当前位置： SCI文献检索 > Biomed Research International期刊下所有文献 > The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients.

The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients.

Abstract：

BACKGROUND:This study investigated whether the 1 : 2 ω-3/ω-6 ratio may reduce proinflammatory response in human alveolar cells (A549) exposed to an ex vivo inflammatory stimulus (bronchoalveolar lavage fluid (BALF) of acute respiratory distress syndrome (ARDS) patients). Methods. We exposed A549 cells to the BALF collected from 12 ARDS patients. After 18 hours, fatty acids (FA) were added as docosahexaenoic acid (DHA, ω-3) and arachidonic acid (AA, ω-6) in two ratios (1 : 2 or 1 : 7). 24 hours later, in culture supernatants were evaluated cytokines (TNF-α, IL-6, IL-8, and IL-10) and prostaglandins (PGE2 and PGE3) release. The FA percentage content in A549 membrane phospholipids, content of COX-2, level of PPARγ, and NF-κB binding activity were determined. RESULTS:The 1 : 2 DHA/AA ratio reversed the baseline predominance of ω-6 over ω-3 in the cell membranes (P < 0.001). The proinflammatory cytokine release was reduced by the 1 : 2 ratio (P < 0.01 to <0.001) but was increased by the 1 : 7 ratio (P < 0.01). The 1 : 2 ratio reduced COX-2 and PGE2 (P < 0.001) as well as NF-κB translocation into the nucleus (P < 0.01), while it increased activation of PPARγ and IL-10 release (P < 0.001). Conclusion. This study demonstrated that shifting the FA supply from ω-6 to ω-3 decreased proinflammatory mediator release in human alveolar cells exposed to BALF of ARDS patients.

journal_name

Biomed Res Int

journal_title

BioMed research international

authors

Cotogni P,Trombetta A,Muzio G,Maggiora M,Canuto RA

doi

10.1155/2015/642520

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

642520

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章

相关文献

Biomed Research International文献大全
  • Comparison of the Effect of Vaginal Zataria multiflora Cream and Oral Metronidazole Pill on Results of Treatments for Vaginal Infections including Trichomoniasis and Bacterial Vaginosis in Women of Reproductive Age.

    abstract：:Effect of Zataria multiflora on bacterial vaginosis and Trichomonas vaginalis is shown in vivo and in vitro. We compare the effectiveness of Zataria multiflora cream and oral metronidazole pill on results of treatment for vaginal infections including Trichomonas and bacterial vaginosis; these infections occur simultan...

    journal_title：BioMed research international

    pub_type： 杂志文章,随机对照试验

    doi：10.1155/2015/683640

    authors： Abdali K,Jahed L,Amooee S,Zarshenas M,Tabatabaee H,Bekhradi R

    更新日期：2015-01-01 00:00:00

  • Systematic analysis of the associations between adverse drug reactions and pathways.

    abstract：:Adverse drug reactions (ADRs) are responsible for drug candidate failure during clinical trials. It is crucial to investigate biological pathways contributing to ADRs. Here, we applied a large-scale analysis to identify overrepresented ADR-pathway combinations through merging clinical phenotypic data, biological pathw...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2015/670949

    authors： Chen X,Wang Y,Wang P,Lian B,Li C,Wang J,Li X,Jiang W

    更新日期：2015-01-01 00:00:00

  • Association between the Urinary Bladder Volume and the Incidence of "De Novo" Overactive Bladder in Patients with Stress Urinary Incontinence Subjected to Sling Surgeries or Burch Procedure.

    abstract：:Aim. The aim of the study was to compare the incidence of "de novo" overactive bladder (OAB) after sling surgeries and Burch procedure and to analyze the effect of the preoperative bladder volume on the incidence of this condition. Methods. This prospective trial included 290 female patients with stress urinary incont...

    journal_title：BioMed research international

    pub_type： 临床试验,杂志文章

    doi：10.1155/2019/9515242

    authors： Ciećwież S,Chełstowski K,Brodowska A,Ptak M,Kotlęga D,Starczewski A

    更新日期：2019-02-12 00:00:00

  • Which Neighborhood Destinations Matter in the Asian Context? The Role of Destinations in Older Adults' Physical Activity and Sedentary Behaviors.

    abstract：Background:Neighborhood destinations play important roles in daily activity levels of older adults. However, little is known about how specific destinations are associated with these activities and/or sedentary behaviors, especially in Asia. This study investigated how neighborhood destinations were associated with phy...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2020/8432934

    authors： Park JH,Park JH,Song S,Lai TF,Liao Y

    更新日期：2020-07-30 00:00:00

  • The role of 18F-FDG PET/CT in large-vessel vasculitis: appropriateness of current classification criteria?

    abstract：:Patients with clinical suspicion of large-vessel vasculitis (LVV) may present with nonspecific signs and symptoms and increased inflammatory parameters and may remain without diagnosis after routine diagnostic procedures. Both the nonspecificity of the radiopharmaceutical (18)F-FDG and the synergy of integrating funct...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2014/687608

    authors： Balink H,Bennink RJ,van Eck-Smit BL,Verberne HJ

    更新日期：2014-01-01 00:00:00

  • Norvaline Reduces Blood Pressure and Induces Diuresis in Rats with Inherited Stress-Induced Arterial Hypertension.

    abstract：:Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase sub...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2020/4935386

    authors： Gilinsky MA,Polityko YK,Markel AL,Latysheva TV,Samson AO,Polis B,Naumenko SE

    更新日期：2020-02-12 00:00:00

  • Clinical and Prognostic Significance of Positive Hepatojugular Reflux on Discharge in Acute Heart Failure: Insights from the ESCAPE Trial.

    abstract：:Background. There has been a decline in emphasis of the value of physical examination in heart failure (HF) with increased reliance on cardiac imaging. We aim to study the clinical and prognostic significance of positive hepatojugular reflux (HJR) on discharge in patients hospitalized with HF. Methods. Using the ESCAP...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2017/5734749

    authors： Omar HR,Guglin M

    更新日期：2017-01-01 00:00:00

  • Plant growth promotion potential is equally represented in diverse grapevine root-associated bacterial communities from different biopedoclimatic environments.

    abstract：:Plant-associated bacteria provide important services to host plants. Environmental factors such as cultivar type and pedoclimatic conditions contribute to shape their diversity. However, whether these environmental factors may influence the plant growth promoting (PGP) potential of the root-associated bacteria is not ...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2013/491091

    authors： Marasco R,Rolli E,Fusi M,Cherif A,Abou-Hadid A,El-Bahairy U,Borin S,Sorlini C,Daffonchio D

    更新日期：2013-01-01 00:00:00

  • Direct Tensile Strength and Characteristics of Dentin Restored with All-Ceramic, Resin-Composite, and Cast Metal Prostheses Cemented with Resin Adhesives.

    abstract：:A dentin-cement-prosthesis complex restored with either all-porcelain, cured resin-composite, or cast base metal alloy and cemented with either of the different resin cements was trimmed into a mini-dumbbell shape for tensile testing. The fractured surfaces and characterization of the dentin-cement interface of bonded...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2015/656948

    authors： Piemjai M,Nakabayashi N

    更新日期：2015-01-01 00:00:00

  • Assessment of the Relationship between Y-Balance Test and Stabilometric Parameters in Youth Footballers.

    abstract：Objectives:The purpose of the study was to evaluate the correlation between dynamic test results obtained on a stabilometric platform and the results achieved on the Y-balance test (Y-BT). Method:The study group consisted of 52 adolescent athletes, aged 14 to 17 years. Each participant was evaluated in the scope of th...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2020/6968473

    authors： Sikora D,Pałac M,Myśliwiec A,Wolny T,Linek P

    更新日期：2020-11-12 00:00:00

  • Incidence and Predictors of Catheterization-Related Cerebral Infarction on Diffusion-Weighted Magnetic Resonance Imaging.

    abstract：:Introduction. The aim of this study was to examine the incidence and risk factors of catheterization-related CI in the contemporary era, using diffusion-weighted magnetic resonance imaging. Methods. We retrospectively analyzed consecutive 84 patients who underwent MRI (magnetic resonance imaging) after 2.81 ± 2.4 days...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2016/6052125

    authors： Morita Y,Kato T,Okano M,Suu K,Kimura M,Minamino-Muta E,Nakane E,Izumi T,Miyamoto S,Haruna T,Ueyama K,Inoko M

    更新日期：2016-01-01 00:00:00

  • Metabolic Comorbidities and Risk of Development and Severity of Drug-Induced Liver Injury.

    abstract：:The incidence and rates of diagnosis of drug-induced liver injury (DILI) have been increasing in recent years as findings from basic research and the examination of clinical databases reveal information about the clinical course, etiology, and prognosis of this complex disease. The prevalence of metabolic comorbiditie...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2019/8764093

    authors： Li X,Gao P,Niu J

    更新日期：2019-08-18 00:00:00

  • Natural Language Processing Based Instrument for Classification of Free Text Medical Records.

    abstract：:According to the Ministry of Labor, Health and Social Affairs of Georgia a new health management system has to be introduced in the nearest future. In this context arises the problem of structuring and classifying documents containing all the history of medical services provided. The present work introduces the instru...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2016/8313454

    authors： Khachidze M,Tsintsadze M,Archuadze M

    更新日期：2016-01-01 00:00:00

  • Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure.

    abstract：:Positive results of MitraClip in terms of improvement in clinical and left ventricular parameters have been described in detail. However, long-term effects on secondary pulmonary hypertension were not investigated in a larger patient cohort to date. 70 patients with severe mitral regurgitation, additional pulmonary hy...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2018/6817832

    authors： Hünlich M,Lubos E,Beuthner BE,Puls M,Bleckmann A,Beißbarth T,Tichelbäcker T,Rudolph V,Baldus S,Schäfer U,Treede H,Von Bardeleben RS,Blankenberg S,Schillinger W

    更新日期：2018-03-14 00:00:00

  • Biotechnological Aspects and Perspective of Microbial Keratinase Production.

    abstract：:Keratinases are proteolytic enzymes predominantly active when keratin substrates are available that attack disulfide bridges in the keratin to convert them from complex to simplified forms. Keratinases are essential in preparation of animal nutrients, protein supplements, leather manufacture, textile processing, deter...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2015/140726

    authors： Gopinath SC,Anbu P,Lakshmipriya T,Tang TH,Chen Y,Hashim U,Ruslinda AR,Arshad MK

    更新日期：2015-01-01 00:00:00

  • Influence of Acquisition Time on MR Image Quality Estimated with Nonparametric Measures Based on Texture Features.

    abstract：:Correlation of parametrized image texture features (ITF) analyses conducted in different regions of interest (ROIs) overcomes limitations and reliably reflects image quality. The aim of this study is to propose a nonparametrical method and classify the quality of a magnetic resonance (MR) image that has undergone cont...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2019/3706581

    authors： Obuchowicz R,Piórkowski A,Urbanik A,Strzelecki M

    更新日期：2019-11-20 00:00:00

  • Gene Variant in the NF-κB Pathway Inhibitor NFKBIA Distinguishes Patients with Psoriatic Arthritis within the Spectrum of Psoriatic Disease.

    abstract：Background and Aims:The NF-κB pathway has been implicated in the genetic aetiology of psoriatic disease. However, since most patients with arthritis have psoriasis, discerning the genetic contributions to both aspects of psoriatic disease is not easy. Our aim was to study the association of common polymorphisms in gene...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2019/1030256

    authors： Coto-Segura P,Coto E,González-Lara L,Alonso B,Gómez J,Cuesta-Llavona E,Queiro R

    更新日期：2019-11-11 00:00:00

  • Meta-analysis: the efficacy and safety of paricalcitol for the treatment of secondary hyperparathyroidism and proteinuria in chronic kidney disease.

    abstract：INTRODUCTION:Previous studies have demonstrated the safety and efficacy of using Paricalcitol for the treatment of secondary hyperparathyroidism (SHPT) in patients on dialysis. The aim of the current meta-analysis was to assess the safety and efficacy of Paricalcitol for the management of SHPT in patients with chronic ...

    journal_title：BioMed research international

    pub_type： 杂志文章,meta分析

    doi：10.1155/2013/320560

    authors： Han T,Rong G,Quan D,Shu Y,Liang Z,She N,Liu M,Yang B,Cheng G,Lv Y,Stern L

    更新日期：2013-01-01 00:00:00

  • Steroid Tumor Environment in Male and Female Mice Model of Canine and Human Inflammatory Breast Cancer.

    abstract：:Canine inflammatory mammary cancer (IMC) shares clinical and histopathological characteristics with human inflammatory breast cancer (IBC) and has been proposed as a good model for studying the human disease. The aim of this study was to evaluate the capacity of female and male mice to reproduce IMC and IBC tumors and...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2016/8909878

    authors： Caceres S,Peña L,Silvan G,Illera MJ,Woodward WA,Reuben JM,Illera JC

    更新日期：2016-01-01 00:00:00

  • Angiopoietin-1 Promotes the Integrity of Neovascularization in the Subcutaneous Matrigel of Type 1 Diabetic Rats.

    abstract：Objective:This study aimed to investigate the effects of Ang-1 on neovascularization of diabetic organs by subcutaneous Matrigel angiogenesis model, established in type 1 diabetic rats. Methods:Ang-1 adenoviral vector was constructed. The rat model was established by STZ and divided into four group. The Matrigel was i...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2019/2016972

    authors： Li S,Zou H,Gong M,Chen Y,Yan X,Yu L,Yang Y

    更新日期：2019-01-09 00:00:00

  • IDH1/IDH2 but not TP53 mutations predict prognosis in Bulgarian glioblastoma patients.

    abstract：:Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. To determine the prevalence of IDH1, IDH2, and TP53 mutations and their impact on overall surviva...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2014/654727

    authors： Stancheva G,Goranova T,Laleva M,Kamenova M,Mitkova A,Velinov N,Poptodorov G,Mitev V,Kaneva R,Gabrovsky N

    更新日期：2014-01-01 00:00:00

  • Highly Soluble Drugs Directly Granulated by Water Dispersions of Insoluble Eudragit® Polymers as a Part of Hypromellose K100M Matrix Systems.

    abstract：:The aim of the present study was to investigate the suitability of insoluble Eudragit® water dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble levetiracetam in order to decrease its burst effect from HPMC K100M matrices. The process characteristics, ss-NMR analysis, in vitro dissolutio...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2019/8043415

    authors： Mašková E,Naiserová M,Kubová K,Mašek J,Pavloková S,Urbanová M,Brus J,Vysloužil J,Vetchý D

    更新日期：2019-03-05 00:00:00

  • The Effects of County Public Hospital Reform on the Consumption and Costs of Antibiotics: Evidence from a Quasinatural Experiment in Jiangsu, China.

    abstract：Background:Overuse of antibiotics is a major driver for rapid spread of antimicrobial resistance worldwide, particularly common in China. The close linkage between hospital revenue and sales of drugs has become the key incentive for overprescription of antibiotics. Since 2009, the Chinese government implemented a serie...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2020/9262170

    authors： Wang Y,Zhu Y,Liu X,Xu X,Fang W,Li X

    更新日期：2020-10-22 00:00:00

  • Inflammatory Cellular Response to Mechanical Ventilation in Elastase-Induced Experimental Emphysema: Role of Preexisting Alveolar Macrophages Infiltration.

    abstract：:An excessive pulmonary inflammatory response could explain the poor prognosis of chronic obstructive pulmonary disease (COPD) patients submitted to invasive mechanical ventilation. The aim of this study was to evaluate the response to normal tidal volume mechanical ventilation in an elastase-induced murine model of pu...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2018/5721293

    authors： Rouze A,Voiriot G,Guivarch E,Roux F,Tran Van Nhieu J,Isabey D,Brochard L,Maitre B,Mekontso-Dessap A,Boczkowski J

    更新日期：2018-12-19 00:00:00

  • Toxic damage increases angiogenesis and metastasis in fibrotic livers via PECAM-1.

    abstract：:Excessive ethanol consumption is one of the main causes of liver fibrosis. However, direct effects of ethanol exposure on endothelial cells and their contribution to fibrogenesis and metastasis were not investigated. Therefore we analysed whether ethanol directly affects endothelial cells and if this plays a role duri...

    journal_title：BioMed research international

    pub_type： 杂志文章

    doi：10.1155/2014/712893

    authors： Raskopf E,Gonzalez Carmona MA,Van Cayzeele CJ,Strassburg C,Sauerbruch T,Schmitz V

    更新日期：2014-01-01 00:00:00

  • Abdominal Hernias, Giant Colon Diverticulum, GIST, Intestinal Pneumatosis, Colon Ischemia, Cold Intussusception, Gallstone Ileus, and Foreign Bodies: Our Experience and Literature Review of Incidental Gastrointestinal MDCT Findings.

    abstract：:Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today's experience of several gastrointestinal acute conditions such as abdominal hernia,...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2017/5716835

    authors： Di Grezia G,Gatta G,Rella R,Donatello D,Falco G,Grassi R,Grassi R

    更新日期：2017-01-01 00:00:00

  • Platelet rich plasma and knee surgery.

    abstract：:In orthopaedic surgery and sports medicine, the knee joint has traditionally been considered the workhorse. The reconstruction of every damaged element in this joint is crucial in achieving the surgeon's goal to restore the knee function and prevent degeneration towards osteoarthritis. In the last fifteen years, the f...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2014/890630

    authors： Sánchez M,Delgado D,Sánchez P,Fiz N,Azofra J,Orive G,Anitua E,Padilla S

    更新日期：2014-01-01 00:00:00

  • Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery in the Sugammadex Era: A Retrospective Study.

    abstract：BACKGROUND:Residual neuromuscular block (NMB) after general anesthesia has been associated with pulmonary dysfunction and hypoxia, which are both associated with postoperative delirium (POD). We evaluated the effects of sugammadex on POD in elderly patients who underwent hip fracture surgery. METHODS:Medical records o...

    journal_title：BioMed research international

    pub_type： 临床试验,杂志文章

    doi：10.1155/2016/1054597

    authors： Oh CS,Rhee KY,Yoon TG,Woo NS,Hong SW,Kim SH

    更新日期：2016-01-01 00:00:00

  • Current Approach in the Diagnosis and Management of Uveitic Glaucoma.

    abstract：:Uveitic glaucoma (UG) typically is associated with very high intraocular pressure (IOP) and more intense optic nerve damage than other glaucoma types. This secondary glaucoma requires an early diagnosis and adequate management of both uveitis and glaucoma. It is mandatory to identify the mechanisms of IOP elevation th...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2015/742792

    authors： Muñoz-Negrete FJ,Moreno-Montañés J,Hernández-Martínez P,Rebolleda G

    更新日期：2015-01-01 00:00:00

  • Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine.

    abstract：:Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States Food and Drug Admini...

    journal_title：BioMed research international

    pub_type： 杂志文章,评审

    doi：10.1155/2016/2346585

    authors： Murata S,Zhang C,Finch N,Zhang K,Campo L,Breuer EK

    更新日期：2016-01-01 00:00:00