A Prospective Randomized Study of Brain Tissue Oxygen Pressure-Guided Management in Moderate and Severe Traumatic Brain Injury Patients.

abstract：:Enzymes play important roles in most of the biological processes. Although only a small fraction of residues are directly involved in catalytic reactions, these catalytic residues are the most crucial parts in enzymes. The study of the fundamental and unique features of catalytic residues benefits the understanding of...

journal_title：BioMed research international

authors： Chien YT,Huang SW

更新日期：2013-01-01 00:00:00

abstract：:Big data bioinformatics aims at drawing biological conclusions from huge and complex biological datasets. Added value from the analysis of big data, however, is only possible if the data is accompanied by accurate metadata annotation. Particularly in high-throughput experiments intelligent approaches are needed to kee...

journal_title：BioMed research international

authors： Friedrich A,Kenar E,Kohlbacher O,Nahnsen S

更新日期：2015-01-01 00:00:00

abstract：:Feed efficiency (FE) is an important trait affecting costs in swine industry. Investigation on FE-related genes in different tissues is valuable for molecular breeding. Hypothalamus is a convergent and integrated centre for multiple nutrient-related signals. The present study identified 363 differentially expressed (D...

journal_title：BioMed research international

authors： Hou Y,Hu M,Zhou H,Li C,Li X,Liu X,Zhao Y,Zhao S

更新日期：2018-12-26 00:00:00

abstract：:Renal dysfunction is one of the most common complications of liver cirrhosis and is associated with increased morbidity and mortality. However, no available technology can simultaneously support liver and renal function in these patients. The aim of this study was to evaluate the safety and efficacy of an artificial l...

journal_title：BioMed research international

authors： Feng L,He G,Cai L,Fu C,Li Y,Weng J,Huo X,Peng Q,Gao Y

更新日期：2018-05-24 00:00:00

abstract：Background:Osteonecrosis of the femoral head (ONFH) is a challenge for surgeons and is still without effective treatment method. This study is aimed at evaluating the combined pharmacotherapy with alendronate and desferoxamine for preventing glucocorticoid-induced osteonecrosis of the femoral head (GIOFH) and evaluatin...

journal_title：BioMed research international

authors： Sheng H,Lao Y,Zhang S,Ding W,Lu D,Xu B

更新日期：2020-09-21 00:00:00

abstract：:Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long h...

journal_title：BioMed research international

authors： Coyle KM,Boudreau JE,Marcato P

更新日期：2017-01-01 00:00:00

abstract：:Small renal masses have been diagnosed increasingly in recent decades, allowing surgical treatment by partial nephrectomy. This treatment option is associated with better renal function preservation, in comparison with radical nephrectomy. However, for obtaining a bloodless field during surgery, occlusion of renal art...

journal_title：BioMed research international

authors： Buys-Gonçalves GF,Abreu LAS,Gregorio BM,Sampaio FJB,Pereira-Sampaio MA,de Souza DB

更新日期：2019-02-07 00:00:00

abstract：:The search for effective methods of myocardial cytoprotection against ischemia is the most significant issue in modern cardiology and cardiac surgery. Glucocorticoids are deemed very strong modulators of inflammatory response and thus can potentially protect heart muscle from postreperfusion injury and myocardial isch...

journal_title：BioMed research international

authors： Kuropka P,Dobrzyński M,Gamian A,Gostomska-Pampuch K,Kuryszko J,Całkosiński I

更新日期：2017-01-01 00:00:00

abstract：:Oyster mushroom Pleurotus florida was cultivated on different combinations of wheat straw (WS) as basal substrate and oyster shell powder (OSP) supplement. The OSP supplementation considerably responded to different cultivation phases. The mycelium grew fast and showed rapid growth rate (8.91 mmd(-1)) in WS + OSP (97 ...

journal_title：BioMed research international

authors： Naraian R,Narayan OP,Srivastava J

更新日期：2014-01-01 00:00:00

abstract：:Muscular dystrophies (MDs) are a heterogeneous group of diseases, caused by mutations in different components of sarcolemma, extracellular matrix, or enzymes. Inflammation and innate or adaptive immune response activation are prominent features of MDs. Various therapies under development are directed toward rescuing t...

journal_title：BioMed research international

authors： Farini A,Sitzia C,Erratico S,Meregalli M,Torrente Y

更新日期：2014-01-01 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. The enhanced nitrative stress plays an important role in homocysteine-induced endothelial dysfunction. Previous studies have showed that phytoestrogen α -zearalanol alleviated endothelial injury in ovariectomized hyperhomocysteinemic rats;...

journal_title：BioMed research international

authors： Liu T,Hou DD,Zhao Q,Liu W,Zhen PP,Xu JP,Wang K,Huang HX,Li X,Zhang H,Xu HB,Wang W

更新日期：2013-01-01 00:00:00

abstract：:This paper presents an ultrasound simulation model for pulsatile blood flow, modulated by the motion of a stenosed vessel wall. It aims at generating more realistic ultrasonic signals to provide an environment for evaluating ultrasound signal processing and imaging and a framework for investigating the behaviors of bl...

journal_title：BioMed research international

authors： Zhang Q,Zhang Y,Zhou Y,Zhang K,Zhang K,Gao L

更新日期：2016-01-01 00:00:00

abstract：:Background. Whether additional benefit can be achieved with the use of L-carnitine (L-C) in patients with chronic heart failure (CHF) remains controversial. We therefore performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of L-C treatment in CHF patients. Methods. Pubmed, Ovid Emba...

journal_title：BioMed research international

authors： Song X,Qu H,Yang Z,Rong J,Cai W,Zhou H

更新日期：2017-01-01 00:00:00

abstract：:Bacteria are a source of a large number of secondary metabolites with several biomedical and biotechnological applications. In recent years, there has been tremendous progress in the development of novel synthetic biology approaches both to increase the production rate of secondary metabolites of interest in native pr...

journal_title：BioMed research international

authors： de Frias UA,Pereira GKB,Guazzaroni ME,Silva-Rocha R

更新日期：2018-07-09 00:00:00

abstract：:The aim of the study is to investigate the relationship between physical activity as assessed by accelerometers and cognitive development across the human age ranges (from children and adolescents to adults). Additionally, this study seeks to explore whether physical activity contributes to cognitive development via m...

journal_title：BioMed research international

authors： Zhao G,Quan M,Su L,Zhang H,Zhang J,Zhang J,Fang H,Cao ZB,Zhu Z,Niu Z,Wang R,Chen P

更新日期：2017-01-01 00:00:00

abstract：:Mucosal immunity consists of innate and adaptive immune responses which can be influenced by systemic immunity. Despite having been the subject of intensive studies, it is not fully elucidated what exactly occurs after HIV contact with the female genital tract mucosa. The sexual route is the main route of HIV transmis...

journal_title：BioMed research international

authors： Reis Machado J,da Silva MV,Cavellani CL,dos Reis MA,Monteiro ML,Teixeira Vde P,Miranda Corrêa RR

更新日期：2014-01-01 00:00:00

abstract：:Adult orthodontics may confront problems related to the bonding performance of orthodontic brackets to new generation restorative materials used for crown or laminate restorations. The aim of the present study was to investigate the shear bond strength of ceramic brackets to two new generation CAD/CAM interpenetrating...

journal_title：BioMed research international

authors： Özarslan MM,Üstün Ö,Buyukkaplan US,Barutcigil Ç,Türker N,Barutcigil K

更新日期：2018-05-30 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Over the past decade, image quality in low-dose computed tomography has been greatly improved by various compressive sensing- (CS-) based reconstruction methods. However, these methods have some disadvantages including high computational cost and slow convergence rate. Many different speed-up t...

journal_title：BioMed research international

authors： Huang HM,Hsiao IT

更新日期：2017-01-01 00:00:00

abstract：:Hitherto, limited clinical impact has been achieved in the treatment of glioblastoma (GBMs). Although phytochemicals found in medicinal herbs can provide mankind with new therapeutic remedies, single agent intervention has failed to bring the expected outcome in clinical trials. Therefore, combinations of several agen...

journal_title：BioMed research international

authors： Elkady AI,Hussein RA,Abu-Zinadah OA

更新日期：2014-01-01 00:00:00

abstract：Background:Fibroid is the most common benign tumor of the uterus and if associated with pregnancy may adversely affect the outcome of pregnancy. Objective of the present study was to assess the obstetric outcome (maternal and fetal) in pregnancy with fibroid. Methods:A prospective observational study was performed ove...

journal_title：BioMed research international

authors： Saleh HS,Mowafy HE,Hameid AAAE,Sherif HE,Mahfouz EM

更新日期：2018-03-26 00:00:00

abstract：OBJECTIVE:To analyze the clinical relevance of the levels of TNFα blockers and anti-drug antibodies (anti-drug Ab) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) treated with adalimumab (ADA), etanercept (ETA), or infliximab (INF) for a prolonged period of time. METHODS:Clinical characteristics...

journal_title：BioMed research international

authors： Arstikyte I,Kapleryte G,Butrimiene I,Venalis A

更新日期：2015-01-01 00:00:00

abstract：:Background and Aims. CIN is a major and serious complication following PCI in patients with ACS. It is unclear whether a higher serum ferritin level is associated with an increased risk of CIN in high-risk patients. Thus, we conducted this study to assess the predictive value of SF for the risk of CIN after PCI. Metho...

journal_title：BioMed research international

authors： Zhu B,Hou J,Gong Y,Yan G,Wang Q,Wang D,Qiao Y,Chen Y,Tang C

更新日期：2016-01-01 00:00:00

abstract：Background:Clinical trials based on FGFR mutation or amplification as a druggable target of FGFR inhibitors have produced disappointing clinical outcomes. Therefore, the identification of predictive biomarkers for FGFR-targeted agents has remained a crucial issue. Methods:Expression profiles of FGFs and FGFRs in 8,111...

journal_title：BioMed research international

authors： Li Y,Wu L,Tao W,Wu D,Ma F,Li N

更新日期：2020-06-03 00:00:00

abstract：:Metastasis is the leading cause of lung cancer-associated death. Downregulated expression of E-cadherin followed by epithelial-mesenchymal transition (EMT) is critical for metastasis initiation in lung cancer. BTBD7 plays essential roles in lung cancer metastasis, but the mechanisms remain unknown. This study aimed to...

journal_title：BioMed research international

authors： Shu J,Wang L,Han F,Chen Y,Wang S,Luo F

更新日期：2019-11-27 00:00:00

abstract：:Owing to its hydrophilicity, negative charge, small size, and labile degradation by endogenous nucleases, small interfering RNA (siRNA) delivery must be achieved by a carrier system. In this study, cationic copolymers composed of low-molecular-weight polyethylenimine and polythiophenes were synthesized and evaluated a...

journal_title：BioMed research international

authors： He P,Hagiwara K,Chong H,Yu HH,Ito Y

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To study effects of a one-year multicomponent intervention on perceived environmental barriers in hip fracture patients. DESIGN:Randomized controlled trial of a 12-month home-based rehabilitation aiming to improve mobility and function (ISRCTN53680197); secondary analyses. Subjects. Community-dwelling hip f...

journal_title：BioMed research international

authors： Portegijs E,Rantakokko M,Edgren J,Salpakoski A,Heinonen A,Arkela M,Kallinen M,Rantanen T,Sipilä S

更新日期：2013-01-01 00:00:00

abstract：:In previous studies, we have demonstrated the function of uc.167 in the heart development. DNA methylation plays a crucial role in regulating the expression of developmental genes during embryonic development. In this study, the methylomic landscape was investigated in order to identify the DNA methylation alterations...

journal_title：BioMed research international

authors： Yin A,Feng M,Cheng Z,Zhang Q,Li H,Xu J,Zhang H,Li Y,Qian L

更新日期：2018-05-30 00:00:00

abstract：Background:The well-known rubber hand paradigm induces an illusion by having participants feel the touch applied to a fake hand. In parallel, the kinesthetic mirror illusion elicits illusions of movement by moving the reflection of a participant's arm. Experimental manipulation of sensory inputs leads to emergence of t...

journal_title：BioMed research international

authors： Metral M,Gonthier C,Luyat M,Guerraz M

更新日期：2017-01-01 00:00:00

abstract：:The administration of probiotic bacteria for health benefit has rapidly expanded in recent years, with a global market worth $32.6 billion predicted by 2014. The oral administration of most of the probiotics results in the lack of ability to survive in a high proportion of the harsh conditions of acidity and bile conc...

journal_title：BioMed research international

authors： Solanki HK,Pawar DD,Shah DA,Prajapati VD,Jani GK,Mulla AM,Thakar PM

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:The aim of this report is to study the graft and patient survival in a large cohort of recipients with an analysis of factors that may affect the final outcomes. METHODS:Between March 1976 and March 2008, 1967 consecutive live-donor renal transplants were carried out. Various variables that may have an im...

journal_title：BioMed research international

authors： Ghoneim MA,Bakr MA,Refaie AF,Akl AI,Shokeir AA,Shehab El-Dein AB,Ammar HM,Ismail AM,Sheashaa HA,El-Baz MA

更新日期：2013-01-01 00:00:00