Abstract:
PURPOSE:To investigate whether P. acnes could induce disc degeneration and Modic changes when inoculated into the discs of rabbits. METHOD:A wild-type strain of P. acnes isolated from a patient associated with Modic change and disc degeneration was inoculated into the intervertebral discs of rabbits. Meanwhile, S. aureus was injected into the discs to establish a model of discitis as the comparison and a standard strain of P. acnes was inoculated as the control. MRI and histological change were observed. RESULTS:Both the P. acnes-inoculated and S. aureus-inoculated rabbits showed hyperintense signals at endplates and hypointense signals at nucleus pulposus on T2WI. However, P. acnes only resulted in moderate disc degeneration and endplates rupture in histological examination, which was different from the pathological change of discitis caused by S. aureus. In addition, higher death rates (2/3 versus 0/5) were observed in S. aureus-inoculated rabbits. CONCLUSION:Compared to S. aureus, the pathological change caused by P. acnes would be considered as Modic-I change and disc degeneration rather than a discitis.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Chen Z,Zheng Y,Yuan Y,Jiao Y,Xiao J,Zhou Z,Cao Pdoi
10.1155/2016/9612437subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9612437eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
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