Abstract:
:With the increasing demand for noninvasive approaches in monitoring head and neck cancer, circulating nucleic acids have been shown to be a promising tool. We focused on the global transcriptome of serum samples of head and neck squamous cell carcinoma (HNSCC) patients in comparison with healthy individuals. We compared gene expression patterns of 36 samples. Twenty-four participants including 16 HNSCC patients (from 12 patients we obtained blood samples 1 year posttreatment) and 8 control subjects were recruited. The Illumina HumanWG-6 v3 Expression BeadChip was used to profile and identify the differences in serum mRNA transcriptomes. We found 159 genes to be significantly changed (Storey's P value <0.05) between normal and cancer serum specimens regardless of factors including p53 and B-cell lymphoma family members (Bcl-2, Bcl-XL). In contrast, there was no difference in gene expression between samples obtained before and after surgery in cancer patients. We suggest that microarray analysis of serum cRNA in patients with HNSCC should be suitable for refinement of early stage diagnosis of disease that can be important for development of new personalized strategies in diagnosis and treatment of tumours but is not suitable for monitoring further development of disease.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Čapková M,Šáchová J,Strnad H,Kolář M,Hroudová M,Chovanec M,Čada Z,Šteffl M,Valach J,Kastner J,Vlček Č,Smetana K Jr,Plzák Jdoi
10.1155/2014/408683subject
Has Abstractpub_date
2014-01-01 00:00:00pages
408683eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Purpose. This meta-analysis is to assess the effectiveness of teriparatide in fracture healing and clinical function improvement of the osteoporotic patients. Methods. We searched PubMed, Embase, Web of Science, and the Cochrane databases for randomized and quasi-randomized controlled trials comparing teriparatide to ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/6040379
更新日期:2016-01-01 00:00:00
abstract::External focus of attention (EFA) and internal focus of attention (IFA) represent commonly used strategies to instruct subjects during exercise. Several studies showed EFA to be more effective than IFA to improve motor performance and learning. To date the role of these strategies on motor performance during finger mo...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/2946465
更新日期:2017-01-01 00:00:00
abstract::Diabetes has become the third most serious threat to human health, after cancer and cardiovascular disease. Notably, Lactobacillus brevis is the most common species of LAB that produces γ-aminobutyric acid (GABA). The aim of this study is to clarify the effect of time, strain types, antibiotic concentrations, differen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7356173
更新日期:2018-09-19 00:00:00
abstract:Objective:We identified differentially expressed microRNAs (DEMs) between esophageal carcinoma (ESCA) tissues and normal esophageal tissues. We then constructed a novel three-miRNA signature to predict the prognosis of ESCA patients using bioinformatics analysis. Materials and Methods. We combined two microarray profil...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5973082
更新日期:2020-02-10 00:00:00
abstract:Background:Oxycodone is a widely used opioid analgesic, which is involved in cancer pain and non-cancer pain. This study is intended to understand the publication characteristics of oxycodone research field and assess the quality of pertinent articles from 1998 to 2017. Methods:Oxycodone-related publications from 1998...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9096201
更新日期:2019-10-31 00:00:00
abstract:Background:The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Methods:Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy childr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5821369
更新日期:2018-02-25 00:00:00
abstract:Background:The aim of our study was to investigate the impact of abdominal wall reconstruction surgery on tissue anatomy and to explore how flap surgery influences the patient's immune status. Methods:Experimental abdominal wall defects were created in 8 Sus scrofa (swine) animal models. The animals were divided into ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2421585
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. MATERIAL...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/783967
更新日期:2014-01-01 00:00:00
abstract::Acute leukemias are the most frequent childhood malignancies worldwide and remain a leading cause of morbidity and mortality of relapsed patients. While remarkable progress has been made in characterizing genetic aberrations that may control these hematological disorders, it has also become clear that abnormalities in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/846724
更新日期:2013-01-01 00:00:00
abstract::Numerous studies have shown that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of human cardiovascular diseases. However, whether lncRNA ezrin antisense RNA 1 (EZR-AS1) is associated with the progression of coronary heart disease (CHD) remains unclear. Accordingly, the aim of th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6840234
更新日期:2020-05-22 00:00:00
abstract:Objective:To characterize and evaluate CT and MRI features of extremity soft tissue adult fibrosarcoma. Methods:CT and MRI images from 10 adult patients with pathologically proven fibrosarcomas were retrospectively analyzed with regard to tumor location, size, number, shape, margins, attenuation, signal intensity, and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6075705
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:Cancer/testis antigens (CTAs) are ideal targets for cancer immunotherapy in virtue of their restricted expression profile in normal tissues. However, CTA-targeted immunotherapy has been rather disappointing clinical setting for CTAs are downregulated by cytosine-phosphate-guanosine (CpG) methylation in their...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/196894
更新日期:2013-01-01 00:00:00
abstract::Polyphenolic compounds are plant nutraceuticals showing a huge structural diversity, including chlorogenic acids, hydrolyzable tannins, and flavonoids (flavonols, flavanones, flavan-3-ols, anthocyanidins, isoflavones, and flavones). Most of them occur as glycosylated derivatives in plants and foods. In order to become...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/905215
更新日期:2015-01-01 00:00:00
abstract::Adverse perinatal outcomes in singleton IVF pregnancies have been most often explained by parental underlying diseases and so far laboratory conditions during embryo culture are still not explored well. The following review discusses the current state of knowledge on the influence of IVF laboratory procedures on the p...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3285179
更新日期:2016-01-01 00:00:00
abstract::In the last decade the number of wireless devices operating at the frequency band of 2.4 GHz has increased in several settings, such as healthcare, occupational, and household. In this work, the emissions from Wi-Fi transceivers applicable to context aware scenarios are analyzed in terms of potential interference and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/784362
更新日期:2015-01-01 00:00:00
abstract::Caudal epidural block is a commonly used technique for surgical anesthesia in children and chronic pain management in adults. It is performed by inserting a needle through the sacral hiatus to gain entrance into the sacral epidural space. Using conventional blind technique, the failure rate of caudal epidural block in...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/9217145
更新日期:2017-01-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in TNFSF4 and ANKRD55 genes have been shown to be associated with several autoimmune diseases, although whether these genes are susceptibility genes for dermatomyositis/polymyositis (DM/PM) has, to date, not been reported. This study aimed to investigate the potential association...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2905987
更新日期:2017-01-01 00:00:00
abstract::The incidence of acute kidney injury induced by contrast media (CI-AKI) is the third cause of AKI in hospitalized patients. Contrast media cause relevant alterations both in renal hemodynamics and in renal tubular cell function that lead to CI-AKI. The vasoconstriction of intrarenal vasculature is the main hemodynamic...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/578974
更新日期:2014-01-01 00:00:00
abstract::The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis t...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/709846
更新日期:2015-01-01 00:00:00
abstract::Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involve...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/290863
更新日期:2014-01-01 00:00:00
abstract::To explore the mechanisms by which andrographolide inhibits gastric cancer cell proliferation and metastasis, we employed the gastric cell line SGC7901 to investigate the anticancer effects of andrographolide. The cell survival ratio, cell migration and invasion, cell cycle, apoptosis, and matrix metalloproteinase act...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6242103
更新日期:2017-01-01 00:00:00
abstract::Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/196034
更新日期:2014-01-01 00:00:00
abstract:Objectives:Obstructive sleep apnea (OSA) is a common disorder influenced by genetic and environmental factors. Mutations of AT-hook DNA-binding motif containing 1 (AHDC1) gene have been implicated which could cause rare syndromes presenting OSA. This study aims to investigate some rare mutations of AHDC1 in Chinese Han...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5907361
更新日期:2019-10-13 00:00:00
abstract::Volatiles emitted by the host's food would be the first signals used by parasitoids in the host location process and are thought to play an important role in host habitat location. In this study, the olfactory responses of Theocolax elegans (Westwood), a Pteromalid wasp that parasitizes immature stages of stored-produ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5460819
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:This study investigates the safety and efficacy of a multimodality approach combining staged endovascular embolizations with subsequent SRS for the management of larger AVMs. METHODS:Ninety-five patients with larger AVMs were treated with staged endovascular embolization followed by SRS between 1996 and 2011...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/306518
更新日期:2014-01-01 00:00:00
abstract::DNA Primase Subunit 1 (PRIM1) is crucial for cancer development and progression. However, there remains a lack of comprehension concerning the clinical implication of PRIM1 in HCC. Here, aberrant expression of PRIM1 was identified in HCC according to available databases. The prognostic value of PRIM1 in patients prese...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9689312
更新日期:2020-08-22 00:00:00
abstract::Data on genotypic diversity of Mycobacterium tuberculosis complex (MTBC) is important to understand its epidemiology, human adaptation, clinical phenotypes, and drug resistance. This study aimed to characterize MTBC clinical isolates circulating in a predominantly pastoralist area in Ethiopia, a country where tubercul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/238532
更新日期:2014-01-01 00:00:00
abstract::This study examines the isoform-specific effects of short-term hindlimb suspension (HS) on the Na,K-ATPase in rat soleus muscle. Rats were exposed to 24-72 h of HS and we analyzed the consequences on soleus muscle mass and contractile parameters; excitability and the resting membrane potential (RMP) of muscle fibers; ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/720172
更新日期:2015-01-01 00:00:00
abstract::Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb, i.e., the aetiological agent); the WHO has established this disease as high priority due to its ensuing mortality. Mtb uses a range of mechanisms for preventing its elimination by an infected host; new, viable alternatives for blocking th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8680935
更新日期:2019-04-14 00:00:00
abstract:Purpose:Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9765162
更新日期:2020-02-22 00:00:00