Abstract:
:As a major tumor suppressor gene, the role of PinX1 in breast cancer and its molecular mechanism remain unclear. In this study, overexpression of PinX1 was generated in 3 breast cancer cell lines, and knockdown of PinX1 was performed in a nontumorigenic breast cell line. The regulation of PinX1 on cell proliferation and cell cycle was observed. A microarray-based lncRNA and mRNA expression profile screening was also performed. We found a lower growth rate, G0/G1 phase arrest, and S phase inhibition in the PinX1 overexpressed breast cancer cells, while a higher growth rate, decreased G0/G1 phase, and increased S phase rate in the PinX1 knocked-down nontumorigenic breast cell. A total of 977 mRNAs and 631 lncRNAs were identified as differentially expressed transcripts between PinX1 overexpressed and control MCF-7 cells. Further analysis identified the involvement of these mRNAs in 52 cancer related pathways and various other biological processes. 11 enhancer-like lncRNAs and 25 lincRNAs with their adjacent mRNA pairs were identified as coregulated transcripts. Our results confirmed the role of PinX1 as a major tumor suppressor gene in breast cancer cell lines and provided information for further research on the molecular mechanisms of PinX1 in tumorigenesis.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Shi R,Zhou JY,Zhou H,Zhao Z,Liang SH,Zheng WL,Ma WLdoi
10.1155/2014/978984subject
Has Abstractpub_date
2014-01-01 00:00:00pages
978984eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjec...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/2025687
更新日期:2016-01-01 00:00:00
abstract::The pathogenesis of intractable epilepsy is not fully clear. In recent years, both animal and clinical trials have shown that the expression of ATP-binding cassette (ABC) transporters is increased in patients with intractable epilepsy; additionally, epileptic seizures can lead to an increase in the number of sites tha...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/194541
更新日期:2015-01-01 00:00:00
abstract::A large number of occupational exposure limit values (OELs) are based on avoiding of sensory irritation of the eyes and the upper respiratory tract. In order to investigate the chemosensory effect range of a chemical, odor and sensory irritation thresholds (lateralization thresholds, LTs) can be assessed. Humidity aff...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2016/6015761
更新日期:2016-01-01 00:00:00
abstract::Glioma of infiltrative nature is challenging for surgeons to achieve tumor-specific and maximal resection. Raman spectroscopy provides structural information on the targeted materials as vibrational shifts. We utilized Raman spectroscopy to distinguish invasive tumors from normal tissues. Spectra obtained from replica...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/860241
更新日期:2014-01-01 00:00:00
abstract:Objective:This study aimed to investigate the effects of Ang-1 on neovascularization of diabetic organs by subcutaneous Matrigel angiogenesis model, established in type 1 diabetic rats. Methods:Ang-1 adenoviral vector was constructed. The rat model was established by STZ and divided into four group. The Matrigel was i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2016972
更新日期:2019-01-09 00:00:00
abstract::Cervical cancer is one of the malignant tumors that seriously threaten women's health. The mechanism of development needs to be deeply studied. In recent years, lncRNA has been identified as one of the important factors affecting the malignant progression of tumors. In this study, we illustrated the important mechanis...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4351671
更新日期:2020-01-03 00:00:00
abstract::Quercetin, a natural flavonol existing in many food resources, has been reported to be an effective antimicrobial and anti-inflammatory agent for restricting the inflammation in periodontitis. In this study, we aimed to investigate the anti-inflammatory effects of quercetin on Porphyromonas gingivalis (P. gingivalis) ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6282635
更新日期:2019-08-20 00:00:00
abstract::Tracking individual-cell/object over time is important in understanding drug treatment effects on cancer cells and video surveillance. A fundamental problem of individual-cell/object tracking is to simultaneously address the cell/object appearance variations caused by intrinsic and extrinsic factors. In this paper, in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8182416
更新日期:2016-01-01 00:00:00
abstract:Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6182464
更新日期:2020-06-07 00:00:00
abstract::Studies pertaining to trans fatty acids (TFA), which have been implicated in development of chronic diseases, are more relevant in developing countries where nutrition transition is changing traditional habits and practices. Measuring TFA is an arduous task because of the need for fat biopsies. This study identifies a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276174
更新日期:2013-01-01 00:00:00
abstract::Chronic obesity is a known risk factor for metabolic syndrome. However, little is known about pathological changes in the small intestine associated with chronic obesity. This study investigated cellular and subcellular level changes in the small intestine of obese mice. In this study, a mouse model of obesity was est...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5251738
更新日期:2016-01-01 00:00:00
abstract:Background and Aims:The present study aimed to develop a simple and sensitive method for quantitative determination of monocrotaline (MCT) in mouse blood employing ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI/MS/MS) using rhynchophylline as an internal standard. Me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1578643
更新日期:2018-08-13 00:00:00
abstract:Background:The predictive values of monocytes in the prognosis of patients with acute paraquat (PQ) poisoning are unclear. This retrospective study investigated the predictive values of monocytes in the prognosis of patients with acute PQ poisoning. Methods:Adult patients who suffered from acute PQ poisoning in the em...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/6360459
更新日期:2019-07-15 00:00:00
abstract:Purpose:To explore the effect of VEGF (vascular endothelial growth factor) on the vasculogenic mimicry (VM) formation of Choroidal Melanoma (CM) through PI3k signal pathway, to find novel targets for CM therapy. Methods:This research investigated the molecular mechanism of VEGF promoting VM formation of CM. First, we ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3909102
更新日期:2019-07-11 00:00:00
abstract:Result:In the denture wearers, HHV8 DNA was detected in 11 cases. Two of the controls amplified HHV8 DNA. Fisher's exact test demonstrates a significant difference between virus infection and using removable dentures (p = 0.015). Conclusion:Our findings suggested that HHV8 detection could be associated with use of den...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9358947
更新日期:2020-04-15 00:00:00
abstract:PURPOSE:Recovery of walking outdoors after hip fracture is important for equal participation in the community. The causes of poor recovery are not fully understood. This study investigates recovery of walking outdoors and associated determinants after hip fracture. METHODS:A prospective follow-up study, among clinical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/289549
更新日期:2014-01-01 00:00:00
abstract:Objectives:Obstructive sleep apnea (OSA) is a common disorder influenced by genetic and environmental factors. Mutations of AT-hook DNA-binding motif containing 1 (AHDC1) gene have been implicated which could cause rare syndromes presenting OSA. This study aims to investigate some rare mutations of AHDC1 in Chinese Han...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5907361
更新日期:2019-10-13 00:00:00
abstract:BACKGROUND:Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse pregnancy complications and neurocognitive deficiencies in the developing fetus. Currently, some researchers demonstrated that body mass index (BMI) is associated with thyroid function in nonpregnant population. Hence, the Ameri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/351831
更新日期:2015-01-01 00:00:00
abstract::Eccentric exercise is characterized by initial unfavorable effects such as subcellular muscle damage, pain, reduced fiber excitability, and initial muscle weakness. However, stretch combined with overload, as in eccentric contractions, is an effective stimulus for inducing physiological and neural adaptations to train...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/193741
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Apoptosis and matrix metalloproteinase (MMP-9) are capable of hydrolysing components of the extracellular matrix and weakening the fetal membranes which leads to eventual rupture, a key process of human parturition. The aim of this study was to determine the effect of supracervical apposition and spontaneous...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/316146
更新日期:2013-01-01 00:00:00
abstract::A large body of evidence has emerged over the past years to show the critical role played by inflammation in the pathogenesis of several diseases including some cardiovascular, neoplastic, and neurodegenerative diseases, previously not considered inflammation-related. The anti-inflammatory action of ω-3 polyunsaturate...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/743171
更新日期:2013-01-01 00:00:00
abstract::Herein the extraction method of fucoidan from Laminaria japonica is reported. Firstly, chitosan, chitosan-N-2-hydroxypropyl trimethyl ammonium chloride (HACC), and hexadecyltrimethylammonium bromide (CPAB) were used to extract the fucoidan. The results showed that chitosan was the optimal extractant compared with the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/193689
更新日期:2013-01-01 00:00:00
abstract::The microbial resistance of fungi and bacteria is currently considered a major public health problem. Esters derived from cinnamic acid have a broad spectrum of pharmacological properties that include antimicrobial activity. In this study, a collection of structurally related 4-chlorocinnamic acid esters was prepared ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3941242
更新日期:2019-04-23 00:00:00
abstract::Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, n = 9) and lo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/169841
更新日期:2015-01-01 00:00:00
abstract::The aims of the present research are to investigate the possible predictors of pancreatic cancer, in particular smoking status, alcohol consumption, hypercholesterolemia, and diabetes mellitus, in patients with histologically confirmed pancreatic carcinoma and to examine the synergism between risk factors. A case-cont...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/481019
更新日期:2014-01-01 00:00:00
abstract::Background. Neuroinflammation which presents as a possible mechanism of delirium is associated with MCP-1, an important proinflammatory factor which is expressed on astrocytes. It is known that dexmedetomidine (DEX) possesses potent anti-inflammatory properties. This study aimed to investigate the potential effects of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6352159
更新日期:2017-01-01 00:00:00
abstract:Objective:To compare the effectiveness of arthroscopic partial meniscectomy (APM) and physical therapy (PT) for degenerative meniscus tears. Method:We conducted a literature search through PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. Randomized controlled trials in adults...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2020/1709415
更新日期:2020-03-03 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the world. Our aim is to identify prognostic biomarkers that contribute to the progression of early stage ccRCC and clarify the mechanism. Here, the mRNA microarray expression profile of ccRCC samples was obtained from Gene Expression Omnibus...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2064582
更新日期:2020-10-29 00:00:00
abstract:Aim:This study aims to evaluate the accuracy of scanned images of 4 clinically used intraoral scanners (CS3600, i500, Trios3, Omnicam) when scanning the surface of full arch models with various kinds of orthodontic brackets in the presence of artificial saliva. Materials and Methods. Four study models were prepared; bo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2920804
更新日期:2020-02-27 00:00:00
abstract::This paper reports the results of an ethnobotanical survey on the use of medicinal plants by community healers "Hampiyachakkuna" in the San Lucas Parish, province of Loja, Ecuador. A particular ethnic group, the indigenous Saraguros, inhabits this region. This study reports 183 plant species used in 75 different curat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9343724
更新日期:2017-01-01 00:00:00