Intra-Abdominal Hypertension Causes Bacterial Growth in Lungs: An Animal Study.

Abstract:

:To study the effect of intra-abdominal hypertension (IAH) on the frequency of pneumonia with an experimental study, thirteen Sprague-Dawley rats were included. Eight out of thirteen animals were randomly assigned to receive 10 ml of benzalkonium chloride 0.2% (megacolon group) and five animals received 10 ml NaCl 0.9% (controls). Animals were anaesthetized by intramuscular delivery of ketamine. The incidence of positivity for bacteria lung tissue cultures and mesenteric lymph node cultures was assessed at the 21st day after animals' sacrification, or before in case of death. All megacolon group animals presented progressive increase of the abdomen and increased IAP (≥10 mmHg) whereas the frequency of their evacuations was almost eliminated. Controls presented normal evacuations, no sign of abdominal distention, and normal IAP. In megacolon group animals, there was evidence of significant amount of bacteria in lung cultures. In contrast, no bacteria were found in control animals.

journal_name

Biomed Res Int

authors

Papakrivou E,Makris D,Manoulakas E,Mitroudi M,Tepetes K,Papazoglou K,Zakynthinos E

doi

10.1155/2017/4601348

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

4601348

eissn

2314-6133

issn

2314-6141

journal_volume

2017

pub_type

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