Abstract:
:Background. With the introduction of three-dimensional (3D) ultrasound it has become possible to measure volumes. The relative increase in embryonic volume (EV) is much larger than that of the crown-rump length (CRL) over the same time period. We examined whether EV is a better parameter to determine growth restriction in fetuses with structural congenital abnormalities. Study Design, Subjects, and Outcome Measures. CRL and EV were measured using a Virtual Reality (VR) system in prospectively collected 3D ultrasound volumes of 56 fetuses diagnosed with structural congenital abnormalities in the first trimester of pregnancy (gestational age 7+5 to 14+5 weeks). Measured CRL and EV were converted to z-scores and to percentages of the expected mean using previously published reference curves of euploid fetuses. The one-sample t-test was performed to test significance. Results. The EV was smaller than expected for GA in fetuses with structural congenital abnormalities (-35% p < 0.001, z-score -1.44 p < 0.001), whereas CRL was not (-6.43% p = 0.118, z-score -0.43 p = 0.605). Conclusions. CRL is a less reliable parameter to determine growth restriction in fetuses with structural congenital abnormalities as compared with EV. By measuring EV, growth restriction in first-trimester fetuses with structural congenital abnormalities becomes more evident and enables an earlier detection of these cases.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Baken L,Benoit B,Koning AHJ,van der Spek PJ,Steegers EAP,Exalto Ndoi
10.1155/2017/1953076subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1953076eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
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