Abstract:
Background:In vitro fertilization and embryo transfer (IVF-ET) technology has been widely used in the therapy of refractory infertility. Previous studies showed that acupuncture can effectively increase the clinical pregnancy rate of IVF-ET. However, the molecular mechanism is unknown. Materials and Methods:In this study, we performed whole transcriptome sequencing for endometrial samples from infertile women who underwent acupuncture and moxibustion therapy or not. Differentially expressed noncoding RNAs (ncRNAs) and mRNAs were identified and their functions were predicted. Besides, a competitive endogenous RNA network was constructed to further interpret the molecular mechanism of acupuncture and moxibustion therapy on infecund patients. In addition, real-time PCR was applied to validate the RNA-seq results. Results:We identified 317 differentially expressed mRNAs and 82 ncRNAs in acupuncture and moxibustion therapy group compared with control group. Functional enrichment analysis suggested that these genes were significantly enriched in GO-BP terms associated with cellular transport, such as ATP hydrolysis coupled proton transport, vacuolar acidification, transferrin transport, and proton transport and metabolic process, including small molecule metabolic process and metabolic process. Pathway enrichment analysis enriched 11 terms, including oxidative phosphorylation, synaptic vesicle cycle, mineral absorption, and metabolic pathways. Four of five selected differentially expressed genes were validated by real-time PCR. Conclusion:Our results suggested that acupuncture and moxibustion therapy might increase the pregnancy rate of patients undergoing IVF-ET by the regulation of ncRNAs.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Cheng J,Jin X,Shen J,Mu Y,Li Q,Xia L,Gao Y,Xia Ydoi
10.1155/2019/4179617subject
Has Abstractpub_date
2019-05-28 00:00:00pages
4179617eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-12-18 00:00:00
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更新日期:2015-01-01 00:00:00