Abstract:
Objective:To assess the application value of perfusion-weighted imaging (PWI) in early diagnosis, quantitation, and hepatic fibrosis staging by analyzing the related parameters in hepatic fibrosis. Methods:A total of 60 rats were randomly divided into the hepatic fibrosis and control groups, and carbon tetrachloride (CCL4) was used to establish the liver fibrosis model. All rats underwent PWI examination, and the trend of the time-signal intensity curve (TIC, automatically generated by the software) was observed. Also, the perfusion parameters, maximum signal reduction ratio (SRRmax), time to peak (TTP), and mean transit time (MTT), were analyzed and compared with pathological staging. Results:The TIC curve was characterized by slow wash-in and wash-out with a low and wide peak. The PWI perfusion parameters were statistically significant in specific groups (P < 0.05): SRRmax values (control group and F3, F4), TTP, and MTT values (control group and F2-F4, F1 and F3, F1 and F4, and F2 and F4 in addition to TTP values for F1 and F2). Pearson's correlation analysis showed a negative correlation of SRRmax with hepatic fibrosis stage (r = -0.439, P < 0.05), while TTP and MTT values were positively correlated with hepatic fibrosis stage (TTP, r = 0.798; MTT, r = 0.647; all P < 0.001). Conclusions:PWI perfusion parameters reflect the degree of hepatic fibrosis, especially TTP and MTT, and PWI is recommended for the early diagnosis of liver fibrosis for timely intervention and treatment of the disease and delaying its progression.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Fan G,Ya Y,Ni X,Hou J,Yu Rdoi
10.1155/2019/5095934subject
Has Abstractpub_date
2019-12-28 00:00:00pages
5095934eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章abstract::Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects. To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, active-controlled noninferiority trial between January 1, 2009...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6875968
更新日期:2017-01-01 00:00:00
abstract::RAW264.7 is a macrophage strain derived from mice tumour and shows a significant ability in antigen uptake. Real-time quantitative PCR (RT-qPCR) is one of the most commonly used methods in gene studies and requires suitable reference genes to normalize and quantitate the expression of gene of interest with sensitivity...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6131879
更新日期:2019-05-16 00:00:00
abstract:Purpose:To evaluate the relationships between objectively measured physical activity and physical fitness among preschool children. Methods:A total of 346 participants (201 boys and 145 girls) aged 3.5-5.5 years (M = 4.5 yr, SD = 0.47) from Shanghai, China, completed physical fitness assessments, including triceps ski...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9314026
更新日期:2017-01-01 00:00:00
abstract::Purpose. To compare the results of extracorporeal shock wave therapy (ESWT) for insertional Achilles tendinopathy (IAT) with or without Haglund's deformity. Methods. Between September 2014 and May 2015, all patients who underwent ESWT were retrospectively enrolled in this study. A total of 67 patients were available f...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6315846
更新日期:2016-01-01 00:00:00
abstract::In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The ex...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/317403
更新日期:2015-01-01 00:00:00
abstract::Tsetse flies (Glossina spp.) are the primary vectors of trypanosomes, which can cause human and animal African trypanosomiasis in Sub-Saharan African countries. The objective of this study was to explore the genome of Glossina morsitans morsitans for evidence of horizontal gene transfer (HGT) from microorganisms. We e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3164624
更新日期:2016-01-01 00:00:00
abstract:Background:Salinity is one of the major abiotic constraints that hinder health and quality of crops. Conversely, halotolerant plant growth-promoting rhizospheric (PGPR) bacteria are considered biologically safe for alleviating salinity stress. Results:We isolated halotolerant PGPR strains from the rhizospheric soil of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9530963
更新日期:2019-10-20 00:00:00
abstract::Dysfunctions of chaperone-mediated autophagy (CMA), the main catabolic pathway for alpha-synuclein, have been linked to the pathogenesis of Parkinson's disease (PD). Since till now there is limited information on how PD-related toxins may affect CMA, in this study we explored the effect of mitochondrial complex I inhi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/846725
更新日期:2013-01-01 00:00:00
abstract::Microbial strain optimisation for the overproduction of a desired phenotype has been a popular topic in recent years. Gene knockout is a genetic engineering technique that can modify the metabolism of microbial cells to obtain desirable phenotypes. Optimisation algorithms have been developed to identify the effects of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/124537
更新日期:2015-01-01 00:00:00
abstract::Malaria is one of the life-threatening diseases in the world. The spread of resistance to antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in the Southeast Asian region. In the previous study, the active compound of Streptomyces hygroscopicus subsp. Hygroscopicus (S. hygroscopic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6135696
更新日期:2020-01-09 00:00:00
abstract::Little is known about the clinical value of the Hadlock and INTERGROWTH-21st EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and the risk of APOs and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7698038
更新日期:2019-01-09 00:00:00
abstract::The search for effective methods of myocardial cytoprotection against ischemia is the most significant issue in modern cardiology and cardiac surgery. Glucocorticoids are deemed very strong modulators of inflammatory response and thus can potentially protect heart muscle from postreperfusion injury and myocardial isch...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2108497
更新日期:2017-01-01 00:00:00
abstract::In preclinical treatment of polytraumatized patients crystalloids are preferentially used. To avoid metabolic acidosis, metabolizable anions like lactate or acetate are used to replace chloride in these solutions. We here studied the effects of malated Ringer's in resuscitation of both shock severities in comparison t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/151503
更新日期:2015-01-01 00:00:00
abstract:Background:Physical activity has been found to maintain and improve cognitive function and consequently improve health-related quality of life (HRQoL). The relationships between different types of physical activities, cognitive function, and HRQoL have not been studied sufficiently and compared in different age and gen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8856284
更新日期:2020-12-18 00:00:00
abstract::This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6915789
更新日期:2016-01-01 00:00:00
abstract::Finding an optimal set of discriminative features is still a crucial but challenging task in biomedical science. The complexity of the task is intensified when any of the two scenarios arise: a highly dimensioned dataset and a small sample-sized dataset. The first scenario poses a big challenge to existing machine lea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8506365
更新日期:2020-08-17 00:00:00
abstract::In our study, we evaluated the feasibility of a new sampling method for splenic stiffness (SS) measurement by Quantitative Acoustic Radiation Force Impulse Elastography (Virtual Touch Tissue Quantification (VTTQ)).We measured SS in 54 patients with HCV-related cirrhosis of whom 28 with esophageal varices (EV), 27 with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/365982
更新日期:2014-01-01 00:00:00
abstract::Netrins, a family of laminin-related proteins, were originally identified as axonal guidance molecules. Subsequently, netrins were found to modulate various biological processes including morphogenesis, tumorogenesis, adhesion, and, recently, angiogenesis. In human placenta, the most vascularized organ, the presence o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/901941
更新日期:2014-01-01 00:00:00
abstract::Spontaneous bacterial peritonitis (SBP) is a common cirrhotic ascites complication which exacerbates the patient's condition. SBP is caused by gram-negative bacilli and, to a lesser extent, gram-positive cocci. Hospital-acquired infections show higher levels of drug-resistant bacteria. Geographical location influences...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/3743962
更新日期:2020-07-06 00:00:00
abstract::Reactive oxygen species (ROS) damage macromolecules and cellular components in nearly all kinds of cells and often generate toxic intracellular byproducts. In this work, aldehyde generation derived from the Escherichia coli membrane oxidation as well as membrane fatty acid profiles, protein oxidation, and bacterial re...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/563756
更新日期:2013-01-01 00:00:00
abstract:Introduction:SATIS-Stroke was developed to measure satisfaction regarding activities and participation among stroke survivors based on the concepts contained in the International Classification of Functioning, Disability, and Health. However, this measure is only available in English and French. Objective:Perform the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8054640
更新日期:2019-02-18 00:00:00
abstract::The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/604385
更新日期:2015-01-01 00:00:00
abstract::Butyrate produced by the intestinal microbiota is essential for proper functioning of the intestinal immune system. Total dependence on parenteral nutrition (PN) is associated with numerous adverse effects, including severe microbial dysbiosis and loss of important butyrate producers. We hypothesised that a lack of bu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7084734
更新日期:2019-02-28 00:00:00
abstract::In previous studies, we have demonstrated the function of uc.167 in the heart development. DNA methylation plays a crucial role in regulating the expression of developmental genes during embryonic development. In this study, the methylomic landscape was investigated in order to identify the DNA methylation alterations...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4658024
更新日期:2018-05-30 00:00:00
abstract::The aim of the present study was to determine the anti-inflammatory effect of IFN-τ on endometritis using a mouse model of S. aureus-induced endometritis and to elucidate the mechanism of action underlying these effects. In the present study, the effect of IFN-τ on S. aureus growth was monitored by turbidimeter at 600...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2350482
更新日期:2017-01-01 00:00:00
abstract::The study aimed to determine the suitability of testing the saliva of kickboxing athletes to show changes in biochemical parameters in dynamic of training. 8 elite male athletes (mean age 17.29± 0.31 years, body mass 66.82± 3.46kg, with 5.62±0.96 years of training experience) participated in the study. Indicators of l...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2014347
更新日期:2019-01-10 00:00:00
abstract:OBJECTIVE:This study aims to explore the usage of intraocular pressure measurements as the early indicator of the increase in intra-abdominal pressure. METHODS:In this prospective study, 40 patients undergoing elective surgery were included. Patients were divided into four groups of 10 patients. The control group (Gro...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/986895
更新日期:2015-01-01 00:00:00
abstract::The cyprinid genus Pteronotropis is endemic to southeastern Gulf of Mexico and Atlantic Ocean of North America. Never before has the genus been demonstrated to be monophyletic. We investigate both the phylogenetic relationships and the phylogeography of some species in the genus using mitochondrial ND2 sequences. In n...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/675260
更新日期:2015-01-01 00:00:00
abstract::Initiation and maintenance of atrial fibrillation (AF) is often associated with pharmacologically or pathologically induced bradycardic states. Even drugs specifically developed in order to counteract cardiac arrhythmias often combine their action with bradycardia and, in turn, with development of AF, via still largel...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/496418
更新日期:2015-01-01 00:00:00
abstract:Objective:To explore multiscale integrated analysis methods in identifying key regulators of esophageal cancer (ESCA). Methods:We downloaded the ESCA dataset from The Cancer Genome Atlas (TCGA) database, which contained RNA-seq data, miRNA-seq data, methylation data, and clinical phenotype information. Then, we combin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5603958
更新日期:2020-08-12 00:00:00