Abstract:
:Bone marrow-derived mesenchymal stem cells (BM-MSCs) represent a modern approach for management of chronic skin injuries. In this work, we describe BM-MSCs application versus their conditioned media (CM) when delivered topically admixed with fibrin glue to enhance the healing of chronic excisional wounds in rats. Fifty-two adult male rats were classified into four groups after induction of large-sized full-thickness skin wound: control group (CG), fibrin only group (FG), fibrin + MSCs group (FG + SCs), and fibrin + CM group (FG + CM). Healing wounds were evaluated functionally and microscopically. Eight days after injury, number of CD68+ macrophages infiltrating granulation tissue was considerably higher in the latter two groups. Although--later--none of the groups depicted a substantially different healing rate, the quality of regenerated skin was significantly boosted by the application of either BM-MSCs or their CM both (1) structurally as demonstrated by the obviously increased mean area percent of collagen fibers in Masson's trichrome-stained skin biopsies and (2) functionally as supported by the interestingly improved epidermal barrier as well as dermal tensile strength. Thus, we conclude that topically applied BM-MSCs and their CM-via fibrin vehicle--could effectively improve the quality of healed skin in chronic excisional wounds in rats, albeit without true acceleration of wound closure.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Mehanna RA,Nabil I,Attia N,Bary AA,Razek KA,Ahmed TA,Elsayed Fdoi
10.1155/2015/846062subject
Has Abstractpub_date
2015-01-01 00:00:00pages
846062eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章abstract:BACKGROUND:The presence of common risk factors suggests that there is a relationship between osteoporosis and cardiovascular disease, possibly via dyslipidemia and inflammation. We investigated the relationships among the lipid profile, the inflammation marker high-sensitivity C-reactive protein (hsCRP), bone turnover ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/398397
更新日期:2014-01-01 00:00:00
abstract::Exclusive enteral nutrition (EEN) has been proven to be effective and safe in treating pediatric Crohn's disease (CD). EEN induces pediatric CD remission possibly through three pathways: (1) direct anti-inflammatory effects, (2) improved epithelial barrier function, and (3) modulation of the gut microbiota. Recent stu...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/8102589
更新日期:2017-01-01 00:00:00
abstract::Purpose. To report pilot data from a novel image analysis software "RetiView," to highlight clinically relevant information in RetCam images of infants with aggressive posterior retinopathy of prematurity (APROP). Methods. Twenty-three imaging sessions of consecutive infants of Asian Indian origin with clinically diag...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/898197
更新日期:2015-01-01 00:00:00
abstract::Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltrati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1267038
更新日期:2018-10-08 00:00:00
abstract:AIM:To create a predictive score for the discrimination between benign and malignant parotid tumors using elastographic parameters and to compare its sensitivity and specificity with standard ultrasound. METHODS:A total of 124 patients with parotid gland lesions for whom surgery was planned were examined using convent...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9234672
更新日期:2017-01-01 00:00:00
abstract::A novel methylamine-selective amperometric bienzyme biosensor based on recombinant primary amine oxidase isolated from the recombinant yeast strain Saccharomyces cerevisiae and commercial horseradish peroxidase is described. Two amine oxidase preparations were used: free enzyme (AMO) and covalently immobilized on the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/480498
更新日期:2014-01-01 00:00:00
abstract::Substitution rates strongly depend on their nucleotide context. One of the most studied examples is the excess of C > T mutations in the CG context in various groups of organisms, including vertebrates. Studies on the molecular mechanisms underlying this mutation regularity have provided insights into evolution, mutag...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/989410
更新日期:2013-01-01 00:00:00
abstract::Purpose. Analysis of early vascular and nerve complications of supracondylar humerus fractures in children. Material and Methods. 220 children hospitalized in the Pediatric Trauma-Orthopedic Department in the years 2004-2014. The group consisted of 143 males and 77 females. Results. Acute neurovascular complications o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2803790
更新日期:2017-01-01 00:00:00
abstract::Over the last years, a number of therapeutic strategies have emerged to promote axonal regeneration. An attractive strategy is the implantation of biodegradable and nonimmunogenic artificial scaffolds into injured peripheral nerves. In previous studies, transplantation of decellularized veins filled with spider silk f...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/906819
更新日期:2014-01-01 00:00:00
abstract::MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/642916
更新日期:2014-01-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral cancer. Inducible nitric oxide synthase (iNOS) and p53 are associated with a variety of human cancers, but their expression and interaction in OSCC have not been fully explored. In this study, we investigated the expression of iNOS and p53 in OSCC ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/637853
更新日期:2015-01-01 00:00:00
abstract::Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune syste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/143504
更新日期:2015-01-01 00:00:00
abstract::Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions and molecular mechanisms in ovarian cancer remain unclear. In this study, we found that TNKS was aberrantly overexpressed in human ovarian cancer ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2686340
更新日期:2019-02-20 00:00:00
abstract::Lipases are water-soluble enzymes that act on insoluble substrates and catalyze the hydrolysis of long-chain triglycerides. Lipases play a vital role in the food, detergent, chemical, and pharmaceutical industries. In the past, fungal lipases gained significant attention in the industries due to their substrate specif...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/154549
更新日期:2013-01-01 00:00:00
abstract::Unipotent spermatogonial stem cells (SSCs) can be transformed into ESC-like cells that exhibit pluripotency in vitro. However, except for mouse models, their characterization and their origins have remained controversies in other models including humans. This controversy has arisen primarily from the lack of the direc...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/143028
更新日期:2013-01-01 00:00:00
abstract::The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient population, implant failu...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/137287
更新日期:2015-01-01 00:00:00
abstract::Chosen aspects of examinations of inorganic gunshot particles by means of scanning electron microscopy and energy dispersive X-ray spectrometry technique are presented. The research methodology of particles was worked out, which included a precise and repeatable procedure of the automatic detection and identification ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/428038
更新日期:2014-01-01 00:00:00
abstract::Stem cell-based therapy has been considered as a promising option in the treatment of ischemic heart disease. Although stem cell administration resulted in the temporary improvement of myocardial contractility in the majority of studies, the formation of new cardiomyocytes within the injured myocardium has not been co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/7874109
更新日期:2020-03-03 00:00:00
abstract:BACKGROUND:Physical activity is associated with reduced mortality and morbidity. Cardiac rehabilitation (CR) is an effective intervention for patients with cardiovascular disease (CVD). Unfortunately, women are less likely to engage in, or sustain, regular physical activity. Objectives were to (1) describe women's guid...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/121030
更新日期:2013-01-01 00:00:00
abstract::A growing body of evidence has indicated that high-fat diet-induced nonalcoholic fatty liver disease is usually accompanied by oxidized low-density lipoprotein (ox-LDL) deposited in the liver. The current study aimed to investigate the effect of quercetin on high-fat diet-induced ox-LDL accumulation in the liver and t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/607531
更新日期:2015-01-01 00:00:00
abstract:Purpose:To evaluate the relationships between objectively measured physical activity and physical fitness among preschool children. Methods:A total of 346 participants (201 boys and 145 girls) aged 3.5-5.5 years (M = 4.5 yr, SD = 0.47) from Shanghai, China, completed physical fitness assessments, including triceps ski...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9314026
更新日期:2017-01-01 00:00:00
abstract::Objective. Duodenal atresia (DA) routinely has been corrected by laparotomy and duodenoduodenostomy with excellent long-term results. We revisited the patients with DA treated in the last 12 years (2004-2016) comparing the open and the minimally invasive surgical (MIS) approach. Methods. We divided our cohort of patie...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4585360
更新日期:2017-01-01 00:00:00
abstract::Due to alarming increase in population and rapid industrialization, drinking water quality is being deteriorated day by day in Pakistan. This review sums up the outcomes of various research studies conducted for drinking water quality status of different areas of Pakistan by taking into account the physicochemical pro...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7908183
更新日期:2017-01-01 00:00:00
abstract::Objective. To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). This prospective, observational cohort included 96 Mexican-Mestizo patients with moderate or severe rheumatoid arthritis (RA), initiating MTX or LEF, genotyped for IL-6 -...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/4193538
更新日期:2016-01-01 00:00:00
abstract::The knowledge on the genetic etiology of complex disorders largely results from the study of rare monogenic disorders. Often these common and rare diseases show phenotypic overlap, though monogenic diseases generally have a more extreme symptomatology. ABCC6, the gene responsible for pseudoxanthoma elasticum, an autos...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/648569
更新日期:2015-01-01 00:00:00
abstract::Mutations in the kinase domain of epidermal growth factor receptor (EGFR) have high levels of basal receptor phosphorylation and are associated with clinical responsiveness to Iressa in patients with nonsmall cell lung cancer (NSCLC). This study aimed to assess the feasibility of morpholino-[(124)I]IPQA derivative as ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/549359
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Hypoxia-induced autophagy and muscle wasting occur in several environmental and pathological conditions. However, the molecular mechanisms underlying the effects of the hypoxia-mimetic agent CoCl2 on autophagy and muscle atrophy are still unclear. METHODS:C2C12 myotubes were exposed to increasing concentrat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7097580
更新日期:2017-01-01 00:00:00
abstract:Aim:To address the impact of noncavity-distorting intramural fibroids on the efficacy of in vitro fertilization-embryo transfer (IVF-ET) outcomes. Methods:The PubMed, Web of Science, Embase, Cochrane Library, and China National Knowledge Infrastructure were searched systematically. A meta-analysis was performed based ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2018/8924703
更新日期:2018-09-04 00:00:00
abstract::Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2196207
更新日期:2020-11-15 00:00:00
abstract::The aim of this study is to investigate the changes in QT, QTc, and Tp-e intervals and Tp-e/QT ratio on surface electrocardiogram (ECG) signals during anaesthesia induction using propofol or sevoflurane after preoperative cefuroxime infusion. Some 120 cases of gynaecological patients are randomly divided into propofol...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8978906
更新日期:2019-01-02 00:00:00