Abstract:
:Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death. In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved. In addition, noncoding RNAs have been shown to be important regulators of gene expression. We present a general overview of what is known about these molecules and their role and dysregulation in cancer, with a special focus on the biogenesis, characteristics, and function of microRNAs. These molecules are important regulators of carcinogenesis, progression, invasion, angiogenesis, and metastases in cancer, including colorectal cancer. For this reason, miRNAs can be used as potential biomarkers for diagnosis, prognosis, and efficacy of chemotherapeutic treatments, or even as therapeutic agents, or as targets by themselves. Thus, this review highlights the importance of miRNAs in the development, progression, diagnosis, and therapy of colorectal cancer and summarizes current therapeutic approaches for the treatment of colorectal cancer.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Lizarbe MA,Calle-Espinosa J,Fernández-Lizarbe E,Fernández-Lizarbe S,Robles MÁ,Olmo N,Turnay Jdoi
10.1155/2017/7354260subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7354260eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章,评审abstract::Inflammation significantly contributes to the progression of chronic kidney disease (CKD). This study aimed to characterize Danggui Buxue Tang (DBT) renoprotection and relationship with NOD-like receptors family pyrin domain-containing 3 (NLRP3) inflammasome expression in rats with unilateral ureteral obstruction (UUO...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9368483
更新日期:2016-01-01 00:00:00
abstract::The incidence of acute kidney injury after cardiac surgery (CS-AKI) ranges from 33% to 94% and is associated with a high incidence of morbidity and mortality. The etiology is suggested to be multifactorial and related to almost all aspects of perioperative management. Numerous studies have reported the risk factors an...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/2985148
更新日期:2016-01-01 00:00:00
abstract::Neuroendocrine tumors (NETs) are tumors originated from neuroendocrine cells in the body. The localization and the detection of the extent of NETs are important for diagnosis and treatment, which should be individualized according to the tumor type, burden, and symptoms. Molecular imaging of NETs with high sensitivity...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/102819
更新日期:2013-01-01 00:00:00
abstract::It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis. Although it has been reported that DGL has a significant pain relief effect in treating oste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/187989
更新日期:2014-01-01 00:00:00
abstract::Astrocytic impairment is a pathologic feature of neuromyelitis optica spectrum disorder (NMOSD). S100B and glial fibrillary acidic protein (GFAP) are the two most commonly used astrocytic markers. The aim of this study was to evaluate whether CSF-S100B could serve as a marker of NMOSD. We enrolled 49 NMOSD patients [2...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/5381239
更新日期:2018-10-22 00:00:00
abstract::Visual motor integration (VMI) is a vital ability in childhood development, which is associated with the performance of many functional skills. By using the Beery Developmental Test Package and Executive Function Tasks, the present study explored the VMI development and its factors (visual perception, motor coordinati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6264254
更新日期:2017-01-01 00:00:00
abstract::Alterations in muscle protein turnover of the unaffected side of stroke patients could contribute to physical disability. We investigated whether hypercatabolic activity occurred in unaffected arm muscle and whether supplemented essential amino acids (EAAs) could limit muscle hypercatabolism (MH). Thirty-eight dysphag...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/964365
更新日期:2014-01-01 00:00:00
abstract::We encapsulated tumor necrosis factor-α (TNF-α), a major proinflammatory cytokine, into cholesteryl pullulan (CHP) to prepare TNF/CHP nanoparticles. In this report, we describe the immune-enhancing capability of the nanoparticles to act as a vaccine adjuvant. TNF/CHP nanoparticles showed excellent storage stability an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/471468
更新日期:2015-01-01 00:00:00
abstract::Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. AS patients also display a high prevalence of features clustered under the name of metabolic syndrome (MeS). Anti-TNF- α therapy was found to be effecti...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/860651
更新日期:2014-01-01 00:00:00
abstract::This study investigated the effect of cilostazol on proangiogenesis functions in human early endothelial progenitor cells (EPCs) in vitro and the therapeutic implication of hybrid therapy with cilostazol and human early EPCs in vivo. Cilostazol significantly increased colony-forming units and enhanced differentiation ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3639868
更新日期:2016-01-01 00:00:00
abstract:Introduction:The incidence of acute kidney injury (AKI) considerably increases the mortality rate in polytrauma victims. Undoubtedly, early identification of patients at risk is crucial for timely implementation of preventive strategies in order to improve their prognosis. Therefore, we aimed to investigate if serum ne...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2687584
更新日期:2018-11-06 00:00:00
abstract::Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3019410
更新日期:2016-01-01 00:00:00
abstract::This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of struct...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/502093
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:To investigate the anesthetic management in premature infants with retinopathy of prematurity (ROP) treated with intravitreal bevacizumab (IVB) injections. METHODS:A retrospective chart review was performed for the patients with ROP who had IVB injection. Clinical characteristics, demographic variables, ane...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/435387
更新日期:2013-01-01 00:00:00
abstract::POZ/BTB domains are widespread modules detected in a variety of different biological contexts. Here, we report a biophysical characterization of the POZ/BTB of KCTD6, a protein that is involved in the turnover of the muscle small ankyrin-1 isoform 5 and, in combination with KCTD11, in the ubiquitination and degradatio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/162674
更新日期:2013-01-01 00:00:00
abstract:Background:This study investigates the differences in the lateral profile and frontal appearance after sagittal split ramus osteotomy (SSRO) and intraoral vertical ramus osteotomy (IVRO) procedures for the correction of mandibular prognathism. Methods:Sixty patients (30 SSRO and 30 IVRO) underwent mandibular setback s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1375085
更新日期:2018-12-18 00:00:00
abstract::Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long no...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/2405351
更新日期:2018-05-22 00:00:00
abstract:Background:The aim of our study was to investigate the impact of abdominal wall reconstruction surgery on tissue anatomy and to explore how flap surgery influences the patient's immune status. Methods:Experimental abdominal wall defects were created in 8 Sus scrofa (swine) animal models. The animals were divided into ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2421585
更新日期:2017-01-01 00:00:00
abstract:Introduction:In literature, it is well documented that migration is associated with adverse perinatal outcomes in many countries over the world. But in Turkey, health care providers and obstetricians had to face the effects of migration for the first time after civil war in Syria. Hence, this situation motivated us to ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2326797
更新日期:2019-11-05 00:00:00
abstract::This study aimed to summarize the clinical features, diagnosis, and treatment of Chiari malformation type I- (CM-1-) associated syringobulbia. We performed a literature review of CM-1-associated syringobulbia in PubMed, Ovid MEDLINE, and Web of Science databases. Our concerns were the clinical features, radiologic pre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4829102
更新日期:2019-03-19 00:00:00
abstract:Background:The chromobox (CBX) proteins CBX2, CBX4, CBX6, CBX7, and CBX8, also known as Polycomb (Pc) proteins, are canonical components of the Polycomb repressive complex 1 (PRC1). Abundant evidence indicates that abnormal expression of Pc proteins is associated with a variety of tumors, but their role in the pathogen...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/6436825
更新日期:2019-05-09 00:00:00
abstract::This study evaluated the presence of Acanthamoeba species in the Puzih River watershed, which features typical subtropical monsoon climate and is located just above the Tropic of Cancer in Taiwan. The relationship between the seasonal and geographical distributions of Acanthamoeba species in this rivershed was also in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/405794
更新日期:2013-01-01 00:00:00
abstract::Tankyrase (TNKS) plays important roles in the malignancy of several cancers such as human lung tumor, breast cancer, and hepatocellular cancer. However, its exact functions and molecular mechanisms in ovarian cancer remain unclear. In this study, we found that TNKS was aberrantly overexpressed in human ovarian cancer ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2686340
更新日期:2019-02-20 00:00:00
abstract::Removal of MTA from dentin by applying 37% hydrochloric acid (HCl) to reduce microhardness and push-out bond strength. Forty dentin slices were filled with WMTA and divided into two groups (n = 20). Ten slices remained untreated while others were exposed to either HCl or phosphate buffer saline (PBS) and all samples w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/469164
更新日期:2013-01-01 00:00:00
abstract::Sun Island Bund Wetland (SIBW) is a river floodplain wetland located at the south part of Heilongjiang Province in Northeast China. An investigation of the influence of habitat type on macroinvertebrates assemblages structure was conducted in July 2016. Nine (9) sampling sites were selected based on sediment type, wat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2650678
更新日期:2019-02-13 00:00:00
abstract::Natural matrices are important sources of new antitumor and antimicrobial compounds. Species such as Laurus nobilis L. (laurel) might be used for this purpose, considering its medicinal properties. Herein, in vitro activity against human tumor cell lines, bacteria, and fungi was evaluated in enriched phenolic extracts...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/520464
更新日期:2014-01-01 00:00:00
abstract::Destruction of extracellular matrix (ECM) is one of the basic steps of tumor invasion and metastasis. Matrix metalloproteinase (MMP) 9, a kind of zinc-ion-dependent endopeptidase, can degrade almost all protein components in the ECM, destroy the histological barrier of tumor cell invasion, and play a key role in tumor...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4350783
更新日期:2020-04-15 00:00:00
abstract:Background and Aims:Concordance between transient elastography (TE) and ultrasonography (US) in assessing liver fibrosis in patients with chronic hepatitis B (CHB) and concurrent nonalcoholic fatty liver disease (NAFLD) has been rarely studied. This study aimed to evaluate the individual and combined performances of TE...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3951574
更新日期:2019-01-23 00:00:00
abstract::Cellulase from Aspergillus niger was immobilized onto β-cyclodextrin-conjugated magnetic particles by silanization and reductive amidation. The immobilized cellulase gained supermagnetism due to the magnetic nanoparticles. Ninety percent of cellulase was immobilized, but the activity of immobilized cellulase decreased...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/409103
更新日期:2015-01-01 00:00:00
abstract::Skin reaction is major problem during whole breast radiotherapy. To identify factors related to skin reactions during whole breast radiotherapy, various personal, clinical, and radiation dosimetric parameters were evaluated. From January 2012 to December 2013, a total of 125 patients who underwent breast conserving su...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3656574
更新日期:2016-01-01 00:00:00