Stromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps.

Abstract:

:Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R injury in ischemic free flaps. Free flaps that underwent ischemia for 3 h were equally randomized into five groups: CaCl2, NPS2143 + CaCl2, SDF-1α + CaCl2, AMD3100 + SDF-1α + CaCl2, and normal saline. The free flaps were harvested to evaluate flap necrosis and neovascularization after 2 h or 7 d of reperfusion. p-CaSR/CaSR was extensively expressed in vascular endothelial cells of free flaps after I/R injury, and activation of the SDF-1α/CXCR4 axis and NPS2143 could reduce the expression of cleaved caspase-3, caspase-9, FAS, Cyt-c, and Bax and increase Bcl-2 expression; the opposite was true after CaSR activation. Interestingly, initiation of the SDF-1α/CXCR4 axis might abrogate CaSR activation-induced I/R injury through enhancement of microvessel density. In conclusion, CaSR might become a novel therapeutic target of free flaps affected by I/R injury. Activation of the SDF-1α/CXCR4 axis and NPS2143 could counteract CaSR activation-mediated I/R injury and promote free flap survival through inhibition of caspase-3/caspase-9-related cell apoptosis and enhancement of neovascularization.

journal_name

Biomed Res Int

authors

Song L,Gao LN,Wang J,Thapa S,Li Y,Zhong XB,Zhao HW,Xiang XR,Zhang FG,Ji P

doi

10.1155/2018/8945850

subject

Has Abstract

pub_date

2018-01-11 00:00:00

pages

8945850

eissn

2314-6133

issn

2314-6141

journal_volume

2018

pub_type

杂志文章
  • Evaluation of electromagnetic interference and exposure assessment from s-health solutions based on Wi-Fi devices.

    abstract::In the last decade the number of wireless devices operating at the frequency band of 2.4 GHz has increased in several settings, such as healthcare, occupational, and household. In this work, the emissions from Wi-Fi transceivers applicable to context aware scenarios are analyzed in terms of potential interference and ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/784362

    authors: de Miguel-Bilbao S,Aguirre E,Lopez Iturri P,Azpilicueta L,Roldán J,Falcone F,Ramos V

    更新日期:2015-01-01 00:00:00

  • Biochemical and Molecular Phylogenetic Study of Agriculturally Useful Association of a Nitrogen-Fixing Cyanobacterium and Nodule Sinorhizobium with Medicago sativa L.

    abstract::Seed inoculation with bacterial consortium was found to increase legume yield, providing a higher growth than the standard nitrogen treatment methods. Alfalfa plants were inoculated by mono- and binary compositions of nitrogen-fixing microorganisms. Their physiological and biochemical properties were estimated. Inocul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/202597

    authors: Karaushu EV,Lazebnaya IV,Kravzova TR,Vorobey NA,Lazebny OE,Kiriziy DA,Olkhovich OP,Taran NY,Kots SY,Popova AA,Omarova E,Koksharova OA

    更新日期:2015-01-01 00:00:00

  • Do Symptoms and Serum Calcium Levels Affect the Results of Surgical Treatment of Primary Hyperparathyroidism?

    abstract:Introduction:The purpose of this study was to investigate the difference in surgical outcomes between symptomatic and asymptomatic patients with primary hyperparathyroidism (PHPT) and between patients with high serum calcium and those with normal blood calcium, as well as to explore the epidemiological trend of PHPT in...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2019/2150159

    authors: Yu Q,Liu K,Ma D,Xie C,Wu Y,Dai W,Jiang H

    更新日期:2019-07-01 00:00:00

  • Efficacy of Sucralfate-Combined Quadruple Therapy on Gastric Mucosal Injury Induced by Helicobacter pylori and Its Effect on Gastrointestinal Flora.

    abstract:Background:This study explored the therapeutic efficacy of standard triple therapy combined with sucralfate suspension gel as well as the mechanisms of action in mouse models of H. pylori infection. Materials and Methods:C57BL/6J mice were randomly divided into 5 groups: NC (natural control), HP (H. pylori infection),...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4936318

    authors: Teng G,Liu Y,Wu T,Wang W,Wang H,Hu F

    更新日期:2020-08-31 00:00:00

  • Treatment of Hemorrhagic Vocal Polyps by Pulsed Dye Laser-Assisted Laryngomicrosurgery.

    abstract:OBJECTIVE:Conventional surgical techniques of laryngomicrosurgery (LMS) on hemorrhagic vocal polyps are often difficult due to obscuration of the surgical field by inadvertent bleeding from the lesion, and there are often significant amounts of mucosal epithelium loss. Here, we introduce our surgical technique using pu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/820654

    authors: Byeon HK,Han JH,Choi BI,Hwang HJ,Kim JH,Choi HS

    更新日期:2015-01-01 00:00:00

  • The Signaling Pathways Involved in the Antiatherosclerotic Effects Produced by Chinese Herbal Medicines.

    abstract::Cardiovascular diseases (CVDs) are considered to be the predominant cause of death in the world. Chinese herb medicines (CHMs) have been widely used for the treatment of CVDs in Asian countries for thousands of years. One reason of high efficacy of CHMs in treating CVDs is attributed to their inhibition in atheroscler...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/5392375

    authors: Lu L,Sun X,Qin Y,Guo X

    更新日期:2018-06-13 00:00:00

  • Dyslipidemia Might Be Associated with an Increased Risk of Osteoarthritis.

    abstract:Background:According to several studies, the autoimmune response may lead to osteoarthritis and dyslipidemia and may affect the homeostasis of the human body's internal environment and then cause its own immune regulation. Consequently, the risk of osteoarthritis might be increased by dyslipidemia, but this association...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析

    doi:10.1155/2020/3105248

    authors: Xiong J,Long J,Chen X,Li Y,Song H

    更新日期:2020-02-15 00:00:00

  • Identification of Potential Biomarkers and Biological Pathways in Juvenile Dermatomyositis Based on miRNA-mRNA Network.

    abstract:Objective:The aim of this study is to explore the potential pathogenesis of juvenile dermatomyositis by bioinformatics analysis of gene chips, which would screen the hub genes, identify potential biomarkers, and reveal the development mechanism of juvenile dermatomyositis. Material and Methods:We retrieved juvenile de...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/7814287

    authors: Qiu CC,Su QS,Zhu SY,Liu RC

    更新日期:2019-12-07 00:00:00

  • Role of the AMPK/ACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation.

    abstract::Transient receptor potential polycystic 2 (TRPP2) exerts vital roles in various types of cancer; however, its underlying mechanisms remain largely unknown. This study is aimed at investigating whether knockdown of TRPP2 affected the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4375075

    authors: Li K,Chen L,Lin Z,Zhu J,Fang Y,Du J,Shen B,Wu K,Liu Y

    更新日期:2020-11-14 00:00:00

  • A comparative analysis of biomarker selection techniques.

    abstract::Feature selection has become the essential step in biomarker discovery from high-dimensional genomics data. It is recognized that different feature selection techniques may result in different set of biomarkers, that is, different groups of genes highly correlated to a given pathological condition, but few direct comp...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/387673

    authors: Dessì N,Pascariello E,Pes B

    更新日期:2013-01-01 00:00:00

  • Contrast-induced acute kidney injury: definition, epidemiology, and outcome.

    abstract::Contrast-induced acute kidney injury (CI-AKI) is commonly defined as a decline in kidney function occurring in a narrow time window after administration of iodinated contrast material. The incidence of AKI after contrast material administration greatly depends on the specific definition and cutoff values used. Althoug...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/859328

    authors: Meinel FG,De Cecco CN,Schoepf UJ,Katzberg R

    更新日期:2014-01-01 00:00:00

  • Prevalence and correlation between TMD based on RDC/TMD diagnoses, oral parafunctions and psychoemotional stress in Polish university students.

    abstract::The aim of the study was to assess the prevalence of temporomandibular disorders (TMD) and oral parafunctions, as well as their correlation with psychoemotional factors in Polish university students. The research was conducted in a group of 456 students (N = 456). The examination form comprised of two parts: survey an...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/472346

    authors: Wieckiewicz M,Grychowska N,Wojciechowski K,Pelc A,Augustyniak M,Sleboda A,Zietek M

    更新日期:2014-01-01 00:00:00

  • Multiparametric MRI for localized prostate cancer: lesion detection and staging.

    abstract::Multiparametric MRI of the prostate combines high-resolution anatomic imaging with functional imaging of alterations in normal tissue caused by neoplastic transformation for the identification and characterization of in situ prostate cancer. Lesion detection relies on a systematic approach to the analysis of both anat...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/684127

    authors: Margolis DJ

    更新日期:2014-01-01 00:00:00

  • Individual IOL surface topography analysis by the WaveMaster Reflex UV.

    abstract:PURPOSE:In order to establish inspection routines for individual intraocular lenses (IOLs), their surfaces have to be measured separately. Currently available measurement devices lack this functionality. The purpose of this study is to evaluate a new topography measurement device based on wavefront analysis for measuri...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/363742

    authors: Kannengießer M,Langenbucher A,Janunts E

    更新日期:2013-01-01 00:00:00

  • Corrigendum to "Peripheral Blood Mononuclear Cells as a Laboratory to Study Dementia in the Elderly".

    abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...

    journal_title:BioMed research international

    pub_type: 已发布勘误

    doi:10.1155/2020/9175369

    authors: Arosio B,D'Addario C,Gussago C,Casati M,Tedone E,Ferri E,Nicolini P,Rossi PD,Maccarrone M,Mari D

    更新日期:2020-09-07 00:00:00

  • In Vitro Protective Effects of Lycium barbarum Berries Cultivated in Umbria (Italy) on Human Hepatocellular Carcinoma Cells.

    abstract::Lycium barbarum is a famous plant in the traditional Chinese medicine. The plant is known to have health-promoting bioactive components. The properties of Lycium barbarum berries cultivated in Umbria (Italy) and their effect on human hepatocellular carcinoma cells (HepG2) have been investigated in this work. The obtai...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7529521

    authors: Ceccarini MR,Vannini S,Cataldi S,Moretti M,Villarini M,Fioretti B,Albi E,Beccari T,Codini M

    更新日期:2016-01-01 00:00:00

  • 1,25-Dihydroxyvitamin D₃ Promotes High Glucose-Induced M1 Macrophage Switching to M2 via the VDR-PPARγ Signaling Pathway.

    abstract::Macrophages, especially their activation state, are closely related to the progression of diabetic nephropathy. Classically activated macrophages (M1) are proinflammatory effectors, while alternatively activated macrophages (M2) exhibit anti-inflammatory properties. 1,25-Dihydroxyvitamin D3 has renoprotective roles th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/157834

    authors: Zhang X,Zhou M,Guo Y,Song Z,Liu B

    更新日期:2015-01-01 00:00:00

  • Role of Wnt/β-Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer.

    abstract::Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality worldwide. To date, chemotherapy plays an important role in the treatment of CRC patients. Multidrug resistance (MDR) is one of the major hurdles in chemotherapy for CRC, and the underlying mechanisms need to be explored. Studies have dem...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/9390878

    authors: Yuan S,Tao F,Zhang X,Zhang Y,Sun X,Wu D

    更新日期:2020-03-18 00:00:00

  • Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma.

    abstract::The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/604385

    authors: Wang WJ,Wu YS,Chen S,Liu CF,Chen SN

    更新日期:2015-01-01 00:00:00

  • In vitro and in vivo effects of suppressor of cytokine signalling 7 knockdown in breast cancer: the influence on cellular response to hepatocyte growth factor.

    abstract:PURPOSE:Suppressor of cytokine signaling 7 (SOCS7) is a member of the SOCS family and is known to interact with phospholipase Cγ-1 (PLCγ-1), a key downstream mediator of the hepatocyte growth factor (HGF)/C-MET axis. Here, we report our observations of the effect of knocking down SOCS7 gene on the behaviour of breast c...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/648040

    authors: Sasi W,Ye L,Jiang WG,Sharma AK,Mokbel K

    更新日期:2014-01-01 00:00:00

  • Extraction and Characterization of Organ Components of the Malaysian Sea Cucumber Holothuria leucospilota Yielded Bioactives Exhibiting Diverse Properties.

    abstract::The aim of the present study was to extract and characterize bioactive components from separate body organs of Holothuria leucospilota. Preliminary qualitative assessment of the crude extracts was positive for phenols, terpenoids, carbohydrates, flavonoids, saponins, glycosides, cardiac glycosides, steroids, phlobatan...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2640684

    authors: Ceesay A,Nor Shamsudin M,Aliyu-Paiko M,Ismail IS,Nazarudin MF,Mohamed Alipiah N

    更新日期:2019-04-15 00:00:00

  • An electromechanical left ventricular wedge model to study the effects of deformation on repolarization during heart failure.

    abstract::Heart failure is a major and costly problem in public health, which, in certain cases, may lead to death. The failing heart undergo a series of electrical and structural changes that provide the underlying basis for disturbances like arrhythmias. Computer models of coupled electrical and mechanical activities of the h...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/465014

    authors: Rocha BM,Toledo EM,Barra LP,dos Santos RW

    更新日期:2015-01-01 00:00:00

  • Agreement among Four Prevalence Metrics for Urogenital Schistosomiasis in the Eastern Region of Ghana.

    abstract::Few studies assess agreement among Schistosoma haematobium eggs, measured hematuria, and self-reported metrics. We assessed agreement among four metrics at a single time point and analyzed the stability of infection across two time points with a single metric. We used data from the Eastern Region of Ghana and construc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7627358

    authors: Kosinski KC,Kulinkina AV,Tybor D,Osabutey D,Bosompem KM,Naumova EN

    更新日期:2016-01-01 00:00:00

  • Effects of 8-Week Hatha Yoga Training on Metabolic and Inflammatory Markers in Healthy, Female Chinese Subjects: A Randomized Clinical Trial.

    abstract::We aimed to determine the effects of an 8 wk Hatha yoga training on blood glucose, insulin, lipid profiles, endothelial microparticles (EMPs), and inflammatory status in healthy, lean, and female Chinese subjects. A total of 30 healthy, female Chinese subjects were recruited and randomized into control or yoga practic...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2016/5387258

    authors: Chen N,Xia X,Qin L,Luo L,Han S,Wang G,Zhang R,Wan Z

    更新日期:2016-01-01 00:00:00

  • Magnitude of Turnover Intention and Associated Factors among Health Professionals Working in Public Health Institutions of North Shoa Zone, Amhara Region, Ethiopia.

    abstract:Background:Health workers are one of the most important building blocks of the health system. High turnover rate contribute to the shortfalls and unbalanced distribution of health personnel in the health workforce. Turnover intention is the strongest predictor of actual turnover. Objective:To assess the magnitude of t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3165379

    authors: Ferede A,Kibret GD,Million Y,Simeneh MM,Belay YA,Hailemariam D

    更新日期:2018-12-23 00:00:00

  • RIRS with Vacuum-Assisted Ureteral Access Sheath versus MPCNL for the Treatment of 2-4 cm Renal Stone.

    abstract:Objective:Comparison of outcomes between RIRS with vacuum-assisted ureteral access sheath (V-UAS) and MPCNL in the treatment of renal stone. Materials and Methods:28 patients with 2-4 cm renal stone were treated using RIRS with 14/16 F V-UAS. The outcomes were compared to those who underwent MPCNL with 16 F Amplatz sh...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8052013

    authors: Lai D,He Y,Li X,Chen M,Zeng X

    更新日期:2020-05-14 00:00:00

  • Nutritional biomarkers in children and adolescents with Beta-thalassemia-major: An Egyptian center experience.

    abstract:BACKGROUND AND AIM:Trace elements and vitamins play a vital role in human body to perform its function properly. Thalassemic patients are at risk of micronutrient deficiency. This study estimated levels of vitamins A, C, E, B12, folic acid, total homocysteine (tHcy), and methylmalonic acid (MMA) along with trace elemen...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/261761

    authors: Sherief LM,Abd El-Salam SM,Kamal NM,El Safy O,Almalky MA,Azab SF,Morsy HM,Gharieb AF

    更新日期:2014-01-01 00:00:00

  • Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria.

    abstract::We identified a nitidine- (NTD-) accumulating organelle and evaluated the net cytotoxicity of accumulated NTD. To evaluate tumor cell selectivity of the drug, we evaluated its selective cytotoxicity against 39 human cancer cell lines (JFCR39 panel), and the profile was compared with those of known anticancer drugs. Or...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2130594

    authors: Iwasaki H,Inafuku M,Taira N,Saito S,Oku H

    更新日期:2017-01-01 00:00:00

  • Understanding the Correlation between Tomographic and Biomechanical Severity of Keratoconic Corneas.

    abstract::Purpose. To evaluate correlation between tomographic gradation of keratoconus (KC) and its corresponding air-puff induced biomechanical response. Methods. Corneal tomography and biomechanics were measured with Scheimpflug imaging in 44 normal and 92 KC corneas. Deformation waveform was also analyzed with Fourier serie...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/294197

    authors: Shetty R,Nuijts RM,Srivatsa P,Jayadev C,Pahuja N,Akkali MC,Sinha Roy A

    更新日期:2015-01-01 00:00:00

  • Control of respiratory motion by hypnosis intervention during radiotherapy of lung cancer I.

    abstract::The uncertain position of lung tumor during radiotherapy compromises the treatment effect. To effectively control respiratory motion during radiotherapy of lung cancer without any side effects, a novel control scheme, hypnosis, has been introduced in lung cancer treatment. In order to verify the suggested method, six ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/574934

    authors: Li R,Deng J,Xie Y

    更新日期:2013-01-01 00:00:00