Crocetin downregulates the proinflammatory cytokines in methylcholanthrene-induced rodent tumor model and inhibits COX-2 expression in cervical cancer cells.

abstract：:Introduction. The poor long-term adherence is known to affect the efficacy of allergen immunotherapy (AIT). In the case of injection AIT (SCIT), one of the main determinants is the inconvenience for patients to undergo prolonged build-up phases. Thus, simplifying the time schedule of the induction protocol could be ef...

journal_title：BioMed research international

authors： Caruso C,Bramé B,Bagnasco D,Cocconcelli A,Ortolani V,Pravettoni V,Scarpa S,Zisa G,Passalacqua G,Colantuono S

更新日期：2020-02-18 00:00:00

abstract：:Aim. To refine the decellularization protocol of whole porcine liver, which holds great promise for liver tissue engineering. Methods. Three decellularization methods for porcine livers (1% sodium dodecyl sulfate (SDS), 1% Triton X-100 + 1% sodium dodecyl sulfate, and 1% sodium deoxycholate + 1% sodium dodecyl sulfate...

journal_title：BioMed research international

authors： Wu Q,Bao J,Zhou YJ,Wang YJ,Du ZG,Shi YJ,Li L,Bu H

更新日期：2015-01-01 00:00:00

abstract：:Among uterine structural abnormalities, myomas and adenomyosis represent two distinct, though frequently coexistent entities, with a remarkable prevalence in women of reproductive age. Various mechanisms have been proposed to explain the impact of each of them on reproductive outcome. In respect to myomas, current evi...

journal_title：BioMed research international

authors： Vlahos NF,Theodoridis TD,Partsinevelos GA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Primary malignant spine/spinal tumors (PMSTs) are rare and life-threatening diseases. In this study, we demonstrated the advantage of volume-based 18F-FDG PET/CT metabolic parameter, metabolic tumor volume (MTV), for assessing the aggressiveness of PMSTs. MATERIALS AND METHODS:We retrospectively...

journal_title：BioMed research international

authors： Matsumoto Y,Baba S,Endo M,Setsu N,Iida K,Fukushi JI,Kawaguchi K,Okada S,Bekki H,Isoda T,Kitamura Y,Honda H,Nakashima Y

更新日期：2017-01-01 00:00:00

abstract：Background:Currently, effective genetic markers are limited to predict the clinical outcome of melanoma. High-throughput multiomics sequencing data have provided a valuable approach for the identification of genes associated with cancer prognosis. Method:The multidimensional data of melanoma patients, including clinic...

journal_title：BioMed research international

authors： Gao Y,Li Y,Niu X,Wu Y,Guan X,Hong Y,Chen H,Song B

更新日期：2020-05-08 00:00:00

abstract：:The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung. For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum....

journal_title：BioMed research international

authors： Wang WJ,Wu YS,Chen S,Liu CF,Chen SN

更新日期：2015-01-01 00:00:00

abstract：Background:Thyroid cancer is the most common endocrine malignancy, with a recent global increase of 20% in age-related incidence. Ultrasonography and ultrasonography-guided fine-needle aspiration biopsy (FNAB) are the most widely used diagnostic tests for thyroid nodules; however, it is estimated that up to 25% of thyr...

journal_title：BioMed research international

authors： Nan BY,Xiong GF,Zhao ZR,Gu X,Huang XS

更新日期：2021-01-12 00:00:00

abstract：:Objectives. The aim of the study is to detect the prevalence and the characteristics of infraorbital canal and Haller's cells on panoramic radiography of edentulous patients. Methods. The study group comprised 291 panoramic radiographs of edentulous patients. Radiographs were interpreted for the visibility and charact...

journal_title：BioMed research international

authors： Yesilova E,Bayrakdar IS

更新日期：2018-07-08 00:00:00

abstract：:The incidence of postoperative nausea and vomiting (PONV) is 30-50% after surgery. PONV occurs frequently, especially after craniotomy. In this study, we investigated the preventive effects on PONV in a randomized study by comparing patients who had been administered fosaprepitant, a neurokinin-1 (NK1) receptor antago...

journal_title：BioMed research international

authors： Tsutsumi YM,Kakuta N,Soga T,Kume K,Hamaguchi E,Tsutsumi R,Tanaka K

更新日期：2014-01-01 00:00:00

abstract：Objectives:Obstructive sleep apnea (OSA) is a common disorder influenced by genetic and environmental factors. Mutations of AT-hook DNA-binding motif containing 1 (AHDC1) gene have been implicated which could cause rare syndromes presenting OSA. This study aims to investigate some rare mutations of AHDC1 in Chinese Han...

journal_title：BioMed research international

authors： Yang S,Li K,Zhu MM,Yuan XD,Jiao XL,Yang YY,Li J,Li L,Zhang HN,Du YH,Wei YX,Qin YW

更新日期：2019-10-13 00:00:00

abstract：:In preclinical treatment of polytraumatized patients crystalloids are preferentially used. To avoid metabolic acidosis, metabolizable anions like lactate or acetate are used to replace chloride in these solutions. We here studied the effects of malated Ringer's in resuscitation of both shock severities in comparison t...

journal_title：BioMed research international

authors： Keitel J,Hussmann B,Lendemans S,de Groot H,Rohrig R

更新日期：2015-01-01 00:00:00

abstract：:Diarrhea is a major clinical problem affecting foals up to 3 months of age. The aim of this study was to identify enteric microorganisms involved in monoinfections and coinfections and the associated virulence factors in healthy and diarrheic foals. Diarrheic (D) (n = 56) and nondiarrheic (ND) foals (n = 60) up to thr...

journal_title：BioMed research international

authors： Olivo G,Lucas TM,Borges AS,Silva RO,Lobato FC,Siqueira AK,da Silva Leite D,Brandão PE,Gregori F,de Oliveira-Filho JP,Takai S,Ribeiro MG

更新日期：2016-01-01 00:00:00

abstract：:Among the different signaling molecules released during reactive gliosis occurring in Alzheimer's disease (AD), the astrocyte-derived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease. The use of pharmacological tools targeting S100B may be crucial to embank its effects and some ...

journal_title：BioMed research international

authors： Cirillo C,Capoccia E,Iuvone T,Cuomo R,Sarnelli G,Steardo L,Esposito G

更新日期：2015-01-01 00:00:00

abstract：:The rising global incidence of obesity cannot be fully explained within the context of traditional risk factors such as an unhealthy diet, physical inactivity, aging, or genetics. Adipose tissue is an endocrine as well as a metabolic organ that may be susceptible to disruption by environmental estrogenic chemicals. Si...

journal_title：BioMed research international

authors： Doke M,Avecilla V,Felty Q

更新日期：2018-01-08 00:00:00

abstract：:Heart rate variability is a physiological feature indicating the influence of the autonomic nervous system on the heart rate. Association of the reduced heart rate variability due to myocardial infarction and the increased postinfarction mortality was first described more than thirty years ago. Many studies have unequ...

journal_title：BioMed research international

authors： Lakusic N,Mahovic D,Kruzliak P,Cerkez Habek J,Novak M,Cerovec D

更新日期：2015-01-01 00:00:00

abstract：:The aim of the present study was to extract and characterize bioactive components from separate body organs of Holothuria leucospilota. Preliminary qualitative assessment of the crude extracts was positive for phenols, terpenoids, carbohydrates, flavonoids, saponins, glycosides, cardiac glycosides, steroids, phlobatan...

journal_title：BioMed research international

authors： Ceesay A,Nor Shamsudin M,Aliyu-Paiko M,Ismail IS,Nazarudin MF,Mohamed Alipiah N

更新日期：2019-04-15 00:00:00

abstract：:Nickel-titanium (NiTi) rotary files have enabled efficient root canal preparations that maintain the canal center with fewer aberrations compared to hand files. However, NiTi rotary files are susceptible to fracture, which can thereby compromise root canal treatment. Therefore, NiTi files have been developed to enhanc...

journal_title：BioMed research international

authors： Oh S,Kum KY,Cho K,Lee SH,You SH,Go J,Jeon BK,Kim SW,Kim TH,Jang JH,Perinpanayagam H,Kim JW,Chang SW

更新日期：2019-11-07 00:00:00

abstract：Purpose:It is well known that interstitial photodynamic therapy (iPDT) of large tumors requires effective planning to ensure efficient delivery of therapeutic dose to the target tumors. This should be achieved in parallel with minimal damage to the nearby intact tissues. To that end, clinical iPDT can be attained using...

journal_title：BioMed research international

authors： Ismael FS,Amasha H,Bachir W

更新日期：2020-03-23 00:00:00

abstract：:Background. Neuroinflammation which presents as a possible mechanism of delirium is associated with MCP-1, an important proinflammatory factor which is expressed on astrocytes. It is known that dexmedetomidine (DEX) possesses potent anti-inflammatory properties. This study aimed to investigate the potential effects of...

journal_title：BioMed research international

authors： Liu H,Davis JR,Wu ZL,Faez Abdelgawad A

更新日期：2017-01-01 00:00:00

abstract：:Objectives. This study aimed to determine the feasibility of cochlear implantation for sensorineural hearing loss in patients with Waardenburg syndrome. Method. A retrospective chart review was performed on patients who underwent cochlear implantation at the University of Tokyo Hospital. Clinical classification, genet...

journal_title：BioMed research international

authors： Koyama H,Kashio A,Sakata A,Tsutsumiuchi K,Matsumoto Y,Karino S,Kakigi A,Iwasaki S,Yamasoba T

更新日期：2016-01-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the most common cause of death in the world. Recent studies have shown an association between adrenal insufficiency (AI) and increased cardiovascular risk (CVR). Patients with AI receive glucocorticoid (GC) replacement therapy which can lead to varying levels of blood cortisol. It was s...

journal_title：BioMed research international

authors： Rahvar AH,Haas CS,Danneberg S,Harbeck B

更新日期：2017-01-01 00:00:00

abstract：Objective:This study aims to investigate the effect of systemically administrated zoledronate on bone-implant fixation in animal models. Methods:We searched MEDLINE, Embase, and EBSCO for studies that explore the role of systemic or local zoledronate delivery in implant osseointegration in animal models. The Review Ma...

journal_title：BioMed research international

authors： He Y,Bao W,Wu XD,Huang W,Chen H,Li Z

更新日期：2019-09-22 00:00:00

abstract：:So far, there is no report regarding the micro-Raman vibrational fingerprint of the bonds between 10-methacryloyloxy-decyl dihydrogen phosphate (10-MDP) and zirconia ceramics. Thus, the aim of this study was to identify the Raman vibrational peaks related to the bonds of 10-MDP with zirconia, as well as the influence ...

journal_title：BioMed research international

authors： De-Paula DM,Loguercio AD,Reis A,Frota NM,Melo R,Yoshihara K,Feitosa VP

更新日期：2017-01-01 00:00:00

abstract：:Mutations in the kinase domain of epidermal growth factor receptor (EGFR) have high levels of basal receptor phosphorylation and are associated with clinical responsiveness to Iressa in patients with nonsmall cell lung cancer (NSCLC). This study aimed to assess the feasibility of morpholino-[(124)I]IPQA derivative as ...

journal_title：BioMed research international

authors： Yeh SH,Lin CF,Kong FL,Wang HE,Hsieh YJ,Gelovani JG,Liu RS

更新日期：2013-01-01 00:00:00

abstract：:In clinical endodontics, preoperative estimation of root canal curvature is crucial regarding the prevention of iatrogenic errors. Reproduction of the two-dimensional radiographic images causes certain proximal view curvatures not seen. Therefore, the present study is aimed at investigating the degree of root canal cu...

journal_title：BioMed research international

authors： Faraj BM

更新日期：2021-01-13 00:00:00

abstract：:The distribution of the induced electric field (E-field) during transcranial magnetic stimulation (TMS) depends on the individual anatomical structure of the brain as well as coil positioning. Inappropriate stimulation may degrade the efficacy of TMS or even induce adverse effects. Therefore, optimizing the E-field ac...

journal_title：BioMed research international

authors： Li C,Liu C,Yang L,He L,Wu T

更新日期：2019-11-03 00:00:00

abstract：AIM:Gastrointestinal mucositis is a frequent complication of antineoplastic chemotherapy, but the effects of chemotherapy on mucosal defense mechanisms remain poorly understood. We studied the effects of cisplatin on mucin, one of the principal defense factors of the gastrointestinal mucosa, and evaluated the efficacy ...

journal_title：BioMed research international

authors： Yamamoto H,Ishihara K,Takeda Y,Koizumi W,Ichikawa T

更新日期：2013-01-01 00:00:00

abstract：:Renal dysfunction is one of the most common complications of liver cirrhosis and is associated with increased morbidity and mortality. However, no available technology can simultaneously support liver and renal function in these patients. The aim of this study was to evaluate the safety and efficacy of an artificial l...

journal_title：BioMed research international

authors： Feng L,He G,Cai L,Fu C,Li Y,Weng J,Huo X,Peng Q,Gao Y

更新日期：2018-05-24 00:00:00

abstract：:With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compar...

journal_title：BioMed research international

authors： Čapková M,Šáchová J,Strnad H,Kolář M,Hroudová M,Chovanec M,Čada Z,Šteffl M,Valach J,Kastner J,Vlček Č,Smetana K Jr,Plzák J

更新日期：2014-01-01 00:00:00

abstract：:Heteronemin is a bioactive marine sesterterpene isolated from the sponge Hyrtios sp. Previous reports have shown that heteronemin possesses anticancer activity. Here, heteronemin displayed cytotoxic effects against three human cancer cell lines (A549, ACHN, and A498) and exhibited potent activity in A498 human renal c...

journal_title：BioMed research international

authors： Wu SY,Sung PJ,Chang YL,Pan SL,Teng CM

更新日期：2015-01-01 00:00:00