Abstract:
UNLABELLED:H. pylori is related to various gastrointestinal diseases. β₂ Microglobulin (β 2M) is an intrinsic element of major histocompatibility complex (MHC I). Serum β₂M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between β₂M and H. pylori bearing CagA strains. METHODS:H. pylori status was determined by histopathology of samples taken from stomach. CagA status and β₂M level were measured from blood samples of patients. Eradication therapy was administered to the patients with H. pylori infection. β₂ Microglobulin levels were measured before and after treatment. RESULTS:35 (29.2%) H. pylori(-) patients and 85 (70.8%) H. pylori (+) patients were included in the study. There were 52 (43.3%) patients with CagA negative and 33 (27.5%) patients with CagA positive H. pylori infection. The mean serum β₂M level was 1.83 mg/L in H. pylori (-) group, 1.76 mg/L in H. pylori (+) CagA (-) group, and 1.93 mg/L in H. pylori and CagA (+) group (P > 0.05). Serum β 2M levels (1.82 versus 1.64 mg/L P < 0.05) were decreased after eradication. CONCLUSION:H. pylori and CagA status did not affect β₂M level. Relationship between low grade systematic inflammation and H. pylori should be investigated to find out new predictors for diseases associated with inflammation.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yeniova AÖ,Kucukazman M,Ata N,Dal K,Kefeli A,Başyiğit S,Aktaş B,Akın KO,Nazlıgül Ydoi
10.1155/2014/615089subject
Has Abstractpub_date
2014-01-01 00:00:00pages
615089eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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