Abstract:
:This work evaluated the physicochemical properties and antioxidant activity of spray dried extracts (SDE) from Psidium guajava L. leaves. Different drying carriers, namely, maltodextrin, colloidal silicon dioxide, Arabic gum, and β -cyclodextrin at concentrations of 40 and 80% relative to solids content, were added to drying composition. SDE were characterized through determination of the total phenolic, tannins, and flavonoid content. Antioxidant potential of the SDE was assessed by two assays: cellular test that measures the luminol-enhanced chemiluminescence (LumCL) produced by neutrophils stimulated with phorbol myristate acetate (PMA) and the DPPH radical scavenging (DPPH∗ method). In both assays the antioxidant activity of the SDE occurred in a concentration-dependent manner and showed no toxicity to the cells. Using the CLlum method, the IC50 ranged from 5.42 to 6.50 µg/mL. The IC50 of the SDE ranged from 7.96 to 8.11 µg/mL using the DPPH(•) method. Psidium guajava SDE presented significant antioxidant activity; thus they show high potential as an active phytopharmaceutical ingredient. Our findings in human neutrophils are pharmacologically relevant since they indicate that P. guajava SDE is a potential antioxidant and anti-inflammatory agent in human cells.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Fernandes MR,Azzolini AE,Martinez ML,Souza CR,Lucisano-Valim YM,Oliveira WPdoi
10.1155/2014/382891subject
Has Abstractpub_date
2014-01-01 00:00:00pages
382891eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Macrophages, especially their activation state, are closely related to the progression of diabetic nephropathy. Classically activated macrophages (M1) are proinflammatory effectors, while alternatively activated macrophages (M2) exhibit anti-inflammatory properties. 1,25-Dihydroxyvitamin D3 has renoprotective roles th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/157834
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/121030
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8367068
更新日期:2018-03-26 00:00:00
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journal_title:BioMed research international
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更新日期:2018-08-14 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/401341
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/542016
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7279036
更新日期:2018-07-26 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/462179
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/926342
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/646347
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/841615
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/495091
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/1498034
更新日期:2019-05-12 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/857327
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/457473
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9483928
更新日期:2018-06-05 00:00:00
abstract::The proper methylation status of histones is essential for appropriate cell lineage and organogenesis. EZH2, a methyltransferase catalyzing H3K27me3, has been abundantly studied in human and mouse embryonic development. The pig is an increasing important animal model for molecular study and pharmaceutical research. Ho...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5315930
更新日期:2020-10-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/328560
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/858907
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/363801
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/965853
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/802841
更新日期:2014-01-01 00:00:00
abstract::Mammalian protection against leishmanial infection depends on the development of an effective immune response. Zoonotic visceral leishmaniasis (ZVL) patients are usually unable to mount an effective immune response against the parasite and indeed appear to be severely immunosuppressed. This suppression has strong nons...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5861453
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5095934
更新日期:2019-12-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6875968
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Wear-related failures and instabilities are frequent failure mechanisms of total knee replacements. High-conforming designs may provide additional stability for the joint. This study analyzes the effects of a ligamentous insufficiency on the stability and the wear behavior of a high-conforming knee design. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/821475
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/420380
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1061979
更新日期:2019-05-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/8234618
更新日期:2020-12-09 00:00:00