The dnd RNA Identifies Germ Cell Origin and Migration in Olive Flounder (Paralichthys olivaceus).

abstract：:Novel and more effective treatment strategies against multiple myeloma (MM) have significantly prolonged patients' survival and raised interest in the depth of response and its association with clinical outcome. Minimal residual disease (MRD) has emerged as one of the most relevant prognostic factors in MM and should ...

journal_title：BioMed research international

authors： Fulciniti M,Munshi NC,Martinez-Lopez J

更新日期：2015-01-01 00:00:00

abstract：:Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 ...

journal_title：BioMed research international

authors： Oikawa M,Owada T,Yamauchi H,Misaka T,Machii H,Yamaki T,Sugimoto K,Kunii H,Nakazato K,Suzuki H,Saitoh S,Takeishi Y

更新日期：2016-01-01 00:00:00

abstract：:Almost forty years ago, it was first hypothesized that an increased dietary intake of omega-3 polyunsaturated fatty acids (PUFA) from fish fat could exert protective effects against several pathologies. Decades of intense preclinical investigation have supported this hypothesis in a variety of model systems. Several c...

journal_title：BioMed research international

authors： Weylandt KH,Serini S,Chen YQ,Su HM,Lim K,Cittadini A,Calviello G

更新日期：2015-01-01 00:00:00

abstract：:In a retrospective study the association of the production of extracellular DNA (eDNA) in biofilms of clinical staphylococcal isolates from 60 patients with prosthetic joint infection (PJI) and the clinical outcome were investigated. Data from a previous study on eDNA production determined in 24-hour biofilms of staph...

journal_title：BioMed research international

authors： Zatorska B,Arciola CR,Haffner N,Segagni Lusignani L,Presterl E,Diab-Elschahawi M

更新日期：2018-10-22 00:00:00

abstract：:Gremlin is a developmental gene upregulated in human chronic kidney disease and in renal cells in response to transforming growth factor-β (TGF-β). Epithelial mesenchymal transition (EMT) is one process involved in renal fibrosis. In tubular epithelial cells we have recently described that Gremlin induces EMT and acts...

journal_title：BioMed research international

authors： Rodrigues-Diez R,Rodrigues-Diez RR,Lavoz C,Carvajal G,Droguett A,Garcia-Redondo AB,Rodriguez I,Ortiz A,Egido J,Mezzano S,Ruiz-Ortega M

更新日期：2014-01-01 00:00:00

abstract：:The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum....

journal_title：BioMed research international

authors： Wang WJ,Wu YS,Chen S,Liu CF,Chen SN

更新日期：2015-01-01 00:00:00

abstract：:In recent years, new prognostic indexes (PIs) for chronic lymphocytic leukemia (CLL), which include clinical, biological, and genetic variables, have been validated, highlighting the MD Anderson Cancer Center prognostic index (MDACC PI), the CLL-international prognostic index (CLL-IPI), and the Barcelona-Brno biomarke...

journal_title：BioMed research international

authors： Muñoz-Novas C,Poza-Santaella M,González-Gascón Y Marín I,Hernández-Sánchez M,Rodríguez-Vicente AE,Infante MS,Heras C,Foncillas MÁ,Marín K,Hernández-Rivas JM,Hernández JÁ

更新日期：2018-03-15 00:00:00

abstract：Background:Glucagon-like peptide 1 (GLP-1) hormone is an incretin hormone that is secreted in the ileum and plays a role in the pancreas to increase insulin secretion, stimulate proliferation, and prevent pancreatic β-cell apoptosis. Currently, diabetes mellitus (DM) treatment based on GLP-1 work is being developed, fo...

journal_title：BioMed research international

authors： Kartinah NT,Fadilah F,Ibrahim EI,Suryati Y

更新日期：2019-11-11 00:00:00

abstract：:Introduction and Objectives. Neutrophil-to-lymphocyte ratio (NLR) has been suggested to be a simple marker of the systemic inflammatory response in critical care patients. We previously assessed the utility of NLR as a biomarker to predict tumor recurrence and cancer death in bladder cancer patients who underwent radi...

journal_title：BioMed research international

authors： Ohtake S,Kawahara T,Kasahara R,Ito H,Osaka K,Hattori Y,Teranishi JI,Makiyama K,Mizuno N,Umemoto S,Miyoshi Y,Nakaigawa N,Miyamoto H,Yao M,Uemura H

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Although binge drinking prevalence and correlates among young people have been extensively studied in the USA and Northern Europe, less is known for Southern Europe countries with relatively healthier drinking cultures. OBJECTIVE:We aimed at analyzing prevalence and correlates of binge drinking in a represe...

journal_title：BioMed research international

authors： Bartoli F,Carretta D,Crocamo C,Schivalocchi A,Brambilla G,Clerici M,Carrà G

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Frail older people are often unable to undertake high-intensity exercise programmes. Chair-based exercises (CBEs) are used as an alternative, for which health benefits are uncertain. OBJECTIVE:To examine the effects of CBE programmes for frail older people through a systematic review of existing literatur...

journal_title：BioMed research international

authors： Anthony K,Robinson K,Logan P,Gordon AL,Harwood RH,Masud T

更新日期：2013-01-01 00:00:00

abstract：:Initiation and maintenance of atrial fibrillation (AF) is often associated with pharmacologically or pathologically induced bradycardic states. Even drugs specifically developed in order to counteract cardiac arrhythmias often combine their action with bradycardia and, in turn, with development of AF, via still largel...

journal_title：BioMed research international

authors： Cacciani F,Zaniboni M

更新日期：2015-01-01 00:00:00

abstract：:Apolipoprotein E4 (Apo E4) is the major genetic risk factor in the causation of Alzheimer's disease (AD). In this study we utilize virtual screening of the world's largest traditional Chinese medicine (TCM) database and investigate potential compounds for the inhibition of ApoE4. We present the top three TCM candidate...

journal_title：BioMed research international

authors： Huang HJ,Chen HY,Lee CC,Chen CY

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study was to investigate the suitability of insoluble Eudragit® water dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble levetiracetam in order to decrease its burst effect from HPMC K100M matrices. The process characteristics, ss-NMR analysis, in vitro dissolutio...

journal_title：BioMed research international

authors： Mašková E,Naiserová M,Kubová K,Mašek J,Pavloková S,Urbanová M,Brus J,Vysloužil J,Vetchý D

更新日期：2019-03-05 00:00:00

abstract：:This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and ...

journal_title：BioMed research international

authors： Tang M,Ou N,Li C,Lu A,Li J,Ma L,Zhong W,Gao J,Zheng Y,Cai Y

更新日期：2015-01-01 00:00:00

abstract：:Carbonic anhydrases (CAs) are enzymes that catalyse the reversible hydration of CO2 to bicarbonate. CA XII is considered a potential biomarker of tumor cells and a promising target for specific therapies. The aim of the current study was to develop new monoclonal antibodies (MAbs) against human recombinant CA XII and ...

journal_title：BioMed research international

authors： Dekaminaviciute D,Lasickiene R,Parkkila S,Jogaite V,Matuliene J,Matulis D,Zvirbliene A

更新日期：2014-01-01 00:00:00

abstract：:Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism. Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism. Activation of skeletal RAS plays an important role in bone metabolic diso...

journal_title：BioMed research international

authors： Gebru Y,Diao TY,Pan H,Mukwaya E,Zhang Y

更新日期：2013-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a central nervous system (CNS) disease resulting from a targeted autoimmune-mediated attack on myelin proteins in the CNS. The release of Th1 inflammatory mediators in the CNS activates macrophages, antibodies, and microglia resulting in myelin damage and the induction of neuropathic pain (N...

journal_title：BioMed research international

authors： Zhu W,Acosta C,MacNeil B,Cortes C,Intrater H,Gong Y,Namaka M

更新日期：2013-01-01 00:00:00

abstract：:Otitis media (OM) is a common inflammatory disease of the middle ear cavity and mainly occurs in children. As a critical regulator of inflammation response, the nuclear factor kappa B (NF-κB) pathway has been found to play an essential role in the pathogenesis of various human diseases. The aim of this study was to ex...

journal_title：BioMed research international

authors： Yang X,Zhang Q,Lu H,Wang C,Xia L

更新日期：2021-01-06 00:00:00

abstract：:Introduction. Infection and apoptosis are combined triggers for inflammation in dental tissues. Octamer-binding transcription factor 4-B1 (OCT4B1), a novel spliced variant of OCT4 family, could respond to the cellular stress and possess antiapoptotic property. However, its specific role in dental pulpitis remains unkn...

journal_title：BioMed research international

authors： Liu L,Huang R,Yang R,Wei X

更新日期：2017-01-01 00:00:00

abstract：:Cognitive decline impacts older adults, particularly their independence. The goal of this project was to increase understanding of how short-term, everyday lifestyle options, including physical activity, help an older adult sustain cognitive independence. Using a secondary analysis of lifestyle choices, we drew on a d...

journal_title：BioMed research international

authors： Howard EP,Morris JN,Steel K,Strout KA,Fries BE,Moore A,Garms-Homolová V

更新日期：2016-01-01 00:00:00

abstract：Background:Visceral leishmaniasis (VL), one of the most neglected tropical diseases, is placing a huge burden on Ethiopia. Despite the introduction of antileishmanial drugs, treatment outcomes across regions are variable due to drug resistance and other factors. Thus, understanding of VL treatment outcomes and its cont...

journal_title：BioMed research international

authors： Gidey K,Belay D,Hailu BY,Kassa TD,Niriayo YL

更新日期：2019-08-21 00:00:00

abstract：:Spinal cord injury (SCI) is a highly debilitating disease and is increasingly being recognized as an important global health priority. However, the mechanisms underlying SCI have not yet been fully elucidated, and effective therapies for SCI are lacking. Long noncoding RNAs (lncRNAs), which form a major class of nonco...

journal_title：BioMed research international

authors： Wang F,Liu J,Wang X,Chen J,Kong Q,Ye B,Li Z

更新日期：2019-10-15 00:00:00

abstract：OBJECTIVE:To assess whether high-molecular-weight proteins excretion predicts outcome and therapy-responsiveness in patients with FSGS and nephrotic syndrome. RESEARCH DESIGN AND METHODS:Thirty-eight patients measured at biopsy fractional excretion of IgG (FEIgG) and urinary α2-macroglobulin/creatinine ratio ( α m/C)....

journal_title：BioMed research international

authors： Bazzi C,Rizza V,Casellato D,Stivali G,Rachele G,Napodano P,Gallieni M,D'Amico G

更新日期：2013-01-01 00:00:00

abstract：Background:The pathogenesis of abdominal aortic aneurysm (AAA) is characterized by atherosclerosis with chronic inflammation in the aortic wall. Montelukast is a selective cys-LT 1 receptor antagonist that can suppress atherosclerotic diseases. We evaluated the in vitro properties of montelukast and its in vivo activit...

journal_title：BioMed research international

authors： Kawai Y,Narita Y,Yamawaki-Ogata A,Usui A,Komori K

更新日期：2019-05-27 00:00:00

abstract：:Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediter...

journal_title：BioMed research international

authors： Karygianni L,Cecere M,Skaltsounis AL,Argyropoulou A,Hellwig E,Aligiannis N,Wittmer A,Al-Ahmad A

更新日期：2014-01-01 00:00:00

abstract：:In renal cell carcinoma, chromophobe renal cell carcinoma (ChRCC) is a distinct subtype, whose clinical manifestations often lack specificity, and the molecular mechanisms of ChRCC tumorigenesis remain generally vague. The target of this study was to discover novel biomarkers involved in ChRCC by integrated bioinforma...

journal_title：BioMed research international

authors： Zhang W,Xu Y,Zhang J,Wu J

更新日期：2020-02-07 00:00:00

abstract：:Although multimodal therapies including surgery, chemotherapy, and radiotherapy have improved clinical outcomes of patients with bone and soft tissue sarcomas, the prognosis of patients has plateaued over these 20 years. Immunotherapies have shown the effectiveness for several types of advanced tumors. Immunotherapies...

journal_title：BioMed research international

authors： Uehara T,Fujiwara T,Takeda K,Kunisada T,Ozaki T,Udono H

更新日期：2015-01-01 00:00:00

abstract：:Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be an important in microRNA let-7 expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (...

journal_title：BioMed research international

authors： Nagai T,Kanasaki M,Srivastava SP,Nakamura Y,Ishigaki Y,Kitada M,Shi S,Kanasaki K,Koya D

更新日期：2014-01-01 00:00:00

abstract：:Tobacco smoking continues to be a leading cause of disease and mortality. Recent research has confirmed the important role of nicotinic acetylcholine receptor (nAChR) gene cluster on chromosome 15q 24-25 in nicotine dependence and smoking. In this study we tested the association of smoking initiation, age at onset of ...

journal_title：BioMed research international

authors： Buczkowski K,Sieminska A,Linkowska K,Czachowski S,Przybylski G,Jassem E,Grzybowski T

更新日期：2015-01-01 00:00:00