Role of the Ubiquitin-Proteasome Systems in the Biology and Virulence of Protozoan Parasites.

abstract：:Detection of single based genetic mutation by using oligonucleotide probes is one of the common methods of detecting single nucleotide polymorphisms at known loci. In this paper, we demonstrated a hybridization system which included a buffer solution that produced selective salt-induced effect and a locked nucleic aci...

journal_title：BioMed research international

authors： Zhang J,Wu H,Chen Q,Zhao P,Zhao H,Yao W,Wei M

更新日期：2015-01-01 00:00:00

abstract：:Gastric cancer is one of the most common cancers and the efficient therapeutic methods are limited. Further study of the exact molecular mechanism of gastric cancer to develop novel targeted therapies is necessary and urgent. We herein systematically examined that miR-204 suppressed both proliferation and metastasis o...

journal_title：BioMed research international

authors： Yuan X,Wang S,Liu M,Lu Z,Zhan Y,Wang W,Xu AM

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To investigate if software simulation is practical for quantifying random error (RE) in phantom dosimetry. MATERIALS AND METHODS:We applied software error simulation to an existing dosimetry study. The specifications and the measurement values of this study were brought into the software (R version 3.0.2) to...

journal_title：BioMed research international

authors： Hoogeveen RC,Martens EP,van der Stelt PF,Berkhout WE

更新日期：2015-01-01 00:00:00

abstract：:Schwannomas are the commonest tumours of peripheral nerves. Despite the classical description that schwannomas are well encapsulated and can be completely enucleated during excision, a portion of them have fascicular involvement and could not be completely shelled out. A retrospective review for 8 patients was carried...

journal_title：BioMed research international

authors： Tang CY,Fung B,Fok M,Zhu J

更新日期：2013-01-01 00:00:00

abstract：Design:From July 2016 to June 2018, 36 women with symptomatic early pregnancy around 4-8 weeks of gestation were recruited into the study. Among them, there were 16 women with viable intrauterine pregnancy (VIP), 9 women with spontaneous abortion (SA), and 11 women of EP. Serum exosomal miRNAs were extracted and measur...

journal_title：BioMed research international

authors： Sun J,Deng G,Ruan X,Chen S,Liao H,Liu X,Li J,Zhao G,Gao J

更新日期：2020-06-11 00:00:00

abstract：:Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions and molecular mechanisms in ovarian cancer remain unclear. In this study, we found that TNKS was aberrantly overexpressed in human ovarian cancer ...

journal_title：BioMed research international

authors： Yang HY,Shen JX,Wang Y,Liu Y,Shen DY,Quan S

更新日期：2019-02-20 00:00:00

abstract：:Due to alarming increase in population and rapid industrialization, drinking water quality is being deteriorated day by day in Pakistan. This review sums up the outcomes of various research studies conducted for drinking water quality status of different areas of Pakistan by taking into account the physicochemical pro...

journal_title：BioMed research international

authors： Daud MK,Nafees M,Ali S,Rizwan M,Bajwa RA,Shakoor MB,Arshad MU,Chatha SAS,Deeba F,Murad W,Malook I,Zhu SJ

更新日期：2017-01-01 00:00:00

abstract：Objective:The objective of this study is to evaluate the effect of simvastatin on the jaw bone microstructural defect and autophagy in rats with high cholesterol diet (HCD). Methods:Male Sprague-Dawley rats were fed a standard rodent chow (NC group) or a high cholesterol diet for 32 weeks and the HCD-fed rats were tre...

journal_title：BioMed research international

authors： Zhou J,Gao X,Huang S,Ma L,Cui Y,Wang H,Qiu J,Wang L,Dong Q,Chen Z,Wang X,Zhang D

更新日期：2018-06-27 00:00:00

abstract：:Heart failure is a major and costly problem in public health, which, in certain cases, may lead to death. The failing heart undergo a series of electrical and structural changes that provide the underlying basis for disturbances like arrhythmias. Computer models of coupled electrical and mechanical activities of the h...

journal_title：BioMed research international

authors： Rocha BM,Toledo EM,Barra LP,dos Santos RW

更新日期：2015-01-01 00:00:00

abstract：:Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long no...

journal_title：BioMed research international

authors： Liu Y,Ding M,Gao Q,He A,Liu Y,Mei H

更新日期：2018-05-22 00:00:00

abstract：:Triple-negative breast cancer (TNBC) has a significant clinical relevance of being associated with a shorter median time to relapse and death and does not respond to endocrine therapy or other available targeted agents. Increased aggressiveness of this tumor, as well as resistance to standard drug therapies, may be as...

journal_title：BioMed research international

authors： Collina F,Di Bonito M,Li Bergolis V,De Laurentiis M,Vitagliano C,Cerrone M,Nuzzo F,Cantile M,Botti G

更新日期：2015-01-01 00:00:00

abstract：:Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Japan. The purpose of this study was to evaluate the correlation between TyG index and the risk of T2DM in the Japanese population. Here, 12732 participants were selected from the ...

journal_title：BioMed research international

authors： Liu EQ,Weng YP,Zhou AM,Zeng CL

更新日期：2020-12-11 00:00:00

abstract：BACKGROUND:It is well established that the Mediterranean and Arab populations are at high risk for thalassemias in general and for alpha-thalassemia in particular. Yet, reports on alpha-thalassemia in Lebanon are still lacking. In this study, we aim at assessing the incidence of alpha-thalassemia in the Lebanese popula...

journal_title：BioMed research international

authors： Farra C,Daher R,Badra R,el Rafei R,Bejjany R,Charafeddine L,Yunis K

更新日期：2015-01-01 00:00:00

abstract：:Background. There are limited epidemiological studies evaluating the effect of age at onset on disease features in vitiligo. Objectives. To identify factors associated with adult onset vitiligo in comparison with childhood onset vitiligo. Patients and Methods. We retrospectively collected medical records of 191 patien...

journal_title：BioMed research international

authors： Lazzeri L,Colucci R,Cammi A,Dragoni F,Moretti S

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND AND AIM:Trace elements and vitamins play a vital role in human body to perform its function properly. Thalassemic patients are at risk of micronutrient deficiency. This study estimated levels of vitamins A, C, E, B12, folic acid, total homocysteine (tHcy), and methylmalonic acid (MMA) along with trace elemen...

journal_title：BioMed research international

authors： Sherief LM,Abd El-Salam SM,Kamal NM,El Safy O,Almalky MA,Azab SF,Morsy HM,Gharieb AF

更新日期：2014-01-01 00:00:00

abstract：:Type 1 diabetes is an autoimmune disease which is due to the lack of β cells. The ideal therapy to cure the disease is pancreas transplantation, but its application is confined to a limited number of people due to the shortage of organ and the need for life-long immunosuppression. Regenerative medicine methods such as...

journal_title：BioMed research international

authors： Wu D,Wan J,Huang Y,Guo Y,Xu T,Zhu M,Fan X,Zhu S,Ling C,Li X,Lu J,Zhu H,Zhou P,Lu Y,Wang Z

更新日期：2015-01-01 00:00:00

abstract：:Diabetic foot ulcers (DFUs) are characterized by an unsatisfactory inflammatory and migratory response. Skin inflammation involves the participation of many cells and particularly macrophages. Macrophage function can be modulated by neuropeptides; however, little is known regarding the role of neurotensin (NT) as a mo...

journal_title：BioMed research international

authors： Moura LI,Silva L,Leal EC,Tellechea A,Cruz MT,Carvalho E

更新日期：2013-01-01 00:00:00

abstract：:Variations in human genome (e.g., single nucleotide polymorphisms, SNPs) may be associated with hereditary diseases, their complications, comorbidities, and drug responses. Using Web service SNP_TATA_Comparator presented in our previous paper, here we analyzed immediate surroundings of known SNP markers of diseases an...

journal_title：BioMed research international

authors： Ponomarenko P,Rasskazov D,Suslov V,Sharypova E,Savinkova L,Podkolodnaya O,Podkolodny NL,Tverdokhleb NN,Chadaeva I,Ponomarenko M,Kolchanov N

更新日期：2016-01-01 00:00:00

abstract：:Although multimodal therapies including surgery, chemotherapy, and radiotherapy have improved clinical outcomes of patients with bone and soft tissue sarcomas, the prognosis of patients has plateaued over these 20 years. Immunotherapies have shown the effectiveness for several types of advanced tumors. Immunotherapies...

journal_title：BioMed research international

authors： Uehara T,Fujiwara T,Takeda K,Kunisada T,Ozaki T,Udono H

更新日期：2015-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is the fourth most common cancer causing death in the United States. Early tumor recurrence is an important contributor to the dismal prognosis. The availability of an accurate prognostic biomarker for predicting disease recurrence following curative resection will be beneficial ...

journal_title：BioMed research international

authors： Osayi SN,Bloomston M,Schmidt CM,Ellison EC,Muscarella P

更新日期：2014-01-01 00:00:00

abstract：:Early Infantile Epileptic Encephalopathy (known as Ohtahara Syndrome) is one of the most severe and earliest forms of epilepsy, characterized by early seizures onset. It affects newborns and children between two and six years old. Among the genes that have been associated with early infantile epileptic encephalopathy,...

journal_title：BioMed research international

authors： Al Mehdi K,Fouad B,Zouhair E,Boutaina B,Yassine N,Chaimaa AEC,Najat S,Hassan R,Rachida R,Abdelhamid B,Halima N

更新日期：2019-12-17 00:00:00

abstract：:Integrin αIIbβ3 plays a crucial role in the process of platelet aggregation. Three integrin αIIbβ3 antagonists (abciximab, eptifibatide, and tirofiban) have been approved by FDA for clinical use. Unfortunately, they all showed severe side effects such as thrombocytopenia and bleeding risk. Thus, researches on the deve...

journal_title：BioMed research international

authors： Ding X,Liu TD,Xie ZL,Zhao Q,Cao Y,Liu XD,Wang CH,Gamariel RR,Ming X,Li ZY,Kong Y

更新日期：2016-01-01 00:00:00

abstract：:Kawasaki disease (KD) is an acute systemic vasculitis of childhood with prolonged fever, and the diagnosis of KD is mainly based on clinical criteria, which is prone to misdiagnosis with other febrile infectious (FI) diseases. Currently, there remain no effective molecular markers for KD diagnosis. In this study, we a...

journal_title：BioMed research international

authors： Zhong J,Huang Q,Wang Y,Gao H,Jia H,Fan J,Liang H

更新日期：2020-04-26 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury is experienced by individuals suffering from cardiovascular diseases such as coronary heart diseases and subsequently undergoing reperfusion treatments in order to manage the conditions. The occlusion of blood flow to the tissue, termed ischemia, can be especially detriment...

journal_title：BioMed research international

authors： Zhou T,Chuang CC,Zuo L

更新日期：2015-01-01 00:00:00

abstract：:Although the application of patient-specific instruments (PSI) for total knee arthroplasty (TKA) increases the cost of the surgical procedure, PSI may reduce operative time and improve implant alignment, which could reduce the number of revision surgeries. We report our experience with TKA using PSI techniques in 120 ...

journal_title：BioMed research international

authors： Kwon OR,Kang KT,Son J,Choi YJ,Suh DS,Koh YG

更新日期：2015-01-01 00:00:00

abstract：:Cognitive decline impacts older adults, particularly their independence. The goal of this project was to increase understanding of how short-term, everyday lifestyle options, including physical activity, help an older adult sustain cognitive independence. Using a secondary analysis of lifestyle choices, we drew on a d...

journal_title：BioMed research international

authors： Howard EP,Morris JN,Steel K,Strout KA,Fries BE,Moore A,Garms-Homolová V

更新日期：2016-01-01 00:00:00

abstract：Background:Doublecortin-like kinase 1 (DCLK1) has been universally identified as a cancer stem cell (CSC) marker and is found to be overexpressed in many types of cancers including breast cancer. However, there is little data regarding the functional role of DCLK1 in breast cancer metastasis. In the present study, we s...

journal_title：BioMed research international

authors： Liu H,Wen T,Zhou Y,Fan X,Du T,Gao T,Li L,Liu J,Yang L,Yao J,Ge Y,An G

更新日期：2019-05-15 00:00:00

abstract：Background:Identification of potential molecular targets of acute myocardial infarction is crucial to our comprehensive understanding of the disease mechanism. However, studies of gene coexpression analysis via jointing multiple microarray data of acute myocardial infarction still remain restricted. Methods:Microarray...

journal_title：BioMed research international

authors： Li Y,He XN,Li C,Gong L,Liu M

更新日期：2019-02-11 00:00:00

abstract：:Pregnancy is associated with various physiological changes which may lead to significant alterations in the pharmacokinetics of many drugs. The present study was aimed to investigate the potential effects of pregnancy on the pharmacokinetic profile of zonisamide (ZNM) in the rabbit. Seven female rabbits were used in t...

journal_title：BioMed research international

authors： Matar KM

更新日期：2013-01-01 00:00:00

abstract：:Although considerable progress has been made in the management of patients with invasive fungal infections, Candida bloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epi...

journal_title：BioMed research international

authors： Caggiano G,Coretti C,Bartolomeo N,Lovero G,De Giglio O,Montagna MT

更新日期：2015-01-01 00:00:00