Abstract:
:Taiwan has very high incidence and prevalence of chronic kidney disease (CKD), which easily progresses to end-stage renal disease (ESRD). The association between inflammation and CKD has been explored in several studies. ORAI1 functions as a pore-forming subunit of the store-operated calcium channels which are involved in the regulation of immune system. Hence, we conducted a case-control study to determine whether the genetic polymorphisms of ORAI1 gene is a susceptibility factor to CKD and its clinical features in a Taiwanese population. Five hundred seventy-nine CKD patients from a hospital-based CKD care program were included in the study. Five tagging single nucleotide polymorphisms (tSNPs) of ORAI1 were selected from the genotyping data of the Han Chinese population from the HapMap project. Among these polymorphisms, rs12313273 was found to be significantly associated with elevated serum calcium levels, which has been linked to increased risk of death in CKD patients. To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Hwang DY,Chien SC,Hsu YW,Kao CC,Cheng SY,Lu HC,Wu MS,Chang JMdoi
10.1155/2014/290863subject
Has Abstractpub_date
2014-01-01 00:00:00pages
290863eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::The aim of this study is to assess the change in intraocular pressure after a road trip, in eyes with different levels of filling with gas tamponade. Five rabbit eyes were subject to pars plana vitrectomy and gas tamponade (filling percentage: 25%, 50%, and 100% of nonexpansile SF6, 100% saline solution, and 100% room...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7326160
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/742792
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1742326
更新日期:2018-12-09 00:00:00
abstract::Recent studies suggest that nucleotide-binding domain leucine-rich repeat protein 1 (NLRP1) is a pivotal factor in the inflammatory process. However, the role of NLRP1 in breast cancer pathogenesis remains unclear. The aim of this study was to examine the expression and function of NLRP1 in breast cancer. We found tha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4938473
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5306509
更新日期:2020-11-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/109275
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/4179617
更新日期:2019-05-28 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/634768
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6096814
更新日期:2020-01-30 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1313586
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9173040
更新日期:2017-01-01 00:00:00
abstract::Emergence and spread of pandemic strains of Vibrio parahaemolyticus have drawn attention to make detailed study on their genomes. The pathogenicity of V. parahaemolyticus has been associated with thermostable-direct hemolysin (TDH) and/or TDH-related hemolysin (TRH). The present study evaluated characteristics of tdh ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/576528
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/356729
更新日期:2015-01-01 00:00:00
abstract::Heart failure (HF) is associated with mitochondrial dysfunction and energy metabolism impairment. MicroRNAs are implicated in the development of heart failure. However, the mitochondria enriched microRNA during heart failure remains elusive. Here, we generated a pressure overload-induced early and late stage heart fai...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4042509
更新日期:2017-01-01 00:00:00
abstract::Although the dynamic motions and peptidyl transferase activity seem to be embedded in the rRNAs, the ribosome contains more than 50 ribosomal proteins (r-proteins), whose functions remain largely elusive. Also, the precise forms of some of these r-proteins, as being part of the ribosome, are not structurally solved du...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/539238
更新日期:2015-01-01 00:00:00
abstract:Background:Identification of potential molecular targets of acute myocardial infarction is crucial to our comprehensive understanding of the disease mechanism. However, studies of gene coexpression analysis via jointing multiple microarray data of acute myocardial infarction still remain restricted. Methods:Microarray...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5742608
更新日期:2019-02-11 00:00:00
abstract::Acute leukemias are the most frequent childhood malignancies worldwide and remain a leading cause of morbidity and mortality of relapsed patients. While remarkable progress has been made in characterizing genetic aberrations that may control these hematological disorders, it has also become clear that abnormalities in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/846724
更新日期:2013-01-01 00:00:00
abstract::Blood compatibility of metallocene polyethylene (mPE) was investigated after modifying the surface using hydrochloric acid. Contact angle of the mPE exposed to HCl poses a decrease in its value which indicates increasing wettability and better blood compatibility. Surface of mPE analyzed by using FTIR revealed no sign...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/963149
更新日期:2014-01-01 00:00:00
abstract::Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism. Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism. Activation of skeletal RAS plays an important role in bone metabolic diso...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/932691
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/428038
更新日期:2014-01-01 00:00:00
abstract::HPV genotypes have distinct distributions among various ethnic populations worldwide. In December 2013, 237 and 159 cervical samples were collected from Hani and Han ethnic women, respectively, in Mojiang, a rural county in southern Yunnan. The overall HPV infection rate (21.1%) among the Hani women was significantly ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/314815
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:The use of unlicensed food and herbal supplements to enhance sexual functions is drastically increasing. This phenomenon, combined with the availability of these products over the Internet, represents a challenge from a clinical and a public health perspective. METHODS:A comprehensive multilingual assessm...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/841798
更新日期:2014-01-01 00:00:00
abstract::A Chinese medicinal fern Blechnum orientale (Linn) was separately collected from polluted and unpolluted sites to determine whether it could accumulate hazardous pollutants or not. Metal concentrations (Cu, Zn, Mn, Pb, Cd, Cr, As, and Hg) both in the fronds and roots and polycyclic aromatic hydrocarbons (PAHs) in the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/192986
更新日期:2013-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to H...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/231474
更新日期:2014-01-01 00:00:00
abstract::Objectives. The aim of the study is to detect the prevalence and the characteristics of infraorbital canal and Haller's cells on panoramic radiography of edentulous patients. Methods. The study group comprised 291 panoramic radiographs of edentulous patients. Radiographs were interpreted for the visibility and charact...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1293124
更新日期:2018-07-08 00:00:00
abstract::Objectives. Osteopontin (OPN) is overexpressed in breast cancers, while its clinical and prognostic significance remained unclear. This study aimed to assess the prognostic value of OPN, especially its splice variants, in breast cancers. Methods. Data were extracted from eligible studies concerning the OPN and OPN-c e...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2016/7310694
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/215135
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3127543
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:In the process of care for disorders of sex development (DSD), clinical decisions should focus on the long-term quality of life (QOL). We sought to investigate the QOL of patients with DSD in China. DESIGN:Case-control study was carried out. PATIENTS:90 patients of DSD participated in the study. Finally, 87...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/342420
更新日期:2015-01-01 00:00:00