Abstract:
Design:From July 2016 to June 2018, 36 women with symptomatic early pregnancy around 4-8 weeks of gestation were recruited into the study. Among them, there were 16 women with viable intrauterine pregnancy (VIP), 9 women with spontaneous abortion (SA), and 11 women of EP. Serum exosomal miRNAs were extracted and measured at the first prenatal visit. Statistical analysis was performed to determine the clinical utility of these biomarkers as single markers and as multimarker panels for EP. Results:Concentrations of miR-378d in serum exosomes were significantly higher in EP than in VIP and also SA group. As a single marker, miR-378d had the highest specificity of 64% at the sensitivity of 89.1%. Comparatively, both combined panels of hCG, progesterone, miR-100-5p and hCG, progesterone, and miR-215-5P yielded the specificity of 96%. Panels for all markers achieved the highest specificity of 80% at the sensitivity of 91%. Conclusions:Although further validation in large-scale prospective studies is necessary, our results suggest that serum exosomal miR-378d, miR-100-5p, and miR-215-5P are promising biomarkers for early EP.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Sun J,Deng G,Ruan X,Chen S,Liao H,Liu X,Li J,Zhao G,Gao Jdoi
10.1155/2020/3521859subject
Has Abstractpub_date
2020-06-11 00:00:00pages
3521859eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::Ultrasound tomography (UST) image segmentation is fundamental in breast density estimation, medicine response analysis, and anatomical change quantification. Existing methods are time consuming and require massive manual interaction. To address these issues, an automatic algorithm based on GrabCut (AUGC) is proposed i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2059036
更新日期:2017-01-01 00:00:00
abstract::Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design. In this study, we developed a theoretical method to discriminate presynapti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3267325
更新日期:2017-01-01 00:00:00
abstract:Background:Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by sacroiliitis and spinal rigidity of the axial joints. The role of oxidative stress and increased proinflammatory cytokines is well documented in AS pathogenesis. Punicalagin (2,3-hexahydroxydiphenoyl-gallagyl-D-glucose), an ellagi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4918239
更新日期:2020-09-23 00:00:00
abstract:Aim:The aim of this study is to detect the prevalence of substance use among tenth-grade students; their thoughts, attitudes, behaviors, and tendencies towards substance use; and risk factors of substance use in tenth-grade students in general. Methods:This study is descriptive and cross-sectional conducted between Ap...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1407649
更新日期:2018-03-15 00:00:00
abstract::Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanism...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/926729
更新日期:2014-01-01 00:00:00
abstract:Background:It is well known that the programmed intermittent epidural bolus (PIEB) technique effectively provides epidural anesthesia in labor. This randomized double-blind trial compared the postoperative analgesic efficacy of PIEB with that of continuous epidural infusion (CEI) in patients undergoing gynecological su...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2018/6297247
更新日期:2018-05-15 00:00:00
abstract::Although considerable progress has been made in the management of patients with invasive fungal infections, Candida bloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/256580
更新日期:2015-01-01 00:00:00
abstract::Purslane, a fleshy herbaceous plant, plays a pivotal role in various preventive and therapeutic purposes. To date, no report has documented the consequence of salt stress on metabolite accumulation in purslane. Herein, we proposed an insight into the metabolic and physiological traits of purslane under saline stress e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4827045
更新日期:2020-06-17 00:00:00
abstract:Objective:Comparison of outcomes between RIRS with vacuum-assisted ureteral access sheath (V-UAS) and MPCNL in the treatment of renal stone. Materials and Methods:28 patients with 2-4 cm renal stone were treated using RIRS with 14/16 F V-UAS. The outcomes were compared to those who underwent MPCNL with 16 F Amplatz sh...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052013
更新日期:2020-05-14 00:00:00
abstract::The purpose of this study was to investigate the impact of polishing methods on the bonding effectiveness and durability of different resin cements to dentin. The dentin surfaces were either treated with a fine-grit diamond bur (polishing A) or further polished by polishing disks (polishing B), and then they were bond...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9189354
更新日期:2018-02-28 00:00:00
abstract::The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controve...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/3571861
更新日期:2017-01-01 00:00:00
abstract::There has been no previous study using three-dimensional (3D) measurement on femoral tunnel characteristics according to the combined influence of various flexion angles of knee and transverse drill angles in single-bundle ACL reconstruction with transportal technique. The purpose of this study was to determine optima...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2643247
更新日期:2018-07-17 00:00:00
abstract:Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6182464
更新日期:2020-06-07 00:00:00
abstract::Background. Neuroinflammation which presents as a possible mechanism of delirium is associated with MCP-1, an important proinflammatory factor which is expressed on astrocytes. It is known that dexmedetomidine (DEX) possesses potent anti-inflammatory properties. This study aimed to investigate the potential effects of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6352159
更新日期:2017-01-01 00:00:00
abstract::Black stain is characterized as a dark line or an incomplete coalescence of dark dots localized on the cervical third of the tooth. Over the last century, the etiology of black stain has been the subject of much debate. Most of the studies concerning this issue were conducted in pediatric population. According to the ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/469392
更新日期:2015-01-01 00:00:00
abstract::Objectives. To investigate the protective effects of tropisetron on acetaminophen- (APAP-) induced liver injury in a mice model. Methods. C57BL/6 male mice were given tropisetron (0.3 to 10 mg/kg) 30 minutes before a hepatotoxic dose of acetaminophen (300 mg/kg) intraperitoneally. Twenty hours after APAP intoxication,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1952947
更新日期:2016-01-01 00:00:00
abstract::In this study, we aimed to assess the effect and possible underlying mechanism of Anacardium occidentale leaves extract on male sexual behaviors in stress-exposed rats. Male Wistar rats were orally given A. occidentale extract at doses of 25, 100, and 200 mg/kg BW before 12-hour-immobilization exposure for 14 days. Se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6452965
更新日期:2018-10-25 00:00:00
abstract:INTRODUCTION:Thiopurine drugs are metabolized via S-methylation and catalyzed by thiopurine S-methyltransferase (TPMT). Patients with very low TPMT activity are at high risk of fatal bone marrow toxicity when standard doses of thiopurine drugs are administered. TPMT genotyping can predict TPMT activity and is not affec...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/305704
更新日期:2013-01-01 00:00:00
abstract::Some degree of external root resorption is a frequent, unpredictable, and unavoidable consequence of orthodontic tooth movement mediated by odontoclasts/cementoclasts originating from circulating precursor cells in the periodontal ligament. Its pathogenesis involves mechanical forces initiating complex interactions be...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/4864195
更新日期:2016-01-01 00:00:00
abstract::Hydrocephalus is a common neurological condition that can have traumatic ramifications and can be lethal without treatment. Nowadays, during therapy radiologists have to spend a vast amount of time assessing the volume of cerebrospinal fluid (CSF) by manual segmentation on Computed Tomography (CT) images. Further, som...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3059170
更新日期:2019-07-07 00:00:00
abstract::Aim. In periodontology lasers have been suggested for the photodynamic therapy (PDT): such therapy can be defined as the inactivation of cells, microorganisms, or molecules induced by light and not by heat. The aim of this study was to evaluate results of PDT using a 980 nm diode laser (Wiser Doctor Smile, Lambda SPA,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1386158
更新日期:2016-01-01 00:00:00
abstract::Astrocytic impairment is a pathologic feature of neuromyelitis optica spectrum disorder (NMOSD). S100B and glial fibrillary acidic protein (GFAP) are the two most commonly used astrocytic markers. The aim of this study was to evaluate whether CSF-S100B could serve as a marker of NMOSD. We enrolled 49 NMOSD patients [2...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/5381239
更新日期:2018-10-22 00:00:00
abstract::DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4590609
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:This study investigated whether the 1 : 2 ω-3/ω-6 ratio may reduce proinflammatory response in human alveolar cells (A549) exposed to an ex vivo inflammatory stimulus (bronchoalveolar lavage fluid (BALF) of acute respiratory distress syndrome (ARDS) patients). Methods. We exposed A549 cells to the BALF colle...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/642520
更新日期:2015-01-01 00:00:00
abstract:Introduction:Pulp regeneration, as a treatment for pulp necrosis, has significant advantages over root canal therapy for the preservation of living pulp. To date, research on pulp regeneration has mainly focused on the transplantation of pulp stem cells into the root canal, but there is still a lack of research on the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4759060
更新日期:2019-07-18 00:00:00
abstract::Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of 99Tc-MDP is unclear. We systematically investigated the effects of 99Tc-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7902760
更新日期:2018-10-14 00:00:00
abstract::Libidibia ferrea (LF) is a medicinal plant that holds many pharmacological properties. We evaluated the antinociceptive effect in the LF aqueous seed extract and Lipidic Portion of Libidibia ferrea (LPLF), partially elucidating their mechanisms. Histochemical tests and Gas chromatography of the LPLF were performed to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/508725
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. METHODS:89 patients (124 eyes) with established myopia ra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8923819
更新日期:2017-01-01 00:00:00
abstract::The study aimed to determine the suitability of testing the saliva of kickboxing athletes to show changes in biochemical parameters in dynamic of training. 8 elite male athletes (mean age 17.29± 0.31 years, body mass 66.82± 3.46kg, with 5.62±0.96 years of training experience) participated in the study. Indicators of l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2014347
更新日期:2019-01-10 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor developm...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/430943
更新日期:2015-01-01 00:00:00