Abstract:
:This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The genes occurring in any shortest path were considered as candidate AMD related genes. As a result, 125 novel AMD genes were predicted. The further analysis based on betweenness and permutation test indicates that there are 10 genes involved in the formation or development of AMD and may be the actual AMD related genes with high probability. We hope that this contribution would promote the study of age-related macular degeneration and discovery of novel effective treatments.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zhang J,Jiang M,Yuan F,Feng KY,Cai YD,Xu X,Chen Ldoi
10.1155/2013/523415subject
Has Abstractpub_date
2013-01-01 00:00:00pages
523415eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::Breast cancer is the leading cause of death in women worldwide. The search for novel compounds with antitumor activity, with less adverse effects and higher efficacy, and the development of methods to evaluate their toxicity is an area of intense research. In this study we implemented the preparation and culture of br...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/618021
更新日期:2015-01-01 00:00:00
abstract::Tsetse flies (Glossina spp.) are the primary vectors of trypanosomes, which can cause human and animal African trypanosomiasis in Sub-Saharan African countries. The objective of this study was to explore the genome of Glossina morsitans morsitans for evidence of horizontal gene transfer (HGT) from microorganisms. We e...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3164624
更新日期:2016-01-01 00:00:00
abstract::Natural matrices are important sources of new antitumor and antimicrobial compounds. Species such as Laurus nobilis L. (laurel) might be used for this purpose, considering its medicinal properties. Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/520464
更新日期:2014-01-01 00:00:00
abstract::Endometrial carcinoma is the most common gynecological tumor worldwide. It can be the presenting malignancy, acting as the harbinger, of an undiagnosed hereditary syndrome. Up to 50% of females with Lynch syndrome present in this manner. Differentiation between Lynch, Muir-Torre, and Cowden syndromes can at times be c...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/219012
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of two foot placements (normal or posterior placement) and three arm positions (hands on the thighs, arms crossed over chest, and augmented arm position with elbow extended) on the five times sit-to-stand (FTSTS) test times of individuals with chronic stroke. DESIGN:Cross-sectional...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/636530
更新日期:2014-01-01 00:00:00
abstract::Breast cancer is the most frequently occurring disease among women worldwide. The early stage of breast cancer identification is the key challenge in cancer control and prevention procedures. Although gene expression profiling helps to understand the molecular mechanism of diseases or disorder in the living system, ge...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3071013
更新日期:2016-01-01 00:00:00
abstract::The ultrasound imaging is one of the most common schemes to detect diseases in the clinical practice. There are many advantages of ultrasound imaging such as safety, convenience, and low cost. However, reading ultrasound imaging is not easy. To support the diagnosis of clinicians and reduce the load of doctors, many u...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/5137904
更新日期:2018-03-04 00:00:00
abstract::The aim of the study is to investigate the relationship between physical activity as assessed by accelerometers and cognitive development across the human age ranges (from children and adolescents to adults). Additionally, this study seeks to explore whether physical activity contributes to cognitive development via m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8568459
更新日期:2017-01-01 00:00:00
abstract::For the induction of robust humoral and cellular immune responses, a strong rationale exists to use vaccine-adjuvant combinations possessing both immune modulatory and enhanced delivery capabilities. Herein, we evaluated the combination of 2 different adjuvants, a TLR9 agonist, composed of synthetic oligodeoxynucleoti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/636847
更新日期:2013-01-01 00:00:00
abstract::Retinal vein occlusion (RVO) is a common vascular disease of retina; however, the pathomechanism leading to RVO is not yet clear. In general, increasing age, hypertension, arteriosclerosis, diabetes mellitus, dyslipidemia, cardiovascular disorder, and cerebral stroke are systemic risk factors of RVO. However, RVO ofte...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/4816527
更新日期:2017-01-01 00:00:00
abstract::The three-dimensional (3D) structures of the right atrial appendage (RAA) and left atrial appendage (LAA) were compared to clarify why thrombus formation less frequently occurs in RAA than in LAA. Morphological differences between RAA and LAA of 34 formalin-preserved cadaver hearts were investigated. Molds of RAA and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6492183
更新日期:2016-01-01 00:00:00
abstract:Aim:This study aims to evaluate the accuracy of scanned images of 4 clinically used intraoral scanners (CS3600, i500, Trios3, Omnicam) when scanning the surface of full arch models with various kinds of orthodontic brackets in the presence of artificial saliva. Materials and Methods. Four study models were prepared; bo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2920804
更新日期:2020-02-27 00:00:00
abstract:PURPOSE:To identify an effective method to prevent myopia progression by characterizing the regulation of matrix metalloproteinase- (MMP-) 2 expression and its secretion from scleral fibroblasts and retinal pigment epithelium (RPE) cells by miR-29a. METHODS:The effects of miR-29a on the growth of scleral fibroblasts a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2647879
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to evaluate the safety and effectiveness of percutaneous transluminal angioplasty and stenting (PTAS) for intracranial atherosclerotic disease (ICAD) by conducting a meta-analysis. Two independent observers searched PubMed, EMBASE, and Cochrane Library for relevant studies up to 31 December 2...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2017/3258681
更新日期:2017-01-01 00:00:00
abstract::Freshly ejaculated spermatozoa are incapable or poorly capable of fertilizing an oocyte. The fertilization aptness of spermatozoa depends on the appropriate and time-dependent acquisition of hyperactivation, chemotaxis, capacitation, and the acrosome reaction, where calcium (Ca(2+)) is extensively involved in almost e...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/841615
更新日期:2014-01-01 00:00:00
abstract:Objective of Study:To investigate, using the FEM, the influence of different notching angles on a zirconium dioxide coping with the aim of establishing the optimal connection conditions with veneering ceramic. Materials and Methods:To calculate the stresses in the connection between zirconia coping and veneering ceram...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7485409
更新日期:2019-07-01 00:00:00
abstract::There has been no previous study using three-dimensional (3D) measurement on femoral tunnel characteristics according to the combined influence of various flexion angles of knee and transverse drill angles in single-bundle ACL reconstruction with transportal technique. The purpose of this study was to determine optima...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2643247
更新日期:2018-07-17 00:00:00
abstract::Spinal cord injury (SCI) is a highly debilitating disease and is increasingly being recognized as an important global health priority. However, the mechanisms underlying SCI have not yet been fully elucidated, and effective therapies for SCI are lacking. Long noncoding RNAs (lncRNAs), which form a major class of nonco...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/3467121
更新日期:2019-10-15 00:00:00
abstract:PURPOSE:Assessing the role of breast MRI compared to galactography in patients with unilateral bloody or serous-bloody nipple discharge. MATERIALS AND METHODS:Retrospective study including 53 unilateral discharge patients who performed galactography and MRI. We evaluated the capability of both techniques in identifyin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/806368
更新日期:2015-01-01 00:00:00
abstract::A Chinese medicinal fern Blechnum orientale (Linn) was separately collected from polluted and unpolluted sites to determine whether it could accumulate hazardous pollutants or not. Metal concentrations (Cu, Zn, Mn, Pb, Cd, Cr, As, and Hg) both in the fronds and roots and polycyclic aromatic hydrocarbons (PAHs) in the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/192986
更新日期:2013-01-01 00:00:00
abstract::This retrospective cohort study aims to describe characteristics of patients with MRONJ, to identify factors associated with MRONJ development, and to examine variables associated with favourable outcome. Totally 32 patients were followed and observed: 21 females and 11 males, in the age range 35-84 in the period from...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2019/8345309
更新日期:2019-03-18 00:00:00
abstract::Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by an impairment of corneal sensory innervation, characterized by decreased or absent corneal sensitivity resulting in epithelial keratopathy, ulceration, and perforation. The aetiopathogenesis of corneal sensory innervation impairment in ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/805876
更新日期:2015-01-01 00:00:00
abstract::Recent progress in microscopy technologies, biological markers, and automated processing methods is making possible the development of gene expression atlases at cellular-level resolution over whole embryos. Raw data on gene expression is usually very noisy. This noise comes from both experimental (technical/methodolo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/986436
更新日期:2015-01-01 00:00:00
abstract::CD13 is a membrane glycoprotein with aminopeptidase activity, expressed on several cell types, including myeloid cells (dendritic cells, monocytes, macrophages, neutrophils, etc.). CD13 participates in several functions such as proteolytic regulation of bioactive peptides, viral receptor, angiogenesis, and tumor metas...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4093435
更新日期:2018-03-29 00:00:00
abstract::L5 spinal nerve ligation (SNL) in rats is one of the most popular models for studying neuropathic pain because of its high reproducibility. During the surgery, a part of the L5 paraspinal muscle is usually removed, which produces extra trauma and may potentially affect the physiological processes involved in neuropath...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6741295
更新日期:2016-01-01 00:00:00
abstract:Objective:The presence of radiological signs of femoroacetabular impingement (FAI) is not necessarily associated with symptoms. Hence, the prevalence of cam and pincer deformities in the overall population may be underestimated. The purpose of this study was to screen an unselected cohort of people without hip symptoms...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8562329
更新日期:2017-01-01 00:00:00
abstract:Purpose:3D nonfluoroscopic mapping systems (NMSs) are generally used in the catheter ablation (CA) of complex ventricular and atrial arrhythmias. The aim of this study was to evaluate the efficacy, safety, and long-term effect of the extended, routine use of NMSs for CA. Methods:Our study involved 1028 patients who un...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4217076
更新日期:2019-03-10 00:00:00
abstract::Xiaoxuming decoction (XXMD), a classic traditional Chinese medicine (TCM) prescription, has been used as a therapeutic in the treatment of stroke in clinical practice for over 1200 years. However, the pharmacological mechanisms of XXMD have not yet been elucidated. The purpose of this study was to develop neuroprotect...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6847685
更新日期:2019-07-10 00:00:00
abstract::Recent research had shown a correlation between aging and decreasing Gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. However, how GABA level varies with age in the medial portion of the brain has not yet been studied. The purpose of this study was to investigate the GABA level var...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6523909
更新日期:2016-01-01 00:00:00
abstract::Spontaneous bacterial peritonitis (SBP) is a common cirrhotic ascites complication which exacerbates the patient's condition. SBP is caused by gram-negative bacilli and, to a lesser extent, gram-positive cocci. Hospital-acquired infections show higher levels of drug-resistant bacteria. Geographical location influences...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/3743962
更新日期:2020-07-06 00:00:00