Serum Cytokine Profile in Relation to the Severity of Coronary Artery Disease.

abstract：:The explosive growth of high-throughput experimental methods and resulting data yields both opportunity and challenge for selecting the correct drug to treat both a specific patient and their individual disease. Ideally, it would be useful and efficient if computational approaches could be applied to help achieve opti...

journal_title：BioMed research international

authors： Cui H,Zhang M,Yang Q,Li X,Liebman M,Yu Y,Xie L

更新日期：2018-03-25 00:00:00

abstract：:Otitis media (OM) is a common inflammatory disease of the middle ear cavity and mainly occurs in children. As a critical regulator of inflammation response, the nuclear factor kappa B (NF-κB) pathway has been found to play an essential role in the pathogenesis of various human diseases. The aim of this study was to ex...

journal_title：BioMed research international

authors： Yang X,Zhang Q,Lu H,Wang C,Xia L

更新日期：2021-01-06 00:00:00

abstract：:The development of multitargeting drugs is an emerging trend in cancer research. To promote further development and clinical application of multitargeting drugs, this research was performed. MTT assay and flow cytometry of Annexin V/propidium iodide staining were used to confirm the proapoptotic efficacy of a novel co...

journal_title：BioMed research international

authors： Zheng H,Liang G,Chen Y,Lin S,Liu W,Fang Y

更新日期：2017-01-01 00:00:00

abstract：:Accumulating evidence reveals that the sirtuin family is involved in the pathology of Parkinson's disease (PD). However, the association between the polymorphisms of the sirtuin gene and the risk of PD remains elusive. Here, we investigated the possible association of nine SIRT1 and SIRT2 SNPs with the risk of PD thro...

journal_title：BioMed research international

authors： Chen X,Mai H,Chen X,Cai Y,Cheng Q,Chen X,Li X,Fan W,Tang P,Ou M,Yang J,Chen Y,Cui L

更新日期：2019-05-12 00:00:00

abstract：Objective:The aim of this study is to explore the potential pathogenesis of juvenile dermatomyositis by bioinformatics analysis of gene chips, which would screen the hub genes, identify potential biomarkers, and reveal the development mechanism of juvenile dermatomyositis. Material and Methods:We retrieved juvenile de...

journal_title：BioMed research international

authors： Qiu CC,Su QS,Zhu SY,Liu RC

更新日期：2019-12-07 00:00:00

abstract：:Metabolomics in maternal-fetal medicine is still an "embryonic" science. However, there is already an increasing interest in metabolome of normal and complicated pregnancies, and neonatal outcomes. Tissues used for metabolomics interrogations of pregnant women, fetuses and newborns are amniotic fluid, blood, plasma, c...

journal_title：BioMed research international

authors： Fanos V,Atzori L,Makarenko K,Melis GB,Ferrazzi E

更新日期：2013-01-01 00:00:00

abstract：:Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...

journal_title：BioMed research international

authors： Mellor LF,Huebner P,Cai S,Mohiti-Asli M,Taylor MA,Spang J,Shirwaiker RA,Loboa EG

更新日期：2017-01-01 00:00:00

abstract：:The interplay between Aspergillus fumigatus and the host immune response in lung infection has been subject of studies over the last years due to its importance in immunocompromised patients. The multifactorial virulence factors of A. fumigatus are related to the fungus biological characteristics, for example, structu...

journal_title：BioMed research international

authors： Sales-Campos H,Tonani L,Cardoso CR,Kress MR

更新日期：2013-01-01 00:00:00

abstract：:Embryology of normal web space creation and the genetics of syndactyly in humans and experimental animals are well described in the literature. In this review, the author offers a 3-step pathway of pathogenesis for syndactyly. The first step is initiated either by the overactivation of the WNT canonical pathway or the...

journal_title：BioMed research international

authors： Al-Qattan MM

更新日期：2019-09-15 00:00:00

abstract：:Alpha-linolenic acid (ALA) is plant-based essential omega-3 polyunsaturated fatty acids that must be obtained through the diet. This could explain in part why the severe deficiency in omega-3 intake pointed by numerous epidemiologic studies may increase the brain's vulnerability representing an important risk factor i...

journal_title：BioMed research international

authors： Blondeau N,Lipsky RH,Bourourou M,Duncan MW,Gorelick PB,Marini AM

更新日期：2015-01-01 00:00:00

abstract：:The polyherbal formulation containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol ex. Maton has been used for hypertension treatment empirically. Our previous study showed its blood pressure-lowering effect on a rat model of hypertension. However, toxicit...

journal_title：BioMed research international

authors： Sholikhah EN,Mustofa M,Nugrahaningsih DAA,Yuliani FS,Purwono S,Sugiyono S,Widyarini S,Ngatidjan N,Jumina J,Santosa D,Koketsu M

更新日期：2020-03-24 00:00:00

abstract：:The influence of biomimetic calcium phosphate coating on osteoblasts behavior in vitro is not well established yet. In this study, we investigated the behavior of osteoblastic rat osteosarcoma 17/2.8 cells (ROS17/2.8) on two groups of biomaterial surfaces: alkaline-treated titanium surface (ATT) and biomimetic calcium...

journal_title：BioMed research international

authors： Yu X,Wei M

更新日期：2013-01-01 00:00:00

abstract：:Acute kidney injury (AKI) is associated with an increased risk of developing advanced chronic kidney disease (CKD). Yet, effective interventions to prevent this conversion are unavailable for clinical practice. In this study, we examined the beneficial effects of Tanshinone IIA on renal fibrosis in a mouse model of fo...

journal_title：BioMed research international

authors： Jiang C,Shao Q,Jin B,Gong R,Zhang M,Xu B

更新日期：2015-01-01 00:00:00

abstract：:Nowadays, several screening strategies are available to prevent cervical cancer, but inadequate resources, sociocultural barriers, and sampling issues impede their success in low-income countries. To overcome these issues, this study aimed to evaluate the performance of human papillomavirus (HPV) testing from dried ur...

journal_title：BioMed research international

authors： Frati ER,Martinelli M,Fasoli E,Colzani D,Bianchi S,Binda S,Olivani P,Tanzi E

更新日期：2015-01-01 00:00:00

abstract：:Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administr...

journal_title：BioMed research international

authors： Kampan NC,Madondo MT,McNally OM,Quinn M,Plebanski M

更新日期：2015-01-01 00:00:00

abstract：Objective:This study aimed to investigate the effects of Ang-1 on neovascularization of diabetic organs by subcutaneous Matrigel angiogenesis model, established in type 1 diabetic rats. Methods:Ang-1 adenoviral vector was constructed. The rat model was established by STZ and divided into four group. The Matrigel was i...

journal_title：BioMed research international

authors： Li S,Zou H,Gong M,Chen Y,Yan X,Yu L,Yang Y

更新日期：2019-01-09 00:00:00

abstract：:Somatostatin (SST) receptors (SSTRs) belong to the typical 7-transmembrane domain family of G-protein-coupled receptors. Five distinct subtypes (termed SSTR1-5) have been identified, with SSTR2 showing the highest affinity for natural SST and synthetic SST analogs. Most neuroendocrine tumors (NETs) have high expressio...

journal_title：BioMed research international

authors： Xu C,Zhang H

更新日期：2015-01-01 00:00:00

abstract：Purpose:To explore the effects of depression on cardiac autonomic nerve function and related metabolic pathways, the heart rate variability (HRV) and urinary differential metabolites were detected on the college students with depression. Methods:12 female freshmen with depression were filtered by the Beck Depression I...

journal_title：BioMed research international

authors： Zhao S,Chi A,Yan J,Yao C

更新日期：2020-02-27 00:00:00

abstract：:Astrocytic impairment is a pathologic feature of neuromyelitis optica spectrum disorder (NMOSD). S100B and glial fibrillary acidic protein (GFAP) are the two most commonly used astrocytic markers. The aim of this study was to evaluate whether CSF-S100B could serve as a marker of NMOSD. We enrolled 49 NMOSD patients [2...

journal_title：BioMed research international

authors： Wei Y,Chang H,Li X,Du L,Xu W,Cong H,Yao Y,Zhang X,Yin L

更新日期：2018-10-22 00:00:00

abstract：:Human dental pulp stem cells (DPSCs) hold great promise in bone regeneration. However, the exact mechanism of osteogenic differentiation of DPSCs remains unknown, especially the role of exosomes played in. The DPSCs were cultured and received osteogenic induction; then, exosomes from osteogenic-induced DPSCs (OI-DPSC-...

journal_title：BioMed research international

authors： Xie L,Guan Z,Zhang M,Lyu S,Thuaksuban N,Kamolmattayakul S,Nuntanaranont T

更新日期：2020-09-28 00:00:00

abstract：BACKGROUND:Hypoxia-induced autophagy and muscle wasting occur in several environmental and pathological conditions. However, the molecular mechanisms underlying the effects of the hypoxia-mimetic agent CoCl2 on autophagy and muscle atrophy are still unclear. METHODS:C2C12 myotubes were exposed to increasing concentrat...

journal_title：BioMed research international

authors： Chen R,Jiang T,She Y,Xu J,Li C,Zhou S,Shen H,Shi H,Liu S

更新日期：2017-01-01 00:00:00

abstract：:Feature selection has become the essential step in biomarker discovery from high-dimensional genomics data. It is recognized that different feature selection techniques may result in different set of biomarkers, that is, different groups of genes highly correlated to a given pathological condition, but few direct comp...

journal_title：BioMed research international

authors： Dessì N,Pascariello E,Pes B

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:This retrospective study was designed to investigate the efficacy and safety of intermittent portal triad clamping (PTC) with low central venous pressure (CVP) in liver resections. METHODS:Between January 2007 and August 2013, 115 patients underwent liver resection with intermittent PTC. The patients' data ...

journal_title：BioMed research international

authors： Topaloglu S,Yesilcicek Calik K,Calik A,Aydın C,Kocyigit S,Yaman H,Kutanis D,Karabulut E,Dohman D,Orem A,Arslan MK

更新日期：2013-01-01 00:00:00

abstract：:This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and ...

journal_title：BioMed research international

authors： Tang M,Ou N,Li C,Lu A,Li J,Ma L,Zhong W,Gao J,Zheng Y,Cai Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Maternal thyroid dysfunction in early pregnancy may increase the risk of adverse pregnancy complications and neurocognitive deficiencies in the developing fetus. Currently, some researchers demonstrated that body mass index (BMI) is associated with thyroid function in nonpregnant population. Hence, the Ameri...

journal_title：BioMed research international

authors： Han C,Li C,Mao J,Wang W,Xie X,Zhou W,Li C,Xu B,Bi L,Meng T,Du J,Zhang S,Gao Z,Zhang X,Yang L,Fan C,Teng W,Shan Z

更新日期：2015-01-01 00:00:00

abstract：Background and Aim:ROHHADNET (rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, neuroendocrine tumor) syndrome is a rare disease with grave outcome. Although early recognition is essential, prompt diagnosis may be challenging due to its extreme rarity. This study aimed to systematically r...

journal_title：BioMed research international

authors： Lee JM,Shin J,Kim S,Gee HY,Lee JS,Cha DH,Rim JH,Park SJ,Kim JH,Uçar A,Kronbichler A,Lee KH,Shin JI

更新日期：2018-11-21 00:00:00

abstract：:This study was performed to assess the efficacy and safety of a topical diclofenac solution in patients with knee osteoarthritis (OA). PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases were searched for randomized controlled trials until June 2020. The WOMAC pain, stiffness, physical function subs...

journal_title：BioMed research international

authors： Ling T,Li JJ,Xu RJ,Wang B,Ge WH

更新日期：2020-11-24 00:00:00

abstract：Introduction:This study examines the utility of electroencephalography (EEG) in clinical decision making in acute ischemic stroke (AIS) patients in regards to the prescription of antiseizure medications. Methods:Patients were grouped as having positive EEG (+) for epileptiform activity or negative EEG (-). These studi...

journal_title：BioMed research international

authors： Rao R,Monlezun DJ,Kimbrough T,Burkett BJ,Samai A,Martin-Schild S

更新日期：2020-12-19 00:00:00

abstract：:The achievement of successful biostimulation of active microbiomes for the cleanup of a polluted site is strictly dependent on the knowledge of the key microorganisms equipped with the relevant catabolic genes responsible for the degradation process. In this work, we present the characterization of the bacterial commu...

journal_title：BioMed research international

authors： Merlino G,Balloi A,Marzorati M,Mapelli F,Rizzi A,Lavazza D,de Ferra F,Carpani G,Daffonchio D

更新日期：2015-01-01 00:00:00

abstract：:Both human adipose tissue-derived mesenchymal stem cells (ASCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs) have been explored as attractive mesenchymal stem cells (MSCs) sources, but very few parallel comparative studies of these two cell types have been made. We designed a side-by-side comparative st...

journal_title：BioMed research international

authors： Hu L,Hu J,Zhao J,Liu J,Ouyang W,Yang C,Gong N,Du L,Khanal A,Chen L

更新日期：2013-01-01 00:00:00