Disease modifying therapies for Alzheimer's disease targeting Aβ oligomers: implications for therapeutic mechanisms.

abstract：:In spite of the declining incidence of gastric cancer (GC) in recent years, the mortality rate is still high. The asymptomatic nature and nonspecific clinical manifestations combined with the lack of efficient screening programs delay the diagnosis of GC. Therefore, the prevalence of advanced gastric cancer (AGC) has ...

journal_title：BioMed research international

authors： Xu W,Beeharry MK,Liu W,Yan M,Zhu Z

更新日期：2016-01-01 00:00:00

abstract：Objective:ANGPTL7 is a member of the angiogenin-like protein family. Compared to other members, ANGPTL7 is the least known. Recent studies have explored the relationship between ANGPTL7 and multiple pathological processes and diseases. However, there is no research about ANGPTL7 in neonates. This study was designed to ...

journal_title：BioMed research international

authors： Xia X,Ren Z,Yan L,Zheng X,Yang H,Kang M,Yan H,Zhong Z,Xu F,Miao J,Wang J,Li Y,Wei W,Yang J

更新日期：2020-11-27 00:00:00

abstract：:Angiopoietin-like protein 4 (ANGPTL4) is widely known as a key regulator of lipid metabolism. We investigated the relationship between ANGPTL4 expression in serum or urine and blood lipid or urine protein levels of patients with hyperlipidemia- (HL-) related proteinuria. Sixty-eight patients with HL-related proteinuri...

journal_title：BioMed research international

authors： Gao X,Zhang M,Feng W,Xu Z,Wang Y,Shi L,Zhang J

更新日期：2020-03-23 00:00:00

abstract：:Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...

journal_title：BioMed research international

authors： Lee H,Kong SY,Sohn JY,Shim H,Youn HS,Lee S,Kim HJ,Eom HS

更新日期：2014-01-01 00:00:00

abstract：:In this study, we prepared PTX-loaded mesoporous hollow SnO2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showe...

journal_title：BioMed research international

authors： Lv H,Wu C,Liu X,Bai A,Cao Y,Shang W,Hu L,Liu Y

更新日期：2018-11-25 00:00:00

abstract：:Introduction. The aim of the present study was to determine the closeness of agreement between a self-reported and an objective measure of physical activity in low back pain patients and healthy controls. Beyond, influencing factors on overestimation were identified. Methods. 27 low back pain patients and 53 healthy c...

journal_title：BioMed research international

authors： Schaller A,Rudolf K,Dejonghe L,Grieben C,Froboese I

更新日期：2016-01-01 00:00:00

abstract：:The cytosolic isozyme of phosphoenolpyruvate carboxykinase (PCK1) was the first rate-limiting enzyme in the gluconeogenesis pathway, which exerted a critical role in maintaining the blood glucose levels. PCK1 has been established to be involved in various physiological and pathological processes, including glucose met...

journal_title：BioMed research international

authors： Yuan Y,Lin JY,Cui HJ,Zhao W,Zheng HL,Jiang ZW,Xiong XD,Xu S,Liu XG

更新日期：2020-02-12 00:00:00

abstract：:We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures. The resulting average accuracy of classification has been proven to be above 95%, whi...

journal_title：BioMed research international

authors： Druzhkov P,Zolotykh N,Meyerov I,Alsaedi A,Shutova M,Ivanchenko M,Zaikin A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Recently antiangiogenic therapy with bevacizumab has shown a high but transient efficacy in glioblastoma (GBM). Indeed, GBM is one of the most angiogenic human tumors and endothelial proliferation is a hallmark of the disease. We therefore hypothesized that tumor cells may participate in endothelial prolifer...

journal_title：BioMed research international

authors： El Hallani S,Colin C,El Houfi Y,Idbaih A,Boisselier B,Marie Y,Ravassard P,Labussière M,Mokhtari K,Thomas JL,Delattre JY,Eichmann A,Sanson M

更新日期：2014-01-01 00:00:00

abstract：:The knowledge on the genetic etiology of complex disorders largely results from the study of rare monogenic disorders. Often these common and rare diseases show phenotypic overlap, though monogenic diseases generally have a more extreme symptomatology. ABCC6, the gene responsible for pseudoxanthoma elasticum, an autos...

journal_title：BioMed research international

authors： De Vilder EY,Hosen MJ,Vanakker OM

更新日期：2015-01-01 00:00:00

abstract：:The complete chloroplast genome of J. flava, an endangered medicinal plant in Saudi Arabia, was sequenced and compared with cp genome of three Acanthaceae species to characterize the cp genome, identify SSRs, and also detect variation among the cp genomes of the sampled Acanthaceae. NOVOPlasty was used to assemble the...

journal_title：BioMed research international

authors： Yaradua SS,Alzahrani DA,Albokhary EJ,Abba A,Bello A

更新日期：2019-08-06 00:00:00

abstract：:The use of modern surgical dressings to prevent wound complications and surgical site infection (SSI) after minimally invasive total knee arthroplasty (MIS-TKA) is lacking. In a prospective, randomized, controlled study, 240 patients were randomized to receive either AQUACEL Ag Surgical dressing (study group) or a sta...

journal_title：BioMed research international

authors： Kuo FC,Chen B,Lee MS,Yen SH,Wang JW

更新日期：2017-01-01 00:00:00

abstract：:As emerging tick born rickettsial diseases caused by A. phagocytophilum and E. chaffeensis, anaplasmosis and ehrlichiosis have become a serious threat to human and animal health throughout the world. In particular, in China, an unusual transmission of nosocomial cases of human granulocytic anaplasmosis occurred in Anh...

journal_title：BioMed research international

authors： Zhang L,Liu H,Xu B,Zhang Z,Jin Y,Li W,Lu Q,Li L,Chang L,Zhang X,Fan D,Cao M,Bao M,Zhang Y,Guan Z,Cheng X,Tian L,Wang S,Yu H,Yu Q,Wang Y,Zhang Y,Tang X,Yin J,Lao S,Wu B,Li J,Li W,Xu Q,Shi Y,Huan

更新日期：2014-01-01 00:00:00

abstract：:Brachial plexus injury often involves traumatic root avulsion resulting in permanent paralysis of the innervated muscles. The lack of sufficient regeneration from spinal motoneurons to the peripheral nerve (PN) is considered to be one of the major causes of the unsatisfactory outcome of various surgical interventions ...

journal_title：BioMed research international

authors： Su H,Yuan Q,Qin D,Yang X,Wong WM,So KF,Wu W

更新日期：2014-01-01 00:00:00

abstract：:Aim. To explore the effects of curcumin on phosphate carrier (PiC) and its role in protection against doxorubicin induced myocyte toxicity. Methods. Using H9c2 cell line, the cardiotoxic effect of doxorubicin and its mitigation by curcumin were studied. H9c2 cells were cultured with doxorubicin and/or curcumin at vari...

journal_title：BioMed research international

authors： Junkun L,Erfu C,Tony H,Xin L,Sudeep KC,Mingliang Z,Yanqin W,XiangQian Q

更新日期：2016-01-01 00:00:00

abstract：:The increased use of imaging modalities in the last years has led to a greater incidence in depicting abdominal incidental lesions. In particular, "incidentalomas" of the kidney are discovered in asymptomatic patients or patients who suffer from diseases not directly related to the kidneys. The aim of this paper is to...

journal_title：BioMed research international

authors： Mazziotti S,Cicero G,D'Angelo T,Marino MA,Visalli C,Salamone I,Ascenti G,Blandino A

更新日期：2017-01-01 00:00:00

abstract：:This study aimed to compare within-subject blood pressure (BP) variabilities from different measurement techniques. Cuff pressures from three repeated BP measurements were obtained from 30 normotensive and 30 hypertensive subjects. Automatic BPs were determined from the pulses with normalised peak amplitude larger tha...

journal_title：BioMed research international

authors： Yang F,Chen F,Zhu M,Chen A,Zheng D

更新日期：2017-01-01 00:00:00

abstract：:Exposure to a variety of environmental factors such as salinity, drought, metal toxicity, extreme temperature, air pollutants, ultraviolet-B (UV-B) radiation, pesticides, and pathogen infection leads to subject oxidative stress in plants, which in turn affects multiple biological processes via reactive oxygen species ...

journal_title：BioMed research international

authors： Xie X,He Z,Chen N,Tang Z,Wang Q,Cai Y

更新日期：2019-05-08 00:00:00

abstract：:The objective of this study is to introduce a method using a percutaneous full-endoscopic interlaminar approach via a surrounding nerve root discectomy (SNRD) operative route that involves removing the protrusive disc via both the shoulder and the axilla of the corresponding nerve root for the treatment of ventral-typ...

journal_title：BioMed research international

authors： Shi C,Kong W,Liao W,Lu Y,Fu Y,Wen H,Du Q,Wu F

更新日期：2018-02-12 00:00:00

abstract：:This review examines studies of radiofrequency ablation (RFA) of nonsmall cell lung cancer (NSCLC) and discusses the role of RFA in treatment of early-stage NSCLC. RFA is usually performed under local anesthesia with computed tomography guidance. RFA-associated mortality, while being rare, can result from pulmonary ev...

journal_title：BioMed research international

authors： Hiraki T,Gobara H,Iguchi T,Fujiwara H,Matsui Y,Kanazawa S

更新日期：2014-01-01 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a metabolic hormone with multiple beneficial effects on lipid and glucose homeostasis. Previous study demonstrated that FGF21 might be one of the Sp1 target genes. However, the transcriptional role of Sp1 on FGF21 in adipose tissue and liver has not been reported. In this study, ...

journal_title：BioMed research international

authors： Chen S,Li H,Zhang J,Jiang S,Zhang M,Xu Y,Dong K,Yang Y,Fang Q,Jia W

更新日期：2017-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with the highest incidence worldwide. HNSCC is often diagnosed at advanced stages, incurring significant high mortality and morbidity. The use of saliva, as a noninvasive tool for the diagnosis of cancer, has recently increased. Salivary mic...

journal_title：BioMed research international

authors： Salazar-Ruales C,Arguello JV,López-Cortés A,Cabrera-Andrade A,García-Cárdenas JM,Guevara-Ramírez P,Peralta P,Leone PE,Paz-Y-Miño C

更新日期：2018-11-21 00:00:00

abstract：:Ambient assisted living (AAL) aims to help older persons "age-in-place" and manage everyday activities using intelligent and pervasive computing technology. AAL research, however, has yet to explore how AAL might support or collaborate with informal care partners (ICPs), such as relatives and friends, who play importa...

journal_title：BioMed research international

authors： Hwang AS,Truong KN,Cameron JI,Lindqvist E,Nygård L,Mihailidis A

更新日期：2015-01-01 00:00:00

abstract：:Adipose-derived stem cells (ADSCs) are an abundant cell source and provide an easy way to harvest mesenchymal stem cells, which are the focus of considerable attention in regenerative medicine. Electric fields (EF) play roles in many biological events and have been reported to promote cell proliferation, migration, an...

journal_title：BioMed research international

authors： Jin M,Zhang Y,Bian Y,Qi R,Gao X

更新日期：2020-11-06 00:00:00

abstract：:In this paper, differences between multichannel EEG signals of artists and nonartists were analyzed during visual perception and mental imagery of some paintings and at resting condition using approximate entropy (ApEn). It was found that ApEn is significantly higher for artists during the visual perception and the me...

journal_title：BioMed research international

authors： Shourie N,Firoozabadi M,Badie K

更新日期：2014-01-01 00:00:00

abstract：Objective:Comparison of outcomes between RIRS with vacuum-assisted ureteral access sheath (V-UAS) and MPCNL in the treatment of renal stone. Materials and Methods:28 patients with 2-4 cm renal stone were treated using RIRS with 14/16 F V-UAS. The outcomes were compared to those who underwent MPCNL with 16 F Amplatz sh...

journal_title：BioMed research international

authors： Lai D,He Y,Li X,Chen M,Zeng X

更新日期：2020-05-14 00:00:00

abstract：:Background and Purposes. The 320-detector row CT scanner enables visualization of whole-brain hemodynamic information (dynamic CT angiography (CTA) derived from CT perfusion scans). However, arterial image quality in dynamic CTA (dCTA) is inferior to arterial image quality in standard CTA. This study evaluates whether...

journal_title：BioMed research international

authors： Ghariq E,Mendrik AM,Willems PW,Joemai RM,Ghariq E,Vonken EJ,van Osch MJ,van Walderveen MA

更新日期：2014-01-01 00:00:00

abstract：:A diffusion theory-based, all-physical ab initio protein folding simulation is described and applied. The model is based upon the drift and diffusion of protein substructures relative to one another in the multiple energy fields present. Without templates or statistical inputs, the simulations were run at physiologic ...

journal_title：BioMed research international

authors： Kang Y,Fortmann CM

更新日期：2013-01-01 00:00:00

abstract：:The aim of the study was to find out whether peripheral blood leukocyte adiponectin receptors 1 and 2 (AdipoR1, AdipoR2) protein expression patterns (flow cytometry) differ between the primary hypertension children (n = 57) and healthy controls (n = 19) and if their expression levels are related to selected clinical p...

journal_title：BioMed research international

authors： Gackowska L,Litwin M,Trojanek J,Eljaszewicz A,Kubiszewska I,Niemirska A,Wierzbicka A,Michalkiewicz J

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Macrosomia has become a worldwide problem with the rapid economic growth in the past few years. However, the detailed mechanism of how the macrosomia happened remains unknown. Growing evidence indicates that miRNAs are involved in maintaining metabolic homeostasis. We hypothesized that serum miRNAs are poten...

journal_title：BioMed research international

authors： Hu L,Han J,Zheng F,Ma H,Chen J,Jiang Y,Jiang H

更新日期：2014-01-01 00:00:00