Abstract:
:The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis that ultimately promotes the premature exit of immature CD4(-)CD8(-) T cells expressing TCR and proinflamatory cytokines to peripheral lymphoid organs, where they may interfere with adaptive immune responses. In what follows, we review recent findings revealing escape of these immature T cells exhibiting an activation profile to peripheral compartments of the immune system in both experimental murine and human models of Chagas disease.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Flávia Nardy A,Santos L,Freire-de-Lima CG,Morrot Adoi
10.1155/2015/709846subject
Has Abstractpub_date
2015-01-01 00:00:00pages
709846eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2015/617143
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1155/2014/520763
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abstract::Hypertrophic Scars (HTSs) are a complex fibroproliferative disorder, and their exact mechanism is still not fully understood. In this study, we first found that cystic fibrosis transmembrane conductance regulator (CFTR) expression was downregulated in human hypertrophic scars at the RNA and protein levels by microarra...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2020/9526289
更新日期:2020-01-02 00:00:00
abstract::Cardiogenic shock (CS) is uncommon in patients suffering from acute myocardial infarction (AMI). Long-term outcome and adverse predictors for outcomes in AMI patients with CS receiving percutaneous coronary interventions (PCI) are unclear. A total of 482 AMI patients who received PCI were collected, including 53 CS an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8530539
更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2017/4673047
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4093435
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/735835
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3845780
更新日期:2019-12-14 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/348017
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2017/3489603
更新日期:2017-01-01 00:00:00