Regulation of Matrix Metalloproteinase-2 Secretion from Scleral Fibroblasts and Retinal Pigment Epithelial Cells by miR-29a.

abstract：BACKGROUND:Cancer/testis antigens (CTAs) are ideal targets for cancer immunotherapy in virtue of their restricted expression profile in normal tissues. However, CTA-targeted immunotherapy has been rather disappointing clinical setting for CTAs are downregulated by cytosine-phosphate-guanosine (CpG) methylation in their...

journal_title：BioMed research international

authors： Sun JZ,Gao L,Gao L,Wang W,Du N,Yang J,Wan L,Liu F,Wang LL,Yu L

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis ...

journal_title：BioMed research international

authors： Södergren A,Karp K,Bengtsson C,Möller B,Rantapää-Dahlqvist S,Wållberg-Jonsson S

更新日期：2015-01-01 00:00:00

abstract：:Epithelial Cl(-) secretion plays important roles in water secretion preventing bacterial/viral infection and regulation of body fluid. We previously suggested that quercetin would be a useful compound for maintaining epithelial Cl(-) secretion at a moderate level irrespective of cAMP-induced stimulation. However, we n...

journal_title：BioMed research international

authors： Sun H,Niisato N,Nishio K,Hamilton KL,Marunaka Y

更新日期：2014-01-01 00:00:00

abstract：:Each year, hundreds of millions of people travel across international borders or even oceans, and up to 230 million may remain for long periods. Among these, 3-5 million settle permanently in their new homes, with about 1 million migrating permanently to the United States of America. This may result in transport of pa...

journal_title：BioMed research international

authors： Smith Darr J,Conn DB

更新日期：2015-01-01 00:00:00

abstract：:It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important role in the immunopath...

journal_title：BioMed research international

authors： Lee IK,Hsieh CJ,Chen RF,Yang ZS,Wang L,Chen CM,Liu CF,Huang CH,Lin CY,Chen YH,Yang KD,Liu JW

更新日期：2013-01-01 00:00:00

abstract：:As the heart transitions from one exercise intensity to another, changes in cardiac output occur, which are modulated by alterations in force development and calcium handling. Although the steady-state force-calcium relationship at various heart rates is well investigated, regulation of these processes during transiti...

journal_title：BioMed research international

authors： Haizlip KM,Milani-Nejad N,Brunello L,Varian KD,Slabaugh JL,Walton SD,Gyorke S,Davis JP,Biesiadecki BJ,Janssen PM

更新日期：2015-01-01 00:00:00

abstract：Purpose:We aimed to identify prognostic factors for survival and recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) for patients with HCC and hepatitis C virus-related cirrhosis (HCV-cirrhosis). Methods:This retrospective cohort study followed all adult patients with HCV-cirrhosis who underw...

journal_title：BioMed research international

authors： Vidal RIO,Vidal EIO,Pereira BB,Assane CC,Ribeiro A,do Nascimento EM,Romeiro FG,Ribeiro Filho J

更新日期：2020-10-17 00:00:00

abstract：OBJECTIVE:Can polymer-based immunohistochemical staining of p57(kip2) replace DNA analysis as an inexpensive means of differentiating complete mole from partial mole or hydropic abortion? METHODS AND MATERIALS:Original paraffin-embedded tissue blocks from 14 equivocal cases were turned over to our laboratory and exami...

journal_title：BioMed research international

authors： Sasaki S,Sasaki Y,Kunimura T,Sekizawa A,Kojima Y,Iino K

更新日期：2015-01-01 00:00:00

abstract：:Endothelial barrier dysfunction, which is a serious problem that occurs in various inflammatory conditions, permits extravasation of serum components into the surrounding tissues, leading to edema formation and organ failure. Pigment epithelium-derived factor (PEDF), which is a major endogenous antagonist, has been im...

journal_title：BioMed research international

authors： He T,Zhao L,Zhang D,Zhang Q,Jia J,Hu J,Huang Y

更新日期：2015-01-01 00:00:00

abstract：Background:A deficiency in steroid 5α-reductase type 2 is an autosomal recessive disorder. Affected individuals manifested ambiguous genitalia, which is caused by decreased dihydrotestosterone (DHT) synthesis in the fetus. Methods:We analyzed 25 patients with 5α-reductase deficiency in China. Seventeen of the 25 patie...

journal_title：BioMed research international

authors： Han B,Cheng T,Zhu H,Yu J,Zhu WJ,Song HD,Yao H,Qiao J

更新日期：2020-06-09 00:00:00

abstract：:Remote organ impairments are frequent and increase patient morbidity and mortality after lower limb ischemia-reperfusion (IR). We challenged the hypothesis that lower limb IR might also impair lung, renal, and liver mitochondrial respiration. Two-hour tourniquet-induced ischemia was performed on both hindlimbs, follow...

journal_title：BioMed research international

authors： Mansour Z,Charles AL,Kindo M,Pottecher J,Chamaraux-Tran TN,Lejay A,Zoll J,Mazzucotelli JP,Geny B

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIM:The sensitivity and specificity of biomarkers used for predicting peripheral neuropathy in patients with systemic lupus erythematosus (SLE) and nephritis (SLE-LN) remain unsatisfactory. This study aimed to determine the autoantibodies levels in SLE-LN patients with peripheral neuropathy. METHODS:Dat...

journal_title：BioMed research international

authors： Su YJ,Huang CR,Chang WN,Tsai NW,Kung CT,Lin WC,Huang CC,Su CM,Cheng BC,Chang YT,Lu CH

更新日期：2014-01-01 00:00:00

abstract：:The rising global incidence of obesity cannot be fully explained within the context of traditional risk factors such as an unhealthy diet, physical inactivity, aging, or genetics. Adipose tissue is an endocrine as well as a metabolic organ that may be susceptible to disruption by environmental estrogenic chemicals. Si...

journal_title：BioMed research international

authors： Doke M,Avecilla V,Felty Q

更新日期：2018-01-08 00:00:00

abstract：:The interaction of patulin with human serum albumin (HSA) was studied in vitro under normal physiological conditions. The study was performed using fluorescence, ultraviolet-visible spectroscopy (UV-Vis), circular dichroism (CD), atomic force microscopy (AFM), and molecular modeling techniques. The quenching mechanism...

journal_title：BioMed research international

authors： Yuqin L,Guirong Y,Zhen Y,Caihong L,Baoxiu J,Jiao C,Yurong G

更新日期：2014-01-01 00:00:00

abstract：:Introduction. Second-line antituberculosis drugs (SLDs) are used for treating multidrug-resistant tuberculosis (MDR-TB). Prolonged delays before confirming MDR-TB with drug susceptibility testing (DST) could result in transmission of drug-resistant strains and inappropriate use of SLDs, thereby increasing the risk of ...

journal_title：BioMed research international

authors： Chen Y,Yuan Z,Shen X,Wu J,Wu Z,Xu B

更新日期：2016-01-01 00:00:00

abstract：:Hydrocephalus is a common neurological condition that can have traumatic ramifications and can be lethal without treatment. Nowadays, during therapy radiologists have to spend a vast amount of time assessing the volume of cerebrospinal fluid (CSF) by manual segmentation on Computed Tomography (CT) images. Further, som...

journal_title：BioMed research international

authors： Klimont M,Flieger M,Rzeszutek J,Stachera J,Zakrzewska A,Jończyk-Potoczna K

更新日期：2019-07-07 00:00:00

abstract：Objective:This study evaluated the bioactivity and physicochemical properties of three commercial calcium silicate-based endodontic materials (MTA, EndoSequence Root Repair Material putty, and Biodentine™). Material and Methods. Horizontal sections of 3 mm thickness from 18 root canals of human teeth were subjected to ...

journal_title：BioMed research international

authors： Talabani RM,Garib BT,Masaeli R

更新日期：2020-05-22 00:00:00

abstract：:Maintenance of proper oral hygiene by dental plaque elimination is one of the most important factors affecting the healing process in postoperative oral wounds. Propolis is a substance produced by bees. Ethanolic extract of propolis has bactericidal, fungicidal, anti-inflammatory, and antioxidative properties. Moreove...

journal_title：BioMed research international

authors： Niedzielska I,Puszczewicz Z,Mertas A,Niedzielski D,Różanowski B,Baron S,Konopka T,Machorowska-Pieniążek A,Skucha-Nowak M,Tanasiewicz M,Paluch J,Markowski J,Orzechowska-Wylęgała B,Król W,Morawiec T

更新日期：2016-01-01 00:00:00

abstract：:Tissues in the anterior segment of the eye are particular vulnerable to oxidative stress. To minimise oxidative stress, ocular tissues utilise a range of antioxidant defence systems which include nonenzymatic and enzymatic antioxidants in combination with repair and chaperone systems. However, as we age our antioxidan...

journal_title：BioMed research international

authors： Umapathy A,Donaldson P,Lim J

更新日期：2013-01-01 00:00:00

abstract：:We review the recent literature concerning the efficiency of antimicrobial photodynamic inactivation toward various microbial species in planktonic and biofilm cultures. The review is mainly focused on biofilm-growing microrganisms because this form of growth poses a threat to chronically infected or immunocompromised...

journal_title：BioMed research international

authors： Taraszkiewicz A,Fila G,Grinholc M,Nakonieczna J

更新日期：2013-01-01 00:00:00

abstract：:The interplay between Aspergillus fumigatus and the host immune response in lung infection has been subject of studies over the last years due to its importance in immunocompromised patients. The multifactorial virulence factors of A. fumigatus are related to the fungus biological characteristics, for example, structu...

journal_title：BioMed research international

authors： Sales-Campos H,Tonani L,Cardoso CR,Kress MR

更新日期：2013-01-01 00:00:00

abstract：:Neoadjuvant radio(chemo)therapy is increasingly used in rectal cancer and induces a number of morphologic changes that affect prognostication after curative surgery, thereby creating new challenges for surgical pathologists, particularly in evaluating morphologic changes and tumour response to preoperative treatment. ...

journal_title：BioMed research international

authors： Hav M,Libbrecht L,Ferdinande L,Geboes K,Pattyn P,Cuvelier CA

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslink...

journal_title：BioMed research international

authors： Chang YL,Lo YJ,Feng SW,Huang YC,Tsai HY,Lin CT,Fan KH,Huang HM

更新日期：2016-01-01 00:00:00

abstract：:We applied a metabolomic approach to monitor the modifications occurring in goat vitreous humor (VH) metabolite composition at different times (0, 6, 12, 18, and 24 hours) after death. The (1)H-NMR analysis of the VH samples was performed for the simultaneous determination of several metabolites (i.e., the metabolite ...

journal_title：BioMed research international

authors： Rosa MF,Scano P,Noto A,Nioi M,Sanna R,Paribello F,De-Giorgio F,Locci E,d'Aloja E

更新日期：2015-01-01 00:00:00

abstract：:Neonatal hyperbilirubinemia is a common problem with potentiality to cause irreversible brain damage. Reduction of serum bilirubin level is essential to minimize such damage. Compact fluorescent tubes, halogen bulbs, fiber optic blankets, and LEDs are commonly used light sources for phototherapy with varying efficacie...

journal_title：BioMed research international

authors： Gutta S,Shenoy J,Kamath SP,Mithra P,Baliga BS,Sarpangala M,Srinivasan M

更新日期：2019-04-11 00:00:00

abstract：:Cardiac pathologies are among the leading causes of mortality and morbidity in industrialized countries, with myocardial infarction (MI) representing one of the major conditions leading to heart failure (HF). Hitherto, the development of consistent, stable, and reproducible models of closed-chest MI in large animals, ...

journal_title：BioMed research international

authors： Biondi-Zoccai G,De Falco E,Peruzzi M,Cavarretta E,Mancone M,Leoni O,Caristo ME,Lotrionte M,Marullo AG,Amodeo A,Pacini L,Calogero A,Petrozza V,Chimenti I,D'Ascenzo F,Frati G

更新日期：2013-01-01 00:00:00

abstract：:This study aimed to examine the expression of and the relationship between CD44V6, CDH11, and β-catenin. The expression of these cell adhesion molecules was detected in 90 osteosarcoma and 20 osteochondroma specimens using immunohistochemistry. Associations between these parameters and clinicopathological data were al...

journal_title：BioMed research international

authors： Deng Z,Niu G,Cai L,Wei R,Zhao X

更新日期：2013-01-01 00:00:00

abstract：:Adiponectin (APN) is an adipokine secreted from adipose tissue and exhibits biological functions such as microcirculation-regulating, hearing-protective, and antiapoptotic. However, the effect of APN on the apoptosis of spiral arterial smooth muscle cells (SMCs) under hypoxic conditions in vitro is not clear. We used ...

journal_title：BioMed research international

authors： Xiao J,Zhang Y,Zhang W,Zhang L,Li L,Si J,Li X,Ma K

更新日期：2020-10-10 00:00:00

abstract：Purpose:To explore the effect of VEGF (vascular endothelial growth factor) on the vasculogenic mimicry (VM) formation of Choroidal Melanoma (CM) through PI3k signal pathway, to find novel targets for CM therapy. Methods:This research investigated the molecular mechanism of VEGF promoting VM formation of CM. First, we ...

journal_title：BioMed research international

authors： Xu X,Zong Y,Gao Y,Sun X,Zhao H,Luo W,Jia S

更新日期：2019-07-11 00:00:00

abstract：:Introduction and Objectives. Neutrophil-to-lymphocyte ratio (NLR) has been suggested to be a simple marker of the systemic inflammatory response in critical care patients. We previously assessed the utility of NLR as a biomarker to predict tumor recurrence and cancer death in bladder cancer patients who underwent radi...

journal_title：BioMed research international

authors： Ohtake S,Kawahara T,Kasahara R,Ito H,Osaka K,Hattori Y,Teranishi JI,Makiyama K,Mizuno N,Umemoto S,Miyoshi Y,Nakaigawa N,Miyamoto H,Yao M,Uemura H

更新日期：2016-01-01 00:00:00