Medication Adherence Measures: An Overview.

Abstract:

:WHO reported that adherence among patients with chronic diseases averages only 50% in developed countries. This is recognized as a significant public health issue, since medication nonadherence leads to poor health outcomes and increased healthcare costs. Improving medication adherence is, therefore, crucial and revealed on many studies, suggesting interventions can improve medication adherence. One significant aspect of the strategies to improve medication adherence is to understand its magnitude. However, there is a lack of general guidance for researchers and healthcare professionals to choose the appropriate tools that can explore the extent of medication adherence and the reasons behind this problem in order to orchestrate subsequent interventions. This paper reviews both subjective and objective medication adherence measures, including direct measures, those involving secondary database analysis, electronic medication packaging (EMP) devices, pill count, and clinician assessments and self-report. Subjective measures generally provide explanations for patient's nonadherence whereas objective measures contribute to a more precise record of patient's medication-taking behavior. While choosing a suitable approach, researchers and healthcare professionals should balance the reliability and practicality, especially cost effectiveness, for their purpose. Meanwhile, because a perfect measure does not exist, a multimeasure approach seems to be the best solution currently.

journal_name

Biomed Res Int

authors

Lam WY,Fresco P

doi

10.1155/2015/217047

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

217047

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章,评审
  • Plant growth promotion potential is equally represented in diverse grapevine root-associated bacterial communities from different biopedoclimatic environments.

    abstract::Plant-associated bacteria provide important services to host plants. Environmental factors such as cultivar type and pedoclimatic conditions contribute to shape their diversity. However, whether these environmental factors may influence the plant growth promoting (PGP) potential of the root-associated bacteria is not ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/491091

    authors: Marasco R,Rolli E,Fusi M,Cherif A,Abou-Hadid A,El-Bahairy U,Borin S,Sorlini C,Daffonchio D

    更新日期:2013-01-01 00:00:00

  • Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties.

    abstract::Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/905215

    authors: Marín L,Miguélez EM,Villar CJ,Lombó F

    更新日期:2015-01-01 00:00:00

  • Corrigendum to "All-Atom Four-Body Knowledge-Based Statistical Potentials to Distinguish Native Protein Structures from Nonnative Folds".

    abstract::[This corrects the article DOI: 10.1155/2017/5760612.]. ...

    journal_title:BioMed research international

    pub_type: 杂志文章,已发布勘误

    doi:10.1155/2018/7108272

    authors: Masso M

    更新日期:2018-01-08 00:00:00

  • EMRlog method for computer security for electronic medical records with logic and data mining.

    abstract::The proper functioning of a hospital computer system is an arduous work for managers and staff. However, inconsistent policies are frequent and can produce enormous problems, such as stolen information, frequent failures, and loss of the entire or part of the hospital data. This paper presents a new method named EMRlo...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/542016

    authors: Martínez Monterrubio SM,Frausto Solis J,Monroy Borja R

    更新日期:2015-01-01 00:00:00

  • Punicalagin Exerts Protective Effects against Ankylosing Spondylitis by Regulating NF-κB-TH17/JAK2/STAT3 Signaling and Oxidative Stress.

    abstract:Background:Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by sacroiliitis and spinal rigidity of the axial joints. The role of oxidative stress and increased proinflammatory cytokines is well documented in AS pathogenesis. Punicalagin (2,3-hexahydroxydiphenoyl-gallagyl-D-glucose), an ellagi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4918239

    authors: Feng X,Yang Q,Wang C,Tong W,Xu W

    更新日期:2020-09-23 00:00:00

  • Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Salivary mic...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9792730

    authors: Salazar-Ruales C,Arguello JV,López-Cortés A,Cabrera-Andrade A,García-Cárdenas JM,Guevara-Ramírez P,Peralta P,Leone PE,Paz-Y-Miño C

    更新日期:2018-11-21 00:00:00

  • Intuitive web-based experimental design for high-throughput biomedical data.

    abstract::Big data bioinformatics aims at drawing biological conclusions from huge and complex biological datasets. Added value from the analysis of big data, however, is only possible if the data is accompanied by accurate metadata annotation. Particularly in high-throughput experiments intelligent approaches are needed to kee...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/958302

    authors: Friedrich A,Kenar E,Kohlbacher O,Nahnsen S

    更新日期:2015-01-01 00:00:00

  • Positive Association between ANKRD55 Polymorphism 7731626 and Dermatomyositis/Polymyositis with Interstitial Lung Disease in Chinese Han Population.

    abstract::Single nucleotide polymorphisms (SNPs) in TNFSF4 and ANKRD55 genes have been shown to be associated with several autoimmune diseases, although whether these genes are susceptibility genes for dermatomyositis/polymyositis (DM/PM) has, to date, not been reported. This study aimed to investigate the potential association...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2905987

    authors: Li L,Chen S,Wen X,Wang Q,Lv G,Li J,Yang F,Zhang F,Li Y

    更新日期:2017-01-01 00:00:00

  • Identification and Progression of Heart Disease Risk Factors in Diabetic Patients from Longitudinal Electronic Health Records.

    abstract::Heart disease is the leading cause of death worldwide. Therefore, assessing the risk of its occurrence is a crucial step in predicting serious cardiac events. Identifying heart disease risk factors and tracking their progression is a preliminary step in heart disease risk assessment. A large number of studies have rep...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/636371

    authors: Jonnagaddala J,Liaw ST,Ray P,Kumar M,Dai HJ,Hsu CY

    更新日期:2015-01-01 00:00:00

  • Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Cardiovascular and Cerebrovascular Diseases.

    abstract::MicroRNAs (miRNAs) are composed of a group of endogenous and noncoding small RNAs which control expression of complementary target mRNAs. The extended functions of miRNAs enhance the complexity of gene-regulatory processes in cardiovascular and cerebrovascular diseases. Indeed, recent studies have shown that miRNAs ar...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/730535

    authors: Li M,Zhang J

    更新日期:2015-01-01 00:00:00

  • Quercetin Alleviates High-Fat Diet-Induced Oxidized Low-Density Lipoprotein Accumulation in the Liver: Implication for Autophagy Regulation.

    abstract::A growing body of evidence has indicated that high-fat diet-induced nonalcoholic fatty liver disease is usually accompanied by oxidized low-density lipoprotein (ox-LDL) deposited in the liver. The current study aimed to investigate the effect of quercetin on high-fat diet-induced ox-LDL accumulation in the liver and t...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/607531

    authors: Liu L,Gao C,Yao P,Gong Z

    更新日期:2015-01-01 00:00:00

  • Phytochemical Composition and Antibacterial Activity of Hydroalcoholic Extracts of Pterospartum tridentatum and Mentha pulegium against Staphylococcus aureus Isolates.

    abstract::Pterospartum tridentatum and Mentha pulegium are largely used in Portuguese folk medicine to treat several human disorders and inflammatory processes but without any consistent evidence for those beneficial pointed properties. Thus, the aim of the current work is to evaluate its benefits and phytochemicals related to ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5201879

    authors: Aires A,Marrinhas E,Carvalho R,Dias C,Saavedra MJ

    更新日期:2016-01-01 00:00:00

  • Libidibia ferrea mature seeds promote antinociceptive effect by peripheral and central pathway: possible involvement of opioid and cholinergic receptors.

    abstract::Libidibia ferrea (LF) is a medicinal plant that holds many pharmacological properties. We evaluated the antinociceptive effect in the LF aqueous seed extract and Lipidic Portion of Libidibia ferrea (LPLF), partially elucidating their mechanisms. Histochemical tests and Gas chromatography of the LPLF were performed to ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/508725

    authors: Sawada LA,Monteiro VS,Rabelo GR,Dias GB,Da Cunha M,do Nascimento JL,Bastos Gde N

    更新日期:2014-01-01 00:00:00

  • Enhanced therapeutic efficacy of iRGD-conjugated crosslinked multilayer liposomes for drug delivery.

    abstract::Targeting nanoparticles by conjugating various specific ligands has shown potential therapeutic efficacy in nanomedicine. However, poor penetration of antitumor drugs into solid tumors remains a major obstacle. Here, we describe a targeting strategy for antitumor drug delivery by conjugating a crosslinked multilamella...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/378380

    authors: Liu Y,Ji M,Wong MK,Joo KI,Wang P

    更新日期:2013-01-01 00:00:00

  • Validation of Reference Genes for Gene Expression Normalization in RAW264.7 Cells under Different Conditions.

    abstract::RAW264.7 is a macrophage strain derived from mice tumour and shows a significant ability in antigen uptake. Real-time quantitative PCR (RT-qPCR) is one of the most commonly used methods in gene studies and requires suitable reference genes to normalize and quantitate the expression of gene of interest with sensitivity...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6131879

    authors: Bao Z,Huang Y,Chen J,Wang Z,Qian J,Xu J,Zhao Y

    更新日期:2019-05-16 00:00:00

  • Assessment of Mycobacterium bovis deleted in p27-p55 virulence operon as candidate vaccine against tuberculosis in animal models.

    abstract::A Mycobacterium bovis knockout in p27-p55 operon was tested as an antituberculosis experimental vaccine in animal models. The mutant MbΔp27-p55 was significantly more attenuated in nude mice than its parental strain but more virulent than BCG Pasteur. Challenge experiments in mice and guinea pigs using M. bovis or M. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/951978

    authors: Bianco MV,Clark S,Blanco FC,Garbaccio S,García E,Cataldi AA,Williams A,Bigi F

    更新日期:2014-01-01 00:00:00

  • Electroacupuncture Pretreatment Alleviates Cerebral Ischemia-Reperfusion Injury by Increasing GSK-3β Phosphorylation Level via Adenosine A1 Receptor.

    abstract:Objective:To observe the effect of adenosine A1 receptor in the hippocampus of mice on GSK-3β phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Α1 receptor mediating cerebral ischemia-reperfusion injury. Method:The model of middle cerebral artery occlusion (...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6848450

    authors: Geng W,Cai L,Han K,Li D,Mo Y,Dai Q,Tang H,Zhang M,Akuetteh PDP,Balelang MF,Wang J

    更新日期:2020-02-20 00:00:00

  • CSF-S100B Is a Potential Candidate Biomarker for Neuromyelitis Optica Spectrum Disorders.

    abstract::Astrocytic impairment is a pathologic feature of neuromyelitis optica spectrum disorder (NMOSD). S100B and glial fibrillary acidic protein (GFAP) are the two most commonly used astrocytic markers. The aim of this study was to evaluate whether CSF-S100B could serve as a marker of NMOSD. We enrolled 49 NMOSD patients [2...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2018/5381239

    authors: Wei Y,Chang H,Li X,Du L,Xu W,Cong H,Yao Y,Zhang X,Yin L

    更新日期:2018-10-22 00:00:00

  • Neuronal Signal Transduction-Involved Genes in Pig Hypothalamus Affect Feed Efficiency as Revealed by Transcriptome Analysis.

    abstract::Feed efficiency (FE) is an important trait affecting costs in swine industry. Investigation on FE-related genes in different tissues is valuable for molecular breeding. Hypothalamus is a convergent and integrated centre for multiple nutrient-related signals. The present study identified 363 differentially expressed (D...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5862571

    authors: Hou Y,Hu M,Zhou H,Li C,Li X,Liu X,Zhao Y,Zhao S

    更新日期:2018-12-26 00:00:00

  • P2Y receptor modulation of ATP release in the urothelium.

    abstract::The release of ATP from the urothelium in response to stretch during filling demonstrates the importance of the purinergic system for the physiological functioning of the bladder. This study examined the effect of P2 receptor agonists on ATP release from two urothelial cell lines (RT4 and UROtsa cells). Hypotonic Kreb...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/830374

    authors: Mansfield KJ,Hughes JR

    更新日期:2014-01-01 00:00:00

  • Multiparametric MRI for localized prostate cancer: lesion detection and staging.

    abstract::Multiparametric MRI of the prostate combines high-resolution anatomic imaging with functional imaging of alterations in normal tissue caused by neoplastic transformation for the identification and characterization of in situ prostate cancer. Lesion detection relies on a systematic approach to the analysis of both anat...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/684127

    authors: Margolis DJ

    更新日期:2014-01-01 00:00:00

  • Walking on a tissue-specific disease-protein-complex heterogeneous network for the discovery of disease-related protein complexes.

    abstract::Besides the pinpointing of individual disease-related genes, associating protein complexes to human inherited diseases is also of great importance, because a biological function usually arises from the cooperative behaviour of multiple proteins in a protein complex. Moreover, knowledge about disease-related protein co...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/732650

    authors: Jacquemin T,Jiang R

    更新日期:2013-01-01 00:00:00

  • Remote effects of lower limb ischemia-reperfusion: impaired lung, unchanged liver, and stimulated kidney oxidative capacities.

    abstract::Remote organ impairments are frequent and increase patient morbidity and mortality after lower limb ischemia-reperfusion (IR). We challenged the hypothesis that lower limb IR might also impair lung, renal, and liver mitochondrial respiration. Two-hour tourniquet-induced ischemia was performed on both hindlimbs, follow...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/392390

    authors: Mansour Z,Charles AL,Kindo M,Pottecher J,Chamaraux-Tran TN,Lejay A,Zoll J,Mazzucotelli JP,Geny B

    更新日期:2014-01-01 00:00:00

  • Halotolerant Rhizobacterial Strains Mitigate the Adverse Effects of NaCl Stress in Soybean Seedlings.

    abstract:Background:Salinity is one of the major abiotic constraints that hinder health and quality of crops. Conversely, halotolerant plant growth-promoting rhizospheric (PGPR) bacteria are considered biologically safe for alleviating salinity stress. Results:We isolated halotolerant PGPR strains from the rhizospheric soil of...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9530963

    authors: Khan MA,Asaf S,Khan AL,Adhikari A,Jan R,Ali S,Imran M,Kim KM,Lee IJ

    更新日期:2019-10-20 00:00:00

  • ID1 As a Prognostic Biomarker and Promising Drug Target Plays a Pivotal Role in Deterioration of Clear Cell Renal Cell Carcinoma.

    abstract::Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the world. Our aim is to identify prognostic biomarkers that contribute to the progression of early stage ccRCC and clarify the mechanism. Here, the mRNA microarray expression profile of ccRCC samples was obtained from Gene Expression Omnibus...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2064582

    authors: Qiu X,Gu Y,Ni Y,Li Q

    更新日期:2020-10-29 00:00:00

  • LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population.

    abstract::The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certa...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/867321

    authors: Gopalai AA,Lim SY,Chua JY,Tey S,Lim TT,Mohamed Ibrahim N,Tan AH,Eow GB,Abdul Aziz Z,Puvanarajah SD,Viswanathan S,Looi I,Lim SK,Tan LP,Chong YB,Tan CT,Zhao Y,Tan EK,Ahmad-Annuar A

    更新日期:2014-01-01 00:00:00

  • Downregulation of miR-224-5p Promotes Migration and Proliferation in Human Dental Pulp Stem Cells.

    abstract:Introduction:Pulp regeneration, as a treatment for pulp necrosis, has significant advantages over root canal therapy for the preservation of living pulp. To date, research on pulp regeneration has mainly focused on the transplantation of pulp stem cells into the root canal, but there is still a lack of research on the ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4759060

    authors: Ke Z,Qiu Z,Xiao T,Zeng J,Zou L,Lin X,Hu X,Lin S,Lv H

    更新日期:2019-07-18 00:00:00

  • Elevated miRNA Inversely Correlates with E-cadherin Gene Expression in Tissue Biopsies from Crohn Disease Patients in contrast to Ulcerative Colitis Patients.

    abstract::Inflammatory bowel disease (IBD) comprises ulcerative colitis (UC) and Crohn disease (CD). Similar symptoms, but different treatment procedures for both diseases require precise diagnosis. MicroRNAs (miRNAs) are major posttranscriptional players that regulate the expression of genes during the inflammation and thus co...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/4250329

    authors: Guz M,Dworzański T,Jeleniewicz W,Cybulski M,Kozicka J,Stepulak A,Celiński K

    更新日期:2020-07-22 00:00:00

  • Malnutrition among 6-59-Month-Old Children at District 2 Hospital, Ho Chi Minh City, Vietnam: Prevalence and Associated Factors.

    abstract:Objectives:Childhood malnutrition is major health concern in many low- and middle-income countries, including Vietnam. It was a major risk factor for child mortality and adult ill-health. Malnutrition could increase the risk of serious infections; conversely current diseases also had a negative impact on the growth of ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/6921312

    authors: Huynh G,Huynh QHN,Nguyen NHT,Do QT,Khanh Tran V

    更新日期:2019-02-05 00:00:00

  • Optimal Condition to Create Femoral Tunnel Considering Combined Influence of Knee Flexion and Transverse Drill Angle in Anatomical Single-Bundle ACL Reconstruction Using Medial Portal Technique: 3D Simulation Study.

    abstract::There has been no previous study using three-dimensional (3D) measurement on femoral tunnel characteristics according to the combined influence of various flexion angles of knee and transverse drill angles in single-bundle ACL reconstruction with transportal technique. The purpose of this study was to determine optima...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2643247

    authors: Kim SH,Kim SJ,Choi CH,Kim D,Jung M

    更新日期:2018-07-17 00:00:00