Abstract:
:In previous studies, we have demonstrated the function of uc.167 in the heart development. DNA methylation plays a crucial role in regulating the expression of developmental genes during embryonic development. In this study, the methylomic landscape was investigated in order to identify the DNA methylation alterations. Methylated DNA immunoprecipitation (MeDIP) was performed to examine the differences in methylation status of overexpressed uc.167 in P19 cells. GO and KEGG pathway analyses of differentially methylated genes were also conducted. We found that the distribution of differentially methylated regions (DMRs) peaks in different components of genome was mainly located in intergenic regions and intron. The biological process associated with uc.167 was focal adhesion and Rap1 signaling pathway. MEF2C was significantly decreased in uc.167 overexpressed group, suggesting that uc.167 may influence the P19 differentiation through MEF2C reduction. Taken together, our findings revealed that the effect of uc.167 on P19 differentiation may be attributed to the altered methylation of specific genes.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yin A,Feng M,Cheng Z,Zhang Q,Li H,Xu J,Zhang H,Li Y,Qian Ldoi
10.1155/2018/4658024subject
Has Abstractpub_date
2018-05-30 00:00:00pages
4658024eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
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