Abstract:
:This work aimed to explore the cardiovascular effects induced by freeze-dried juice from Syzygium jambolanum (Lam.) DC fruits (JSJ). JSJ presented high polyphenol content and steroids. HPLC analysis revealed that 2,5-dihydroxybenzoic and caffeic acid were present in higher amounts in the JSJ extract. In rat, JSJ induces hypotension and vasodilatation in mesenteric arteries, with or without vascular endothelium. JSJ-mediated vasodilation response against contractions induced with KCl (60 mM) depolarizing solution was significantly lower than the responses induced by JSJ when evaluated against phenylephrine-induced contractions. To investigate the involvement of potassium channels we used Tyrode's solution with KCl (20 mM) or tetraethylammonium (1.0, 3.0, or 5.0 mM). In these conditions JSJ-induced effects were significantly attenuated. To investigate the potassium channel subtypes involved in the response, we used 4-aminopyridine, glibenclamide, BaCl2, and iberiotoxin. In the presence (simultaneous) of different potassium channel blockers we observed a significant attenuation of JSJ-induced effect. Inhibition was also observed when using BaCl2, glibenclamide, or 4-aminopyridine, separately. However, incubation with iberiotoxin did not promote changes in either maximum effect, or potency. We also evidenced a discrete participation of CaV channels in the JSJ-induced vasorelaxant effect. In addition, patch-clamp studies demonstrated that JSJ could activate potassium channels. In conclusion, JSJ promotes hypotension and vasorelaxation in rats, involving, at least, the activation of potassium channels.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Assis KS,Araújo IGA,de Azevedo FLAA,Maciel PMP,Machado Calzerra NT,da Silva TAF,Assis VL,de Vasconcelos AP,Santos CAG,Meireles BRLA,Cordeiro AMTM,Araújo DAM,Ribeiro TP,Medeiros IAdoi
10.1155/2018/4827461subject
Has Abstractpub_date
2018-10-08 00:00:00pages
4827461eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章abstract::Exposure to engineered nanoparticles (NPs) and to ambient particles (PM) has increased significantly. During the last decades the application of nano-objects to daily-life goods and the emissions produced in highly urbanized cities have considerably augmented. As a consequence, the understanding of the possible effect...
journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00