Suppressive effects of D-glucosamine on the 5-HT sensitive nociceptive units in the rat tooth pulpal nerve.

Abstract:

:It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis. Although it has been reported that DGL has a significant pain relief effect in treating osteoarthritis, little is known about the characteristics of the effects of this compound on dental pain. The present study was undertaken to evaluate the applicability of DGL as a medicament to control pulpalgia. Using an in vitro rat mandible-inferior alveolar nerve preparation (jaw-nerve preparation), we evaluated the effects of DGL on 5-hydroxytryptamine (5-HT) sensitive nociceptive responses in the tooth pulpal nerve. 5-HT-induced nociceptive responses were fairly suppressed by direct application of DGL, suggesting that DGL have a pain relief effect on patients with dental pain.

journal_name

Biomed Res Int

authors

Kaida K,Yamashita H,Toda K,Hayashi Y

doi

10.1155/2014/187989

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

187989

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

杂志文章
  • Somatostatin receptor based imaging and radionuclide therapy.

    abstract::Somatostatin (SST) receptors (SSTRs) belong to the typical 7-transmembrane domain family of G-protein-coupled receptors. Five distinct subtypes (termed SSTR1-5) have been identified, with SSTR2 showing the highest affinity for natural SST and synthetic SST analogs. Most neuroendocrine tumors (NETs) have high expressio...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/917968

    authors: Xu C,Zhang H

    更新日期:2015-01-01 00:00:00

  • Clinical and Prognostic Significance of Positive Hepatojugular Reflux on Discharge in Acute Heart Failure: Insights from the ESCAPE Trial.

    abstract::Background. There has been a decline in emphasis of the value of physical examination in heart failure (HF) with increased reliance on cardiac imaging. We aim to study the clinical and prognostic significance of positive hepatojugular reflux (HJR) on discharge in patients hospitalized with HF. Methods. Using the ESCAP...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/5734749

    authors: Omar HR,Guglin M

    更新日期:2017-01-01 00:00:00

  • Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord.

    abstract::Umbilical cords as a source of stem cells are of increasing interest for cell therapies as they present little ethical consideration and are reported to contain immune privileged cells which may be suitable for allogeneic based therapies. Mesenchymal stem cells (MSCs) sourced from several different cord regions, inclu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/916136

    authors: Mennan C,Wright K,Bhattacharjee A,Balain B,Richardson J,Roberts S

    更新日期:2013-01-01 00:00:00

  • Speed of Retinal Vascularization in Retinopathy of Prematurity: Risk and Protective Factors.

    abstract:Objective:The objective was to study the risk and protective factors involved in retinal vascular development of preterm infants with retinopathy of prematurity. Methods:Between 2000 and 2017, 185 preterm infants were included in the protocol for retinopathy of prematurity. Risk factors associated with speed of retina...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2721578

    authors: Solans Pérez de Larraya AM,Ortega Molina JM,Uberos Fernández J,González Ramírez AR,García Serrano JL

    更新日期:2019-04-24 00:00:00

  • Rapid Enkephalin Delivery Using Exosomes to Promote Neurons Recovery in Ischemic Stroke by Inhibiting Neuronal p53/Caspase-3.

    abstract::No pharmacological treatment is currently available to protect brain from neuronal damage after ischemic stroke. Recent studies found that enkephalin may play an important role in neuron regeneration. We assembled a homogeneous size vesicle constituted by transferrin, exosomes, and enkephalin. Immunofluorescence assay...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/4273290

    authors: Liu Y,Fu N,Su J,Wang X,Li X

    更新日期:2019-03-04 00:00:00

  • Effects of a pragmatic lifestyle intervention for reducing body mass in obese adults with obstructive sleep apnoea: a randomised controlled trial.

    abstract::This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The interventi...

    journal_title:BioMed research international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1155/2014/102164

    authors: Moss J,Tew GA,Copeland RJ,Stout M,Billings CG,Saxton JM,Winter EM,Bianchi SM

    更新日期:2014-01-01 00:00:00

  • Technetium-99 Conjugated with Methylene Diphosphonate Ameliorates Glucocorticoid Induced Osteoporosis by Inhibiting Osteoclastogenesis.

    abstract::Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of 99Tc-MDP is unclear. We systematically investigated the effects of 99Tc-...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7902760

    authors: Shi L,Ning Y,Xu L,Li J,Zhang X

    更新日期:2018-10-14 00:00:00

  • Antitumor and antiangiogenic activities of curcumin in cervical cancer xenografts in nude mice.

    abstract::To evaluate the effects of curcumin (CUR) on tumor progression and angiogenesis in cervical cancer- (CaSki-) implanted nude mice and on the angiogenic biomarkers: vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and epidermal growth factor receptor (EGFR). CaSki cells were subcutaneously injected i...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/817972

    authors: Yoysungnoen-Chintana P,Bhattarakosol P,Patumraj S

    更新日期:2014-01-01 00:00:00

  • A Prospective Noninterventional, Observational Study to Describe the Effectiveness and Safety of Trandolapril and Verapamil Single-Pill Combination in the Management of Patients with Hypertension and Type 2 Diabetes Mellitus: A Harvest TR Study.

    abstract::Maintaining regular blood pressure control usually requires multidrug regimens rather than monotherapy. The objective of this study was to describe the effectiveness and safety of an angiotensin-converting enzyme inhibitor and a nondihydropyridine calcium channel blocker in a single-tablet combination in patients with...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2123601

    authors: Atalar E,Eskin F,Tugtekin HB,Karabulut A,Kanyilmaz S,Kirbiyik H,Ozyildiz AG

    更新日期:2020-09-05 00:00:00

  • Delivery after Operation for Deeply Infiltrating Endometriosis.

    abstract::Background. It has been suggested that, during pregnancy, endometriosis can cause a variety of disease-related complications. Objectives. The purpose of the study was to find out if women with histologically confirmed endometriosis do have a higher risk of adverse pregnancy outcome and if they suffer from a higher rat...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/8271452

    authors: Allerstorfer C,Oppelt P,Enzelsberger SH,Shamiyeh A,Schimetta W,Shebl OJ,Mayer RB

    更新日期:2016-01-01 00:00:00

  • Species Identification and Clarithromycin Susceptibility Testing of 278 Clinical Nontuberculosis Mycobacteria Isolates.

    abstract::Purpose of this paper is to analyze different species' proportion of nontuberculosis mycobacteria (NTM) and susceptibility to clarithromycin of different species. 278 clinical NTM isolates were identified into species by using 16S rRNA, rpoB and hsp65. Then clarithromycin susceptibility testing against different speci...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/506598

    authors: Nie W,Duan H,Huang H,Lu Y,Chu N

    更新日期:2015-01-01 00:00:00

  • Assessing age-related etiologic heterogeneity in the onset of islet autoimmunity.

    abstract::Type 1 diabetes (T1D), a chronic autoimmune disease, is often preceded by a preclinical phase of islet autoimmunity (IA) where the insulin-producing beta cells of the pancreas are destroyed and circulating autoantibodies can be detected. The goal of this study was to demonstrate methods for identifying exposures that ...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1155/2015/708289

    authors: Frederiksen BN,Kroehl M,Barón A,Lamb MM,Crume TL,Sontag MK,Rewers M,Norris JM

    更新日期:2015-01-01 00:00:00

  • The Effect of Longer versus Shorter Duration of Supervised Physiotherapy after ACL Reconstruction on the Vertical Jump Landing Limb Symmetry.

    abstract::The study investigated the vertical jump landing limb symmetry after ACLR between a group of patients receiving a longer supervised physiotherapeutic procedure and following a shorter supervised physiotherapy. Group I (n = 20) and Group II (n = 15) were males averagely 30 weeks after ACLR. The time since ACLR in both ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7519467

    authors: Królikowska A,Czamara A,Szuba Ł,Reichert P

    更新日期:2018-04-23 00:00:00

  • Incidence, Risk Factors, and Epidemiology of Cystic Echinococcosis: A Complex Socioecological Emerging Infectious Disease in Khyber Pakhtunkhwa, Province of Pakistan.

    abstract::Cystic echinococcosis is a serious zoonotic disease caused by Echinococcus granulosus species complex. The current study is the first attempt to determine the level of infection in domestic livestock and to explore the CE-related knowledge and awareness among livestock farmers in different districts of Khyber Pakhtunk...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/5042430

    authors: Haleem S,Niaz S,Qureshi NA,Ullah R,Alsaid MS,Alqahtani AS,Shahat AA

    更新日期:2018-09-12 00:00:00

  • Epidemiological Characterization of Drug Resistance among Mycobacterium tuberculosis Isolated from Patients in Northeast of Iran during 2012-2013.

    abstract:INTRODUCTION:Tuberculosis is still one of the most important health problems in developing countries and increasing drug resistance is the main concern for its treatment. This study was designed to characterize the drug resistant Mycobacterium tuberculosis isolated from patients suffering from pulmonary tuberculosis in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/747085

    authors: Tavanaee Sani A,Shakiba A,Salehi M,Bahrami Taghanaki HR,Ayati Fard SF,Ghazvini K

    更新日期:2015-01-01 00:00:00

  • Demineralized Bone Matrix Add-On for Acceleration of Bone Healing in Atypical Subtrochanteric Femoral Fracture: A Consecutive Case-Control Study.

    abstract:BACKGROUND:Delayed union and nonunion are common complications in atypical femoral fractures (AFFs) despite having good fracture fixation. Demineralized bone matrix (DBM) is a successfully proven method for enhancing fracture healing of the long bone fracture and nonunion and should be used in AFFs. This study aimed to...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2016/4061539

    authors: Kulachote N,Sa-ngasoongsong P,Sirisreetreerux N,Chanplakorn P,Fuangfa P,Suphachatwong C,Wajanavisit W

    更新日期:2016-01-01 00:00:00

  • The Effect of Immigration on Adverse Perinatal Outcomes: Analysis of Experiences at a Turkish Tertiary Hospital.

    abstract:Introduction:In literature, it is well documented that migration is associated with adverse perinatal outcomes in many countries over the world. But in Turkey, health care providers and obstetricians had to face the effects of migration for the first time after civil war in Syria. Hence, this situation motivated us to ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/2326797

    authors: Col Madendag I,Eraslan Sahin M,Madendag Y,Sahin E,Demir MB,Ozdemir F,Acmaz G,Muderris II

    更新日期:2019-11-05 00:00:00

  • Environmental Pollutant Benzo[a]pyrene Induces Recurrent Pregnancy Loss through Promoting Apoptosis and Suppressing Migration of Extravillous Trophoblast.

    abstract:Methods:The implantation sites, fetus resorption, and abnormal fetuses were studied in pregnant mice treated with different doses of BaP by oral gavage from day 1 to day 10 of gestation. Additionally, apoptosis and related signaling pathway, and the migration and invasion of trophoblasts, were assessed before and after...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8983494

    authors: Ye Y,Jiang S,Zhang C,Cheng Y,Zhong H,Du T,Xu W,Azziz R,Zhang H,Zhao X

    更新日期:2020-10-16 00:00:00

  • A Prospective Randomized Study of Brain Tissue Oxygen Pressure-Guided Management in Moderate and Severe Traumatic Brain Injury Patients.

    abstract::The purpose of this study was to compare the effect of PbtO2-guided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 20...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2015/529580

    authors: Lin CM,Lin MC,Huang SJ,Chang CK,Chao DP,Lui TN,Ma HI,Liu MY,Chung WY,Shih YH,Tsai SH,Chiou HY,Lin MR,Jen SL,Wei L,Wu CC,Lin EY,Liao KH,Chiang YH,Chiu WT,Lin JW

    更新日期:2015-01-01 00:00:00

  • Transversus Abdominis Plane Block: An Updated Review of Anatomy and Techniques.

    abstract:Purpose of Review:Transversus abdominis plane (TAP) block is a regional technique for analgesia of the anterolateral abdominal wall. This review highlights the nomenclature system and recent advances in TAP block techniques and proposes directions for future research. Recent Findings:Ultrasound guidance is now conside...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/8284363

    authors: Tsai HC,Yoshida T,Chuang TY,Yang SF,Chang CC,Yao HY,Tai YT,Lin JA,Chen KY

    更新日期:2017-01-01 00:00:00

  • Comparison of behaviour in different liquids and in cells of gold nanorods and spherical nanoparticles modified by linear polyethyleneimine and bovine serum albumin.

    abstract::Gold nanorods (GNRs) are considered one of the most promising forms of nanoparticles for nanobiotechnology; however, the problem of their toxicity is currently not resolved. We synthesised GNRs, modified with linear polyethyleneimine (PEI-GNRs), and examined their physicochemical and some biological properties in comp...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/908175

    authors: Pyshnaya IA,Razum KV,Poletaeva JE,Pyshnyi DV,Zenkova MA,Ryabchikova EI

    更新日期:2014-01-01 00:00:00

  • P2Y receptor modulation of ATP release in the urothelium.

    abstract::The release of ATP from the urothelium in response to stretch during filling demonstrates the importance of the purinergic system for the physiological functioning of the bladder. This study examined the effect of P2 receptor agonists on ATP release from two urothelial cell lines (RT4 and UROtsa cells). Hypotonic Kreb...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/830374

    authors: Mansfield KJ,Hughes JR

    更新日期:2014-01-01 00:00:00

  • Diagnostic Utility of Serum Neutrophil Gelatinase-Associated Lipocalin in Polytraumatized Patients Suffering Acute Kidney Injury: A Prospective Study.

    abstract:Introduction:The incidence of acute kidney injury (AKI) considerably increases the mortality rate in polytrauma victims. Undoubtedly, early identification of patients at risk is crucial for timely implementation of preventive strategies in order to improve their prognosis. Therefore, we aimed to investigate if serum ne...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/2687584

    authors: Negrin LL,Hahn R,Heinz T,Hajdu S

    更新日期:2018-11-06 00:00:00

  • Heteroplasmy Detection of Mitochondrial DNA A3243G Mutation Using Quantitative Real-Time PCR Assay Based on TaqMan-MGB Probes.

    abstract::A point mutation of mitochondrial DNA (mtDNA) at nucleotide position 3243 A to G (mt.3243A>G) is involved in many common diseases, including maternally inherited diabetes and deafness (MIDD) and mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes (MELAS). However, the mutant level of mt.3243A>G ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1286480

    authors: Rong E,Wang H,Hao S,Fu Y,Ma Y,Wang T

    更新日期:2018-11-13 00:00:00

  • MetaRNA-Seq: An Interactive Tool to Browse and Annotate Metadata from RNA-Seq Studies.

    abstract::The number of RNA-Seq studies has grown in recent years. The design of RNA-Seq studies varies from very simple (e.g., two-condition case-control) to very complicated (e.g., time series involving multiple samples at each time point with separate drug treatments). Most of these publically available RNA-Seq studies are d...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/318064

    authors: Kumar P,Halama A,Hayat S,Billing AM,Gupta M,Yousri NA,Smith GM,Suhre K

    更新日期:2015-01-01 00:00:00

  • Neck Circumference as a Predictive Indicator of CKD for High Cardiovascular Risk Patients.

    abstract:BACKGROUND:Neck circumference (NC) is an anthropometric measure of obesity for upper subcutaneous adipose tissue distribution which is associated with cardiometabolic risk. This study investigated whether NC is associated with indicators of chronic kidney disease (CKD) for high cardiometabolic risk patients. METHODS:A...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/745410

    authors: Liu YF,Chang ST,Lin WS,Hsu JT,Chung CM,Chang JJ,Hung KC,Chen KH,Chang CW,Chen FC,Shih YW,Chu CM

    更新日期:2015-01-01 00:00:00

  • Destabilization of akt promotes the death of myeloma cell lines.

    abstract::Constitutive activation of Akt is believed to be an oncogenic signal in multiple myeloma and is associated with poor patient prognosis and resistance to available treatment. The stability of Akt proteins is regulated by phosphorylating the highly conserved turn motif (TM) of these proteins and the chaperone protein HS...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/190629

    authors: Zhang Y,Fu Y,Zhang F,Liu J

    更新日期:2014-01-01 00:00:00

  • Different Genotype Distribution of Human Papillomavirus between Cervical and Esophageal Cancers: A Study in Both High-Incidence Areas, Xinjiang, China.

    abstract::The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high-incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin-embedded esophageal tissues and 152 paraffin-embedd...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7926754

    authors: Zheng Y,Fan Y,Zeng Y,Liu S,Gao L

    更新日期:2020-12-02 00:00:00

  • Acupoint Catgut Embedding Improves the Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats.

    abstract:Background:This study investigated the potential therapeutic effects of acupoint catgut embedding (ACE) at ST36 and BL13 on lipopolysaccharide- (LPS-) induced acute respiratory distress syndrome (ARDS) in rats. Materials and Methods:Male Sprague-Dawley rats were randomized into the normal saline (NS group with a sham ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2394734

    authors: Li D,Sun T,Chi L,Zhao D,Li W

    更新日期:2020-05-02 00:00:00

  • An ANOCEF genomic and transcriptomic microarray study of the response to irinotecan and bevacizumab in recurrent glioblastomas.

    abstract:BACKGROUND:We performed a retrospective study to assess whether the initial molecular characteristics of glioblastomas (GBMs) were associated with the response to the bevacizumab/irinotecan chemotherapy regimen given at recurrence. RESULTS:Comparison of the genomic and gene expression profiles of the responders (n = 1...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1155/2014/282815

    authors: Laffaire J,Di Stefano AL,Chinot O,Idbaih A,Gallego Perez-Larraya J,Marie Y,Vintonenko N,Boisselier B,Farina P,Delattre JY,Figarella-Branger D,Honnorat J,Sanson M,Ducray F

    更新日期:2014-01-01 00:00:00