Abstract:
:This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n = 5), a drug-free hybrid stent (group 2, n = 5), a 50% (50 : 100, w/w) paclitaxel (PTX)/poly-lactide-co-glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n = 5), and a 30% (30 : 100, w/w) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n = 5). We performed follow-up angiography and intravascular ultrasonography (IVUS) at 4 and 8 weeks. In a comparison of groups 1, 2, 3, and 4, less diameter stenosis was observed in the angiographic analysis for group 4 at the 4-week follow-up (19.0% ± 12.7% versus 39.3% ± 18.1% versus 46.8% ± 38.0% versus 4.8% ± 4.2%, resp.; p = 0.032). IVUS findings further suggested that the neointima of the patients in group 4 tended to be lesser than those of the others. Our new biodegradable 30% PTX/PLGA (slow-releasing form) stent showed more favorable results for patency than the other stent types.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Lee JH,Kim SJ,Park SI,Ko YG,Choi D,Hong MK,Jang Ydoi
10.1155/2016/6915789subject
Has Abstractpub_date
2016-01-01 00:00:00pages
6915789eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/701682
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
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doi:10.1155/2016/4676505
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7485409
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journal_title:BioMed research international
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doi:10.1155/2016/6507350
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6728128
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/930795
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/523415
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2014/408683
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/5760612.]. ...
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pub_type: 杂志文章,已发布勘误
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更新日期:2018-01-08 00:00:00
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2123601
更新日期:2020-09-05 00:00:00
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doi:10.1155/2013/565431
更新日期:2013-01-01 00:00:00
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doi:10.1155/2013/276417
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1155/2016/4193538
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pub_type: 杂志文章
doi:10.1155/2014/675363
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8403642
更新日期:2017-01-01 00:00:00