Magnetic resonance spectroscopy: an in vivo molecular imaging biomarker for Parkinson's disease?

abstract：:A point mutation of mitochondrial DNA (mtDNA) at nucleotide position 3243 A to G (mt.3243A>G) is involved in many common diseases, including maternally inherited diabetes and deafness (MIDD) and mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes (MELAS). However, the mutant level of mt.3243A>G ...

journal_title：BioMed research international

authors： Rong E,Wang H,Hao S,Fu Y,Ma Y,Wang T

更新日期：2018-11-13 00:00:00

abstract：Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...

journal_title：BioMed research international

authors： You J,Wang Z,Lu G,Chen Z

更新日期：2020-03-07 00:00:00

abstract：:In the present study, we determined whether there is a delay in the eruption of permanent teeth (PT) among Filipino adolescents with stunting or thinness. Height, weight, and number of PT were recorded in 1554 Filipino 10- to 13-year-olds (711 boys; 843 girls). z-scores for height (HAZ) and body mass index (BMI) were ...

journal_title：BioMed research international

authors： Heinrich-Weltzien R,Zorn C,Monse B,Kromeyer-Hauschild K

更新日期：2013-01-01 00:00:00

abstract：Background:In patients with reduced systolic function, the natriuretic peptide system affects heart failure (HF) progression, but the expression of key activating (corin) and degrading enzymes (neprilysin) is not well understood. Methods and Results:This pilot study (n=48) compared plasma levels of corin, neprilysin, ...

journal_title：BioMed research international

authors： Zaidi SS,Ward RD,Ramanathan K,Yu X,Gladysheva IP,Reed GL

更新日期：2018-07-26 00:00:00

abstract：:Aim. The aim of this study was to describe PCa characteristics and long-term outcomes in young men aged ≤55 years after radical prostatectomy (RP) and to compare them with older men cohort. Methods. Among 2,200 patients who underwent RP for clinically localized PCa at our centre between 2001 and 2015, 277 (10.3%) men ...

journal_title：BioMed research international

authors： Milonas D,Venclovas Z,Gudinaviciene I,Zviniene K,Matjosaitis AJ

更新日期：2017-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/2643862.]. ...

journal_title：BioMed research international

authors： Cheng LG,He W,Zhang HX,Song Q,Ning B,Li HZ,He Y,Lin S

更新日期：2017-01-01 00:00:00

abstract：Background:Gegen Qinlian (GGQL) decoction is a common Chinese herbal compound for the treatment of ulcerative colitis (UC). In this study, we aimed to identify its molecular target and the mechanism involved in UC treatment by network pharmacology and molecular docking. Material and Methods. The active ingredients of P...

journal_title：BioMed research international

authors： Wei M,Li H,Li Q,Qiao Y,Ma Q,Xie R,Wang R,Liu Y,Wei C,Li B,Zheng C,Sun B,Yu B

更新日期：2020-11-24 00:00:00

abstract：:Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. The enhanced nitrative stress plays an important role in homocysteine-induced endothelial dysfunction. Previous studies have showed that phytoestrogen α -zearalanol alleviated endothelial injury in ovariectomized hyperhomocysteinemic rats;...

journal_title：BioMed research international

authors： Liu T,Hou DD,Zhao Q,Liu W,Zhen PP,Xu JP,Wang K,Huang HX,Li X,Zhang H,Xu HB,Wang W

更新日期：2013-01-01 00:00:00

abstract：:Objectives. To investigate the potential association of a set of serum cytokines with the severity of coronary artery disease (CAD). Methods. A total of 201 patients who underwent coronary angiography for chest discomfort were enrolled. The concentrations of serum IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-9, and IL-17...

journal_title：BioMed research international

authors： Min X,Lu M,Tu S,Wang X,Zhou C,Wang S,Pang S,Qian J,Ge Y,Guo Y,Xu D,Cao K

更新日期：2017-01-01 00:00:00

abstract：Objective:To investigate the effects of arteriovenous thrombolysis combined with mechanical thrombectomy on clinical efficacy, neurological function, and the changes of nerve injury markers of acute cerebral infarct (ACI) patients. Methods:A total of 143 cases with ACI admitted to our hospital from June 2017 to June 2...

journal_title：BioMed research international

authors： Ding T,Tang L,Hu B,Yuan J,Li X,Wen J

更新日期：2020-10-09 00:00:00

abstract：:Uterine fibroids (UFs) are benign tumors of the reproductive tract, arising from smooth muscle cells of the uterus. Steroid hormones, estrogen, and progesterone are considered to be the most important links in the pathophysiology of UFs. Alpha-tocopherol (AT) is the most active form of vitamin E. What is important as ...

journal_title：BioMed research international

authors： Ciebiera M,Szymańska-Majchrzak J,Sentkowska A,Kilian K,Rogulski Z,Nowicka G,Jakiel G,Tomaszewski P,Włodarczyk M

更新日期：2018-07-24 00:00:00

abstract：:Introduction. In the field of orthopaedic surgery, the use of osteogenic material in larger defects is essential. Autograft and allograft are both known methods, and autograft is believed to be the best choice. But autograft is associated with additional invasive procedures which can prove difficult in fragile patient...

journal_title：BioMed research international

authors： Dreyer CH,Rasmussen M,Pedersen RH,Overgaard S,Ding M

更新日期：2020-03-03 00:00:00

abstract：:Background. For development of individualized treatment on a routine basis, transfer of patients' tumor tissue in a xenograft model (i.e., generation of patient-derived xenografts (PDX)) is desirable for molecular, biochemical, or functional analyses. Drawbacks are dissatisfactory tumor take rates, the necessity of fa...

journal_title：BioMed research international

authors： Gock M,Kühn F,Mullins CS,Krohn M,Prall F,Klar E,Linnebacher M

更新日期：2016-01-01 00:00:00

abstract：:This study tested the hypothesis that sensitivity of Escherichia coli to lactic acid at concentrations relevant for fermented sausages (pH 4.6, 150 mM lactic acid, aw = 0.92, temperature = 20 or 27°C) increases with increasing growth rate. For E. coli strain 683 cultured in TSB in chemostat or batch, subsequent inacti...

journal_title：BioMed research international

authors： Lindqvist R,Barmark G

更新日期：2014-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/3746232.]. ...

journal_title：BioMed research international

authors： Liu Q,Wang C,Li P,Liu J,Huang G,Song S

更新日期：2016-01-01 00:00:00

abstract：:Tau tubulin kinase 2 (TTBK2) is a kinase known to phosphorylate tau and tubulin. It has recently drawn much attention due to its involvement in multiple important cellular processes. Here, we review the current understanding of TTBK2, including its sequence, structure, binding sites, phosphorylation substrates, and ce...

journal_title：BioMed research international

authors： Liao JC,Yang TT,Weng RR,Kuo CT,Chang CW

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Foreign object ingestion and food bolus impaction are a common clinical problem. We report our clinical experiences in endoscopic management for adults, foreign body ingestion, and food bolus impaction. METHOD:A retrospective chart review study was conducted on adult patients with foreign body ingestion and...

journal_title：BioMed research international

authors： Yao CC,Wu IT,Lu LS,Lin SC,Liang CM,Kuo YH,Yang SC,Wu CK,Wang HM,Kuo CH,Chiou SS,Wu KL,Chiu YC,Chuah SK,Tai WC

更新日期：2015-01-01 00:00:00

abstract：:This study compared the coadministration among the three nematode predatory fungi, Duddingtonia flagrans, Monacrosporium thaumasium, and Arthrobotrys robusta, in the biological control of cattle gastrointestinal nematodiasis in comparison with the use of the fungus D. flagrans alone. Five groups consisting of eight Gi...

journal_title：BioMed research international

authors： Luns FD,Assis RCL,Silva LPC,Ferraz CM,Braga FR,de Araújo JV

更新日期：2018-03-26 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have bee...

journal_title：BioMed research international

authors： Jia Q,Deng Y,Qing H

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Thiopurine drugs are metabolized via S-methylation and catalyzed by thiopurine S-methyltransferase (TPMT). Patients with very low TPMT activity are at high risk of fatal bone marrow toxicity when standard doses of thiopurine drugs are administered. TPMT genotyping can predict TPMT activity and is not affec...

journal_title：BioMed research international

authors： Kim S,Lee HW,Lee W,Chun S,Min WK

更新日期：2013-01-01 00:00:00

abstract：:Ampelopsis brevipedunculata (Maxim.) Trautv. (AB), a traditional East Asian medicine, exhibits protective effects against several inflammatory diseases. Our search for an inhibitor of IL-6-induced JAK2/STAT3 activation revealed that AB ethanolic extract (ABE) had a significant inhibitory effect on IL-6-induced STAT3 e...

journal_title：BioMed research international

authors： Jang HJ,Lee SJ,Lim HJ,Jung K,Lee S,Park CS,Lee SW,Rho MC

更新日期：2018-06-10 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) have an intrinsic property for homing towards tumor sites and can be used as tumor-tropic vectors for tumor therapy. But very limited studies investigated the antitumor properties of MSCs themselves. In this study we investigated the antiglioma properties of two easily accessible MS...

journal_title：BioMed research international

authors： Yang C,Lei D,Ouyang W,Ren J,Li H,Hu J,Huang S

更新日期：2014-01-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BM-MSCs) represent a modern approach for management of chronic skin injuries. In this work, we describe BM-MSCs application versus their conditioned media (CM) when delivered topically admixed with fibrin glue to enhance the healing of chronic excisional wounds in rats. Fift...

journal_title：BioMed research international

authors： Mehanna RA,Nabil I,Attia N,Bary AA,Razek KA,Ahmed TA,Elsayed F

更新日期：2015-01-01 00:00:00

abstract：:The cyprinid genus Pteronotropis is endemic to southeastern Gulf of Mexico and Atlantic Ocean of North America. Never before has the genus been demonstrated to be monophyletic. We investigate both the phylogenetic relationships and the phylogeography of some species in the genus using mitochondrial ND2 sequences. In n...

journal_title：BioMed research international

authors： Mayden RL,Allen J

更新日期：2015-01-01 00:00:00

abstract：:Purpose. Atherosclerosis is a diseased condition of blood vessel. It causes partial blockage in lumen of vessel and affects hemodynamic of localized flowing blood. Complex geometries like region of bifurcation also affects hemodynamic to a larger extent. Complexity further increases in presence of stenoses at region o...

journal_title：BioMed research international

authors： Bit A,Ghagare D,Rizvanov AA,Chattopadhyay H

更新日期：2017-01-01 00:00:00

abstract：:Despite being identified as a high risk cohort for psychosis, there has been relatively little research on the clinical presentation and assessment of Schizotypal Personality Disorder (SPD) in childhood. The current study aimed to develop a measure of childhood SPD (Melbourne Assessment of Schizotypy in Kids (MASK)) a...

journal_title：BioMed research international

authors： Jones HP,Testa RR,Ross N,Seal ML,Pantelis C,Tonge B

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To determine the predictive factors that affect short term and long term postoperative drift in intermittent exotropia after bilateral lateral rectus recession and to evaluate its effect on surgical outcome. METHODS:Retrospective review of 203 patients with diagnosis of intermittent exotropia, who had surgical...

journal_title：BioMed research international

authors： Yam JC,Chong GS,Wu PK,Wong US,Chan CW,Ko ST

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:To study effects of a one-year multicomponent intervention on perceived environmental barriers in hip fracture patients. DESIGN:Randomized controlled trial of a 12-month home-based rehabilitation aiming to improve mobility and function (ISRCTN53680197); secondary analyses. Subjects. Community-dwelling hip f...

journal_title：BioMed research international

authors： Portegijs E,Rantakokko M,Edgren J,Salpakoski A,Heinonen A,Arkela M,Kallinen M,Rantanen T,Sipilä S

更新日期：2013-01-01 00:00:00

abstract：Objective:This study aims to (i) translate, culturally adapt, and preliminarily validate the arrhythmia-specific Umea22 (U22) questionnaire and (ii) assess the impact of radiofrequency (RF) ablation and medical treatment on the quality of life of patients with supraventricular tachycardias (SVTs). Methods:A total of 1...

journal_title：BioMed research international

authors： Domeyer PR,Giannakidou SC,Kyriakou P,Katsari V,Antoniadis AP,Lagos IK,Fragakis N,Varaklioti A,Vassilikos VP

更新日期：2018-10-09 00:00:00

abstract：Objective:We compared the prostate cancer (PCa) detection rates of targeted biopsy (TB) and saturation biopsy (SB) in patients with previous negative biopsy and the accuracy of TB and SB stratified by different serum prostate-specific antigen (PSA) levels. Materials and Methods:Overall 185 patients were enrolled. In t...

journal_title：BioMed research international

authors： Chang CH,Chiu HC,Lin WC,Ho TL,Chang H,Chang YH,Huang CP,Wu HC,Yang CR,Hsieh PF

更新日期：2017-01-01 00:00:00