Abstract:
:Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to better dissect the role of morphine in cancer cell growth and angiogenesis we performed in vitro studies on ER-negative human breast carcinoma cells, MDA.MB231 and in vivo studies on heterotopic mouse model of human triple negative breast cancer, TNBC. We demonstrated that morphine in vitro enhanced the proliferation and inhibited the apoptosis of MDA.MB231 cells. In vivo studies performed on xenograft mouse model of TNBC revealed that tumours of mice treated with morphine were larger than those observed in other groups. Moreover, morphine was able to enhance the neoangiogenesis. Our data showed that morphine at clinical relevant doses promotes angiogenesis and increases breast cancer progression.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Bimonte S,Barbieri A,Rea D,Palma G,Luciano A,Cuomo A,Arra C,Izzo Fdoi
10.1155/2015/161508subject
Has Abstractpub_date
2015-01-01 00:00:00pages
161508eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4601348
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/635745
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journal_title:BioMed research international
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journal_title:BioMed research international
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doi:10.1155/2020/4725141
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/460106
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2020/8506365
更新日期:2020-08-17 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2017/4673047
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2020/6968473
更新日期:2020-11-12 00:00:00
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doi:10.1155/2019/1762537
更新日期:2019-04-03 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/8961805
更新日期:2018-07-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/361329
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2538765
更新日期:2018-01-29 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2019-01-10 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2019/6274719
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9472939
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/687826
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/769867
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/305367
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2020-10-17 00:00:00