Abstract:
Background:Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of YAP1 in patients with gastrointestinal cancer. Methods:A systematic search was performed through the PubMed, Web of Science, Embase, and Cochrane library databases to collect eligible studies. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were used to evaluate the relationship between YAP1 expression and gastrointestinal cancer clinical outcomes. Results:A total of 2941 patients from 18 studies were enrolled. The results showed that elevated YAP1 expression predicted a poor prognosis in gastrointestinal cancer (HR = 1.56; 95% CI: 1.29-1.89; P < 0.001). Subgroup analyses indicated significant association between YAP1 overexpression and shorter OS of patients with esophageal squamous cell carcinoma (HR = 1.85; 95% CI: 1.25-2.73; P = 0.002), gastric cancer (HR = 1.41,95% CI: 1.02-1.95; P = 0.037), and colorectal cancer (pooled HR = 1.75; 95% CI: 1.42-2.15; P < 0.001). However, YAP1 expression did not affect DFS of patients with gastrointestinal cancer (pooled HR = 1.33; 95% CI: 0.95-1.88; P = 0.101). Conclusion:Elevated YAP1 expression in patients with gastrointestinal cancer might be related to shorter OS. YAP1 protein could serve as a potential predictor of poor prognosis in gastrointestinal cancer.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zhang L,Song X,Li X,Wu C,Jiang Jdoi
10.1155/2018/4039173subject
Has Abstractpub_date
2018-11-14 00:00:00pages
4039173eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章,meta分析abstract:OBJECTIVE:Lipoprotein-associated phospholipase A2 (Lp-PLA2), a marker of vascular inflammation, is associated with cardiovascular disease. This prospective study of an inception cohort aimed to investigate whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis ...
journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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journal_title:BioMed research international
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abstract::Several studies suggested that migraine attack onset shows a circadian variation; however, there has not been an overview and synthesis of these findings. A PubMed search with keywords "migraine" AND "circadian" resulted in ten studies directly investigating this topic. Results of these studies mostly show that migrai...
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journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
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更新日期:2016-01-01 00:00:00
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更新日期:2018-10-21 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2019-05-09 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-12-03 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1898671
更新日期:2018-09-25 00:00:00