Abstract:
AIM:To investigate the role and mechanism of miR-15b in the proliferation and apoptosis of glioma. METHODS:The miR-15b mimics were transfected into human glioma cells to upregulate the miR-15b expression. Cyclin D1 was determined by both western blotting analysis and luciferase reporter assay. Methylthiazol tetrazolium (MTT) and flow cytometry were employed to detect the cell proliferation, cell cycle, and apoptosis. RESULTS:Overexpression of miR-15b inhibits proliferation by arrested cell cycle progression and induces apoptosis, possibly by directly targeting Cyclin D1. Both luciferase assay and bioinformatics search revealed a putative target site of miR-15b binding to the 3'-UTR of Cyclin D1. Moreover, expression of miR-15b in glioma tissues was found to be inversely correlated with Cyclin D1 expression. Enforced Cyclin D1 could abrogate the miR-15b-mediated cell cycle arrest and apoptosis. CONCLUSIONS:Our findings identified that miR-15b may function as a glioma suppressor by targeting the Cyclin D1, which may provide a novel therapeutic strategy for treatment of glioma.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Sun G,Shi L,Yan S,Wan Z,Jiang N,Fu L,Li M,Guo Jdoi
10.1155/2014/687826subject
Has Abstractpub_date
2014-01-01 00:00:00pages
687826eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract:Background:In resource limited settings, HIV/AIDS patients lack access to sufficient nutritious foods, which poses challenges to the success of antiretroviral therapy. HIV/AIDS and malnutrition are still major public health problems in Ethiopia. Though measuring nutritional status is an essential part of ART program, l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1913534
更新日期:2018-05-06 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease. NAFLD encompasses a wide range of pathologies, from simple steatosis to steatosis with inflammation to fibrosis. The pathogenesis of NAFLD progression has not been completely elucidated, and different liver cells could be imp...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/768071
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Identification of the factors that influence sedentary behaviour in older adults is important for the design of appropriate intervention strategies. In this study, we determined the prevalence of sedentary behaviour and its association with physical, cognitive, and psychosocial status among older adults resid...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9160504
更新日期:2017-01-01 00:00:00
abstract::(124)Iodine ((124)I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of (124)I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecul...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/672094
更新日期:2014-01-01 00:00:00
abstract::The 13 million nurses worldwide constitute most of the global healthcare workforce and are uniquely positioned to engage with others to address disparities in healthcare to achieve the goal of better health for all. A new vision for nurses involves active participation and collaboration with international colleagues a...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3127543
更新日期:2016-01-01 00:00:00
abstract::We encapsulated tumor necrosis factor-α (TNF-α), a major proinflammatory cytokine, into cholesteryl pullulan (CHP) to prepare TNF/CHP nanoparticles. In this report, we describe the immune-enhancing capability of the nanoparticles to act as a vaccine adjuvant. TNF/CHP nanoparticles showed excellent storage stability an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/471468
更新日期:2015-01-01 00:00:00
abstract:Purpose:To evaluate the diagnostic performance of deep learning with a multichannel fusion three-dimensional convolutional neural network (MCF-3DCNN) in the differentiation of the pathologic grades of hepatocellular carcinoma (HCC) based on dynamic contrast-enhanced magnetic resonance images (DCE-MR images). Methods a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9783106
更新日期:2019-04-28 00:00:00
abstract::Retinoblastoma protein (pRB) interacts with E2F and other protein factors to play a pivotal role in regulating the expression of target genes that induce cell cycle arrest, apoptosis, and differentiation. pRB controls the local promoter activity and has the ability to change the structure of nucleosomes and/or chromos...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/5959721
更新日期:2016-01-01 00:00:00
abstract:Purpose:Osteosarcoma is one of the most common primary malignant, aggressive bone neoplasms. However, the mechanisms of osteosarcoma proliferation, migration, and invasion are not well understood. To explore the possible mechanism of osteosarcoma progression, we used a public database for gene analysis to identify the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4068521
更新日期:2019-11-30 00:00:00
abstract:Purpose:To explore the effects of depression on cardiac autonomic nerve function and related metabolic pathways, the heart rate variability (HRV) and urinary differential metabolites were detected on the college students with depression. Methods:12 female freshmen with depression were filtered by the Beck Depression I...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5246350
更新日期:2020-02-27 00:00:00
abstract::A dentin-cement-prosthesis complex restored with either all-porcelain, cured resin-composite, or cast base metal alloy and cemented with either of the different resin cements was trimmed into a mini-dumbbell shape for tensile testing. The fractured surfaces and characterization of the dentin-cement interface of bonded...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/656948
更新日期:2015-01-01 00:00:00
abstract::Objectives. The aim of the study is to detect the prevalence and the characteristics of infraorbital canal and Haller's cells on panoramic radiography of edentulous patients. Methods. The study group comprised 291 panoramic radiographs of edentulous patients. Radiographs were interpreted for the visibility and charact...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1293124
更新日期:2018-07-08 00:00:00
abstract:BACKGROUND:Sarcopenia is the presence of low muscle mass and low muscle function. The aim of this study was to establish cutoffs for low muscle mass using three published methods and to compare the prevalence of sarcopenia in older Australians. METHODS:Gender specific cutoffs levels were identified for low muscle mass...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/361790
更新日期:2014-01-01 00:00:00
abstract::Despite many advances in the diagnosis and treatment of colorectal cancer (CRC), its incidence and mortality rates continue to make an impact worldwide and in some countries rates are mounting. Over the past decade, liquid biopsies have been the object of fundamental and clinical research with regard to the different ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/5953036
更新日期:2019-12-04 00:00:00
abstract::Introduction. The aim of the present study was to determine the closeness of agreement between a self-reported and an objective measure of physical activity in low back pain patients and healthy controls. Beyond, influencing factors on overestimation were identified. Methods. 27 low back pain patients and 53 healthy c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1497213
更新日期:2016-01-01 00:00:00
abstract::Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μ g%; C14:0, myristic acid, 6.9 μ g%; C16:0, palmitic acid, 35.3 μ g%; C16:1, palmitoleic acid, 16.4 μ g%; C18:0, stearic acid, 8.5 μ g%; C18:1 cis, oleic acid, 18.4 μ g%; C18:1 trans, elaidic aci...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/121794
更新日期:2013-01-01 00:00:00
abstract::D-Ribose is a five-carbon sugar and generally used as an energy source to improve athletic performance and the ability. The culture conditions for maximum D-ribose production performance from cheap raw material corn starch hydrolysate were improved by using one-factor-at-a-time experiments and a three-level Box-Behnke...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/535097
更新日期:2015-01-01 00:00:00
abstract::The study aimed to determine the suitability of testing the saliva of kickboxing athletes to show changes in biochemical parameters in dynamic of training. 8 elite male athletes (mean age 17.29± 0.31 years, body mass 66.82± 3.46kg, with 5.62±0.96 years of training experience) participated in the study. Indicators of l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2014347
更新日期:2019-01-10 00:00:00
abstract::Neoadjuvant radio(chemo)therapy is increasingly used in rectal cancer and induces a number of morphologic changes that affect prognostication after curative surgery, thereby creating new challenges for surgical pathologists, particularly in evaluating morphologic changes and tumour response to preoperative treatment. ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/574540
更新日期:2015-01-01 00:00:00
abstract::We aimed to determine the effects of an 8 wk Hatha yoga training on blood glucose, insulin, lipid profiles, endothelial microparticles (EMPs), and inflammatory status in healthy, lean, and female Chinese subjects. A total of 30 healthy, female Chinese subjects were recruited and randomized into control or yoga practic...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/5387258
更新日期:2016-01-01 00:00:00
abstract::Background. Acute graft-versus-host disease (aGVHD) involving skin is one of the most frequent complications of allogeneic hematopoietic stem cell transplantation (alloHSCT), usually diagnosed based on clinical manifestations. So far, skin biopsy with histopathological evaluation is the only method to confirm the diag...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4535717
更新日期:2016-01-01 00:00:00
abstract::Toxoplasma gondii infects all warm-blooded animals, including humans, causing serious public health problems and great economic loss for the food industry. Commonly used serological tests require costly and hazardous preparation of whole Toxoplasma lysate antigens from tachyzoites. Here, we have evaluated an alternati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/690529
更新日期:2014-01-01 00:00:00
abstract::Variations in human genome (e.g., single nucleotide polymorphisms, SNPs) may be associated with hereditary diseases, their complications, comorbidities, and drug responses. Using Web service SNP_TATA_Comparator presented in our previous paper, here we analyzed immediate surroundings of known SNP markers of diseases an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8642703
更新日期:2016-01-01 00:00:00
abstract::Human mesenchymal stem cells (MSCs) have an intrinsic property for homing towards tumor sites and can be used as tumor-tropic vectors for tumor therapy. But very limited studies investigated the antitumor properties of MSCs themselves. In this study we investigated the antiglioma properties of two easily accessible MS...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/109389
更新日期:2014-01-01 00:00:00
abstract:Introduction:The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6038106
更新日期:2018-01-02 00:00:00
abstract:Background:The predictive values of monocytes in the prognosis of patients with acute paraquat (PQ) poisoning are unclear. This retrospective study investigated the predictive values of monocytes in the prognosis of patients with acute PQ poisoning. Methods:Adult patients who suffered from acute PQ poisoning in the em...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/6360459
更新日期:2019-07-15 00:00:00
abstract:Background:BMPER has been reported to be associated with the biological behavior of a few malignant tumors, but the mechanism is still unclear. We aimed to detect BMPER expression in ovarian epithelial tumor tissues and its effects on their biological behaviors, as well as to elucidate the possible mechanism. Methods:...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3607436
更新日期:2020-03-24 00:00:00
abstract:Aim:Little is known about the association between cancer antigen 125 (MUC16/CA125) concentrations and tumor diameter of patients with hepatocellular carcinoma (HCC) and low AFP levels. To fill this gap in our knowledge, we conducted a retrospective study of 427 patients with HCC with AFP ≤200 ng/mL who underwent R0 res...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6959637
更新日期:2019-09-29 00:00:00
abstract::In patients with sepsis and septic shock, the hemodynamic management in both early and later phases of these "organ dysfunction syndromes" is a key therapeutic component. It needs, however, to be differentiated between "early goal-directed therapy" (EGDT) as proposed for the first 6 hours of emergency department treat...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/8268569
更新日期:2016-01-01 00:00:00
abstract::Previous studies have shown the therapeutic properties of ginseng and ginsenosides on hyperactive and impulsive behaviors in several psychiatric diseases. Herein, we investigated the effect of Panax ginseng Meyer (PG) on hyperactive/impulsive behaviors in a manic-like animal model, sleep deprivation (SD) rats. Male ra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3636874
更新日期:2020-10-17 00:00:00