Abstract:
OBJECTIVE:This study investigates the safety and efficacy of a multimodality approach combining staged endovascular embolizations with subsequent SRS for the management of larger AVMs. METHODS:Ninety-five patients with larger AVMs were treated with staged endovascular embolization followed by SRS between 1996 and 2011. RESULTS:The median volume of AVM in this series was 28 cm(3) and 47 patients (48%) were Spetzler-Martin grade IV or V. Twenty-seven patients initially presented with hemorrhage. Sixty-one patients underwent multiple embolizations while a single SRS session was performed in 64 patients. The median follow-up after SRS session was 32 months (range 9-136 months). Overall procedural complications occurred in 14 patients. There were 13 minor neurologic complications and 1 major complication (due to embolization) while four patients had posttreatment hemorrhage. Thirty-eight patients (40%) were cured radiographically. The postradiosurgery actuarial rate of obliteration was 45% at 5 years, 56% at 7 years, and 63% at 10 years. In multivariate analysis, larger AVM size, deep venous drainage, and the increasing number of embolization/SRS sessions were negative predictors of obliteration. The number of embolizations correlated positively with the number of stereotactic radiosurgeries (P < 0.005). CONCLUSIONS:Multimodality endovascular and radiosurgical approach is an efficacious treatment strategy for large AVM.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Dalyai R,Theofanis T,Starke RM,Chalouhi N,Ghobrial G,Jabbour P,Dumont AS,Fernando Gonzalez L,Gordon DS,Rosenwasser RH,Tjoumakaris SIdoi
10.1155/2014/306518subject
Has Abstractpub_date
2014-01-01 00:00:00pages
306518eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
临床试验,杂志文章abstract::Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2957941
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/636530
更新日期:2014-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-12-09 00:00:00
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更新日期:2020-12-12 00:00:00
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更新日期:2018-08-29 00:00:00
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更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00