Participation of GABAA chloride channels in the anxiolytic-like effects of a fatty acid mixture.

Abstract:

:Human amniotic fluid and a mixture of eight fatty acids (FAT-M) identified in this maternal fluid (C12:0, lauric acid, 0.9 μ g%; C14:0, myristic acid, 6.9 μ g%; C16:0, palmitic acid, 35.3 μ g%; C16:1, palmitoleic acid, 16.4 μ g%; C18:0, stearic acid, 8.5 μ g%; C18:1 cis, oleic acid, 18.4 μ g%; C18:1 trans, elaidic acid, 3.5 μ g%; C18:2, linoleic acid, 10.1 μ g%) produce anxiolytic-like effects that are comparable to diazepam in Wistar rats, suggesting the involvement of γ -aminobutyric acid-A (GABA(A)) receptors, a possibility not yet explored. Wistar rats were subjected to the defensive burying test, elevated plus maze, and open field test. In different groups, three GABA(A) receptor antagonists were administered 30 min before FAT-M administration, including the competitive GABA binding antagonist bicuculline (1 mg/kg), GABA(A) benzodiazepine antagonist flumazenil (5 mg/kg), and noncompetitive GABA(A) chloride channel antagonist picrotoxin (1 mg/kg). The FAT-M exerted anxiolytic-like effects in the defensive burying test and elevated plus maze, without affecting locomotor activity in the open field test. The GABA(A) antagonists alone did not produce significant changes in the behavioral tests. Picrotoxin but not bicuculline or flumazenil blocked the anxiolytic-like effect of the FAT-M. Based on the specific blocking action of picrotoxin on the effects of the FAT-M, we conclude that the FAT-M exerted its anxiolytic-like effects through GABA(A) receptor chloride channels.

journal_name

Biomed Res Int

authors

Rodríguez-Landa JF,García-Ríos RI,Cueto-Escobedo J,Bernal-Morales B,Contreras CM

doi

10.1155/2013/121794

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

121794

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

杂志文章
  • The Effects of Tooth Brushing on Whole Salivary Flow Rate in Older Adults.

    abstract:Objectives:(1) To determine whether manual (MTB), or electric, tooth brushing (ETB) modulates whole salivary flow rate in older adults who are free of systemic disease. (2) To determine the duration of the brushing-related modulation of salivary flow rate. (3) To compare salivary flow rate modulation associated with MT...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3904139

    authors: Affoo RH,Trottier K,Garrick R,Mascarenhas T,Jang Y,Martin RE

    更新日期:2018-02-26 00:00:00

  • Automatic Classification of Specific Melanocytic Lesions Using Artificial Intelligence.

    abstract:BACKGROUND:Given its propensity to metastasize, and lack of effective therapies for most patients with advanced disease, early detection of melanoma is a clinical imperative. Different computer-aided diagnosis (CAD) systems have been proposed to increase the specificity and sensitivity of melanoma detection. Although s...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8934242

    authors: Jaworek-Korjakowska J,Kłeczek P

    更新日期:2016-01-01 00:00:00

  • Endothelial Glycocalyx Layer: A Possible Therapeutic Target for Acute Lung Injury during Lung Resection.

    abstract:Background:Shedding of the endothelial glycocalyx layer (EGL) is known to occur during major surgery, but its degradation associated with minimally invasive video-assisted thoracoscopy (VATS) remains unclear. We investigated if serum biomarkers of EGL disruption were elevated during VATS lobectomy, and whether the urin...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1155/2017/5969657

    authors: Wang J,Wu A,Wu Y

    更新日期:2017-01-01 00:00:00

  • Diversity and seasonal impact of Acanthamoeba species in a subtropical rivershed.

    abstract::This study evaluated the presence of Acanthamoeba species in the Puzih River watershed, which features typical subtropical monsoon climate and is located just above the Tropic of Cancer in Taiwan. The relationship between the seasonal and geographical distributions of Acanthamoeba species in this rivershed was also in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/405794

    authors: Kao PM,Chou MY,Tao CW,Huang WC,Hsu BM,Shen SM,Fan CW,Chiu YC

    更新日期:2013-01-01 00:00:00

  • Age dependent differences in collagen alignment of glutaraldehyde fixed bovine pericardium.

    abstract::Bovine pericardium is used for heart valve leaflet replacement where the strength and thinness are critical properties. Pericardium from neonatal animals (4-7 days old) is advantageously thinner and is considered as an alternative to that from adult animals. Here, the structures of adult and neonatal bovine pericardiu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/189197

    authors: Sizeland KH,Wells HC,Higgins J,Cunanan CM,Kirby N,Hawley A,Mudie ST,Haverkamp RG

    更新日期:2014-01-01 00:00:00

  • IL-4 Alleviates Ischaemia-Reperfusion Injury by Inducing Kupffer Cells M2 Polarization via STAT6-JMJD3 Pathway after Rat Liver Transplantation.

    abstract:Background:Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods:Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2953068

    authors: Deng M,Wang J,Wu H,Wang M,Cao D,Li J,Wu Y,Gong J

    更新日期:2020-03-18 00:00:00

  • Experimental susceptibility of gilthead sea bream, Sparus aurata, via challenge with Anisakis pegreffii larvae.

    abstract::The endoscopic and histopathological findings detected in Sparus aurata experimentally infected with third-stage Anisakis larvae without intermediate host are evaluated and discussed. In six fish, live nematode larvae were introduced by gastroscopy into the stomach. The first observation by endoscope, 15 days after ch...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/701828

    authors: Marino F,Lanteri G,Passantino A,De Stefano C,Costa A,Gaglio G,Macrì F

    更新日期:2013-01-01 00:00:00

  • Lung Involvements in Rheumatic Diseases: Update on the Epidemiology, Pathogenesis, Clinical Features, and Treatment.

    abstract::Lung illness encountered in patients with rheumatic diseases bears clinical significance in terms of increased morbidity and mortality as well as potential challenges placed on patient care. Although our understanding of natural history of this important illness is still limited, epidemiologic knowledge has been accum...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6930297

    authors: Ha YJ,Lee YJ,Kang EH

    更新日期:2018-05-08 00:00:00

  • Aerobic sludge granulation in a full-scale sequencing batch reactor.

    abstract::Aerobic granulation of activated sludge was successfully achieved in a full-scale sequencing batch reactor (SBR) with 50,000 m(3) d(-1) for treating a town's wastewater. After operation for 337 days, in this full-scale SBR, aerobic granules with an average SVI30 of 47.1 mL g(-1), diameter of 0.5 mm, and settling veloc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/268789

    authors: Li J,Ding LB,Cai A,Huang GX,Horn H

    更新日期:2014-01-01 00:00:00

  • Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats.

    abstract::Although disorders of the stomatognathic system are common, the mechanisms involved are unknown. Our objective was to study the changes in the masseter muscles after unilateral exodontia. Molar extraction was performed on Wistar rats (left side), and the animals were sacrificed after either 14 or 26 days. The masseter...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/563463

    authors: Guerra Cde S,Carla Lara Pereira Y,Issa JP,Luiz KG,Guimarães EA,Gerlach RF,Iyomasa MM

    更新日期:2014-01-01 00:00:00

  • The Effect of Teriparatide on Fracture Healing of Osteoporotic Patients: A Meta-Analysis of Randomized Controlled Trials.

    abstract::Purpose. This meta-analysis is to assess the effectiveness of teriparatide in fracture healing and clinical function improvement of the osteoporotic patients. Methods. We searched PubMed, Embase, Web of Science, and the Cochrane databases for randomized and quasi-randomized controlled trials comparing teriparatide to ...

    journal_title:BioMed research international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1155/2016/6040379

    authors: Lou S,Lv H,Wang G,Zhang L,Li M,Li Z,Zhang L,Tang P

    更新日期:2016-01-01 00:00:00

  • Numerical Solution of Blood Flow and Mass Transport in an Elastic Tube with Multiple Stenoses.

    abstract::The simultaneous effect of flexible wall and multiple stenoses on the flow and mass transfer of blood is investigated through numerical computation and simulations. The solution is obtained using the Marker and Cell technique on an axisymmetric model of Newtonian blood flow. The results compare favorably with physical...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7609562

    authors: Alsemiry RD,Sarifuddin,Mandal PK,Sayed HM,Amin N

    更新日期:2020-01-31 00:00:00

  • Ghostman: augmented reality application for telerehabilitation and remote instruction of a novel motor skill.

    abstract::This paper describes a pilot study using a prototype telerehabilitation system (Ghostman). Ghostman is a visual augmentation system designed to allow a physical therapist and patient to inhabit each other's viewpoint in an augmented real-world environment. This allows the therapist to deliver instruction remotely and ...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/646347

    authors: Chinthammit W,Merritt T,Pedersen S,Williams A,Visentin D,Rowe R,Furness T

    更新日期:2014-01-01 00:00:00

  • Characterization of a Thioredoxin-1 Gene from Taenia solium and Its Encoding Product.

    abstract::Taenia solium thioredoxin-1 gene (TsTrx-1) has a length of 771 bp with three exons and two introns. The core promoter gene presents two putative stress transcription factor binding sites, one putative TATA box, and a transcription start site (TSS). TsTrx-1 mRNA is expressed higher in larvae than in adult. This gene en...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/453469

    authors: Jiménez L,Rodríguez-Lima O,Ochoa-Sánchez A,Landa A

    更新日期:2015-01-01 00:00:00

  • Candida Bloodstream Infections in Italy: Changing Epidemiology during 16 Years of Surveillance.

    abstract::Although considerable progress has been made in the management of patients with invasive fungal infections, Candida bloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/256580

    authors: Caggiano G,Coretti C,Bartolomeo N,Lovero G,De Giglio O,Montagna MT

    更新日期:2015-01-01 00:00:00

  • The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients.

    abstract:BACKGROUND:This study investigated whether the 1 : 2 ω-3/ω-6 ratio may reduce proinflammatory response in human alveolar cells (A549) exposed to an ex vivo inflammatory stimulus (bronchoalveolar lavage fluid (BALF) of acute respiratory distress syndrome (ARDS) patients). Methods. We exposed A549 cells to the BALF colle...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/642520

    authors: Cotogni P,Trombetta A,Muzio G,Maggiora M,Canuto RA

    更新日期:2015-01-01 00:00:00

  • Incidence and Predictors of Catheterization-Related Cerebral Infarction on Diffusion-Weighted Magnetic Resonance Imaging.

    abstract::Introduction. The aim of this study was to examine the incidence and risk factors of catheterization-related CI in the contemporary era, using diffusion-weighted magnetic resonance imaging. Methods. We retrospectively analyzed consecutive 84 patients who underwent MRI (magnetic resonance imaging) after 2.81 ± 2.4 days...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6052125

    authors: Morita Y,Kato T,Okano M,Suu K,Kimura M,Minamino-Muta E,Nakane E,Izumi T,Miyamoto S,Haruna T,Ueyama K,Inoko M

    更新日期:2016-01-01 00:00:00

  • Resin Bonding of Self-Etch Adhesives to Bovine Dentin Bleached from Pulp Chamber.

    abstract::This study evaluated the microtensile bond strength (μTBS) of 1-step self-etch adhesives (1-SEAs) and 2-step self-etch adhesives (2-SEAs) to pulp chamber dentin immediately after bleaching with 2 types of common bleaching techniques. Pulp chamber dentin of bovine teeth was bleached using 30% hydrogen peroxide (H2O2) s...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1313586

    authors: Haruyama A,Kameyama A,Kato J,Takemoto S,Oda Y,Kawada E,Takahashi T,Furusawa M

    更新日期:2016-01-01 00:00:00

  • Gastric antiulcerogenic and hypokinetic activities of Terminalia fagifolia Mart. & Zucc. (Combretaceae).

    abstract::The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have be...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/261745

    authors: Nunes PH,Martins Mdo C,Oliveira Rde C,Chaves MH,Sousa EA,Leite JR,Véras LM,Almeida FR

    更新日期:2014-01-01 00:00:00

  • Invasive Hemodynamic Assessment of Cardiac Output State after MitraClip Therapy in Nonanaesthetized Patients with Functional Mitral Regurgitation.

    abstract::Background. Surgical correction of mitral regurgitation (MR) can lead to postoperative low cardiac output state. We aimed to assess the acute hemodynamic changes after percutaneous MitraClip therapy (a unique model without influence of factors linked to surgical procedure) in patients with functional MR without the in...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2016/6296972

    authors: Bednar F,Budesinsky T,Linkova H,Kocka V

    更新日期:2016-01-01 00:00:00

  • Bioconversion of p-Tyrosol into Hydroxytyrosol under Bench-Scale Fermentation.

    abstract::Tyrosol hydroxylating Pseudomonas strain was previously isolated from olive mill wastewaters-irrigated soil. In the present work, experimental design was used to study the bioconversion of tyrosol in laboratory fermenters aiming at the recovery of the highest yields of hydroxytyrosol. The effects of biocatalyst loadin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7390751

    authors: Bouallagui Z,Sayadi S

    更新日期:2018-07-09 00:00:00

  • Role of 99mTc-ECD SPECT in the management of children with craniosynostosis.

    abstract:PURPOSE OF THE REPORT:There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of (99m)Tc-ECD SPECT in a large number of subjects with craniosynostosis. MATERIALS AND METHODS:We prospectively analyzed a coh...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/172646

    authors: Barik M,Bajpai M,Das RR,Malhotra A,Panda SS,Sahoo MK,Dwivedi S

    更新日期:2014-01-01 00:00:00

  • Dissociation of Calcium Transients and Force Development following a Change in Stimulation Frequency in Isolated Rabbit Myocardium.

    abstract::As the heart transitions from one exercise intensity to another, changes in cardiac output occur, which are modulated by alterations in force development and calcium handling. Although the steady-state force-calcium relationship at various heart rates is well investigated, regulation of these processes during transiti...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/468548

    authors: Haizlip KM,Milani-Nejad N,Brunello L,Varian KD,Slabaugh JL,Walton SD,Gyorke S,Davis JP,Biesiadecki BJ,Janssen PM

    更新日期:2015-01-01 00:00:00

  • An experimental approach for selecting appropriate rodent diets for research studies on metabolic disorders.

    abstract::Diverse high energy diets have been utilized to precipitate obesity and related metabolic disorders in rodent models, though the dietary intervention has not absolutely been standardized. The present study established usage of a customized semipurified normal control diet (NCD) and high fat diet (HFD), for research st...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/752870

    authors: Sasidharan SR,Joseph JA,Anandakumar S,Venkatesan V,Ariyattu Madhavan CN,Agarwal A

    更新日期:2013-01-01 00:00:00

  • Analysis of the Clinicopathological Characteristics and Risk Factors in Patients with Lung Cancer and Chronic Obstructive Pulmonary Disease.

    abstract:Objective:To investigate the clinicopathological characteristics and risk factors in patients with lung cancer and COPD. Materials and Methods:We retrospectively reviewed the clinical data of 282 patients with lung cancer, including 174 and 108 patients with and without COPD, respectively. Information on age, sex, smo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/8398156

    authors: Miao JL,Cai JJ,Qin XF,Liu RJ

    更新日期:2018-02-14 00:00:00

  • Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites.

    abstract::In eukaryotic cells, proteasomes perform crucial roles in many cellular pathways by degrading proteins to enforce quality control and regulate many cellular processes such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein-quality control, and development. The catalytic h...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/141526

    authors: Muñoz C,San Francisco J,Gutiérrez B,González J

    更新日期:2015-01-01 00:00:00

  • Influence of Polishing Methods on the Bonding Effectiveness and Durability of Different Resin Cements to Dentin.

    abstract::The purpose of this study was to investigate the impact of polishing methods on the bonding effectiveness and durability of different resin cements to dentin. The dentin surfaces were either treated with a fine-grit diamond bur (polishing A) or further polished by polishing disks (polishing B), and then they were bond...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9189354

    authors: Ren L,Li M,Pan Y,Meng X

    更新日期:2018-02-28 00:00:00

  • Controversial indications for sentinel lymph node biopsy in breast cancer patients.

    abstract::Sentinel lymph node biopsy (SLNB) emerged in the 1990s as a new technique in the surgical management of the axilla for patients with early breast cancer, resulting in lower complication rates and better quality of life than axillary lymph node dissection (ALND). Today SLNB is firmly established in the armamentarium of...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/405949

    authors: Assi H,Sbaity E,Abdelsalam M,Shamseddine A

    更新日期:2015-01-01 00:00:00

  • Pediatric tuberculosis in young children in India: a prospective study.

    abstract:BACKGROUND:India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. METHODS:Young children (≤ 5 years) with suspected TB were prospectively enrolled at a tertiary hospital...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/783698

    authors: Jain SK,Ordonez A,Kinikar A,Gupte N,Thakar M,Mave V,Jubulis J,Dharmshale S,Desai S,Hatolkar S,Kagal A,Lalvani A,Gupta A,Bharadwaj R

    更新日期:2013-01-01 00:00:00

  • New bioactive fungal molecules with high antioxidant and antimicrobial capacity isolated from Cerrena unicolor idiophasic cultures.

    abstract::Three bioactive fractions, extracellular laccase (ex-LAC), crude endopolysaccharides (c-EPL), and a low molecular subfraction of secondary metabolites (ex-LMS), were isolated from the idiophasic cultures of the white rot fungus Cerrena unicolor. For the first time, we determined the antioxidant properties of these sam...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/497492

    authors: Jaszek M,Osińska-Jaroszuk M,Janusz G,Matuszewska A,Stefaniuk D,Sulej J,Polak J,Ruminowicz M,Grzywnowicz K,Jarosz-Wilkołazka A

    更新日期:2013-01-01 00:00:00