Abstract:
:Background. There has been a decline in emphasis of the value of physical examination in heart failure (HF) with increased reliance on cardiac imaging. We aim to study the clinical and prognostic significance of positive hepatojugular reflux (HJR) on discharge in patients hospitalized with HF. Methods. Using the ESCAPE trial data, patients were compared according to the presence or absence of a positive HJR on discharge. The primary study endpoints were all-cause mortality and a composite endpoint of death, rehospitalization, and cardiac transplant during the first 6 months after discharge. Results. Among 392 patients (age: 56 years, 74% men), the HJR correlated well with clinical and objective hemodynamic markers of volume overload including right atrial pressure (RAP, P = 0.002), pulmonary capillary wedge pressure (PCWP, P = 0.006), and inferior vena cava size during inspiration (P = 0.005) and expiration (P = 0.003). The RAP had the highest AUC for predicting a positive HJR on admission (AUC: 0.655, P = 0.004) and discharge (AUC: 0.672, P = 0.001). Cox's proportional hazards analysis revealed that a positive HJR on discharge is an independent predictor of 6-month mortality (estimated hazard ratio: 1.689; 95% CI: 1.032-2.764; P = 0.037) after adjusting for age, baseline creatinine, baseline hematocrit, baseline NYHA class, chronic obstructive pulmonary disease, and the presence of tricuspid regurgitation. Conclusion. The HJR should be routinely checked in patients admitted with acute HF throughout hospitalization and especially on discharge as it serves as an important prognostic marker for postdischarge outcomes.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Omar HR,Guglin Mdoi
10.1155/2017/5734749subject
Has Abstractpub_date
2017-01-01 00:00:00pages
5734749eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::Large amounts of various biological networks exist for representing different types of interaction data, such as genetic, metabolic, gene regulatory, and protein-protein relationships. Recent approaches on biological network study are based on different mathematical concepts. It is necessary to construct a uniform fra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7457131
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2017/2168767
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2015/538786
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/978984
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/703792
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/685426
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2016/8450712
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/703130
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2018/2687584
更新日期:2018-11-06 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/701758
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8526190
更新日期:2018-11-25 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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abstract:Objectives:Assessing the therapeutic efficacy of superparamagnetic iron oxide nanoparticles (SPIO) labeled bone marrow-derived mesenchymal stem cells (BM-MSCs) on experimental liver fibrosis and associated dysplasia. Materials and Methods:MSCs were obtained from 10 male Sprague-Dawley rats while 50 female rats were di...
journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2019-11-06 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6560234
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2019/4831459
更新日期:2019-11-11 00:00:00
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journal_title:BioMed research international
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6937328
更新日期:2017-01-01 00:00:00