Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress.

Abstract:

Background:Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by sacroiliitis and spinal rigidity of the axial joints. The role of oxidative stress and increased proinflammatory cytokines is well documented in AS pathogenesis. Punicalagin (2,3-hexahydroxydiphenoyl-gallagyl-D-glucose), an ellagitannin widely present in pomegranates, is found to exhibit potent anti-inflammatory, antiproliferative, and antioxidative effects. The present study was undertaken to investigate the effects of punicalagin in a rodent model of AS. Methods:BALB/c mice induced spondylitis were sacrificed 24 h after the last injection of proteoglycan extract. Histological scoring was done to assess the degree of the disease. The expression of JAK2/STAT3 proteins and proteins of the nuclear factor-κB (NF-κB) pathway was determined by immunoblotting. Serum levels of inflammatory mediators-TNF-α, IL-1β, IL-6, IL-17A, and IL-23-were assessed. Levels of lipid peroxidation and reactive oxygen species (ROS) were quantified. Antioxidant status as a measure of activities of antioxidant enzymes-catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD)-was determined. Results:Punicalagin effectively improved antioxidant status and decreased lipid peroxidation, ROS production, and serum levels of inflammatory mediators. NF-κB pathway and JAK2/STAT3 signaling were significantly (p < 0.05) downregulated. Punicalagin effectively regulated the production of cytokines by the Th17 cells and the IL-17A/IL-23 axis. Conclusion:The observations suggest that punicalagin exerts a protective role in AS via reducing oxidative stress and regulating NF-κB/TH17/JAK2/STAT3 signal. Punicalagin thus could be explored further as a potent candidate compound in the treatment of AS.

journal_name

Biomed Res Int

authors

Feng X,Yang Q,Wang C,Tong W,Xu W

doi

10.1155/2020/4918239

subject

Has Abstract

pub_date

2020-09-23 00:00:00

pages

4918239

eissn

2314-6133

issn

2314-6141

journal_volume

2020

pub_type

杂志文章
  • The Clinical Characteristics and Treatment of Cerebral Microarteriovenous Malformation Presenting with Intracerebral Hemorrhage: A Series of 13 Cases.

    abstract:OBJECT:The aim of this report was to explore the clinical presentation, radiological features, treatment methods, and outcome of micro-AVMs presenting with intracerebral hemorrhage. METHODS:The clinical data, radiological features, treatment, and follow-up results for a consecutive series of 13 cases with micro-AVMs w...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/257153

    authors: Hong JF,Song YF,Liu HB,Liu Z,Wang SS

    更新日期:2015-01-01 00:00:00

  • The Relationship of Oxidation Sensitivity of Red Blood Cells and Carbonic Anhydrase Activity in Stored Human Blood: Effect of Certain Phenolic Compounds.

    abstract::It has been reported that many modifications occur with the increase of oxidative stress during storage in erythrocytes. In order to delay these negative changes, we evaluated whether the addition of substances likely to protect antioxidant capacity in stored blood would be useful. Therefore, we investigated the effec...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3057384

    authors: Huyut Z,Şekeroğlu MR,Balahoroğlu R,Karakoyun T,Çokluk E

    更新日期:2016-01-01 00:00:00

  • Automatic epileptic seizure detection using scalp EEG and advanced artificial intelligence techniques.

    abstract::The epilepsies are a heterogeneous group of neurological disorders and syndromes characterised by recurrent, involuntary, paroxysmal seizure activity, which is often associated with a clinicoelectrical correlate on the electroencephalogram. The diagnosis of epilepsy is usually made by a neurologist but can be difficul...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/986736

    authors: Fergus P,Hignett D,Hussain A,Al-Jumeily D,Abdel-Aziz K

    更新日期:2015-01-01 00:00:00

  • Bacterial Extracellular DNA Production Is Associated with Outcome of Prosthetic Joint Infections.

    abstract::In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staph...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/1067413

    authors: Zatorska B,Arciola CR,Haffner N,Segagni Lusignani L,Presterl E,Diab-Elschahawi M

    更新日期:2018-10-22 00:00:00

  • Extensive Use of 3D Nonfluoroscopic Mapping Systems for Reducing Radiation Exposure during Catheter Ablation Procedures: An Analysis of 10 Years of Activity.

    abstract:Purpose:3D nonfluoroscopic mapping systems (NMSs) are generally used in the catheter ablation (CA) of complex ventricular and atrial arrhythmias. The aim of this study was to evaluate the efficacy, safety, and long-term effect of the extended, routine use of NMSs for CA. Methods:Our study involved 1028 patients who un...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4217076

    authors: Marini M,Martin M,Ravanelli D,Del Greco M,Quintarelli S,Guarracini F,Coser A,Valentini A,Bonmassari R

    更新日期:2019-03-10 00:00:00

  • Do Different LED Colours Influence Sand Fly Collection by Light Trap in the Mediterranean?

    abstract::Light traps represent the most used attractive system to collect and monitor phlebotomine sand flies. Recent studies have suggested that light traps can be easily upgraded by the use of light-emitting diode (LED) with positive effects on trap design, weight, and battery life. However, scant data on the effect of diffe...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6432637

    authors: Gaglio G,Napoli E,Arfuso F,Abbate JM,Giannetto S,Brianti E

    更新日期:2018-06-27 00:00:00

  • Inhibitory Effects of Compounds and Extracts from Ampelopsis brevipedunculata on IL-6-Induced STAT3 Activation.

    abstract::Ampelopsis brevipedunculata (Maxim.) Trautv. (AB), a traditional East Asian medicine, exhibits protective effects against several inflammatory diseases. Our search for an inhibitor of IL-6-induced JAK2/STAT3 activation revealed that AB ethanolic extract (ABE) had a significant inhibitory effect on IL-6-induced STAT3 e...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3684845

    authors: Jang HJ,Lee SJ,Lim HJ,Jung K,Lee S,Park CS,Lee SW,Rho MC

    更新日期:2018-06-10 00:00:00

  • Effect of curcumin on the increase in hepatic or brain phosphatidylcholine hydroperoxide levels in mice after consumption of excessive alcohol.

    abstract::Curcumin is a bright yellow compound found in Curcuma longa L., a member of the family Zingiberaceae. In the present study, we determined whether curcumin protects against oxidative stress in liver and brain in mice fed excessive alcohol. BALB/c mice were administered 20% alcohol (16 g/kg body weight) with or without ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/242671

    authors: Pyun CW,Han KH,Hong GE,Lee CH

    更新日期:2013-01-01 00:00:00

  • Pinelliae Rhizoma Praeparatum Cum Alumine Extract: Sedative and Hypnotic Effects in Mice and Component Compounds.

    abstract::Pinelliae Rhizoma Praeparatum Cum Alumine (PRPCA) is useful for eliminating dampness and phlegm in clinical settings, targeting the main mechanisms of insomnia as defined in traditional Chinese medicine. However, little is known regarding the sedative and hypnotic effects of PRPCA. In the present study, we examined th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6198067

    authors: Lin S,Nie B,Song K,Ye R,Yuan Z

    更新日期:2019-04-28 00:00:00

  • Macleaya cordata Extract Decreased Diarrhea Score and Enhanced Intestinal Barrier Function in Growing Piglets.

    abstract::Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract su...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/1069585

    authors: Liu G,Guan G,Fang J,Martínez Y,Chen S,Bin P,Duraipandiyan V,Gong T,Tossou MC,Al-Dhabi NA,Yin Y

    更新日期:2016-01-01 00:00:00

  • Deep Response in Multiple Myeloma: A Critical Review.

    abstract::Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should ...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/832049

    authors: Fulciniti M,Munshi NC,Martinez-Lopez J

    更新日期:2015-01-01 00:00:00

  • Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze Dried Syzygium jambolanum (Lam.) DC Fruit Juice.

    abstract::This work aimed to explore the cardiovascular effects induced by freeze-dried juice from Syzygium jambolanum (Lam.) DC fruits (JSJ). JSJ presented high polyphenol content and steroids. HPLC analysis revealed that 2,5-dihydroxybenzoic and caffeic acid were present in higher amounts in the JSJ extract. In rat, JSJ induc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4827461

    authors: Assis KS,Araújo IGA,de Azevedo FLAA,Maciel PMP,Machado Calzerra NT,da Silva TAF,Assis VL,de Vasconcelos AP,Santos CAG,Meireles BRLA,Cordeiro AMTM,Araújo DAM,Ribeiro TP,Medeiros IA

    更新日期:2018-10-08 00:00:00

  • Potentiated Osteoinductivity via Cotransfection with BMP-2 and VEGF Genes in Microencapsulated C2C12 Cells.

    abstract::Microcapsules with entrapped cells hold great promise for repairing bone defects. Unfortunately, the osteoinductivity of microcapsules has been restricted by many factors, among which the deficiency of functional proteins is a significant priority. We potentiated the osteoinductivity of microencapsulated cells via cot...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/435253

    authors: Shen Y,Qiao H,Fan Q,Zhang S,Tang T

    更新日期:2015-01-01 00:00:00

  • Therapeutic Effects of CUR-Activated Human Umbilical Cord Mesenchymal Stem Cells on 1-Methyl-4-phenylpyridine-Induced Parkinson's Disease Cell Model.

    abstract::The purpose of this study is to evaluate the therapeutic effects of human umbilical cord-derived mesenchymal stem cells (hUC-MSC) activated by curcumin (CUR) on PC12 cells induced by 1-methyl-4-phenylpyridinium ion (MPP+), a cell model of Parkinson's disease (PD). The supernatant of hUC-MSC and hUC-MSC activated by 5 ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/9140541

    authors: Jinfeng L,Yunliang W,Xinshan L,Yutong W,Shanshan W,Peng X,Xiaopeng Y,Zhixiu X,Qingshan L,Honglei Y,Xia C,Hongwei W,Bingzhen C

    更新日期:2016-01-01 00:00:00

  • Sex steroid metabolism in benign and malignant intact prostate biopsies: individual profiling of prostate intracrinology.

    abstract::In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in prostate homeostasis. Most of the studies evaluated intraprostatic hormone metabolism using cell lines or preprocessed specimens. Using an ex vivo model of intact tissue cultures with preserved architecture, we characteriz...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/464869

    authors: Gianfrilli D,Pierotti S,Pofi R,Leonardo C,Ciccariello M,Barbagallo F

    更新日期:2014-01-01 00:00:00

  • The International Prognostic Index for Patients with Chronic Lymphocytic Leukemia Has the Higher Value in Predicting Overall Outcome Compared with the Barcelona-Brno Biomarkers Only Prognostic Model and the MD Anderson Cancer Center Prognostic Index.

    abstract::In recent years, new prognostic indexes (PIs) for chronic lymphocytic leukemia (CLL), which include clinical, biological, and genetic variables, have been validated, highlighting the MD Anderson Cancer Center prognostic index (MDACC PI), the CLL-international prognostic index (CLL-IPI), and the Barcelona-Brno biomarke...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9506979

    authors: Muñoz-Novas C,Poza-Santaella M,González-Gascón Y Marín I,Hernández-Sánchez M,Rodríguez-Vicente AE,Infante MS,Heras C,Foncillas MÁ,Marín K,Hernández-Rivas JM,Hernández JÁ

    更新日期:2018-03-15 00:00:00

  • Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells.

    abstract::The effect of crocetin (C20H24O4) on methylcholanthrene- (MCA-) induced uterine cervical cancer in mice was studied in this paper. After the mice were treated orally with crocetin, maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were examined by ELISA...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/829513

    authors: Chen B,Hou ZH,Dong Z,Li CD

    更新日期:2015-01-01 00:00:00

  • In vitro culture-induced pluripotency of human spermatogonial stem cells.

    abstract::Unipotent spermatogonial stem cells (SSCs) can be transformed into ESC-like cells that exhibit pluripotency in vitro. However, except for mouse models, their characterization and their origins have remained controversies in other models including humans. This controversy has arisen primarily from the lack of the direc...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2013/143028

    authors: Lim JJ,Kim HJ,Kim KS,Hong JY,Lee DR

    更新日期:2013-01-01 00:00:00

  • Modulation of Diabetes Mellitus-Induced Male Rat Reproductive Dysfunction with Micro-Nanoencapsulated Echinacea purpurea Ethanol Extract.

    abstract::Diabetes mellitus is a major health problem that affects a patient's life quality throughout the world due to its worst complications. It was recognized that chronic hyperglycemia with oxidative stress was the major cause of male infertility. Echinacea purpurea ethanol extract (EE) contains phenolic acid and isobutyla...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4237354

    authors: Mao CF,Zhang XR,Johnson A,He JL,Kong ZL

    更新日期:2018-08-30 00:00:00

  • Microcystins Presence in Mussels (M. galloprovincialis) and Water of Two Productive Mediterranean's Lagoons (Sardinia, Italy).

    abstract::Microcystins (MCs) are hepatotoxins harmful for animal and human health. The most toxic type between them is MC-LR whose presence has been investigated in different reservoirs all around the world. In this work microcystins were monitored in spring and summer in water and mussels (Mytilus galloprovincialis) of two Sar...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/3769245

    authors: Baralla E,Varoni MV,Sedda T,Pasciu V,Floris A,Demontis MP

    更新日期:2017-01-01 00:00:00

  • Diverse Reductive Dehalogenases Are Associated with Clostridiales-Enriched Microcosms Dechlorinating 1,2-Dichloroethane.

    abstract::The achievement of successful biostimulation of active microbiomes for the cleanup of a polluted site is strictly dependent on the knowledge of the key microorganisms equipped with the relevant catabolic genes responsible for the degradation process. In this work, we present the characterization of the bacterial commu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/242856

    authors: Merlino G,Balloi A,Marzorati M,Mapelli F,Rizzi A,Lavazza D,de Ferra F,Carpani G,Daffonchio D

    更新日期:2015-01-01 00:00:00

  • Unilateral Multifocality and Bilaterality Could Be Two Different Multifocal Entities in Patients with Papillary Thyroid Microcarcinoma.

    abstract:Objective:Multifocality within an affected lobe (unilateral multifocality) or two lobes (bilaterality) is commonly denoted as multifocality without differentiation. Recently, there has been molecular evidence indicating that unilateral multifocality and bilaterality could be two different entities. However, few studies...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9854964

    authors: Cai J,Fang F,Chen J,Xiang D

    更新日期:2020-07-03 00:00:00

  • Specific Binding Peptides from Rv3632: A Strategy for Blocking Mycobacterium tuberculosis Entry to Target Cells?

    abstract::Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb, i.e., the aetiological agent); the WHO has established this disease as high priority due to its ensuing mortality. Mtb uses a range of mechanisms for preventing its elimination by an infected host; new, viable alternatives for blocking th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/8680935

    authors: Sánchez-Barinas CD,Ocampo M,Tabares L,Bermúdez M,Patarroyo MA,Patarroyo ME

    更新日期:2019-04-14 00:00:00

  • Analyzing Active Constituents and Optimal Steaming Conditions Related to the Hematopoietic Effect of Steamed Panax notoginseng by Network Pharmacology Coupled with Response Surface Methodology.

    abstract::During hundreds of years of medication, it is believed that the steamed Panax notoginseng (SPN) can enrich and regulate the blood, replenish the body, and improve the health. The aim of this study was to optimize the steaming conditions of SPN which are related to the hematopoietic effect. In the study, network pharma...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9371426

    authors: Zhou S,Jiang N,Zhang M,Xiao X,Liu Z,Xu X,Gao Q,Lv W

    更新日期:2020-07-26 00:00:00

  • Recent Treatment Advances and New Trials in Adult Nephrotic Syndrome.

    abstract::The etiology of nephrotic syndrome is complex and ranges from primary glomerulonephritis to secondary forms. Patients with nephrotic syndrome often need immunosuppressive treatment with its side effects and may progress to end stage renal disease. This review focuses on recent advances in the treatment of primary caus...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/7689254

    authors: Königshausen E,Sellin L

    更新日期:2017-01-01 00:00:00

  • Tyrosine kinase inhibitors induced thyroid dysfunction: a review of its incidence, pathophysiology, clinical relevance, and treatment.

    abstract::Tyrosine kinase inhibitors (TKI) belong to a new class of molecular multitargeted anticancer therapy which targets different growth factor receptors and hence attenuates cancer cell survival and growth. Since their introduction as adjunct treatment for renal cell carcinoma and gastrointestinal stromal tumors (GIST), a...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/725410

    authors: Ahmadieh H,Salti I

    更新日期:2013-01-01 00:00:00

  • Effect of Chronic Kidney Disease on Changes in Vasopressin System Expression in the Kidney Cortex in Rats with Nephrectomy.

    abstract::It is believed that the vasopressinergic system plays an important role in the pathogenesis of chronic kidney disease (CKD). The aim of this study was to evaluate the effect of CKD on changes in vasopressin system expression in the kidney cortex in rats with nephrectomy. The study was performed on 4 groups of Sprague ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2607928

    authors: Czarzasta K,Cudnoch-Jedrzejewska A,Niemczyk L,Wrzesien R,Tkaczyk M,Puchalska L,Saracyn M,Zmudzki W,Niemczyk S

    更新日期:2018-06-14 00:00:00

  • Characterization of Positional Distribution of Fatty Acids and Triacylglycerol Molecular Compositions of Marine Fish Oils Rich in Omega-3 Polyunsaturated Fatty Acids.

    abstract::The regiospecific characteristics of n-3 polyunsaturated fatty acids (PUFAs) in triacylglycerol (TAG) significantly affect the physicochemical and physiological properties of marine fish oils. In this study, the TAG molecular species composition and positional distributions of fatty acids were investigated in three ma...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/3529682

    authors: Zhang H,Zhao H,Zhang Y,Shen Y,Su H,Jin J,Jin Q,Wang X

    更新日期:2018-07-10 00:00:00

  • Monitoring the modifications of the vitreous humor metabolite profile after death: an animal model.

    abstract::We applied a metabolomic approach to monitor the modifications occurring in goat vitreous humor (VH) metabolite composition at different times (0, 6, 12, 18, and 24 hours) after death. The (1)H-NMR analysis of the VH samples was performed for the simultaneous determination of several metabolites (i.e., the metabolite ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/627201

    authors: Rosa MF,Scano P,Noto A,Nioi M,Sanna R,Paribello F,De-Giorgio F,Locci E,d'Aloja E

    更新日期:2015-01-01 00:00:00

  • The influence of simulated microgravity on purinergic signaling is different between individual culture and endothelial and smooth muscle cell coculture.

    abstract::Exposure to microgravity conditions causes cardiovascular deconditioning in astronauts during spaceflight. Until now, no specific drugs are available for countermeasure, since the underlying mechanism is largely unknown. Endothelial cells (ECs) and smooth muscle cells (SMCs) play key roles in various vascular function...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/413708

    authors: Zhang Y,Lau P,Pansky A,Kassack M,Hemmersbach R,Tobiasch E

    更新日期:2014-01-01 00:00:00