Abstract:
BACKGROUND:Cancer/testis antigens (CTAs) are ideal targets for cancer immunotherapy in virtue of their restricted expression profile in normal tissues. However, CTA-targeted immunotherapy has been rather disappointing clinical setting for CTAs are downregulated by cytosine-phosphate-guanosine (CpG) methylation in their promoter regions, so that tumor cells have low immunogenicity. METHODS:We reinduced mouse CTA P1A through demethylation process and generated P1A-specific cytotoxic lymphocytes (CTLs) by immunizing BALB/c (H-2(d)) mice with dendritic cells pulsed with a P1A-specific peptide and CpG oligodeoxynucleotide (ODN) immune adjuvant. RESULTS:We found that demethylation and CpG ODN immune adjuvant stimulation facilitated DC maturation and enhanced the allogenic capacity of P1A-specific CTLs against target cells both in vitro and in vivo. CONCLUSIONS:Our results suggested that CTA induction and immune adjuvant stimulation is a feasible strategy in cancer immunotherapy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Sun JZ,Gao L,Gao L,Wang W,Du N,Yang J,Wan L,Liu F,Wang LL,Yu Ldoi
10.1155/2013/196894subject
Has Abstractpub_date
2013-01-01 00:00:00pages
196894eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
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journal_title:BioMed research international
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