Abstract:
:Neurotrophic keratitis (NK) is a rare degenerative disease of the cornea caused by an impairment of corneal sensory innervation, characterized by decreased or absent corneal sensitivity resulting in epithelial keratopathy, ulceration, and perforation. The aetiopathogenesis of corneal sensory innervation impairment in children recognizes the same range of causes as adults, although they are much less frequent in the pediatric population. Some extremely rare congenital diseases could be considered in the aetiopathogenesis of NK in children. Congenital corneal anesthesia is an extremely rare condition that carries considerable diagnostic and therapeutic problems. Typically the onset is up to 3 years of age and the cornea may be affected in isolation or the sensory deficit may exist as a component of a congenital syndrome, or it may be associated with systemic somatic anomalies. Accurate diagnosis and recognition of risk factors is important for lessening long-term sequelae of this condition. Treatment should include frequent topical lubrication and bandage corneal or scleral contact lenses. Surgery may be needed in refractory cases. The purpose of this review is to summarize and update data available on congenital causes and treatment of corneal hypo/anesthesia and, in turn, on congenital NK.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Mantelli F,Nardella C,Tiberi E,Sacchetti M,Bruscolini A,Lambiase Adoi
10.1155/2015/805876subject
Has Abstractpub_date
2015-01-01 00:00:00pages
805876eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1155/2017/9469548
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pub_type: 杂志文章,meta分析,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/390789
更新日期:2013-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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