Abstract:
:Sciatic nerve crush injury in rat animal model is one of the most common experimental models used in regenerative research. However, the availability of transgenic mouse for nerve regeneration studies is constantly increasing and, therefore, the shift from rat model to mouse model is, in some cases, necessary. Moreover, since most of the human nerve lesions occur in the upper limb, it is also advantageous to shift from sciatic nerve to median nerve. In this study we described an experimental model which involves lesions of the median nerve in the mouse. Data showed that the finger flexor muscle contraction strength, assessed to evaluate the motor function recovery, and reached values not different from the control already 20 days after injury. The degree of nerve regeneration evaluated with stereological methods in light microscopy showed that, 25 days after injury, the number of regenerated myelinated fibers was comparable to the control, but they were smaller with a thinner myelin thickness. Stereological analysis made in electron microscopy confirmed these results, although the total number of fibers quantified was significantly higher compared to light microscopy analysis, due to the very small size of some fibers that can be detected only in electron microscopy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Jager SB,Ronchi G,Vaegter CB,Geuna Sdoi
10.1155/2014/701682subject
Has Abstractpub_date
2014-01-01 00:00:00pages
701682eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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pub_type: 临床试验,杂志文章,多中心研究
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