Abstract:
:Cigarette smoke is highly toxic, and it can promote increased production of reactive species and inflammatory response and leads to liver diseases. Quercetin is a flavonoid that displays antioxidant and anti-inflammatory activities in liver diseases. This study aimed at evaluating the protective effects of quercetin on livers from mice exposed to long-term cigarette smoke exposure. Male C57BL/6 mice were divided into five groups: control (CG), vehicle (VG), quercetin (QG), cigarette smoke (CSG), quercetin, and cigarette smoke (QCSG). CSG and QCSG were exposed to cigarette smoke for sixty consecutive days; at the end of the exposures, all animals were euthanized. Mice that received quercetin daily and were exposed to cigarette smoke showed a reduced influx of inflammatory cells, oxidative stress, inflammatory reaction, and histopathological changes in the liver, compared to CSG. These results suggest that quercetin may be an effective adjuvant for treating damage to the liver due to cigarette smoke exposure.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Machado-Junior PA,Araújo NPS,Souza ABF,Castro TF,Oliveira M,Costa GP,Matos NA,Vieira PMA,Talvani A,Bezerra FS,Cangussú SDdoi
10.1155/2020/2196207subject
Has Abstractpub_date
2020-11-15 00:00:00pages
2196207eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death. In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved...
journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
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doi:10.1155/2020/8052013
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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doi:10.1155/2014/695713
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7614634
更新日期:2020-07-25 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/402536
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8421418
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7926754
更新日期:2020-12-02 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/289549
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9568351
更新日期:2018-05-23 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9358947
更新日期:2020-04-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6416187
更新日期:2019-03-25 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7908183
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/452625
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2019-05-21 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5397838
更新日期:2020-02-24 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/189197
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/759361
更新日期:2013-01-01 00:00:00
abstract::Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/981841
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/143109
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5974693
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2013/769645
更新日期:2013-01-01 00:00:00