Abstract:
:Glioma of infiltrative nature is challenging for surgeons to achieve tumor-specific and maximal resection. Raman spectroscopy provides structural information on the targeted materials as vibrational shifts. We utilized Raman spectroscopy to distinguish invasive tumors from normal tissues. Spectra obtained from replication-competent avian sarcoma-(RCAS-) based infiltrative glioma cells and glioma tissues (resembling low-grade human glioma) were compared with those obtained from normal mouse astrocytes and normal tissues. In cell analysis, the spectra at 950-1000, 1030, 1050-1100, 1120-1130, 1120-1200, 1200-1300, 1300-1350, and 1450 cm(-1) were significantly higher in infiltrative glioma cells than in normal astrocytes. In brain tissue analysis, the spectra at 1030, 1050-1100, and 1200-1300 cm(-1) were significantly higher in infiltrative glioma tissues than in normal brain tissues. These spectra reflect the structures of proteins, lipids, and DNA content. The sensitivity and specificity to predict glioma cells by distinguishing normal cells were 98.3% and 75.0%, respectively. Principal component analysis elucidated the significance of spectral difference between tumor tissues and normal tissues. It is possible to distinguish invasive tumors from normal tissues by using Raman spectroscopy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Tanahashi K,Natsume A,Ohka F,Momota H,Kato A,Motomura K,Watabe N,Muraishi S,Nakahara H,Saito Y,Takeuchi I,Wakabayashi Tdoi
10.1155/2014/860241subject
Has Abstractpub_date
2014-01-01 00:00:00pages
860241eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::The aim of the study was to assess the granulocyte colony-stimulating factor (G-CSF) effects on unresponsive thin (<7 mm) endometrium in women undergoing in vitro fertilization (IVF). We included thirty-seven subjects who had thin unresponsive endometrium on the day of triggering ovulation. These patients also failed ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/913235
更新日期:2014-01-01 00:00:00
abstract::It is unclear whether the methyltransferase-like 14 (METTL14) protein promotes or suppresses cancer growth. We examined the association between METTL14 expression, cancer progression, and patient prognosis in a total of 398 breast cancer tissue specimens. Significantly fewer cancer tissue specimens compared with norma...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8823270
更新日期:2020-10-20 00:00:00
abstract::The energy generated by an extremely low frequency electromagnetic field (ELF-EMF) is too weak to directly induce genotoxicity. However, it is reported that an extremely low frequency magnetic field (ELF-MF) is related to DNA strand breakage and apoptosis. The testes that conduct spermatogenesis through a dynamic cell...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/567183
更新日期:2014-01-01 00:00:00
abstract::Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/341308
更新日期:2015-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have bee...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/837157
更新日期:2014-01-01 00:00:00
abstract::Historically, the colistin has been thought to kill bacteria through membrane lysis. Here, we present an alternative mechanism that colistin induces rapid Paenibacillus polymyxa death through reactive oxygen species production. This significantly augments our understanding of the mechanism of colistin action, which is...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5437139
更新日期:2017-01-01 00:00:00
abstract:Aim:To evaluate thiol/disulphide homeostasis as a new indicator of oxidative stress in AKI patients and to determine the effect of HD on antioxidant balance and oxidative stress through plasma thiols. Methods:This study was performed in patients aged between 12 months and 18 years prospectively who underwent hemodialy...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1898671
更新日期:2018-09-25 00:00:00
abstract::Psoriasis is one of the most prevalent immune mediated skin diseases worldwide. Despite the large prevalence in both men and women, the pathogenesis of this disease has not yet been fully clarified. Nowadays, it is believed that psoriasis is most likely a T helper Th1/Th17 induced inflammatory disease. Stressful life ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/571912
更新日期:2013-01-01 00:00:00
abstract::Background. It has been suggested that, during pregnancy, endometriosis can cause a variety of disease-related complications. Objectives. The purpose of the study was to find out if women with histologically confirmed endometriosis do have a higher risk of adverse pregnancy outcome and if they suffer from a higher rat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8271452
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Sarcoidosis is a multisystemic granulomatous disorder characterized by multiple noncaseating granulomas involving intrathoracic lymph nodes and lung parenchyma. Recently, the use of anti-tumor necrosis factor alpha (anti-TNFα) agents has been introduced for therapy of chronic and refractory sarcoidosis wit...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/401341
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2326797
更新日期:2019-11-05 00:00:00
abstract:Aim:The aim of this study was to explore the correlation of chemokine receptor CXCR3 with M2 macrophage infiltration, various clinicopathological features, and prognosis in patients diagnosed with gastric cancer (GC). Methods:Expression of CXCR3 protein and M2 macrophage was evaluated in 156 GC patients and correspond...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6832867
更新日期:2019-05-21 00:00:00
abstract::The exosomes are derived from mesenchymal stem cells (MSCs) and may be potentially used as an alternative for cell therapy, for treating diabetic wounds, and aid in angiogenesis. This study, aimed to investigate whether exosomes originated from bone marrow-derived MSCs (BMSCs) preconditioned by deferoxamine (DFO-Exos)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9742765
更新日期:2019-05-05 00:00:00
abstract::A dentin-cement-prosthesis complex restored with either all-porcelain, cured resin-composite, or cast base metal alloy and cemented with either of the different resin cements was trimmed into a mini-dumbbell shape for tensile testing. The fractured surfaces and characterization of the dentin-cement interface of bonded...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/656948
更新日期:2015-01-01 00:00:00
abstract::To study the effect of intra-abdominal hypertension (IAH) on the frequency of pneumonia with an experimental study, thirteen Sprague-Dawley rats were included. Eight out of thirteen animals were randomly assigned to receive 10 ml of benzalkonium chloride 0.2% (megacolon group) and five animals received 10 ml NaCl 0.9%...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4601348
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/409658
更新日期:2013-01-01 00:00:00
abstract::Antibiotics are among the most counterfeited anti-infectious medicines in developing countries. Amoxicillin is one of the commonly prescribed, affordable, and easily accessible antibiotic in Kenya. It is a broad-spectrum antibiotic hence commonly used in chemotherapy. This study sought to determine the quality and ide...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7091278
更新日期:2020-06-12 00:00:00
abstract:Objective:Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in pati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8676343
更新日期:2020-05-21 00:00:00
abstract::Waldenström macroglobulinemia (WM) is a malignant lymphoplasma-proliferative disorder with IgM monoclonal gammopathy. A recent whole-genome study identified MYD88 L265P as the key mutation in WM. We investigated MYD88 mutations in conjunction with cytogenetic study in 22 consecutive Korean WM patients. Conventional G-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/363540
更新日期:2014-01-01 00:00:00
abstract::Ureteroplasty using onlay grafts or flaps emerged as an innovative procedure for the management of proximal and midureteral strictures. Autologous grafts or flaps used commonly in ureteroplasty include the oral mucosae, bladder mucosae, ileal mucosae, and appendiceal mucosae. Oral mucosa grafts, especially buccal muco...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6178286
更新日期:2020-07-27 00:00:00
abstract:Objectives:Patients with stage 3 medication-related osteonecrosis of the jaw (MRONJ) suffer from severe complications. Chemotherapeutic agents and targeted drugs are considered to be associated with the development of MRONJ. However, little is known regarding the association of those agents with stage 3 MRONJ. The purp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5847429
更新日期:2020-10-15 00:00:00
abstract::Robot-Assisted Rehabilitation (RAR) is relevant for treating patients affected by nervous system injuries (e.g., stroke and spinal cord injury). The accurate estimation of the joint angles of the patient limbs in RAR is critical to assess the patient improvement. The economical prevalent method to estimate the patient...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2581924
更新日期:2016-01-01 00:00:00
abstract:Objective:This study is aimed at evaluating the effects of platelet-rich plasma (PRP) on proliferation, viability, and odontogenic differentiation of neural crest stem-like cells (NCSCs) derived from human dental apical papilla. Materials and Methods:Cells from apical papillae were obtained and then induced to form ne...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4671989
更新日期:2020-05-09 00:00:00
abstract::Lycium barbarum is a famous plant in the traditional Chinese medicine. The plant is known to have health-promoting bioactive components. The properties of Lycium barbarum berries cultivated in Umbria (Italy) and their effect on human hepatocellular carcinoma cells (HepG2) have been investigated in this work. The obtai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7529521
更新日期:2016-01-01 00:00:00
abstract::Many topical agents are available for treating the acute phase of acne; however, few agents have been proven beneficial during the maintenance phase. Objective. To evaluate the efficacy and safety of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid during the maintenance phase of ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2857812
更新日期:2020-10-16 00:00:00
abstract::The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/632570
更新日期:2014-01-01 00:00:00
abstract::Primary open angle glaucoma (POAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss. It is known that alterations in intraocular pressure (IOP), blood pressure (BP), and ocular perfusion pressure (OPP) can play a significant role in the pathogenesis of the dise...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/141905
更新日期:2015-01-01 00:00:00
abstract::Interactions between proteins and drugs, which can lead to formation of stable drug-protein complexes, have important implications on several processes related to human health. These interactions can affect, for instance, free concentration, biological activity, and metabolism of the drugs in the blood stream. Here, w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/872701
更新日期:2014-01-01 00:00:00
abstract:Objective:We identified differentially expressed microRNAs (DEMs) between esophageal carcinoma (ESCA) tissues and normal esophageal tissues. We then constructed a novel three-miRNA signature to predict the prognosis of ESCA patients using bioinformatics analysis. Materials and Methods. We combined two microarray profil...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5973082
更新日期:2020-02-10 00:00:00
abstract::Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/989175
更新日期:2014-01-01 00:00:00