Abstract:
:Human mesenchymal stem cells (MSCs) have an intrinsic property for homing towards tumor sites and can be used as tumor-tropic vectors for tumor therapy. But very limited studies investigated the antitumor properties of MSCs themselves. In this study we investigated the antiglioma properties of two easily accessible MSCs, namely, human adipose tissue-derived mesenchymal stem cells (ASCs) and umbilical cord-derived mesenchymal stem cells (UC-MSCs). We found (1) MSC conditioned media can significantly inhibit the growth of human U251 glioma cell line; (2) MSC conditioned media can significantly induce apoptosis in human U251 cell line; (3) real-time PCR experiments showed significant upregulation of apoptotic genes of both caspase-3 and caspase-9 and significant downregulation of antiapoptotic genes such as survivin and XIAP after MSC conditioned media induction in U 251 cells; (4) furthermore, MSCs conditioned media culture induced rapid and complete differentiation in U251 cells. These results indicate MSCs can efficiently induce both apoptosis and differentiation in U251 human glioma cell line. Whereas UC-MSCs are more efficient for apoptosis induction than ASCs, their capability of differentiation induction is not distinguishable from each other. Our findings suggest MSCs themselves have favorable antitumor characteristics and should be further explored in future glioma therapy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yang C,Lei D,Ouyang W,Ren J,Li H,Hu J,Huang Sdoi
10.1155/2014/109389subject
Has Abstractpub_date
2014-01-01 00:00:00pages
109389eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1155/2015/169841
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2018/8759459
更新日期:2018-12-03 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/263897
更新日期:2014-01-01 00:00:00
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更新日期:2018-06-04 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/1898671
更新日期:2018-09-25 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7923874
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
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journal_title:BioMed research international
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更新日期:2019-04-15 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2013/958465
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/6935123.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2020-11-05 00:00:00