Abstract:
:The insulin pathway is an anabolic pathway that controls, amongst other things, glucose homeostasis. It is an evolutionarily conserved pathway. Disruptions in insulin pathway functions can lead to diabetic states. Diabetes, a very common occurrence in modern life, afflicts a significant portion of the population of developed and developing countries worldwide. Yet, few studies have addressed the evolution of diabetic states on a long-term basis. Here, we cultured three different insulin pathway signaling compromised flies (heteroallelic mutant combinations, akin to diabetes mellitus type II) and wild type control flies, for the extent of one generation in different isocaloric diets fed at libitum, with or without extra methionine added. All fly stocks have a homogenized genetic background. We measured weight, total lipid, and carbohydrate content of adults at two different time points, and survival of adults reared in some of the different diets. Results show that, despite the fact that all diet regimes allow survival of at least a fraction of flies to adulthood, life histories are significantly different. Higher protein content diets promote better survival compared to higher percentage lipid and carbohydrate diets, and added methionine promotes survival in moderately reduced protein content diets. In mutants, survival is significantly reduced, and added methionine generally has an effect, albeit a more modest one. Our results highlight the value of higher percentage protein diets, and differences in effects in "healthy" versus "diabetic" states. They also show that added methionine, proposed as a "sensor" for protein content in food for flies, leads to differential effects depending on the adequacy of the diet regime.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Otero-Moreno D,Murillo-Maldonado JM,Riesgo-Escovar JRdoi
10.1155/2019/1451623subject
Has Abstractpub_date
2019-01-22 00:00:00pages
1451623eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章abstract:PURPOSE:Suppressor of cytokine signaling 7 (SOCS7) is a member of the SOCS family and is known to interact with phospholipase Cγ-1 (PLCγ-1), a key downstream mediator of the hepatocyte growth factor (HGF)/C-MET axis. Here, we report our observations of the effect of knocking down SOCS7 gene on the behaviour of breast c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/648040
更新日期:2014-01-01 00:00:00
abstract::Cancer metastasis has been demonstrated as it is the culmination of a cascade of priming steps. Increasing evidence has shown that tumor-derived molecular components (TDMCs) are known as extra cellular vesicle and nonvesicle factors and serve as versatile intercellular communication vehicles which can mediate signalin...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9258075
更新日期:2019-06-12 00:00:00
abstract::Purpose. To report pilot data from a novel image analysis software "RetiView," to highlight clinically relevant information in RetCam images of infants with aggressive posterior retinopathy of prematurity (APROP). Methods. Twenty-three imaging sessions of consecutive infants of Asian Indian origin with clinically diag...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/898197
更新日期:2015-01-01 00:00:00
abstract::Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comp...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/908175
更新日期:2014-01-01 00:00:00
abstract::Mental rotation task (MRT) incorporates elements of spatial abilities, important in many professions, with people of both genders involved. Importantly, these are the areas where spatial tasks might be performed for long time periods; thus adverse effects of mental fatigue are highly unwanted. Substantial variation of...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/741758
更新日期:2014-01-01 00:00:00
abstract::The neural dysfunction is triggered by cellular and molecular events that provoke neurotoxicity and neural death. Currently, neurodegenerative diseases are increasingly common, and available treatments are focused on relieving symptoms. Based on the above, in this review we describe the participation of vitexin in the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4785089
更新日期:2018-12-05 00:00:00
abstract::Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and in vivo studies showed that morphine also modulates angiogenesis and regulates tumour cell growth. Unfortunately, the results obtained by these studies are still contradictory. In order to bet...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/161508
更新日期:2015-01-01 00:00:00
abstract::Sulfated polysaccharides (GSP) were isolated from the cloned Grateloupia filicina which was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral sugar analysis showed...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/612352
更新日期:2015-01-01 00:00:00
abstract::Cardiovascular disease (CVD) is the most common cause of death in the world. Recent studies have shown an association between adrenal insufficiency (AI) and increased cardiovascular risk (CVR). Patients with AI receive glucocorticoid (GC) replacement therapy which can lead to varying levels of blood cortisol. It was s...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/3691913
更新日期:2017-01-01 00:00:00
abstract::A novel approach for selecting a rectangular template around periocular region optimally potential for human recognition is proposed. A comparatively larger template of periocular image than the optimal one can be slightly more potent for recognition, but the larger template heavily slows down the biometric system by ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/481431
更新日期:2013-01-01 00:00:00
abstract::Moringa grows in the tropical and subtropical regions of the world. The genus Moringa belongs to family Moringaceae. It is found to possess various medicinal uses including hypoglycemic, analgesic, anti-inflammatory, hypolipidemic, and antioxidant activities. In this study, we investigated the antimicrobial and the an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2698570
更新日期:2019-01-01 00:00:00
abstract:Background:The aim of this study was to assess changes in skin microbiota of wrestlers during training sessions and to determine the sensitivity of hemolytic bacterial isolates to antiseptics. Methods:The main skin bacterial isolates obtained from the skin of 15 wrestlers were identified by cultivation method, with th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9843781
更新日期:2019-01-10 00:00:00
abstract::Keratinases are proteolytic enzymes predominantly active when keratin substrates are available that attack disulfide bridges in the keratin to convert them from complex to simplified forms. Keratinases are essential in preparation of animal nutrients, protein supplements, leather manufacture, textile processing, deter...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/140726
更新日期:2015-01-01 00:00:00
abstract::Engineering three-dimensional (3D) vascularized constructs remains a challenge due to the inability to form rich microvessel networks. In this study we engineered a prevascularized 3D cell sheet construct for tissue regeneration using human bone marrow-derived mesenchymal stem cells (hMSCs) and human umbilical vein en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/301279
更新日期:2014-01-01 00:00:00
abstract::Background. The aim of this study was to assess the effects of low concentrations of H2O2 on angiogenesis of human umbilical vein endothelial cells (HUVECs) in vitro and explore the underlying mechanisms. Methods. HUVECs were cultured and stimulated with different concentrations of H2O2. Flow cytometric analysis was u...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6895730
更新日期:2017-01-01 00:00:00
abstract::Puffer fishes were collected from the central sea in Vietnam from spring to summer season. The eggs were incubated in MRS broth that was used to test the toxicity in mice and isolate the lactic acid bacteria community that could produce tetrodotoxin (TTX). Thin layer chromatography (TLC) and high performance lipid chr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/973235
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:To investigate the anesthetic management in premature infants with retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IVB) injections. METHODS:A retrospective chart review was performed for the patients with ROP who had IVB injection. Clinical characteristics, demographic variables, ane...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/435387
更新日期:2013-01-01 00:00:00
abstract::Coronary artery disease complicates only 0.01% of all pregnancies. For this reason, more exhaustive data on the management of such cases is lacking. Even guidelines on management of cardiovascular disease in pregnant women are scarce focusing mainly on acute myocardial infarction. This is a complex issue involving tho...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/957027
更新日期:2013-01-01 00:00:00
abstract::The relationship between oxidative stress and miRNA changes in placenta as a potential mechanism involved in preeclampsia (PE) is not fully elucidated. We investigated the impact of oxidative stress on miRNAs and mRNA expression profiles of genes associated with PE in villous 3A first trimester trophoblast cells expos...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/257090
更新日期:2015-01-01 00:00:00
abstract::Objective. This study aims to extract motor ingredients through data mining from wearable sensors in a virtual reality goal-directed shoulder rehabilitation (GDSR) system and to examine their effects toward clinical assessment. Design. A single-group before/after comparison. Setting. Outpatient research hospital. Subj...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7075464
更新日期:2016-01-01 00:00:00
abstract::This work evaluated the physicochemical properties and antioxidant activity of spray dried extracts (SDE) from Psidium guajava L. leaves. Different drying carriers, namely, maltodextrin, colloidal silicon dioxide, Arabic gum, and β -cyclodextrin at concentrations of 40 and 80% relative to solids content, were added to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/382891
更新日期:2014-01-01 00:00:00
abstract::Blocking glioma cell invasion has been challenging due to cancer cells that can swiftly switch their migration mode, and agents that can block more than one migration mode are sought after. We found that small molecule 2-(1H-indole-3-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE), an endogenous aryl hydrocarb...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2616930
更新日期:2020-10-03 00:00:00
abstract::Arthritogenic alphaviruses, including Ross River virus (RRV), Chikungunya virus (CHIKV), Sindbis virus (SINV), Mayaro virus (MAYV), O'nyong-nyong virus (ONNV), and Barmah Forest virus (BFV), cause incapacitating and long lasting articular disease/myalgia. Outbreaks of viral arthritis and the global distribution of the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/973516
更新日期:2013-01-01 00:00:00
abstract::To provide an overview of the currently available literature regarding local control of primary tumor and oligometastases in metastatic prostate cancer and salvage lymph node dissection of clinical lymph node relapse after curative treatment of prostate cancer. Evidence Acquisition. A systematic literature search was ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/501213
更新日期:2014-01-01 00:00:00
abstract::Objectives. This study aimed to determine the feasibility of cochlear implantation for sensorineural hearing loss in patients with Waardenburg syndrome. Method. A retrospective chart review was performed on patients who underwent cochlear implantation at the University of Tokyo Hospital. Clinical classification, genet...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2854736
更新日期:2016-01-01 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the world. Our aim is to identify prognostic biomarkers that contribute to the progression of early stage ccRCC and clarify the mechanism. Here, the mRNA microarray expression profile of ccRCC samples was obtained from Gene Expression Omnibus...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2064582
更新日期:2020-10-29 00:00:00
abstract:Purpose:To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods:A retrospective analysis was conducted in 34 eyes from 24 progressive...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1762537
更新日期:2019-04-03 00:00:00
abstract::Myostatin, a TGF-β family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Mu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/129048
更新日期:2014-01-01 00:00:00
abstract::Although ginseng has long been broadly used in clinical settings around the world, few clinical trials on ginseng have been conducted. The objective of this study was to provide a comprehensive evaluation of the characteristics of ginseng clinical trials registered in the WHO International Clinical Trials Registry Pla...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1843142
更新日期:2018-02-06 00:00:00
abstract::Background. It has been suggested that, during pregnancy, endometriosis can cause a variety of disease-related complications. Objectives. The purpose of the study was to find out if women with histologically confirmed endometriosis do have a higher risk of adverse pregnancy outcome and if they suffer from a higher rat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8271452
更新日期:2016-01-01 00:00:00