Single nucleotide polymorphism in the promoter of the human interleukin-13 gene is associated with asthma in Malaysian adults.

Abstract:

:Asthma susceptibility genes are mapped to a region on human chromosome 5q31-q33, which contains a cluster of proinflammatory cytokine genes such as interleukin-13 (IL-13), which is associated with asthma. This study investigated the allele frequencies of two single nucleotide polymorphisms (SNPs) (-1111C>T and 4257C>A) in the IL-13 gene between asthmatics and healthy volunteers as well as the relationship between these SNPs and IL-13 production. DNA extracted from buffy coat of asthmatic and control subjects was genotyped using the PCR-RFLP method. Amount of IL-13 produced by mitogen-stimulated peripheral blood leucocytes PBLs (PBLs) was determined by ELISA. The frequencies of the -1111C and 4257G wild-type alleles were 0.52 and 0.55 in asthmatics and were 0.67 and 0.56 in controls. A significant (P < 0.05) association was found between genotype and allele frequencies of SNP at position -1111C>T between asthmatic and control groups (OR, 1.810; 95% CI = 1.184 to 2.767; P < 0.05). The mitogen-stimulated PBLs from asthmatics produced higher amounts of IL-13 production (P < 0.001). The 4257GA heterozygous and 4257AA homozygous mutant alleles were associated with higher IL-13 production in asthmatics (P < 0.05). Our results show that the -1111T mutant allele are associated with asthma and the 4257A mutant alleles are associated with elevated IL-13 production.

journal_name

Biomed Res Int

authors

Radhakrishnan AK,Raj VL,Tan LK,Liam CK

doi

10.1155/2013/981012

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

981012

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

杂志文章
  • Factors Affecting the Foveal Avascular Zone Area in Healthy Eyes among Young Chinese Adults.

    abstract:Purpose:To evaluate the influence of systemic and ocular factors on the foveal avascular zone (FAZ) area in young Chinese subjects' healthy eyes. Methods:The current observational, cross-sectional study included 344 eyes from 172 healthy individuals (103 women, 69 men). Optical coherence tomography angiography realize...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/7361492

    authors: Zhou Y,Zhou M,Gao M,Liu H,Sun X

    更新日期:2020-03-24 00:00:00

  • Biofilm Formation by Helicobacter pylori and Its Involvement for Antibiotic Resistance.

    abstract::Bacterial biofilms are communities of microorganisms attached to a surface. Biofilm formation is critical not only for environmental survival but also for successful infection. Helicobacter pylori is one of the most common causes of bacterial infection in humans. Some studies demonstrated that this microorganism has b...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/914791

    authors: Yonezawa H,Osaki T,Kamiya S

    更新日期:2015-01-01 00:00:00

  • Advantages and Limitations of Direct PCR Amplification of Bacterial 16S-rDNA from Resected Heart Tissue or Swabs Followed by Direct Sequencing for Diagnosing Infective Endocarditis: A Retrospective Analysis in the Routine Clinical Setting.

    abstract::Infective endocarditis (IE) is a life-threatening disease that is associated with high morbidity and mortality. Its long-term prognosis strongly depends on a timely and optimized antibiotic treatment. Therefore, identification of the causative pathogen is crucial and currently based on blood cultures followed by chara...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7923874

    authors: Maneg D,Sponsel J,Müller I,Lohr B,Penders J,Madlener K,Hunfeld KP

    更新日期:2016-01-01 00:00:00

  • Pulmonary Rehabilitation Can Improve the Functional Capacity and Quality of Life for Pneumoconiosis Patients: A Systematic Review and Meta-Analysis.

    abstract::This study evaluated the efficacy and safety of pulmonary rehabilitation (PR) for pneumoconiosis. We systematically searched PubMed, Embase, The Cochrane Library, Web of Science, SinoMed, CNKI, VIP databases and Wanfang Data from their inception to June 1, 2019. A systematic review and meta-analysis of randomized cont...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/6174936

    authors: Zhao H,Xie Y,Wang J,Li X,Li J

    更新日期:2020-07-28 00:00:00

  • MicroRNAs: new regulators of Toll-like receptor signalling pathways.

    abstract::Toll-like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are responsible for the innate immune responses via signalling pathways to provide effective host defence against pathogen infections. However, TLR-signalling pathways are also likely to stringently regulate tissue maintenance and h...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/945169

    authors: He X,Jing Z,Cheng G

    更新日期:2014-01-01 00:00:00

  • Heteroplasmy Detection of Mitochondrial DNA A3243G Mutation Using Quantitative Real-Time PCR Assay Based on TaqMan-MGB Probes.

    abstract::A point mutation of mitochondrial DNA (mtDNA) at nucleotide position 3243 A to G (mt.3243A>G) is involved in many common diseases, including maternally inherited diabetes and deafness (MIDD) and mitochondrial encephalomyopathy, lactic acidosis with stroke-like episodes (MELAS). However, the mutant level of mt.3243A>G ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/1286480

    authors: Rong E,Wang H,Hao S,Fu Y,Ma Y,Wang T

    更新日期:2018-11-13 00:00:00

  • Placental ABCA1 Expression Is Increased in Spontaneous Preterm Deliveries Compared with Iatrogenic Preterm Deliveries and Term Deliveries.

    abstract:OBJECTIVE:Abnormal expression of ABCA1 and ABCG1 in the placenta can elicit lipid metabolism disorder and adverse pregnancy outcomes. However, whether it is associated with preterm delivery remains unclear. Our present study aimed to evaluate the relationship between abnormal expression of ABCA1 or ABCG1 and preterm de...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2017/8248094

    authors: Cheng-Mao X,Yan L,Li L,Hua J,Xiao-Ju W,Jie-Wen Z

    更新日期:2017-01-01 00:00:00

  • The Assessment of the Integrated Antioxidant System of the Body in the Course of Radon Therapy: A Pilot Study.

    abstract:Introduction:The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/6038106

    authors: Kuciel-Lewandowska J,Gnus J,Pawlik-Sobecka L,Płaczkowska S,Kokot I,Kasperczak M,Paprocka-Borowicz M

    更新日期:2018-01-02 00:00:00

  • Histological, histochemical, and protein changes after induced malocclusion by occlusion alteration of Wistar rats.

    abstract::Although disorders of the stomatognathic system are common, the mechanisms involved are unknown. Our objective was to study the changes in the masseter muscles after unilateral exodontia. Molar extraction was performed on Wistar rats (left side), and the animals were sacrificed after either 14 or 26 days. The masseter...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/563463

    authors: Guerra Cde S,Carla Lara Pereira Y,Issa JP,Luiz KG,Guimarães EA,Gerlach RF,Iyomasa MM

    更新日期:2014-01-01 00:00:00

  • Evaluation of the Effectiveness and Implementation of an Adapted Evidence-Based Mammography Intervention for African American Women.

    abstract::Breast cancer mortality disparities continue, particularly for uninsured and minority women. A number of effective evidence-based interventions (EBIs) exist for addressing barriers to mammography screening; however, their uptake and use in community has been limited. Few cancer-specific studies have evaluated adapted ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/240240

    authors: Highfield L,Hartman MA,Bartholomew LK,Balihe P,Ausborn VA

    更新日期:2015-01-01 00:00:00

  • Horizontally Transferred Genetic Elements in the Tsetse Fly Genome: An Alignment-Free Clustering Approach Using Batch Learning Self-Organising Map (BLSOM).

    abstract::Tsetse flies (Glossina spp.) are the primary vectors of trypanosomes, which can cause human and animal African trypanosomiasis in Sub-Saharan African countries. The objective of this study was to explore the genome of Glossina morsitans morsitans for evidence of horizontal gene transfer (HGT) from microorganisms. We e...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/3164624

    authors: Nakao R,Abe T,Funayama S,Sugimoto C

    更新日期:2016-01-01 00:00:00

  • Antagonistic interactions of "Ya-Sa-Marn-Phlae" ethanol extract in combination with topical antiseptics against clinical isolates of Staphylococcus aureus.

    abstract::This investigation was aimed at assessing a possible interaction of a traditional Thai herbal recipe, "Ya-Sa-Marn-Phlae (YSMP)," used for wound treatments with topical antiseptics, povidone-iodine (PI) solution and hydrogen peroxide (H2O2), and effects of THR-SK010 alone and the combinations on Staphylococcus aureus. ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/867603

    authors: Chusri S,Tongrod S,Chokpaisarn J,Limsuwan S,Voravuthikunchai SP

    更新日期:2014-01-01 00:00:00

  • miR-331-3p Inhibits Inflammatory Response after Intracerebral Hemorrhage by Directly Targeting NLRP6.

    abstract:Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/6182464

    authors: Nie H,Hu Y,Guo W,Wang W,Yang Q,Dong Q,Tang Y,Li Q,Tang Z

    更新日期:2020-06-07 00:00:00

  • Automatic Segmentation of Ultrasound Tomography Image.

    abstract::Ultrasound tomography (UST) image segmentation is fundamental in breast density estimation, medicine response analysis, and anatomical change quantification. Existing methods are time consuming and require massive manual interaction. To address these issues, an automatic algorithm based on GrabCut (AUGC) is proposed i...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2059036

    authors: Wu S,Yu S,Zhuang L,Wei X,Sak M,Duric N,Hu J,Xie Y

    更新日期:2017-01-01 00:00:00

  • The Effect of Longer versus Shorter Duration of Supervised Physiotherapy after ACL Reconstruction on the Vertical Jump Landing Limb Symmetry.

    abstract::The study investigated the vertical jump landing limb symmetry after ACLR between a group of patients receiving a longer supervised physiotherapeutic procedure and following a shorter supervised physiotherapy. Group I (n = 20) and Group II (n = 15) were males averagely 30 weeks after ACLR. The time since ACLR in both ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/7519467

    authors: Królikowska A,Czamara A,Szuba Ł,Reichert P

    更新日期:2018-04-23 00:00:00

  • Effects of the combined PDL/Nd:YAG laser on surgical scars: vascularity and collagen changes evaluated by in vivo confocal microscopy.

    abstract::The aim of this study was to investigate the efficacy of the sequential combined 585 nm PDL and the 1064 nm neodymium:yttrium-aluminium-garnet laser (PDL/Nd:YAG) in the treatment of surgical scars and to evaluate the short-term effects by in vivo confocal microscopy (RCM) and the long-term effects by clinical assessme...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2014/204532

    authors: Vas K,Gaál M,Varga E,Kovács R,Bende B,Kocsis A,Kemény L

    更新日期:2014-01-01 00:00:00

  • Estimation Accuracy of Root Canal Curvatures from Different Dental Diagnostic Imaging Techniques: An In Vitro Experimental Study.

    abstract::In clinical endodontics, preoperative estimation of root canal curvature is crucial regarding the prevention of iatrogenic errors. Reproduction of the two-dimensional radiographic images causes certain proximal view curvatures not seen. Therefore, the present study is aimed at investigating the degree of root canal cu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2021/6699635

    authors: Faraj BM

    更新日期:2021-01-13 00:00:00

  • Disease modifying therapies for Alzheimer's disease targeting Aβ oligomers: implications for therapeutic mechanisms.

    abstract::Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease. However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive. Here, we showed that the anti-AβO antibody (monoclonal 72D9)...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/984041

    authors: Matsubara E,Takamura A,Okamoto Y,Oono H,Nakata T,Wakasaya Y,Kawarabayashi T,Shoji M

    更新日期:2013-01-01 00:00:00

  • Improving Physical Fitness of Children with Intellectual and Developmental Disabilities through an Adapted Rhythmic Gymnastics Program in China.

    abstract:Background:Health-related physical fitness is vital for children with intellectual and developmental disabilities (IDD) to gain healthier lives. The adapted rhythmic gymnastics (ARG) program was designed for children with IDD and is aimed at testing the effects of the exercise program on children's physical fitness. M...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/2345607

    authors: Xu C,Yao M,Kang M,Duan G

    更新日期:2020-08-10 00:00:00

  • Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine.

    abstract::Cancer treatment is undergoing a significant revolution from "one-size-fits-all" cytotoxic therapies to tailored approaches that precisely target molecular alterations. Precision strategies for drug development and patient stratification, based on the molecular features of tumors, are the next logical step in a long h...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/9620870

    authors: Coyle KM,Boudreau JE,Marcato P

    更新日期:2017-01-01 00:00:00

  • Potassium Channel Activation Is Involved in the Cardiovascular Effects Induced by Freeze Dried Syzygium jambolanum (Lam.) DC Fruit Juice.

    abstract::This work aimed to explore the cardiovascular effects induced by freeze-dried juice from Syzygium jambolanum (Lam.) DC fruits (JSJ). JSJ presented high polyphenol content and steroids. HPLC analysis revealed that 2,5-dihydroxybenzoic and caffeic acid were present in higher amounts in the JSJ extract. In rat, JSJ induc...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4827461

    authors: Assis KS,Araújo IGA,de Azevedo FLAA,Maciel PMP,Machado Calzerra NT,da Silva TAF,Assis VL,de Vasconcelos AP,Santos CAG,Meireles BRLA,Cordeiro AMTM,Araújo DAM,Ribeiro TP,Medeiros IA

    更新日期:2018-10-08 00:00:00

  • Ultrasound-mediated local drug and gene delivery using nanocarriers.

    abstract::With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imagi...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/963891

    authors: Zhou QL,Chen ZY,Wang YX,Yang F,Lin Y,Liao YY

    更新日期:2014-01-01 00:00:00

  • In vitro ultrastructural changes of MCF-7 for metastasise bone cancer and induction of apoptosis via mitochondrial cytochrome C released by CaCO3/Dox nanocrystals.

    abstract::Bones are the most frequent site for breast cancer cells to settle and spread (metastasise); bone metastasis is considered to have a substantial impact on the quality of patients with common cancers. However, majority of breast cancers develop insensitivity to conventional chemotherapy which provides only palliation a...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/391869

    authors: Kamba AS,Ismail M,Ibrahim TA,Zakaria ZA,Gusau LH

    更新日期:2014-01-01 00:00:00

  • Acinetobacter baumannii Infection in Transfusion Dependent Thalassemia Patients with Sepsis.

    abstract:PURPOSE:To identify the Acinetobacter baumannii infection among transfusion dependent thalassemia patients. METHODS:A quantitative approach was employed to assess Acinetobacter baumannii infection in transfusion dependent thalassemia patients. Samples were collected from 916 patients, which have shown bacterial growth...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2351037

    authors: Abdul Rasheed M,Alzahrani FM,Sattar Shaikh S

    更新日期:2017-01-01 00:00:00

  • The roles of hyaluronan/RHAMM/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression.

    abstract::Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts. Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin. ECMs are complicated structures that s...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/929531

    authors: Nikitovic D,Kouvidi K,Karamanos NK,Tzanakakis GN

    更新日期:2013-01-01 00:00:00

  • Surface modifications of dental ceramic implants with different glass solder matrices: in vitro analyses with human primary osteoblasts and epithelial cells.

    abstract::Ceramic materials show excellent esthetic behavior, along with an absence of hypersensitivity, making them a possible alternative implant material in dental surgery. However, their surface properties enable only limited osseointegration compared to titanium implants. Within this study, a novel surface coating techniqu...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/742180

    authors: Markhoff J,Mick E,Mitrovic A,Pasold J,Wegner K,Bader R

    更新日期:2014-01-01 00:00:00

  • Detecting Genetic Interactions for Quantitative Traits Using m-Spacing Entropy Measure.

    abstract::A number of statistical methods for detecting gene-gene interactions have been developed in genetic association studies with binary traits. However, many phenotype measures are intrinsically quantitative and categorizing continuous traits may not always be straightforward and meaningful. Association of gene-gene inter...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/523641

    authors: Yee J,Kwon MS,Jin S,Park T,Park M

    更新日期:2015-01-01 00:00:00

  • The Roles of Hedgehog Signaling in Upper Lip Formation.

    abstract::Craniofacial development consists of a highly complex sequence of the orchestrated growth and fusion of facial processes. It is also known that craniofacial abnormalities can be detected in 1/3 of all patients with congenital diseases. Within the various craniofacial abnormalities, orofacial clefting is one of the mos...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/901041

    authors: Kurosaka H

    更新日期:2015-01-01 00:00:00

  • Varicocele Repair Improves Testicular Histology in Men with Nonobstructive Azoospermia.

    abstract:OBJECTIVE:To determine the histopathological differences after varicocele repair in testicular tissue in males with nonobstructive azoospermia. METHODS:Between 2009 and 2014, 45 men with complete azoospermia and palpable varicocele, presenting with primary infertility of at least 1 year, undergoing varicocele repair a...

    journal_title:BioMed research international

    pub_type: 临床试验,杂志文章

    doi:10.1155/2015/709452

    authors: Ustuner M,Yilmaz H,Yavuz U,Ciftci S,Saribacak A,Aynur BS,Yasar H,Culha MM

    更新日期:2015-01-01 00:00:00

  • Physiological and Neural Adaptations to Eccentric Exercise: Mechanisms and Considerations for Training.

    abstract::Eccentric exercise is characterized by initial unfavorable effects such as subcellular muscle damage, pain, reduced fiber excitability, and initial muscle weakness. However, stretch combined with overload, as in eccentric contractions, is an effective stimulus for inducing physiological and neural adaptations to train...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/193741

    authors: Hedayatpour N,Falla D

    更新日期:2015-01-01 00:00:00