Abstract:
PURPOSE OF THE REPORT:There is a paucity of data on correlation of various imaging modalities with clinical findings in craniosynostosis. Moreover, no study has specifically reported the role of (99m)Tc-ECD SPECT in a large number of subjects with craniosynostosis. MATERIALS AND METHODS:We prospectively analyzed a cohort of 85 patients with craniosynostosis from year 2007 to 2012. All patients underwent evaluation with (99m)Tc-ECD SPECT and the results were correlated with radiological and surgical findings. RESULTS:(99m)Tc-ECD SPECT revealed regional perfusion abnormalities in the cerebral hemisphere corresponding to the fused sutures preoperatively that disappeared postoperatively in all the cases. Corresponding to this, the mean mental performance quotient (MPQ) increased significantly (P < 0.05) postoperatively only in those children with absent perfusion defect postoperatively. CONCLUSIONS:Our study suggests that early surgery and release of craniosynostosis in patients with preoperative perfusion defects (absent on (99m)Tc-ECD SPECT study) are beneficial, as they lead to improved MPQ after surgery.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Barik M,Bajpai M,Das RR,Malhotra A,Panda SS,Sahoo MK,Dwivedi Sdoi
10.1155/2014/172646subject
Has Abstractpub_date
2014-01-01 00:00:00pages
172646eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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journal_title:BioMed research international
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journal_title:BioMed research international
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pub_type: 杂志文章
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doi:10.1155/2014/686505
更新日期:2014-01-01 00:00:00
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doi:10.1155/2015/973235
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doi:10.1155/2016/7562368
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journal_title:BioMed research international
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,meta分析
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