In vivo evaluation of TNF-alpha in the lungs of patients affected by sarcoidosis.

Abstract:

INTRODUCTION:Sarcoidosis is a multisystemic granulomatous disorder characterized by multiple noncaseating granulomas involving intrathoracic lymph nodes and lung parenchyma. Recently, the use of anti-tumor necrosis factor alpha (anti-TNFα) agents has been introduced for therapy of chronic and refractory sarcoidosis with controversial results. Infliximab (Remicade) is a chimeric monoclonal antibody (mAb) that recognizes and binds TNFα, neutralizing its biological effects. In the present study,   (99m)Tc labelled infliximab was used to study the expression of TNFα in sarcoid lesions and to evaluate its role as a predictive marker in response to therapy with Remicade. MATERIAL AND METHODS:A total of 10 patients with newly diagnosed sarcoidosis were enrolled together with 10 control patients affected by rheumatoid arthritis. All patients were studied by planar imaging of the chest with   (99m)Tc-infliximab at 6 h and 24 h and total body [(18)F]-FDG PET/CT. Regions of interest were drawn over the lungs and the right arm and target-to-background ratios were analysed for   (99m)Tc-infliximab. SUV mean and SUV max were calculated over lungs for FDG. RESULTS AND DISCUSSION:Image analysis showed low correlation between T/B ratios and BAL results in patients despite positivity at [(18)F]-FDG PET. CONCLUSION:In conclusion, patients with newly diagnosed pulmonary sarcoidosis, with FDG-PET and BAL positivity, showed a negative   (99m)Tc-infliximab scintigraphy.

journal_name

Biomed Res Int

authors

Galli F,Lanzolla T,Pietrangeli V,Malviya G,Ricci A,Bruno P,Ragni P,Scopinaro F,Mariotta S,Signore A

doi

10.1155/2015/401341

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

401341

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

临床试验,杂志文章
  • Transpseudarthrosis Osteotomy with Interbody Fusion for Kyphotic Spinal Pseudarthrosis in Ankylosing Spondylitis by a Single Posterior Approach: A Retrospective Study and a Brief Relevant Literature Review.

    abstract:OBJECTIVE:To explore the safety and efficacy of transpseudarthrosis osteotomy with interbody fusion in the treatment of Ankylosing Spondylitis (AS) patients with kyphotic spinal pseudarthrosis by a single posterior approach. METHODS:Twelve consecutive patients with spinal pseudarthrosis underwent transpseudarthrosis o...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/4079849

    authors: Yang E,Cao L,Zhang G,Lian X,Xu J

    更新日期:2017-01-01 00:00:00

  • Improvement of endurance of DMD animal model using natural polyphenols.

    abstract::Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is characterized by muscular wasting caused by dystrophin deficiency that ultimately ends in force reduction and premature death. In addition to primary genetic defect, several mechanisms contribute to DMD pathogenesis. Recently, antioxidan...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/680615

    authors: Sitzia C,Farini A,Colleoni F,Fortunato F,Razini P,Erratico S,Tavelli A,Fabrizi F,Belicchi M,Meregalli M,Comi G,Torrente Y

    更新日期:2015-01-01 00:00:00

  • NFIL3 Acts as a Nuclear Factor to Increase Osteosarcoma Progression.

    abstract:Purpose:Osteosarcoma is one of the most common primary malignant, aggressive bone neoplasms. However, the mechanisms of osteosarcoma proliferation, migration, and invasion are not well understood. To explore the possible mechanism of osteosarcoma progression, we used a public database for gene analysis to identify the ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4068521

    authors: Xu J,Xu G,Zhang T,Chen T,Zhao W,Wang G

    更新日期:2019-11-30 00:00:00

  • Analyzing Active Constituents and Optimal Steaming Conditions Related to the Hematopoietic Effect of Steamed Panax notoginseng by Network Pharmacology Coupled with Response Surface Methodology.

    abstract::During hundreds of years of medication, it is believed that the steamed Panax notoginseng (SPN) can enrich and regulate the blood, replenish the body, and improve the health. The aim of this study was to optimize the steaming conditions of SPN which are related to the hematopoietic effect. In the study, network pharma...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/9371426

    authors: Zhou S,Jiang N,Zhang M,Xiao X,Liu Z,Xu X,Gao Q,Lv W

    更新日期:2020-07-26 00:00:00

  • Incidence, Risk Factors, and Epidemiology of Cystic Echinococcosis: A Complex Socioecological Emerging Infectious Disease in Khyber Pakhtunkhwa, Province of Pakistan.

    abstract::Cystic echinococcosis is a serious zoonotic disease caused by Echinococcus granulosus species complex. The current study is the first attempt to determine the level of infection in domestic livestock and to explore the CE-related knowledge and awareness among livestock farmers in different districts of Khyber Pakhtunk...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5042430

    authors: Haleem S,Niaz S,Qureshi NA,Ullah R,Alsaid MS,Alqahtani AS,Shahat AA

    更新日期:2018-09-12 00:00:00

  • The role of M1 and M2 macrophages in prostate cancer in relation to extracapsular tumor extension and biochemical recurrence after radical prostatectomy.

    abstract:INTRODUCTION:The aim of our work was to investigate the causal connection between M1 and M2 macrophage phenotypes occurrence and prostate cancer, their correlation with tumor extension (ECE), and biochemical recurrence (BR). PATIENT AND METHODS:Clinical and pathological data were prospectively gathered from 93 patient...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/486798

    authors: Lanciotti M,Masieri L,Raspollini MR,Minervini A,Mari A,Comito G,Giannoni E,Carini M,Chiarugi P,Serni S

    更新日期:2014-01-01 00:00:00

  • Horizontally Transferred Genetic Elements in the Tsetse Fly Genome: An Alignment-Free Clustering Approach Using Batch Learning Self-Organising Map (BLSOM).

    abstract::Tsetse flies (Glossina spp.) are the primary vectors of trypanosomes, which can cause human and animal African trypanosomiasis in Sub-Saharan African countries. The objective of this study was to explore the genome of Glossina morsitans morsitans for evidence of horizontal gene transfer (HGT) from microorganisms. We e...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3164624

    authors: Nakao R,Abe T,Funayama S,Sugimoto C

    更新日期:2016-01-01 00:00:00

  • A simple method to estimate the number of autophagic elements by electron microscopic morphometry in real cellular dimensions.

    abstract::Autophagic elements typically appear as spherical bodies. During their life they undergo a series of changes (e.g., fusion, degradation of content, and swelling) which influence their size in a way that may be characteristic for cell type, stage of maturation, or various experimentally manipulated parameters. A simple...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/578698

    authors: Kovács AL

    更新日期:2014-01-01 00:00:00

  • Tyrosine kinase inhibitors induced thyroid dysfunction: a review of its incidence, pathophysiology, clinical relevance, and treatment.

    abstract::Tyrosine kinase inhibitors (TKI) belong to a new class of molecular multitargeted anticancer therapy which targets different growth factor receptors and hence attenuates cancer cell survival and growth. Since their introduction as adjunct treatment for renal cell carcinoma and gastrointestinal stromal tumors (GIST), a...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/725410

    authors: Ahmadieh H,Salti I

    更新日期:2013-01-01 00:00:00

  • Exopolysaccharide from Ganoderma applanatum as a promising bioactive compound with cytostatic and antibacterial properties.

    abstract::A new exopolysaccharide preparation isolated from stationary cultures of the white rot fungus Ganoderma applanatum (GpEPS) was tested in terms of its bioactive properties including its cytotoxic and immunostimulatory effect. The results indicate that the tested GpEPS (at concentrations above 22.85 µg/mL and 228.5 µg/m...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/743812

    authors: Osińska-Jaroszuk M,Jaszek M,Mizerska-Dudka M,Błachowicz A,Rejczak TP,Janusz G,Wydrych J,Polak J,Jarosz-Wilkołazka A,Kandefer-Szerszeń M

    更新日期:2014-01-01 00:00:00

  • The Preoperative CT-Scan Can Help to Predict Postoperative Complications after Pancreatoduodenectomy.

    abstract::After pancreatoduodenectomy, complication rates are up to 40%. To predict the risk of developing postoperative pancreatic fistula or severe complications, various factors were evaluated. 110 consecutive patients undergoing pancreatoduodenectomy at our institute between January 2012 and September 2014 with complete CT ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/824525

    authors: Schröder FF,de Graaff F,Bouman DE,Brusse-Keizer M,Slump KH,Klaase JM

    更新日期:2015-01-01 00:00:00

  • A novel closed-chest porcine model of chronic ischemic heart failure suitable for experimental research in cardiovascular disease.

    abstract::Cardiac pathologies are among the leading causes of mortality and morbidity in industrialized countries, with myocardial infarction (MI) representing one of the major conditions leading to heart failure (HF). Hitherto, the development of consistent, stable, and reproducible models of closed-chest MI in large animals, ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/410631

    authors: Biondi-Zoccai G,De Falco E,Peruzzi M,Cavarretta E,Mancone M,Leoni O,Caristo ME,Lotrionte M,Marullo AG,Amodeo A,Pacini L,Calogero A,Petrozza V,Chimenti I,D'Ascenzo F,Frati G

    更新日期:2013-01-01 00:00:00

  • The Usefulness of Performing Biochemical Tests in the Saliva of Kickboxing Athletes in the Dynamic of Training.

    abstract::The study aimed to determine the suitability of testing the saliva of kickboxing athletes to show changes in biochemical parameters in dynamic of training. 8 elite male athletes (mean age 17.29± 0.31 years, body mass 66.82± 3.46kg, with 5.62±0.96 years of training experience) participated in the study. Indicators of l...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2014347

    authors: Volodchenko OA,Podrigalo LV,Iermakov SS,Żychowska MT,Jagiełło W

    更新日期:2019-01-10 00:00:00

  • Effect of eNOS on Ischemic Postconditioning-Induced Autophagy against Ischemia/Reperfusion Injury in Mice.

    abstract::Autophagy is involved in the development of numerous illnesses, including ischemia/reperfusion (I/R). Endothelial nitric oxide synthase (eNOS) participates in the protective effects of ischemic postconditioning (IPostC). However, it remains unclear whether eNOS-mediated autophagy serves as a critical role in IPostC in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5201014

    authors: Shao J,Miao C,Geng Z,Gu M,Wu Y,Li Q

    更新日期:2019-02-10 00:00:00

  • The SDF-1α3'A genetic variation is correlated with susceptibility of asthma in Iranian patients.

    abstract:BACKGROUND AND AIM:Chemokine/receptor axis is a predominant actor of clinical disorders. They are key factors of pathogenesis of almost all clinical situations including asthma. Correspondingly, CXCL12 is involved in the immune responses. Therefore, this study was designed to explore the association between gene polymo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/759361

    authors: Rafatpanah H,Amin M,Ghasemshirazi M,Kazemiarababadi M,Khorramdelazad H,Abousaidi H,Shabani Z,Sayadi A,Hassanshahi G,Samadi J

    更新日期:2013-01-01 00:00:00

  • In Vivo Confocal Microscopy of the Human Cornea in the Assessment of Peripheral Neuropathy and Systemic Diseases.

    abstract::In vivo confocal microscopy (IVCM) of the living human cornea offers the ability to perform repeated imaging without tissue damage. Studies using corneal IVCM have led to significant contributions to scientific and clinical knowledge of the living cornea in health and pathological states. Recently the application of c...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/951081

    authors: Wang EF,Misra SL,Patel DV

    更新日期:2015-01-01 00:00:00

  • Phylogenetic and in silico functional analyses of thermostable-direct hemolysin and tdh-related encoding genes in Vibrio parahaemolyticus and other Gram-negative bacteria.

    abstract::Emergence and spread of pandemic strains of Vibrio parahaemolyticus have drawn attention to make detailed study on their genomes. The pathogenicity of V. parahaemolyticus has been associated with thermostable-direct hemolysin (TDH) and/or TDH-related hemolysin (TRH). The present study evaluated characteristics of tdh ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/576528

    authors: Bhowmik SK,Pazhani GP,Ramamurthy T

    更新日期:2014-01-01 00:00:00

  • Modic Changes and Disc Degeneration Caused by Inoculation of Propionibacterium acnes inside Intervertebral Discs of Rabbits: A Pilot Study.

    abstract:PURPOSE:To investigate whether P. acnes could induce disc degeneration and Modic changes when inoculated into the discs of rabbits. METHOD:A wild-type strain of P. acnes isolated from a patient associated with Modic change and disc degeneration was inoculated into the intervertebral discs of rabbits. Meanwhile, S. aur...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/9612437

    authors: Chen Z,Zheng Y,Yuan Y,Jiao Y,Xiao J,Zhou Z,Cao P

    更新日期:2016-01-01 00:00:00

  • Analysis of Self-Adhesive Resin Cement Microshear Bond Strength on Leucite-Reinforced Glass-Ceramic with/without Pure Silane Primer or Universal Adhesive Surface Treatment.

    abstract:OBJECTIVE:To evaluate the microshear bond strength (μSBS) of self-adhesive resin (SA) cement on leucite-reinforced glass-ceramic using silane or universal adhesive. MATERIALS AND METHODS:Ceramic blocks were etched with 9.5% hydrofluoric acid and divided into three groups (n = 16): (1) negative control (NC) without tre...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/361893

    authors: Lee Y,Kim JH,Woo JS,Yi YA,Hwang JY,Seo DG

    更新日期:2015-01-01 00:00:00

  • Medication Adherence Measures: An Overview.

    abstract::WHO reported that adherence among patients with chronic diseases averages only 50% in developed countries. This is recognized as a significant public health issue, since medication nonadherence leads to poor health outcomes and increased healthcare costs. Improving medication adherence is, therefore, crucial and revea...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/217047

    authors: Lam WY,Fresco P

    更新日期:2015-01-01 00:00:00

  • Identification of the Roles of Chromobox Family Members in Gastric Cancer: A Study Based on Multiple Datasets.

    abstract:Background:As the important components in polycomb repressive complexes 1 (PRC1) and heterochromatin protein 1 (HP1), Chromobox (CBX) family members are involved in epigenetic regulatory function, transcriptional repression, and other cellular metabolisms. Increasing studies have indicated significant associations betw...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5306509

    authors: Chen ZY,Sun SX,Zhu SX,Bu J

    更新日期:2020-11-05 00:00:00

  • Non-VKA Oral Anticoagulants: Accurate Measurement of Plasma Drug Concentrations.

    abstract::Non-VKA oral anticoagulants (NOACs) have now widely reached the lucrative market of anticoagulation. While the marketing authorization holders claimed that no routine monitoring is required and that these compounds can be given at fixed doses, several evidences arisen from the literature tend to demonstrate the opposi...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/345138

    authors: Douxfils J,Mani H,Minet V,Devalet B,Chatelain B,Dogné JM,Mullier F

    更新日期:2015-01-01 00:00:00

  • Efficacy of rhBMP-2 Loaded PCL/β-TCP/bdECM Scaffold Fabricated by 3D Printing Technology on Bone Regeneration.

    abstract::This study was undertaken to evaluate the effect of 3D printed polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) scaffold containing bone demineralized and decellularized extracellular matrix (bdECM) and human recombinant bone morphogenetic protein-2 (rhBMP-2) on bone regeneration. Scaffolds were divided into PCL/...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2876135

    authors: Bae EB,Park KH,Shim JH,Chung HY,Choi JW,Lee JJ,Kim CH,Jeon HJ,Kang SS,Huh JB

    更新日期:2018-02-27 00:00:00

  • Blood biomarkers for amyotrophic lateral sclerosis: myth or reality?

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal condition primarily characterized by the selective loss of upper and lower motor neurons. At present, the diagnosis and monitoring of ALS is based on clinical examination, electrophysiological findings, medical history, and exclusion of confounding disorders. There is the...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/525097

    authors: Robelin L,Gonzalez De Aguilar JL

    更新日期:2014-01-01 00:00:00

  • Demineralized Bone Matrix Add-On for Acceleration of Bone Healing in Atypical Subtrochanteric Femoral Fracture: A Consecutive Case-Control Study.

    abstract:BACKGROUND:Delayed union and nonunion are common complications in atypical femoral fractures (AFFs) despite having good fracture fixation. Demineralized bone matrix (DBM) is a successfully proven method for enhancing fracture healing of the long bone fracture and nonunion and should be used in AFFs. This study aimed to...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2016/4061539

    authors: Kulachote N,Sa-ngasoongsong P,Sirisreetreerux N,Chanplakorn P,Fuangfa P,Suphachatwong C,Wajanavisit W

    更新日期:2016-01-01 00:00:00

  • Urinary IgG and α2-macroglobulin are powerful predictors of outcome and responsiveness to steroids and cyclophosphamide in idiopathic focal segmental glomerulosclerosis with nephrotic syndrome.

    abstract:OBJECTIVE:To assess whether high-molecular-weight proteins excretion predicts outcome and therapy-responsiveness in patients with FSGS and nephrotic syndrome. RESEARCH DESIGN AND METHODS:Thirty-eight patients measured at biopsy fractional excretion of IgG (FEIgG) and urinary α2-macroglobulin/creatinine ratio ( α m/C)....

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/941831

    authors: Bazzi C,Rizza V,Casellato D,Stivali G,Rachele G,Napodano P,Gallieni M,D'Amico G

    更新日期:2013-01-01 00:00:00

  • Antimania-Like Effect of Panax ginseng Regulating the Glutamatergic Neurotransmission in REM-Sleep Deprivation Rats.

    abstract::Previous studies have shown the therapeutic properties of ginseng and ginsenosides on hyperactive and impulsive behaviors in several psychiatric diseases. Herein, we investigated the effect of Panax ginseng Meyer (PG) on hyperactive/impulsive behaviors in a manic-like animal model, sleep deprivation (SD) rats. Male ra...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/3636874

    authors: Leem KH,Kim SA,Park HJ

    更新日期:2020-10-17 00:00:00

  • Metabolic Syndrome and Hypertension Resulting from Fructose Enriched Diet in Wistar Rats.

    abstract::Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C; n = 14)...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2494067

    authors: Dupas J,Feray A,Goanvec C,Guernec A,Samson N,Bougaran P,Guerrero F,Mansourati J

    更新日期:2017-01-01 00:00:00

  • The role of insula-associated brain network in touch.

    abstract::The insula is believed to be associated with touch-evoked effects. In this work, functional MRI was applied to investigate the network model of insula function when 20 normal subjects received tactile stimulation over segregated areas. Data analysis was performed with SPM8 and Conn toolbox. Activations in the contrala...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/734326

    authors: Wei P,Bao R

    更新日期:2013-01-01 00:00:00

  • Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease.

    abstract::This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/6915789

    authors: Lee JH,Kim SJ,Park SI,Ko YG,Choi D,Hong MK,Jang Y

    更新日期:2016-01-01 00:00:00