Abstract:
:Xiaoxuming decoction (XXMD), a classic traditional Chinese medicine (TCM) prescription, has been used as a therapeutic in the treatment of stroke in clinical practice for over 1200 years. However, the pharmacological mechanisms of XXMD have not yet been elucidated. The purpose of this study was to develop neuroprotective models for identifying neuroprotective compounds in XXMD against hypoxia-induced and H2O2-induced brain cell damage. In this study, a phenotype-based classification method was designed by machine learning to identify neuroprotective compounds and to clarify the compatibility of XXMD components. Four different single classifiers (AB, kNN, CT, and RF) and molecular fingerprint descriptors were used to construct stacked naïve Bayesian models. Among them, the RF algorithm had a better performance with an average MCC value of 0.725±0.014 and 0.774±0.042 from 5-fold cross-validation and test set, respectively. The probability values calculated by four models were then integrated into a stacked Bayesian model. In total, two optimal models, s-NB-1-LPFP6 and s-NB-2-LPFP6, were obtained. The two validated optimal models revealed Matthews correlation coefficients (MCC) of 0.968 and 0.993 for 5-fold cross-validation and of 0.874 and 0.959 for the test set, respectively. Furthermore, the two models were used for virtual screening experiments to identify neuroprotective compounds in XXMD. Ten representative compounds with potential therapeutic effects against the two phenotypes were selected for further cell-based assays. Among the selected compounds, two compounds significantly inhibited H2O2-induced and Na2S2O4-induced neurotoxicity simultaneously. Together, our findings suggested that machine learning algorithms such as combination Bayesian models were feasible to predict neuroprotective compounds and to preliminarily demonstrate the pharmacological mechanisms of TCM.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yang S,Shen Y,Lu W,Yang Y,Wang H,Li L,Wu C,Du Gdoi
10.1155/2019/6847685subject
Has Abstractpub_date
2019-07-10 00:00:00pages
6847685eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章abstract:Background:Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods:Profile dat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7147824
更新日期:2020-07-31 00:00:00
abstract::Exposure to a variety of environmental factors such as salinity, drought, metal toxicity, extreme temperature, air pollutants, ultraviolet-B (UV-B) radiation, pesticides, and pathogen infection leads to subject oxidative stress in plants, which in turn affects multiple biological processes via reactive oxygen species ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9732325
更新日期:2019-05-08 00:00:00
abstract::Bone loss and fractures may call for the use of bone substituting materials, such as calcium phosphate cements (CPCs). CPCs can be degradable, and, to determine their limitations in terms of applications, their mechanical as well as chemical properties need to be evaluated over longer periods of time, under physiologi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/575079
更新日期:2015-01-01 00:00:00
abstract:Objectives:Percutaneous coronary intervention (PCI) is the mainstay treatment for coronary artery disease but complications such as in-stent restenosis and thrombosis remain problematic. Radiofrequency balloon angioplasty (RBA) can improve lumen dimension, fusing intimal tears, and artery dissection but is associated w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7459276
更新日期:2018-12-23 00:00:00
abstract::The rising global incidence of obesity cannot be fully explained within the context of traditional risk factors such as an unhealthy diet, physical inactivity, aging, or genetics. Adipose tissue is an endocrine as well as a metabolic organ that may be susceptible to disruption by environmental estrogenic chemicals. Si...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6821601
更新日期:2018-01-08 00:00:00
abstract::Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-old male rats were randomly divided into 2 groups: control (C; n = 14)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2494067
更新日期:2017-01-01 00:00:00
abstract::The neural dysfunction is triggered by cellular and molecular events that provoke neurotoxicity and neural death. Currently, neurodegenerative diseases are increasingly common, and available treatments are focused on relieving symptoms. Based on the above, in this review we describe the participation of vitexin in the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4785089
更新日期:2018-12-05 00:00:00
abstract::Craniofacial development consists of a highly complex sequence of the orchestrated growth and fusion of facial processes. It is also known that craniofacial abnormalities can be detected in 1/3 of all patients with congenital diseases. Within the various craniofacial abnormalities, orofacial clefting is one of the mos...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/901041
更新日期:2015-01-01 00:00:00
abstract::It has been reported that diabetes mellitus (DM) was an epidemiologically identified risk factor for development of dengue hemorrhagic fever (DHF)/severe dengue in dengue virus (DENV) affected patients, and T helper 2 (Th2) cytokines such as interleukin-4 (IL-4) and IL-10 each plays an important role in the immunopath...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/965853
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI). METHODS:Forty patients with SAP and 20 with UAP/n-ST...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/401357
更新日期:2015-01-01 00:00:00
abstract::A reliable in vivo imaging method to localize transplanted cells and monitor their viability would enable a systematic investigation of cell therapy. Most stem cell transplantation studies have used immunohistological staining, which does not provide information about the migration of transplanted cells in vivo in the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/231805
更新日期:2015-01-01 00:00:00
abstract::Impact of bone mesenchymal stem cell (BMSC) transfusion on chronic smoking-induced lung inflammation is poorly understood. In this study, a rat model of smoking-related lung injury was induced and the rats were treated with vehicle or BMSCs for two weeks. Different subsets of CD4+ T cells, cytokines, and anti-elastin ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/932923
更新日期:2015-01-01 00:00:00
abstract::The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/632570
更新日期:2014-01-01 00:00:00
abstract::Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of 99Tc-MDP is unclear. We systematically investigated the effects of 99Tc-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7902760
更新日期:2018-10-14 00:00:00
abstract::[This corrects the article DOI: 10.1155/2018/2109865.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2019/6212386
更新日期:2019-12-13 00:00:00
abstract::To establish a reliable isoproterenol induced heart dysfunction fetal rat model and understand the switches of contractile proteins, 45 pregnant rats were divided into 15 mg/kg-once, 15 mg/kg-twice, sham-operated once, sham-operated twice, and control groups. And 18 adult rats were divided into isoproterenol-treated a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/360687
更新日期:2014-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract:Objective:It is sometimes difficult to obtain complete/partial response of large hepatocellular carcinoma (HCC) nodules by trans-arterial chemoembolization/embolization (TACE/TAE). The aim is retrospective investigation of tumor response of large HCC nodules (>7 cm) treated by the new TACE technique, repeated alternate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9289321
更新日期:2020-01-19 00:00:00
abstract:Objective:The aim of this study was to investigate the respective correlation between the height (H) of a posterior malleolar fracture (PMF) and the involved area (S) of an articular surface and the presence of "die-punch." Methods:Patients with closed posterior malleolar fractures admitted to our hospital from Januar...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2903537
更新日期:2020-07-29 00:00:00
abstract::Solid lipid nanoparticle is an efficient lipid based drug delivery system which can enhance the bioavailability of poorly water soluble drugs. Efavirenz is a highly lipophilic drug from nonnucleoside inhibitor category for treatment of HIV. Present work illustrates development of an SLN formulation for Efavirenz with ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/363404
更新日期:2014-01-01 00:00:00
abstract::The quantitative and reproducible analysis of the standard body movement in Tai Chi Chuan (TCC) was performed in this study. We aimed to provide a reference of the upper extremities for standardizing TCC practice. Microsoft Kinect was used to record the motion during the practice of TCC. The preparation form and eight...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2538765
更新日期:2018-01-29 00:00:00
abstract::The most frequently seen types of tremor are essential (ET) and parkinsonian tremor (PT) and in some patients clinical characteristics of these tremor types overlap. It is vital to distinguish between these two types of tremor in order to reach the right diagnosis and select the appropriate treatment. One of the widel...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/934746
更新日期:2014-01-01 00:00:00
abstract::The complexity and diversity of eukaryotic organisms are a feat of nature's engineering. Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental signals perceived ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/407263
更新日期:2013-01-01 00:00:00
abstract::Approximately 40% of patients admitted to the medical intensive care unit (ICU) require mechanical ventilation. An accurate prediction of successful extubation in patients is a key clinical problem in ICU due to the fact that the successful extubation is highly associated with prolonged ICU stay. The prolonged ICU sta...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6820975
更新日期:2018-01-04 00:00:00
abstract::Persistent catecholamine-resistant shock in children causes severe morbidity and mortality. We aimed to analyze the association between hemodynamics and serum lactate at different time points and 28-day mortality in children with persistent catecholamine-resistant shock. Methods. Twenty-six children with persistent ca...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1341326
更新日期:2020-06-19 00:00:00
abstract::The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4020249
更新日期:2020-07-18 00:00:00
abstract::Tongue diagnosis is a noninvasive diagnosis and is traditionally one of the most important tools for physicians who practice Kampo (traditional Japanese) medicine. However, it is a subjective process, and its results can depend on the experience of the physician performing it. Previous studies have reported how to mea...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/249609
更新日期:2015-01-01 00:00:00
abstract::There is an emerging body of evidence that chemoresistance and minimal residual disease result from selective resistance of a cell subpopulation from the original tumor that is molecularly and phenotypically distinct. These cells are called "cancer stem cells" (CSCs). In this review, we analyze the potential targeting...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/859871
更新日期:2014-01-01 00:00:00
abstract::Influenza vaccination for health care personnel (HCP) is recommended particularly because it indirectly protects patients from contracting the disease. Vaccinating can therefore be interpreted as a prosocial act. However, HCP vaccination rates are often far too low to prevent nosocomial infections. Effective intervent...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6870984
更新日期:2016-01-01 00:00:00
abstract::Pure HA and 1, 3, 5, and 10 vol% multiwalled carbon nanotube- (MWNT-) reinforced hydroxyapatite (HA) were consolidated using a spark plasma sintering (SPS) technique. The relative density of pure HA increased with increasing sintering temperature, but that of the MWNT/HA composite reached almost full density at 900°C,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/768254
更新日期:2014-01-01 00:00:00