7636290eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract:BACKGROUND:An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7963972
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The presence of common risk factors suggests that there is a relationship between osteoporosis and cardiovascular disease, possibly via dyslipidemia and inflammation. We investigated the relationships among the lipid profile, the inflammation marker high-sensitivity C-reactive protein (hsCRP), bone turnover ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/398397
更新日期:2014-01-01 00:00:00
abstract:Background:This study investigated the potential therapeutic effects of acupoint catgut embedding (ACE) at ST36 and BL13 on lipopolysaccharide- (LPS-) induced acute respiratory distress syndrome (ARDS) in rats. Materials and Methods:Male Sprague-Dawley rats were randomized into the normal saline (NS group with a sham ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2394734
更新日期:2020-05-02 00:00:00
abstract::A series of halo-substituted mixed ester/amide-based analogues 4a-l have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8867407
更新日期:2020-12-24 00:00:00
abstract::Esthetic evaluation of cleft lip and palate rehabilitation outcomes may assist in the determination of new surgical interventions and aid in reevaluation of treatment protocols. Our objective was to compare esthetics assessments of the nasolabial region in children with a unilateral cleft lip and palate between health...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/460106
更新日期:2014-01-01 00:00:00
abstract::Modern orthopaedic surgery provides a variety of techniques for cartilage repair. The Autologous Matrix-Induced Chondrogenesis (AMIC) procedure is a single-step technique with a collagen I/III scaffold for the treatment of full-thickness cartilage lesions. The aim of the study was to analyze the outcome of the AMIC pr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6363245
更新日期:2018-05-08 00:00:00
abstract::Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8945850
更新日期:2018-01-11 00:00:00
abstract:Objective:This paper included a retrospective review of the effect of tranexamic acid (TXA) combined with pressure bandaging on hemostasis of patients who received a unilateral total knee arthroplasty (TKA) from 2017 to 2019. Methods:A total of 197 patients undergoing TKA were chosen to be classified into 2 groups, th...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/2739560
更新日期:2020-11-02 00:00:00
abstract::In patients with sepsis and septic shock, the hemodynamic management in both early and later phases of these "organ dysfunction syndromes" is a key therapeutic component. It needs, however, to be differentiated between "early goal-directed therapy" (EGDT) as proposed for the first 6 hours of emergency department treat...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/8268569
更新日期:2016-01-01 00:00:00
abstract:Objective:Epidemiological studies have shown a correlation between periodontal disease (PD) and age-related macular degeneration (AMD). However, the results have been inconsistent, and no relevant meta-analysis has been performed on this topic. Hence, we performed a meta-analysis to evaluate whether the two diseases ar...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4753645
更新日期:2020-09-28 00:00:00
abstract::Aim. To explore the effects of curcumin on phosphate carrier (PiC) and its role in protection against doxorubicin induced myocyte toxicity. Methods. Using H9c2 cell line, the cardiotoxic effect of doxorubicin and its mitigation by curcumin were studied. H9c2 cells were cultured with doxorubicin and/or curcumin at vari...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1980763
更新日期:2016-01-01 00:00:00
abstract::By measuring messenger RNA levels for all genes in a sample, RNA-seq provides an attractive option to characterize the global changes in transcription. RNA-seq is becoming the widely used platform for gene expression profiling. However, real transcription signals in the RNA-seq data are confounded with measurement and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/916352
更新日期:2015-01-01 00:00:00
abstract::To provide an overview of the currently available literature regarding local control of primary tumor and oligometastases in metastatic prostate cancer and salvage lymph node dissection of clinical lymph node relapse after curative treatment of prostate cancer. Evidence Acquisition. A systematic literature search was ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/501213
更新日期:2014-01-01 00:00:00
abstract:Background:This study explored the therapeutic efficacy of standard triple therapy combined with sucralfate suspension gel as well as the mechanisms of action in mouse models of H. pylori infection. Materials and Methods:C57BL/6J mice were randomly divided into 5 groups: NC (natural control), HP (H. pylori infection),...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4936318
更新日期:2020-08-31 00:00:00
abstract::Myosin VI (MVI) is a unique motor protein moving towards the minus end of actin filaments unlike other known myosins. Its important role has recently been postulated for striated muscle and myogenic cells. Since MVI functions through interactions of C-terminal globular tail (GT) domain with tissue specific partners, w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/816019
更新日期:2015-01-01 00:00:00
abstract:Background:Flaviviridae viruses are single-stranded, positive-sense RNA viruses, which threat human constantly mediated by mosquitoes, ticks, and sandflies. Considering the recent increase in the prevalence of the family virus and its risk potential, we investigated the codon usage pattern to understand its evolutionar...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5857285
更新日期:2019-06-27 00:00:00
abstract::We evaluated single nucleotide polymorphism (SNP) detection via a target-capture, C-probe ligation, and RAM assay in a single-blind comparison to clinical samples that had been tested with FDA-cleared tests for up to 4 different vascular disease-related SNPs. In the RAM assay circulizable linear probes (C- or padlock ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/641090
更新日期:2014-01-01 00:00:00
abstract:Objectives:To evaluate the role of short-term low-dose glucocorticoids in mild COVID-19 patients. Methods:We conducted a retrospective, cross-sectional, single-center study in Kunming, China. A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2854186
更新日期:2020-09-23 00:00:00
abstract::Introduction. The aim of this study was to examine the incidence and risk factors of catheterization-related CI in the contemporary era, using diffusion-weighted magnetic resonance imaging. Methods. We retrospectively analyzed consecutive 84 patients who underwent MRI (magnetic resonance imaging) after 2.81 ± 2.4 days...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6052125
更新日期:2016-01-01 00:00:00
abstract::Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3019410
更新日期:2016-01-01 00:00:00
abstract::Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, inclu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/916136
更新日期:2013-01-01 00:00:00
abstract::Ischemia-reperfusion injury (IRI) is a major contributor to acute kidney injury (AKI). At present, there are no effective therapies to prevent AKI. The aim of this study was to analyse whether valproic acid (VPA), a histone deacetylase inhibitor with anti-inflammatory properties, prevents renal IRI. Male Wistar rats w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5985903
更新日期:2016-01-01 00:00:00
abstract::Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to asept...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3687415
更新日期:2018-06-05 00:00:00
abstract::Targeted drug delivery using folate receptors is one of the most interesting chemotherapeutic research areas over the past few years. A novel folate targeted copolymer was synthesized using dextran stearate coupled to folic acid. FT-IR and NMR spectroscopy were used to confirm successful conjugation. Micelles prepared...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/708593
更新日期:2014-01-01 00:00:00
abstract::Trichoderma spp. are important biocontrol filamentous fungi, which are widely used for their adaptability, broad antimicrobial spectrum, and various antagonistic mechanisms. In our previous studies, we cloned thga1 gene encoding GαI protein from Trichoderma harzianum Th-33. Its knockout mutant showed that the growth r...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8329513
更新日期:2016-01-01 00:00:00
abstract::In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in prostate homeostasis. Most of the studies evaluated intraprostatic hormone metabolism using cell lines or preprocessed specimens. Using an ex vivo model of intact tissue cultures with preserved architecture, we characteriz...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/464869
更新日期:2014-01-01 00:00:00
abstract::In a bioprospecting effort towards novel thermostable lipases, we assessed the lipolytic profile of 101 bacterial strains isolated from the volcanic area of Santorini, Aegean Sea, Greece. Screening of lipase activity was performed both in agar plates and liquid cultures using olive oil as carbon source. Significant di...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/703130
更新日期:2013-01-01 00:00:00
abstract::Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to bet...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/161508
更新日期:2015-01-01 00:00:00
abstract::Mental rotation task (MRT) incorporates elements of spatial abilities, important in many professions, with people of both genders involved. Importantly, these are the areas where spatial tasks might be performed for long time periods; thus adverse effects of mental fatigue are highly unwanted. Substantial variation of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/741758
更新日期:2014-01-01 00:00:00
abstract::To identify novel susceptibility genes and gene sets for obesity, we conducted a genomewide expression association analysis of obesity via integrating genomewide association study (GWAS) and expression quantitative trait loci (eQTLs) data. GWAS summary data of body mass index (BMI) and waist-to-hip ratio (WHR) was dri...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/3848560
更新日期:2018-05-08 00:00:00